Toppublikationer från FyFa

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Här listas aktuella publikationer i högt rankade vetenskapliga tidskrifter (Impact Factor >9) där forskare vid institutionen för fysiologi och farmakologi medverkat. 


Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.
Yao N, Skiteva O, Zhang X, Svenningsson P, Chergui K
Mol. Psychiatry 2017 Nov;():

Regenerative medicine: Cartilage stem cells identified, but can they heal?
Chagin A, Medvedeva E
Nat Rev Rheumatol 2017 Sep;13(9):522-524

Mechanical isolation, and measurement of force and myoplasmic free [Ca] in fully intact single skeletal muscle fibers.
Cheng A, Westerblad H
Nat Protoc 2017 Sep;12(9):1763-1776

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.
Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton J, et al
Proc. Natl. Acad. Sci. U.S.A. 2017 08;114(34):E7187-E7196

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.
Petersen J, Wright S, Rodríguez D, Matricon P, Lahav N, Vromen A, et al
Nat Commun 2017 08;8(1):226

The immune response of the human brain to abdominal surgery.
Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen L, Zetterberg H, Erlandsson Harris H, et al
Ann. Neurol. 2017 Apr;81(4):572-582

Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Wu X, Stener-Victorin E, Kuang H, Ma H, Gao J, Xie L, et al
JAMA 2017 06;317(24):2502-2514

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine D, Bonner F, Crozier J, Denning C, Fontana R, et al
Hepatology 2017 02;65(2):710-721

Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
Glatz P, Sandin R, Pedersen N, Bonamy A, Eriksson L, Granath F
JAMA Pediatr 2017 Jan;171(1):e163470


Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairmentM M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, et al, . Molecular Psychiatry, 29 november 2016, doi: 10.1038/mp.2016.204.

Association of Anesthesia and Surgery During Childhood With Academic PerformancePia Glatz, Rolf H Sandin, Nancy L Pedersen, Anna-Karin Bonamy, Lars I Eriksson, et al. JAMA Pediatrics, 7 november 2016. doi: 10.1001./jamapediatrics.2016.347

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke V, Vorrink S, Moro S, Rezayee F, Nordling , Hendriks D, et al
Hepatology 2016 11;64(5):1743-1756

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.
Ivanov M, Kals M, Lauschke V, Barragan I, Ewels P, Käller M, et al
Nucleic Acids Res. 2016 08;44(14):6756-69

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 08;113(33):9304-9

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, et al
Sci Transl Med 2016 08;8(350):350ra103

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Bouderlique T, Vuppalapati K, Newton P, Li L, Barenius B, Chagin A
Ann. Rheum. Dis. 2016 Mar;75(3):627-31

Precision Medicine and Rare Genetic Variants.
Lauschke V, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016 Feb;37(2):85-86


A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder.
Sellgren C, Kegel M, Bergen S, Ekman C, Olsson S, Larsson M, et al
Mol. Psychiatry 2016 10;21(10):1342-50

Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome.
Dumesic D, Oberfield S, Stener-Victorin E, Marshall J, Laven J, Legro R
Endocr. Rev. 2015 Oct;36(5):487-525

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism.
Wigerblad G, Bas D, Fernades-Cerqueira C, Krishnamurthy A, Nandakumar K, Rogoz K, et al
Ann. Rheum. Dis. 2016 Apr;75(4):730-8

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, et al
Ann. Rheum. Dis. 2016 Apr;75(4):721-9

Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Newton P, Vuppalapati K, Bouderlique T, Chagin A
Autophagy 2015 ;11(9):1594-607

Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise
Placea N, Ivarsson N, Venckunas T, Neyroud D, Brazaitis M, Cheng A, et al
PNASNov 2, 2015

Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring
Hu M, Richard J, Maliqueo M, Kokosar M, Fornes R, Benrick A, et al
PNAS, online Early Edition the week of November 2, 2015

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis
Ferguson A, Wang L, Altman R, Terry D, Juette M, Burnett B, et al
Molecular Cell ;60:1–12

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Hayes M, Urbanek M, Ehrmann D, Armstrong L, Lee J, Sisk R, et al
Nat Commun 2015 Aug;6():7502

Safety and efficacy of re-treatments with pyronaridine-artesunate in African patients with malaria: a substudy of the WANECAM randomised trial.
Sagara I, Beavogui A, Zongo I, Soulama I, Borghini-Fuhrer I, Fofana B, et al
Lancet Infect Dis 2016 Feb;16(2):189-98

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L
Physiological Reviews (Invited review) Jul;95(3):1025-1109

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.

Lancet Infect Dis 2015 Jun;15(6):692-702

Renal autoregulation in health and disease.
Carlström M, Wilcox C, Arendshorst W
Physiol. Rev. 2015 Apr;95(2):405-511


Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo L, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014 Sep;159(1):33-45

Glial origin of mesenchymal stem cells in a tooth model system.
Kaukua N, Shahidi M, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, et al
Nature 2014 Sep;513(7519):551-4

Epigenetic mechanisms of importance for drug treatment.
Ivanov M, Barragan I, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2014 Aug;35(8):384-96

Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
Dyachuk V, Furlan A, Shahidi M, Giovenco M, Kaukua N, Konstantinidou C, et al
Science 2014 Jul;345(6192):82-7

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.
Chagin A, Vuppalapati K, Kobayashi T, Guo J, Hirai T, Chen M, et al
Nat Commun 2014 Apr;5():3673

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
Pader I, Sengupta R, Cebula M, Xu J, Lundberg J, Holmgren A, et al
Proc. Natl. Acad. Sci. U.S.A. 2014 May;111(19):6964-9

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.
Sorge R, Martin L, Isbester K, Sotocinal S, Rosen S, Tuttle A, et al
Nat. Methods 2014 Jun;11(6):629-32

TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea.
Meltser I, Cederroth C, Basinou V, Savelyev S, Lundkvist G, Canlon B
Curr. Biol. 2014 Mar;24(6):658-63

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.
Persson A, Sim S, Virding S, Onishchenko N, Schulte G, Ingelman-Sundberg M
Mol. Psychiatry 2014 Jun;19(6):733-41

Cognitive impairment and dentate gyrus synaptic dysfunction in experimental parkinsonism.
Bonito-Oliva A, Pignatelli M, Spigolon G, Yoshitake T, Seiler S, Longo F, et al
Biol. Psychiatry 2014 May;75(9):701-10

The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.
Lavebratt C, Olsson S, Backlund L, Frisén L, Sellgren C, Priebe L, et al
Mol. Psychiatry 2014 Mar;19(3):334-41

Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.
Yamada T, Fedotovskaya O, Cheng A, Cornachione A, Minozzo F, Aulin C, et al
Ann. Rheum. Dis. 2015 Oct;74(10):1907-14