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Om mig

Jag är professor i obstetrik och gynekologi, med särskild inriktning på reproduktionsmedicin, Institutionen för kvinnors och barns hälsa, Karolinska Institutet och överläkare med medicinskt ansvar för gynekologisk endokrinologi vid PO Gynekologi och Reproduktionsmedicin, Karolinska Universitetssjukhuset, Stockholm, Sverige.

Utbildning

Läkarexamen, Karolinska Institutet 1984
Med dr, Institutionen för farmakologi, Karolinska Institutet 1989
Legitimerad läkare, Karolinska Institutet 1993
Docent i experimentell obstetrik och gynekologi 1995
Specialist i obstetrik och gynekologi 2000
Överläkare i obstetrik och gynekologi, ansvarig för gynekologisk endokrinologi sedan 2002
Professor i obstetrik och gynekologi, med särskild inriktning på reproduktionsmedicin, Karolinska Institutet 2007

Forskningsbeskrivning

Min forskning är inriktad på störningar i reproduktionsförmågan och könsutvecklingen hos kvinnor. Det övergripande målet är att förbättra diagnos, fertilitet och långsiktig hälsa hos kvinnor med hård fysisk träning, fetma, polycystiskt ovariesyndrom (PCOS), primär ovariell insufficiens (POI) och påverkad könsutveckling (DSD). Forskningen är translationell från experimentella in vitro studier av endometriefunktion till randomiserade kontrollerade hormonbehandlingsstudier och populationbaserade epidemiologiska undersökningar som utförs i samarbete med nationella och internationella forskningsnätverk. Den kliniska forskningen utförs på Kvinnohälsan, Karolinska Universitetssjukhuset, Solna och den experimentella delen vid BioClinicum, Karolinska Institutet, Solna.

Pedagogiska meriter

Jag är kursansvarig för den studentvalda kursen (SVK) Kvinnor, könshormoner och fruktsamhet (7.5 hp) på Läkarprogrammet Karolinska Institutet. Jag är också kursansvarig för specialistutbildningskursen Reproduktionsendokrinologi och infertilitet, inom Svensk förening för obstetrik och gynekologi (SFOG). Jag har författat mer än 25 bokkapitel om kvinnor och idrott, polycystiskt ovariesyndrom, amenorré, aptitreglering och ätstörningar.

Akademiska priser och utmärkelser

Konungens Serafimermedalj, 8: e storlek, 2018
SCIF:s stora forskningspris i idrottsvetenskap 2016
Livmedikus sedan 2009
Styrelseledamot i the International Society of Gynecological Endocrinology (ISGE)
Styrelseledamot i European Menopaus and Andropause Society (EMAS)
Medicinsk rådgivare till International Association of Athletics Federations (IAAF) och Internationella olympiska kommittén (IOC)
Officiell gynekolog för Sveriges Olympiska Kommitté (SOK)
Ledamot av fakultetsnämnden, Karolinska Institutet
Studierektor för forskarutbildningen vid Institutionen för kvinnors och barns hälsa, Karolinska Institutet

Länkar

Publikationer

Changes in premenstrual symptoms in women starting or discontinuing use of oral contraceptives
Ekenros L, Bäckström T, Hirschberg Al, Fridén C
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2019;35(5):422-426

Hyperandrogenism in Female Athletes
Hirschberg Al
The Journal of clinical endocrinology and metabolism 2019;104(2):503-505

Improved menstrual function in obese women with polycystic ovary syndrome after behavioural modification intervention-A randomized controlled trial
Oberg E, Gidlöf S, Jakson I, Mitsell M, Tollet Egnell P, Hirschberg Al
Clinical endocrinology 2019;90(3):468-478

Increased Risk of Autoimmune Disorders in 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study
Falhammar H, Frisén L, Hirschberg Al, Nordenskjöld A, Almqvist C, Nordenström A
Journal of the Endocrine Society 2019;3(5):1039-1052

Maternal transfer of anti HPV 6 and 11 antibodies upon immunization with the 9-valent HPV vaccine
Guevara Am, Suarez E, Victoria A, Ngan Hy, Hirschberg Al, Fedrizzi E, et al
Human vaccines & immunotherapeutics 2019;15(1):141-145

Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver
Fornes R, Manti M, Qi X, Vorontsov E, Sihlbom C, Nyström J, et al
International journal of obesity (2005) 2019;():-

Sexuality in adults with Differences/disorders of Sex Development (DSD): Findings from the dsd-LIFE study
Dsd-life Group, Kreukels Bpc, Cohen-kettenis Pt, Roehle R, Van De Grift Tc, Slowikowska-hilczer J, et al
Journal of sex & marital therapy 2019;():1-37

Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial
Løvvik Ts, Carlsen Sm, Salvesen Ø, Steffensen B, Bixo M, Gómez-real F, et al
The lancet. Diabetes & endocrinology 2019;7(4):256-266

Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance
Handelsman Dj, Hirschberg Al, Bermon S
Endocrine reviews 2018;39(5):803-829

Cognitive abilities in women with complete androgen insensitivity syndrome and women with gonadal dysgenesis
Strandqvist A, Herlitz A, Nordenskjöld A, Örtqvist L, Frisén L, Hirschberg Al, et al
Psychoneuroendocrinology 2018;98():233-241

Hormonal Contraceptives Do Not Impact Economic Preferences: Evidence from a Randomized Trial
Ranehill E, Zethraeus N, Blomberg L, Von Schoultz B, Hirschberg Al, Johannesson M, et al
MANAGEMENT SCIENCE 2018;64(10):4515-4532

Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer
Rådestad Af, Estekizadeh A, Cui Hl, Kostopoulou On, Davoudi B, Hirschberg Al, et al
Translational oncology 2018;11(6):1292-1300

Letter to the editor: Sex and the eye test
Strandqvist A, Herlitz A, Nordenskjöld A, Örtqvist L, Frisén L, Hirschberg Al, et al
Psychoneuroendocrinology 2018;98():242-243

Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring
Manti M, Fornes R, Qi X, Folmerz E, Lindén Hirschberg A, De Castro Barbosa T, et al
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018;32(8):4158-4171

Pregnancy greatly affects the steroidal module of the Athlete Biological Passport
Mullen J, Gadot Y, Eklund E, Andersson A, J Schulze J, Ericsson M, et al
Drug testing and analysis 2018;():-

Prokineticin 1 is up-regulated by insulin in decidualizing human endometrial stromal cells
Ujvari D, Jakson I, Oldmark C, Attarha S, Alkasalias T, Salamon D, et al
Journal of cellular and molecular medicine 2018;22(1):163-172

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
Int Pcos Network, Teede Hj, Misso Ml, Costello Mf, Dokras A, Laven J, et al
CLINICAL ENDOCRINOLOGY 2018;89(3):251-268

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
International Pcos Network, Teede Hj, Misso Ml, Costello Mf, Dokras A, Laven J, et al
Fertility and sterility 2018;110(3):364-379

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
International Pcos Network, Teede Hj, Misso Ml, Costello Mf, Dokras A, Laven J, et al
Human reproduction (Oxford, England) 2018;33(9):1602-1618

Replik till Hilde Löfqvist: - Mer kunskap behövs om bioidentiska hormoner
Lindén Hirschberg A
Lakartidningen 2018;115():-

Serum androgen levels are positively correlated with athletic performance and competition results in elite female athletes
Bermon S, Hirschberg Al, Kowalski J, Eklund E
British journal of sports medicine 2018;52(23):1531-1532

A first-choice combined oral contraceptive influences general well-being in healthy women: a double-blind, randomized, placebo-controlled trial
Zethraeus N, Dreber A, Ranehill E, Blomberg L, Labrie F, Von Schoultz B, et al
Fertility and sterility 2017;107(5):1238-1245

An empirical comparison of models for the phenology of bird migration
Linden A, Meller K, Knape J
JOURNAL OF AVIAN BIOLOGY 2017;48(2):255-265

Are carriers of CYP21A2 mutations less vulnerable to psychological stress? A population-based national cohort study
Nordenström A, Butwicka A, Lindén Hirschberg A, Almqvist C, Nordenskjöld A, Falhammar H, et al
Clinical endocrinology 2017;86(3):317-324

Characterization of secondary care for COPD in Sweden
Sundh J, Janson C, Johansson G, Lindén A, Löfdahl Cg, Sandström T, et al
European clinical respiratory journal 2017;4(1):1270079-

Circulating androgens and SHBG during the normal menstrual cycle in two ethnic populations
Rezaii T, Gustafsson Tp, Axelson M, Zamani L, Ernberg M, Hirschberg Al, et al
Scandinavian journal of clinical and laboratory investigation 2017;77(3):184-189

Dysregulation of In Vitro Decidualization of Human Endometrial Stromal Cells by Insulin via Transcriptional Inhibition of Forkhead Box Protein O1
Ujvari D, Jakson I, Babayeva S, Salamon D, Rethi B, Gidlöf S, et al
PloS one 2017;12(1):e0171004-

Effect of age on serum prostate-specific antigen in women
Diamandis Ep, Eklund E, Muytjens C, Fiala C, Wheeler S, Nikolenko G, et al
Clinical chemistry and laboratory medicine 2017;55(12):e271-e272

Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle
Ekenros L, Papoutsi Z, Fridén C, Dahlman Wright K, Lindén Hirschberg A
Acta physiologica (Oxford, England) 2017;219(2):486-493

Fertility outcome and information on fertility issues in individuals with different forms of disorders of sex development: findings from the dsd-LIFE study
Dsd-life Group, Słowikowska-hilczer J, Hirschberg Al, Claahsen-van Der Grinten H, Reisch N, Bouvattier C, et al
Fertility and sterility 2017;108(5):822-831

Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial
Huh Wk, Joura Ea, Giuliano Ar, Iversen Oe, De Andrade Rp, Ault Ka, et al
Lancet (London, England) 2017;390(10108):2143-2159

Increased fibre and reduced trans fatty acid intake are primary predictors of metabolic improvement in overweight polycystic ovary syndrome-Substudy of randomized trial between diet, exercise and diet plus exercise for weight control
Nybacka Å, Hellström Pm, Hirschberg Al
Clinical endocrinology 2017;87(6):680-688

Increased psychiatric morbidity in women with complete androgen insensitivity syndrome or complete gonadal dysgenesis
Engberg H, Strandqvist A, Nordenström A, Butwicka A, Nordenskjöld A, Hirschberg Al, et al
Journal of psychosomatic research 2017;101():122-127

In Reply
Kočoska-maraš L, Hirschberg Al, Bergendal A, Kieler H, Sundström A
Menopause (New York, N.Y.) 2017;24(2):232-233

Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life
Pinola P, Puukka K, Piltonen Tt, Puurunen J, Vanky E, Sundström-poromaa I, et al
Fertility and sterility 2017;107(3):788-795.e2

Progesterone Receptors and Proliferation of the Endometrium in Obese Women With Polycystic Ovary Syndrome-A Lifestyle Intervention Study
Paulson M, Sahlin L, Hirschberg Al
The Journal of clinical endocrinology and metabolism 2017;102(4):1244-1253

Reduced Frequency of Biological and Increased Frequency of Adopted Children in Males With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study
Falhammar H, Frisén L, Norrby C, Almqvist C, Hirschberg Al, Nordenskjöld A, et al
The Journal of clinical endocrinology and metabolism 2017;102(11):4191-4199

Role of testosterone and Y chromosome genes for the masculinization of the human brain
Savic I, Frisen L, Manzouri A, Nordenstrom A, Lindén Hirschberg A
Human brain mapping 2017;38(4):1801-1814

Serum androgen profile and physical performance in women Olympic athletes
Eklund E, Berglund B, Labrie F, Carlström K, Ekström L, Hirschberg Al
British journal of sports medicine 2017;51(17):1301-1308

Serum complexed and free prostate specific antigen levels are lower in female elite athletes in comparison to control women
Eklund E, Diamandis Ep, Muytjens C, Wheeler S, Mathew A, Stengelin M, et al
F1000Research 2017;6():1131-

Should we individualize lipid profiling in women with polycystic ovary syndrome?
Poromaa Is, Mellembakken Jr, Morin-papunen L, Piltonen T, Puurenen J, Tapanainen Js, et al
Human reproduction (Oxford, England) 2017;32(4):966-

The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS
Pelanis R, Mellembakken Jr, Sundström-poromaa I, Ravn P, Morin-papunen L, Tapanainen Js, et al
Human reproduction (Oxford, England) 2017;32(11):2279-2286

Treatment of premenstrual dysphoric disorder with the GABAA receptor modulating steroid antagonist Sepranolone (UC1010)-A randomized controlled trial
Bixo M, Ekberg K, Poromaa Is, Hirschberg Al, Jonasson Af, Andréen L, et al
Psychoneuroendocrinology 2017;80():46-55

Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial
Zethraeus N, Dreber A, Ranehill E, Blomberg L, Labrie F, Von Schoultz B, et al
The Journal of clinical endocrinology and metabolism 2016;101(11):4046-4053

Endometrial Expression of Estrogen Receptors and the Androgen Receptor in Women With Polycystic Ovary Syndrome: A Lifestyle Intervention Study
Hulchiy M, Nybacka Å, Sahlin L, Hirschberg Al
The Journal of clinical endocrinology and metabolism 2016;101(2):561-71

[Hypothyroidism during pregnancy risks the child's neurocognitive development. New guidelines and remaining knowledge gaps]
Skalkidou A, Bixo M, Sköldebrand Sparre Ac, Strandell A, Lindén Hirschberg A, Filipsson Nyström H
Lakartidningen 2016;113():-

"It's Part of Me, Not All of Me": Young Women's Experiences of Receiving a Diagnosis Related to Diverse Sex Development
Lundberg T, Roen K, Hirschberg Al, Frisén L
Journal of pediatric and adolescent gynecology 2016;29(4):338-43

Lost workdays in uterine cervical cancer survivors compared to the general population: impact of treatment and relapse
Everhov Åh, Ekberg S, Hirschberg Al, Bergmark K, Rådestad Af, Glimelius I, et al
Journal of cancer survivorship : research and practice 2016;10(3):514-23

Risk of venous thromboembolism associated with local and systemic use of hormone therapy in peri- and postmenopausal women and in relation to type and route of administration
Bergendal A, Kieler H, Sundström A, Hirschberg Al, Kocoska-maras L
Menopause (New York, N.Y.) 2016;23(6):593-9

Serum Androgen Levels and Sexual Function Before and One Year After Treatment of Uterine Cervical Cancer: A Pilot Study
Everhov Åh, Flöter Rådestad A, Nyberg T, Smedby Ke, Bergmark K, Lindén Hirschberg A
The journal of sexual medicine 2016;13(3):413-24

Should we individualize lipid profiling in women with polycystic ovary syndrome?
Sundström Poromaa I, Mellembakken Jr, Morin-papunen L, Piltonen T, Puurunen J, Tapanainen Js, et al
Human reproduction (Oxford, England) 2016;31(12):2791-2795

Biomarkers of nutrition and stress in pregnant women with a history of eating disorders in relation to head circumference and neurocognitive function of the offspring
Koubaa S, Hällström T, Brismar K, Hellström Pm, Hirschberg Al
BMC pregnancy and childbirth 2015;15():318-

Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study
Engberg H, Butwicka A, Nordenström A, Hirschberg Al, Falhammar H, Lichtenstein P, et al
Psychoneuroendocrinology 2015;60():195-205

Congenital Adrenal Hyperplasia, Polycystic Ovary Syndrome and criminal behavior: A Swedish population based study
Ohlsson Gotby A, Nordenström A, Falhammar H, Nordenskjöld A, Linden Hirschberg A, Frisén L, et al
Psychiatry research 2015;229(3):953-9

Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women--a PET study
Jovanovic H, Kocoska-maras L, Rådestad Af, Halldin C, Borg J, Hirschberg Al, et al
NeuroImage 2015;106():47-54

Hormone therapy after uterine cervical cancer treatment: a Swedish population-based study
Everhov Åh, Nyberg T, Bergmark K, Citarella A, Rådestad Af, Hirschberg Al, et al
Menopause (New York, N.Y.) 2015;22(6):633-9

Identification and prediction of the fertile window using NaturalCycles
Berglund Scherwitzl E, Lindén Hirschberg A, Scherwitzl R
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 2015;20(5):403-8

Increased Cardiovascular and Metabolic Morbidity in Patients With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study
Falhammar H, Frisén L, Hirschberg Al, Norrby C, Almqvist C, Nordenskjöld A, et al
The Journal of clinical endocrinology and metabolism 2015;100(9):3520-8

[Not yet shown that estradiol and "natural" progesterone is safe. Evidence lacking for breast and endometrial protection]
Bixo M, Lindén Hirschberg A
Lakartidningen 2015;112():-

Sex hormone levels as determinants of bone mineral density and osteoporosis in Vietnamese women and men
Nguyen Ht, Von Schoultz B, Nguyen Tv, Thang Tx, Chau Tt, Duc Pt, et al
Journal of bone and mineral metabolism 2015;33(6):658-65

Anti-Müllerian hormone in premenopausal women following treatment of uterine cervical cancer
Hallqvist Everhov A, Bergmark K, Smedby Ke, Lindén Hirschberg A, Flöter Rådestad A
Acta obstetricia et gynecologica Scandinavica 2014;93(9):949-53

Estrogenic action on innate defense mechanisms in the urinary tract
Lüthje P, Hirschberg Al, Brauner A
Maturitas 2014;77(1):32-6

Identification of a duplication within the GDF9 gene and novel candidate genes for primary ovarian insufficiency (POI) by a customized high-resolution array comparative genomic hybridization platform
Norling A, Hirschberg Al, Rodriguez-wallberg Ka, Iwarsson E, Wedell A, Barbaro M
Human reproduction (Oxford, England) 2014;29(8):1818-27

Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Falhammar H, Frisén L, Norrby C, Hirschberg Al, Almqvist C, Nordenskjöld A, et al
The Journal of clinical endocrinology and metabolism 2014;99(12):E2715-21

Lifestyle intervention up-regulates gene and protein levels of molecules involved in insulin signaling in the endometrium of overweight/obese women with polycystic ovary syndrome
Ujvari D, Hulchiy M, Calaby A, Nybacka A, Bystrom B, Hirschberg Al
HUMAN REPRODUCTION 2014;29(7):1526-35

No mutations in the PSMC3IP gene identified in a Swedish cohort of women with primary ovarian insufficiency
Norling A, Hirschberg Al, Karlsson L, Rodriguez-wallberg Ka, Iwarsson E, Wedell A, et al
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2014;8(4):146-50

Serum androgen levels in elite female athletes
Bermon S, Garnier Py, Hirschberg Al, Robinson N, Giraud S, Nicoli R, et al
The Journal of clinical endocrinology and metabolism 2014;99(11):4328-35

Suboptimal psychosocial outcomes in patients with congenital adrenal hyperplasia: epidemiological studies in a nonbiased national cohort in Sweden
Strandqvist A, Falhammar H, Lichtenstein P, Hirschberg Al, Wedell A, Norrby C, et al
The Journal of clinical endocrinology and metabolism 2014;99(4):1425-32

The impact of genetics and hormonal contraceptives on the steroid profile in female athletes
Schulze Jj, Mullen Je, Berglund Lindgren E, Ericsson M, Ekström L, Hirschberg Al
Frontiers in endocrinology 2014;5():50-

Are the New Policies on Hyperandrogenism in Elite Female Athletes Really Out of Bounds? Response to "Out of Bounds? A Critique of the New Policies on Hyperandrogenism in Elite Female Athletes"
Bermon S, Ritzen M, Hirschberg Al, Murray Th
AMERICAN JOURNAL OF BIOETHICS 2013;13(5):63-5

Body composition and endocrine profile of male Olympic athletes striving for leanness
Hagmar M, Berglund B, Brismar K, Hirschberg Al
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2013;23(3):197-201

CBX2 gene analysis in patients with 46,XY and 46,XX gonadal disorders of sex development
Norling A, Hirschberg Al, Iwarsson E, Wedell A, Barbaro M
FERTILITY AND STERILITY 2013;99(3):819-826.e3

Cognitive function in association with sex hormones in postmenopausal women
Kocoska-maras L, Rådestad Af, Carlström K, Bäckström T, Von Schoultz B, Hirschberg Al
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2013;29(1):59-62

Estrogen supports urothelial defense mechanisms
Lüthje P, Brauner H, Ramos Nl, Ovregaard A, Gläser R, Hirschberg Al, et al
Science translational medicine 2013;5(190):190ra80-

Novel candidate genes for 46,XY gonadal dysgenesis identified by a customized 1 M array-CGH platform
Norling A, Lindén Hirschberg A, Iwarsson E, Persson B, Wedell A, Barbaro M
European journal of medical genetics 2013;56(12):661-8

Oral contraceptives do not affect muscle strength and hop performance in active women
Ekenros L, Hirschberg Al, Heijne A, Fridén C
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2013;23(3):202-7

Retarded head growth and neurocognitive development in infants of mothers with a history of eating disorders: longitudinal cohort study
Koubaa S, Hällström T, Hagenäs L, Hirschberg Al
BJOG : an international journal of obstetrics and gynaecology 2013;120(11):1413-22

Serum antimüllerian hormone in response to dietary management and/or physical exercise in overweight/obese women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial
Nybacka Å, Carlström K, Fabri F, Hellström Pm, Hirschberg Al
Fertility and sterility 2013;100(4):1096-102

Defining exercise prescription in lifestyle modification programs for overweight/obese polycystic ovary syndrome women REPLY
Nybacka A, Carlstrom K, Stahle A, Nyren S, Hellstrom P, Hirschberg Al
FERTILITY AND STERILITY 2012;97(2):E6-E6

Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus
Hulchiy M, Zhang H, Cline Jm, Hirschberg Al, Sahlin L
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 2012;19(3):332-8

Effects of oestrogen and testosterone therapy on serum metabolites in postmenopausal women
Zang H, Moritz T, Norstedt G, Hirschberg Al, Tollet-egnell P
Clinical endocrinology 2012;77(2):288-95

Low aglycone content in commercial soy drink products
Nguyen Htt, Pourian M, Bystrom B, Dahlin I, Duc Ptm, Nguyen Tv, et al
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION 2012;21(1):52-6

Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment
Hulchiy M, Zhang H, Cline Jm, Hirschberg Al, Sahlin L
Menopause (New York, N.Y.) 2012;19(11):1253-9

Sex hormones, appetite and eating behaviour in women
Hirschberg Al
MATURITAS 2012;71(3):248-56

The influence of menstrual phases on pain modulation in healthy women
Rezaii T, Hirschberg Al, Carlström K, Ernberg M
The journal of pain : official journal of the American Pain Society 2012;13(7):646-55

Vitamin D deficiency in northern Vietnam: prevalence, risk factors and associations with bone mineral density
Nguyen Ht, Von Schoultz B, Nguyen Tv, Dzung Dn, Duc Pt, Thuy Vt, et al
Bone 2012;51(6):1029-34

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women
Kocoska-maras L, Zethraeus N, Raddestad Af, Ellingsen T, Von Schoultz B, Johannesson M, et al
FERTILITY AND STERILITY 2011;95(1):152-7

Digitized assessment of mammographic breast density - Effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo
Lundstrom E, Hirschberg Al, Soderqvist G
MATURITAS 2011;70(4):361-4

Postural control in women with premenstrual symptoms during oral contraceptive treatment
Ekenros L, Hirschberg Al, Backstrom T, Friden C
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2011;90(1):97-102

Randomized comparison of the influence of dietary management and/or physical exercise on ovarian function and metabolic parameters in overweight women with polycystic ovary syndrome
Nybacka A, Carlstrom K, Stahle A, Nyren S, Hellstrom Pm, Hirschberg Al
FERTILITY AND STERILITY 2011;96(6):1508-13

Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal
Naessen S, Carlstrom K, Holst Jj, Hellstrom Pm, Hirschberg Al
AMERICAN JOURNAL OF CLINICAL NUTRITION 2011;94(4):967-72

A randomized controlled study of taper-down or abrupt discontinuation of hormone therapy in women treated for vasomotor symptoms
Lindh-astrand L, Bixo M, Hirschberg Al, Sundstrom-poromaa I, Hammar M
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 2010;17(1):72-9

Effects of oral contraceptives on diurnal profiles of insulin, insulin-like growth factor binding protein-1, growth hormone and cortisol in endurance athletes with menstrual disturbance
Rickenlund A, Thoren M, Nybacka A, Frystyk J, Hirschberg Al
HUMAN REPRODUCTION 2010;25(1):85-93

A randomized trial of the effect of estrogen and testosterone on economic behavior
Zethraeus N, Kocoska-maras L, Ellingsen T, Von Schoultz B, Hirschberg Al, Johannesson M
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(16):6535-8

High Fetal Testosterone and Sexually Dimorphic Cerebral Networks in Females
Ciumas C, Hirschberg Al, Savic I
CEREBRAL CORTEX 2009;19(5):1167-74

Hyperandrogenism May Explain Reproductive Dysfunction in Olympic Athletes
Hagmar M, Berglund B, Brismar K, Hirschberg Al
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 2009;41(6):1241-8

Polycystic ovary syndrome, obesity and reproductive implications
Hirschberg Al
Women's health (London, England) 2009;5(5):529-40

Reduced bone mineral density in adult women diagnosed with menstrual disorders during adolescence
Wiksten-almstromer M, Hirschberg Al, Hagenfeldt K
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2009;88(5):543-9

Testosterone addition to estrogen therapy - Effects on inflammatory markers for cardiovascular disease
Kocoska-maras L, Hirschberg Al, Bystrom B, Von Schoultz B, Radestad Af
GYNECOLOGICAL ENDOCRINOLOGY 2009;25(12):823-7

Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen Editorial Comment
Aphrodite Study Team Collaborators, Seftel A
JOURNAL OF UROLOGY 2009;181(5):2246-2247

The Effect of Transdermal Testosterone on Mammographic Density in Postmenopausal Women Not Receiving Systemic Estrogen Therapy
Davis Sr, Hirschberg Al, Wagner Lk, Lodhi I, Von Schoultz B
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2009;94(12):4907-13

Early maternal adjustment in women with eating disorders
Koubaa S, Hallstrom T, Hirschberg Al
INTERNATIONAL JOURNAL OF EATING DISORDERS 2008;41(5):405-10

Effects of testosterone and estrogen treatment on the distribution of sex hormone receptors in the endometrium of postmenopausal women
Zang H, Sahlin L, Masironi B, Hirschberg Al
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 2008;15(2):233-9

Key lipogenic gene expression can be decreased by estrogen in human adipose tissue
Lundholm L, Zang H, Hirschberg Al, Gustafsson Ja, Arner P, Dahlman-wright K
FERTILITY AND STERILITY 2008;90(1):44-8

Pregnancy and neonatal outcomes in women with eating disorders (vol 105, pg 255, 2005)
Kouba S, Hallstrom T, Lindholm C, Hirschberg Al
OBSTETRICS AND GYNECOLOGY 2008;111(5):1217-1217

Prospective follow-up of menstrual disorders in adolescence and prognostic factors
Wiksten-almstromer M, Hirschberg Al, Hagenfeldt K
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2008;87(11):1162-8

Special attention to the weight-control strategies employed by Olympic athletes striving for leanness is required
Hagmar M, Hirschberg Al, Berglund L, Berglund B
CLINICAL JOURNAL OF SPORT MEDICINE 2008;18(1):5-9

Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen
Aphrodite Study Team, Davis Sr, Moreau M, Kroll R, Bouchard C, Panay N, et al
NEW ENGLAND JOURNAL OF MEDICINE 2008;359(19):2005-17

An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women
Hirschberg Al, Edlund M, Svane G, Azavedo E, Skoog L, Von Schoultz B
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 2007;14(1):89-96

Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women
Naessen S, Carlstrom K, Bystrom B, Pierre Y, Hirschberg Al
PSYCHONEUROENDOCRINOLOGY 2007;32(5):548-54

Effects of testosterone and estrogen treatment on lipolysis signaling pathways in subcutaneous adipose tissue of postmenopausal women
Zang H, Ryden M, Wahlen K, Dahlman-wright K, Arner P, Hirschberg Al
FERTILITY AND STERILITY 2007;88(1):100-6

Effects of testosterone treatment on endometrial proliferation in postmenopausal women
Zang H, Sahlin L, Masironi B, Eriksson E, Hirschberg Al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2007;92(6):2169-75

Menstrual disorders and associated factors among adolescent girls visiting a youth clinic
Wiksten-almstromer M, Hirschberg Al, Hagenfeldt K
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 2007;86(1):65-72

Parity, pregnancy and neonatal outcomes in women treated for hyperprolactinaemia compared with a control group
Berinder K, Hulting Al, Granath F, Hirschberg Al, Akre O
CLINICAL ENDOCRINOLOGY 2007;67(3):393-7

Plasma ghrelin and gastric pacing in morbidly obese patients
Cigaina V, Hirschberg Al
METABOLISM-CLINICAL AND EXPERIMENTAL 2007;56(8):1017-21

Testosterone addition during menopausal hormone therapy: effects on mammographic breast density
Hofling M, Lundstrom E, Azavedo E, Svane G, Hirschberg Al, Von Schoultz B
CLIMACTERIC 2007;10(2):155-63

Testosterone inhibits estrogen/progestogen-induced breast cell proliferation in postmenopausal women
Hofling M, Hirschberg Al, Skoog L, Tani E, Hagerstrom T, Von Schoultz B
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 2007;14(2):183-90

Bone mineral density in bulimic women - influence of endocrine factors and previous anorexia
Naessen S, Carlstrom K, Glant R, Jacobsson H, Hirschberg Al
EUROPEAN JOURNAL OF ENDOCRINOLOGY 2006;155(2):245-51

Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women
Zang H, Carlstrom K, Arner P, Hirschberg Al
FERTILITY AND STERILITY 2006;86(1):136-44

Endothelial function in post-menopausal former elite athletes
Hagmar M, Eriksson Mj, Lindholm C, Schenck-gustafsson K, Hirschberg Al
CLINICAL JOURNAL OF SPORT MEDICINE 2006;16(3):247-52

Knee joint kinaesthesia and neuromuscular coordination during three phases of the menstrual cycle in moderately active women
Friden C, Hirschberg Al, Saartok T, Renstrom P
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 2006;14(4):383-9

Polycystic ovary syndrome in bulimic women - an evaluation based on the new diagnostic criteria
Naessen S, Carlstrom K, Garoff L, Glant R, Hirschberg Al
GYNECOLOGICAL ENDOCRINOLOGY 2006;22(7):388-94

Altered postural control during the luteal phase in women with premenstrual symptoms
Friden C, Ramsey Dk, Backstrom T, Benoit Dl, Saartok T, Hirschberg Al
NEUROENDOCRINOLOGY 2005;81(3):150-7

Amenorrhea in female athletes is associated with endothelial dysfunction and unfavorable lipid profile
Rickenlund A, Eriksson Mj, Schenck-gustafsson K, Hirschberg Al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2005;90(3):1354-9

Athlete's heart in postmenopausal former elite endurance female athletes
Hagmar M, Hirschberg Al, Lindholm C, Schenck-gustafsson K, Eriksson Mj
CLINICAL JOURNAL OF SPORT MEDICINE 2005;15(4):255-260

Athlete's heart in postmenopausal former elite endurance female athletes
Hagmar M, Hirschberg Al, Lindholm C, Schenck-gustafsson K, Eriksson Mj
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 2005;15(4):257-62

Hyperprolactinaemia in 271 women: up to three decades of clinical follow-up
Berinder K, Stackenas I, Akre O, Hirschberg Al, Hulting Al
CLINICAL ENDOCRINOLOGY 2005;63(4):450-5

Luteal phase dosing with paroxetine controlled release (CR) in the treatment of premenstrual dysphoric disorder
Steiner M, Hirschberg Al, Bergeron R, Holland F, Gee Md, Van Erp E
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 2005;193(2):352-60

Oral contraceptives improve endothelial function in amenorrheic athletes
Rickenlund A, Eriksson Mj, Schenck-gustafsson K, Hirschberg Al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2005;90(6):3162-7

Pregnancy and neonatal outcomes in women with eating disorders
Kouba S, Hallstrom T, Lindholm C, Hirschberg Al
OBSTETRICS AND GYNECOLOGY 2005;105(2):255-60

Association of estrogen receptor beta gene polymorphisms with bulimic disease in women
Nilsson M, Naessen S, Dahlman I, Hirschberg Al, Gustafsson Ja, Dahlman-wright K
MOLECULAR PSYCHIATRY 2004;9(1):28-34

Diurnal profiles of testosterone and pituitary hormones suggest different mechanisms for menstrual disturbances in endurance athletes
Rickenlund A, Thoren M, Carlstrom K, Von Schoultz B, Hirschberg Al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2004;89(2):702-7

Effects of oral contraceptives on body composition and physical performance in female athletes
Rickenlund Am, Carlstrom K, Ekblom B, Brismar T, Von Schoultz B, Hirschberg Al
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 2004;36(5):S34-S34

Effects of oral contraceptives on body composition and physical performance in female athletes
Rickenlund A, Carlstrom K, Ekblom B, Brismar Tb, Von Schoultz B, Hirschberg Al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2004;89(9):4364-70

Effects of oral contraceptives on diurnal profiles of insulin and IGFBP-1 in endurance athletes with menstrual disturbances
Hirschberg Al, Rickenlund A, Thoren M, Calstrom K, Von Schoultz B
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 2004;36(5):S280-S281

Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome
Hirschberg Al, Naessen S, Stridsberg M, Bystrom B, Holte J
GYNECOLOGICAL ENDOCRINOLOGY 2004;19(2):79-87

Gastric pacing for morbid obesity: Plasma levels of gastrointestinal peptides and leptin
Cigaina V, Hirschberg Al
OBESITY RESEARCH 2003;11(12):1456-62

Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance
Rickenlund A, Carlstrom K, Ekblom B, Brismar Tb, Von Schoultz B, Hirschberg Al
FERTILITY AND STERILITY 2003;79(4):947-55

Muscle strength and endurance do not significantly vary across 3 phases of the menstrual cycle in moderately active premenopausal women
Friden C, Hirschberg Al, Saartok T
CLINICAL JOURNAL OF SPORT MEDICINE 2003;13(4):238-41

The influence of premenstrual symptoms on postural balance and kinesthesia during the menstrual cycle
Friden C, Hirschberg Al, Saartok T, Backstrom T, Leanderson J, Renstrom P
GYNECOLOGICAL ENDOCRINOLOGY 2003;17(6):433-9

Women endurance runners with menstrual dysfunction have prolonged interruption of training due to injury
Henriksson Gb, Schnell C, Hirschberg Al
GYNECOLOGIC AND OBSTETRIC INVESTIGATION 2000;49(1):41-6

[Athletic amenorrhea and its consequences. Hard physical training at an early age can cause serious bone damage]
Hirschberg Al, Hagenfeldt K
Lakartidningen 1998;95(50):5765-70

Hormonal regulation of appetite and food intake
Hirschberg Al
ANNALS OF MEDICINE 1998;30(1):7-20

Reduced meal related gastrointestinal hormone response to adrenocorticotropic hormone stimulation test in female athletes
Hirschberg Al, Lindholm C, Vonschoultz B
GYNECOLOGICAL ENDOCRINOLOGY 1997;11(2):83-89

Reduced meal-related gastrointestinal hormone response to adrenocorticotropic hormone stimulation test in female athletes
Lindén Hirschberg A, Lindholm C, Von Schoultz B
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 1997;11(2):83-9

Reduced serum cholecystokinin and increase in body fat during oral contraception
Hirschberg Al, Bystrom B, Carlstrom K, Vonschoultz B
CONTRACEPTION 1996;53(2):109-13

ALTERED ADRENAL-STEROID METABOLISM UNDERLYING HYPERCORTISOLISM IN FEMALE ENDURANCE ATHLETES
Lindholm C, Hirschberg Al, Carlstrom K, Vonschoultz B
FERTILITY AND STERILITY 1995;63(6):1190-4

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