Funktionell Precisionsmedicin – Brinton Seashore-Ludlows team

Publikationer

Alla gruppmedlemmars publikationer

Journal article: ISCIENCE. 2026;29(8):116673
A host-centric morphological profiling approach to identify repurposed antiviral drugs
Asp E; Rietdijk J; Tampere M; Axelsson H; Njenda D; Potdar S; Kalman A; Georgieva P; Lapins M; Ballante F; Soler A; de Kort M; Aittokallio T; Zaliani A; Kuzikov M; Gribbon P; Lo D; Carreras-Puigvert J; Seashore-Ludlow B; Spjuth O; Stling P
Journal article: NPJ PRECISION ONCOLOGY. 2026;10(1):301
Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance
Gudoityte G; Berkovska O; Orre LM; Moussaud-Lamodiere E; Bergstrom R; Lindberg J; Haraldsson M; Nafeh SB; Louhaur M; Kallioniemi O; Fernebro J; Joneborg U; Seashore-Ludlow B
Article: BIOMEDICINE & PHARMACOTHERAPY. 2026;200:119575
Standardized workflow enables reproducibility of drug synergism detection: Results from a multi-center in vitro ring test on complex drug combinations in pancreatic cancer models.
Barile V; Kuzikov M; Cui W; Ianevski A; Iannelli F; Roca MS; Reinshagen J; Axelsson H; Leone A; Jenmalm Jensen A; Aittokallio T; Gribbon P; Seashore-Ludlow B; Budillon A
Article: STAR PROTOCOLS. 2026;7(2):104480
Protocol for culture, drug treatment, and dissociation of patient-derived 3D ovarian cancer microspheroids for flow cytometry
Haffa M; Juhani K; Gudoityte G; Otvos RH-G; Wallin E; Kallioniemi O-P; Fernebro J; Joneborg U; Seashore-Ludlow B
Article: PATTERNS. 2026;7(4):101453
Experimental and machine learning-based exploration of repurposed drugs reveals chemical features underlying phospholipidosis
Kuzikov M; Kalman A; Karki R; Reinshagen J; Huchting J; Qian K; Axelsson H; Tampere M; Ostling P; Seashore-Ludlow B; Gadiya Y; Gribbon P; Zaliani A
Article: NPJ PRECISION ONCOLOGY. 2026;10(1):117
Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics
Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Rico Pizarro L; Vesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Hamberg Levedahl K; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
Doctoral thesis: 2026
Integrative analysis of morphological and chemical signatures for understanding drug perturbations in diverse cancer cell models
Sharma O
Doctoral thesis: 2025
Functional precision medicine approaches to identify novel therapeutic strategies in ovarian cancer
Gudoityte G
Article: BIOMEDICINE & PHARMACOTHERAPY. 2025;191:118447
Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing.
Tampere M; H Le T; Asp E; Kalman A; Kaimal JM; Njenda D; Bäckström A; Axelsson U; Xu H; Ouyang W; Axelsson H; Marabita F; Moussaud-Lamodière E; Sepulveda CO; Seashore-Ludlow B; Vernersson C; Mirazimi A; Lundberg E; Östling P; Stadler C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2025;102(4):e70055
Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma
Qu H; Neog M; Palmblad K; Sundberg E; Lovquist A; Melen E; Aulin C; Harris HE
Article: MOLECULAR ONCOLOGY. 2025;19(9):2574-2593
Systematic profiling of cancer-fibroblast interactions reveals drug combinations in ovarian cancer
Gudoityte G; Sharma O; Leuenberger L; Wallin E; Fernebro J; Ostling P; Bergstroem R; Lindberg J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
Article: FRONTIERS IN IMMUNOLOGY. 2025;16:1599747
Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis
Wen X; Aulin C; Sundberg E; Qu H; Struglics A; Merritt A-S; Melen E; Altman M; Harris HE
Article: CANCERS. 2025;17(14):2363
Ex Vivo Drug Sensitivity of Pleural Effusion-Derived Cells from Lung Cancer and Pleural Mesothelioma Patients Is Linked to Clinical Response
Hutyra-Gram Otvos R; Krynska H; Gudoityte G; Skribek M; Oniscu A; Berkovska O; Strauss K; Zipprick J; Tamborero D; Alexeyenko A; Gad AKB; Seashore-Ludlow B; Dobra K
Journal article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2025;44(1):199
PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy
Prokarenkaite R; Kuodyte K; Gudoityte G; Budginaite E; Naumovas D; Strainiene E; Velickevicius K; Dulskas A; Sileika E; Venius J; Tunaitis V; Pivoriunas A; Starkuviene V; Stankevicius V; Suziedelis K
Review: NATURE REVIEWS DRUG DISCOVERY. 2025;24(7):521-542
Computational drug repurposing: approaches, evaluation of in silico resources and case studies
Tanoli Z; Fernandez-Torras A; Ozcan UO; Kushnir A; Nader KM; Gadiya Y; Fiorenza L; Ianevski A; Vaha-Koskela M; Miihkinen M; Seemab U; Leinonen H; Seashore-Ludlow B; Tampere M; Kalman A; Ballante F; Benfenati E; Saunders G; Potdar S; Garcia IG; Garcia-Serna R; Talarico C; Beccari AR; Schaal W; Polo A; Costantini S; Cabri E; Jacobs M; Saarela J; Budillon A; Spjuth O; Ostling P; Xhaard H; Quintana J; Mestres J; Gribbon P; Ussi AE; Lo DC; de Kort M; Wennerberg K; Fratelli M; Carreras-Puigvert J; Aittokallio T
Book chapter: HIGH CONTENT IMAGING IN DRUG DISCOVERY. 2025;p. 168-208
High Content Imaging Applications of Advanced and Translational Disease Models in Drug Discovery and Development
Cui W; Haffa M; Massai F; Qian K; Vallin M; Axelsson H; Seashore-Ludlow B
Journal article: 2025
High Content Imaging in Drug Discovery
Editor(s): Pilling J; Carragher N
Article: CELL DEATH & DISEASE. 2025;16(1):318
Targeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growth
Treis D; Lundberg KI; Bell N; Polychronopoulos PA; Tuemmler C; Akerlund E; Aliverti S; Lilienthal I; Pepich A; Seashore-Ludlow B; Sakaguchi K; Kogner P; Johnsen JI; Wickstroem M
Journal article: LANCET. 2025;405(10482):927-936
Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial
Veltkamp R; Korompoki E; Harvey KH; Harvey ER; Fiessler C; Malzahn U; Montaner J; Caso V; Sibon I; Ringleb P; Halse O; Ullmann S; Schuhmann C; Todd GP; Haas K; Lachaize M; D'Aoust T; Enzinger C; Ropele S; Fandler-Hoefler S; Haidegger M; Wang Y; Wafa HA; Cancelloni V; Mosconi MG; Lip GYH; Lane DA; Haefeli WE; Foerster I; Wurmbach VS; Nielsen PB; Hajjar K; Mueller P; Poli S; Purrucker J; Laible M; D'Anna L; Silva Y; Chacon RDT; Martinez-Sanchez P; Boulanger M; Norrving B; Pare G; Wachter R; Ntaios G; Wolfe CDA; Heuschmann PU
Journal article: CANCER RESEARCH. 2025;85(5):b026
Leveraging patient-derived models to identify novel treatment options in high-grade serous ovarian cancer
Gudoityte G; Berkovska O; Orre L; Moussaud-Lemoderie E; Fernebro J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
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