PubMed search FyFa

Decoding the neuroimmune axis in the atopic march: mechanisms and implications.

Brabenec L, Gupta S, Eichwald T, Rafei M, Talbot S.
Curr Opin Immunol. 2024 Nov 22;91:102507. doi: 10.1016/j.coi.2024.102507. Online ahead of print.
PMID: 39579588 Review.

Accuracy of left ventricular mechanical dyssynchrony indices for mechanical characteristics of left bundle branch block using cardiovascular magnetic resonance feature tracking.

Loewenstein DE, Wieslander B, Heiberg E, Axelsson J, Klem I, Nijveldt R, Schelbert EB, Sörensson P, Sigfridsson A, Strauss DG, Kim RJ, Atwater BD, Ugander M.
Eur Heart J Cardiovasc Imaging. 2024 Nov 22:jeae301. doi: 10.1093/ehjci/jeae301. Online ahead of print.
PMID: 39576753

Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young.

Horwath O, Moberg M, Hodson N, Edman S, Johansson M, Andersson E, van Hall G, Rooyackers O, Philp A, Apró W. J Cachexia Sarcopenia Muscle. 2024 Nov 19. doi: 10.1002/jcsm.13613. Online ahead of print.
PMID: 39558870

Position paper on the physiology and nomenclature of dual circulation during venoarterial ECMO in adults.

Badulak J, Abrams D, Luks AM, Zakhary B, Conrad SA, Bartlett R, MacLaren G, Vercaemst L, Lorusso R, Broman LM, Agerstrand C, Price S, Combes A, Peek G, Fan E, Shekar K, Fraser J, Brodie D; Extracorporeal Life Support Organization (ELSO). 
Intensive Care Med. 2024 Nov 18. doi: 10.1007/s00134-024-07645-8. Online ahead of print.
PMID: 39557688 Review.

Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.

McIlvried LA, Martel Matos AA, Yuan MM, Atherton MA, Obuekwe F, Nilsen ML, Nikpoor AR, Talbot S, Bruno TC, Taggart DN, Johnson LK, Ferris RL, P Zandberg D, Scheff NN.
J Immunother Cancer. 2024 Nov 17;12(11):e009962. doi: 10.1136/jitc-2024-009962.
PMID: 39551606 Free PMC article.

Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome? : A critical review.

Pawlik MT, Rinneberg G, Koch A, Meyringer H, Loew TH, Kjellberg A.
Eur Arch Psychiatry Clin Neurosci. 2024 Dec;274(8):1797-1817. doi: 10.1007/s00406-024-01911-y. Epub 2024 Nov 15.
PMID: 39545965 Free PMC article. Review.

Risk Factors Associated with Weight Gain during Treatment with Dupilumab among Patients with Moderate to Severe Atopic Dermatitis.

Tayefi M, Svedbom A, Ivert L, Lundqvist M, Ruas J, Bradley M, Johansson E.
Acta Derm Venereol. 2024 Nov 15;104:adv40796. doi: 10.2340/actadv.v104.40796.
PMID: 39545373

PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes.

Tremmel R, Zhou Y, Camara MD, Laarif S, Eliasson E, Lauschke VM.
Nucleic Acids Res. 2024 Nov 14:gkae1016. doi: 10.1093/nar/gkae1016. Online ahead of print.
PMID: 39540424

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms.

Pham TCP, Raun SH, Havula E, Henriquez-Olguín C, Rubalcava-Gracia D, Frank E, Fritzen AM, Jannig PR, Andersen NR, Kruse R, Ali MS, Irazoki A, Halling JF, Ringholm S, Needham EJ, Hansen S, Lemminger AK, Schjerling P, Petersen MH, de Almeida ME, Jensen TE, Kiens B, Hostrup M, Larsen S, Ørtenblad N, Højlund K, Kjær M, Ruas JL, Trifunovic A, Wojtaszewski JFP, Nielsen J, Qvortrup K, Pilegaard H, Richter EA, Sylow L.
Nat Commun. 2024 Nov 13;15(1):9826. doi: 10.1038/s41467-024-54183-4.
PMID: 39537626 Free PMC article.

Correction: The impact of preoperative stroke on 1-year mortality and days at home alive after major surgery: an observational cohort study.

Widaeus M, Cedermark A, Bell M.
Perioper Med (Lond). 2024 Nov 12;13(1):109. doi: 10.1186/s13741-024-00467-8.
PMID: 39533339 Free PMC article. No abstract available.

Specialized post-arterial capillaries facilitate adult bone remodelling.

Mohanakrishnan V, Sivaraj KK, Jeong HW, Bovay E, Dharmalingam B, Bixel MG, Dinh VV, Petkova M, Paredes Ugarte I, Kuo YT, Gurusamy M, Raftrey B, Chu NTL, Das S, Rios Coronado PE, Stehling M, Sävendahl L, Chagin AS, Mäkinen T, Red-Horse K, Adams RH.
Nat Cell Biol. 2024 Nov 11. doi: 10.1038/s41556-024-01545-1. Online ahead of print.
PMID: 39528700

Correction to: Modelling to decipher physiological determinants of improved muscle endurance.

Place N, Westerblad H.
Eur J Appl Physiol. 2024 Nov 7. doi: 10.1007/s00421-024-05634-9. Online ahead of print.
PMID: 39505789 No abstract available.

Capnodynamic assessment of mixed venous oxygen saturation in a porcine experimental endotoxemic model.

Svedmyr A, Hedov J, Lipcsey M, Wallin M, Hallbäck M, Lönnqvist PA, Karlsson J.
Sci Rep. 2024 Nov 5;14(1):26807. doi: 10.1038/s41598-024-77483-7.
PMID: 39500994 Free PMC article.

Evaluation of the potential of Ergostatrien-3β-ol for treating Sjögren's syndrome.

Wu PC, Chao YH, Zhang X, Chen TT, Kuo YH, Lin CC, Chang HH.
Int J Rheum Dis. 2024 Nov;27(11):e15341. doi: 10.1111/1756-185X.15341.
PMID: 39498888

The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth.

Edman S, Jones Iii RG, Jannig PR, Fernandez-Gonzalo R, Norrbom J, Thomas NT, Khadgi S, Koopmans PJ, Morena F, Chambers TL, Peterson CS, Scott LN, Greene NP, Figueiredo VC, Fry CS, Zhengye L, Lanner JT, Wen Y, Alkner B, Murach KA, von Walden F.
EMBO Rep. 2024 Oct 31. doi: 10.1038/s44319-024-00299-z. Online ahead of print.
PMID: 39482487

Comprehensive review on leucine-rich pentatricopeptide repeat-containing protein (LRPPRC, PPR protein): A burgeoning target for cancer therapy.

Ge Y, Janson V, Liu H.
Int J Biol Macromol. 2024 Oct 29;282(Pt 3):136820. doi: 10.1016/j.ijbiomac.2024.136820. Online ahead of print.
PMID: 39476900 Review.

Ageing leads to selective type II myofibre deterioration and denervation independent of reinnervative capacity in human skeletal muscle.

Horwath O, Moberg M, Edman S, Philp A, Apró W.
Exp Physiol. 2024 Oct 28. doi: 10.1113/EP092222. Online ahead of print.
PMID: 39466960

A novel model of cardiovascular-kidney-metabolic syndrome combining unilateral nephrectomy and high-salt-sugar-fat diet in mice.

Carvalho LRRA, Shimari M, Boeder AM, Zhuge Z, Cai M, Leijding C, Gastaldello S, Kleschyov AL, Schiffer TA, Guimarães DD, Picozzi G, Lund LH, Fellström B, Weitzberg E, Lundberg JO, Hagberg CE, Pironti G, Andersson DC, Carlström M.
Lab Anim (NY). 2024 Nov;53(11):336-346. doi: 10.1038/s41684-024-01457-5. Epub 2024 Oct 22.
PMID: 39438661 Free PMC article.

A 5-week centrifuge-based G training with feedback on the magnitude of G force does not improve the perception of roll tilt during simulated coordinated turns.

Keramidas ME, Kölegård R, Brink A, Eiken O.
J Neurophysiol. 2024 Nov 1;132(5):1571-1576. doi: 10.1152/jn.00311.2024. Epub 2024 Oct 9.
PMID: 39382978

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.

de Haan S, Corbat AA, Cederroth CR, Autrum LG, Hankeova S, Driver EC, Canlon B, Kelley MW, Andersson ER.
Development. 2024 Nov 1;151(21):dev202949. doi: 10.1242/dev.202949. Epub 2024 Nov 5.
PMID: 39373109 Free PMC article.

Does one biopsy cut it? Revisiting human muscle fiber type composition variability using repeated biopsies in the vastus lateralis and gastrocnemius medialis.

Van de Casteele F, Van Thienen R, Horwath O, Apró W, Van der Stede T, Moberg M, Lievens E, Derave W.
J Appl Physiol (1985). 2024 Nov 1;137(5):1341-1353. doi: 10.1152/japplphysiol.00394.2024. Epub 2024 Oct 3.
PMID: 39359186

Molecular Profiling Defines Three Subtypes of Synovial Sarcoma.

Chen Y, Su Y, Cao X, Siavelis I, Leo IR, Zeng J, Tsagkozis P, Hesla AC, Papakonstantinou A, Liu X, Huang WK, Zhao B, Haglund C, Ehnman M, Johansson H, Lin Y, Lehtiö J, Zhang Y, Larsson O, Li X, de Flon FH.
Adv Sci (Weinh). 2024 Nov;11(41):e2404510. doi: 10.1002/advs.202404510. Epub 2024 Sep 10.
PMID: 39257029

Tocilizumab reduces hypercoagulation in COVID-19 - Perspectives from the coagulation and immunomodulation Covid assessment (Coag-ImmCovA) clinical trial.

Almskog LM, Sjöström A, Sundén-Cullberg J, Taxiarchis A, Ågren A, Freyland S, Börjesson M, Wikman A, Wahlgren CM, Wanecek M, van der Linden J, Antovic J, Lampa J, Magnusson M.
Thromb Res. 2024 Nov;243:109135. doi: 10.1016/j.thromres.2024.109135. Epub 2024 Aug 30.
PMID: 39226747 Clinical Trial.

Senescence detection using reflected light.

Dedic B, Westerberg L, Mosqueda Solís A, Dumont KD, Ruas JL, Thorell A, Näslund E, Spalding KL.
Aging Cell. 2024 Nov;23(11):e14295. doi: 10.1111/acel.14295. Epub 2024 Aug 5.
PMID: 39102872 Free PMC article.

Population-scale variability of the human UDP-glycosyltransferase gene family.

González-Padilla D, Camara MD, Lauschke VM, Zhou Y.
J Genet Genomics. 2024 Nov;51(11):1228-1236. doi: 10.1016/j.jgg.2024.06.018. Epub 2024 Jul 4.
PMID: 38969258

Standardized nomenclature for peripheral percutaneous cannulation of the pulmonary artery in extracorporeal membrane oxygenation: Current uptake and recommendations for improvement.

Brewer JM, Broman LM, Swol J, Lorusso R, Conrad SA, Maybauer MO.
Perfusion. 2024 Nov;39(8):1538-1544. doi: 10.1177/02676591231210457. Epub 2023 Nov 6.
PMID: 37930875 Free PMC article. Review.

Changes in circulating extracellular vesicle cargo are associated with cognitive decline after major surgery: an observational case-control study.

Mkrtchian S, Eldh M, Ebberyd A, Gabrielsson S, Végvári Á, Ricksten SE, Danielson M, Oras J, Wiklund A, Eriksson LI, Gómez-Galán M.

Br J Anaesth. 2024 Oct 18:S0007-0912(24)00553-1. doi: 10.1016/j.bja.2024.07.040. Online ahead of print.

PMID: 39426921

Integrating priorities at the intersection of cancer and neuroscience.

Hwang WL, Perrault EN, Birbrair A, Mattson BJ, Gutmann DH, Mabbott DJ, Cukierman E, Repasky EA, Sloan EK, Zong H, Demir IE, Saloman JL, Borniger JC, Hu J, Dietrich J, Breunig JJ, Çifcibaşı K, Ahmad Kasm KA, Valiente M, Wintermark M, Acharya MM, Scheff NN, D'Silva NJ, Vermeer PD, Wong RJ, Talbot S, Hervey-Jumper SL, Wang TC, Ye Y, Pan Y, Bunimovich YL, Amit M.

Cancer Cell. 2024 Oct 15:S1535-6108(24)00362-3. doi: 10.1016/j.ccell.2024.09.014. Online ahead of print.

PMID: 39423816

Generation and characterization of a conditional eNOS knock out mouse model for cell-specific reactivation of eNOS in gain-of-function studies.

LoBue A, Li Z, Heuser SK, Li J, Leo F, Vornholz L, Dunaway LS, Suvorava T, Isakson BE, Cortese-Krott MM.

Nitric Oxide. 2024 Oct 15:S1089-8603(24)00136-8. doi: 10.1016/j.niox.2024.10.009. Online ahead of print.

PMID: 39419166

The 75-Year Anniversary of the Department of Physiology and Pharmacology at Karolinska Institutet-Examples of Recent Accomplishments and Future Perspectives.

Weitzberg E, Ingelman-Sundberg M, Lundberg JO, Engberg G, Schulte G, Lauschke VM.

Pharmacol Rev. 2024 Oct 16;76(6):1089-1101. doi: 10.1124/pharmrev.124.001433.

PMID: 39414365 Review.

TGF-β-mediated crosstalk between TIGIT⁺ Tregs and CD226⁺CD8⁺ T cells in the progression and remission of type 1 diabetes.

Zhong T, Li X, Lei K, Tang R, Deng Q, Love PE, Zhou Z, Zhao B, Li X.

Nat Commun. 2024 Oct 15;15(1):8894. doi: 10.1038/s41467-024-53264-8.

PMID: 39406740 

Free PMC article.
 

Insulin requirement trajectories during COVID-19 versus non-COVID-19 critical illness-A retrospective cohort study.

Soltani N, Häbel H, Balintescu A, Lind M, Grip J, Thobaben R, Nelson D, Mårtensson J.

Acta Anaesthesiol Scand. 2024 Oct 14. doi: 10.1111/aas.14536. Online ahead of print.

PMID: 39402855
 

The effect of eccentric arm cycling on muscle damage and injury-related biomarkers.

Gottschalk F, Gennser M, Eiken O, Elia A.

Clin Physiol Funct Imaging. 2024 Oct 13. doi: 10.1111/cpf.12911. Online ahead of print.

PMID: 39400488
 

Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1.

Wu R, Li P, Hao B, Fredimoses M, Ge Y, Zhou Y, Tang L, Li Y, Liu H, Janson V, Hu Y, Liu H.

Bioorg Chem. 2024 Oct 6;153:107878. doi: 10.1016/j.bioorg.2024.107878. Online ahead of print.

PMID: 39395319

Neurologic Recovery at Discharge and Long-Term Survival After Cardiac Arrest.

Dillenbeck E, Svensson L, Rawshani A, Hollenberg J, Ringh M, Claesson A, Awad A, Jonsson M, Nordberg P.

JAMA Netw Open. 2024 Oct 1;7(10):e2439196. doi: 10.1001/jamanetworkopen.2024.39196.

PMID: 39392629

A 5-week centrifuge-based G training with feedback on the magnitude of G force, does not improve the perception of roll tilt during simulated coordinated turns.

Keramidas ME, Kölegård R, Brink A, Eiken O.

J Neurophysiol. 2024 Oct 9. doi: 10.1152/jn.00311.2024. Online ahead of print.

PMID: 39382978

Skeletal stem and progenitor cells in bone physiology, ageing and disease.

Melis S, Trompet D, Chagin AS, Maes C.

Nat Rev Endocrinol. 2024 Oct 8. doi: 10.1038/s41574-024-01039-y. Online ahead of print.

PMID: 39379711 Review.
 

Sudden cardiac death after myocardial infarction: individual participant data from pooled cohorts.

Peek N, Hindricks G, Akbarov A, Tijssen JGP, Jenkins DA, Kapacee Z, Parkes LM, van der Geest RJ, Longato E, Sprague D, Taleb Y, Ong M, Miller CA, Shamloo AS, Albert C, Barthel P, Boveda S, Braunschweig F, Johansen JB, Cook N, de Chillou C, Elders P, Faxén J, Friede T, Fusini L, Gale CP, Jarkovsky J, Jouven X, Junttila J, Kautzner J, Kiviniemi A, Kutyifa V, Leclercq C, Lee DC, Leigh J, Lenarczyk R, Leyva F, Maeng M, Manca A, Marijon E, Marschall U, Merino JL, Mont L, Nielsen JC, Olsen T, Pester J, Pontone G, Roca I, Schmidt G, Schwartz PJ, Sticherling C, Suleiman M, Taborsky M, Tan HL, Tfelt-Hansen J, Thiele H, Tomaselli GF, Verstraelen T, Vinayagamoorthy M, Olesen KKW, Wilde A, Willems R, Wu KC, Zabel M, Martin GP, Dagres N.

Eur Heart J. 2024 Oct 8:ehae326. doi: 10.1093/eurheartj/ehae326. Online ahead of print.

PMID: 39378245

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea.

de Haan S, Corbat AA, Cederroth CR, Autrum LG, Hankeova S, Driver EC, Canlon B, Kelley MW, Andersson ER.

Development. 2024 Oct 7:dev.202949. doi: 10.1242/dev.202949. Online ahead of print.

PMID: 39373109
 

The phage anti-restriction induced system: new insights into bacterial immunity and bacteriophage escape strategies.

Zhong Y, Lauschke VM.

Signal Transduct Target Ther. 2024 Oct 5;9(1):269. doi: 10.1038/s41392-024-01995-x.

PMID: 39369022 

Free PMC article. Review. No abstract available.
 

Scoping review finds insufficient evidence on potential risks of procedural sedation with dexmedetomidine in children.

Båtelsson A, Lannsjö C, Fläring U, Rooyackers O.

Acta Paediatr. 2024 Oct 4. doi: 10.1111/apa.17435. Online ahead of print.

PMID: 39367630 Review.

The impact of preoperative stroke on 1-year mortality and days at home alive after major surgery: an observational cohort study.

Widaeus M, Cederlund A, Bell M.

Perioper Med (Lond). 2024 Oct 4;13(1):97. doi: 10.1186/s13741-024-00453-0.

PMID: 39367494 

Free PMC article.
 

The future is here: an overview of technology in diabetes.

Mallik R, Kar P, Mulder H, Krook A.

Diabetologia. 2024 Oct;67(10):2019-2026. doi: 10.1007/s00125-024-06235-z.

PMID: 39212678 Review. No abstract available.
 

Pharmacological Approaches to Hearing Loss.

Cederroth CR, Dyhrfjeld-Johnsen J, Canlon B.

Pharmacol Rev. 2024 Oct 16;76(6):1063-1088. doi: 10.1124/pharmrev.124.001195.

PMID: 39164117 Review.

Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study.

Karamchandani K, Nasa P, Jarzebowski M, Brewster DJ, De Jong A, Bauer PR, Berkow L, Brown CA 3rd, Cabrini L, Casey J, Cook T, Divatia JV, Duggan LV, Ellard L, Ergan B, Jonsson Fagerlund M, Gatward J, Greif R, Higgs A, Jaber S, Janz D, Joffe AM, Jung B, Kovacs G, Kwizera A, Laffey JG, Lascarrou JB, Law JA, Marshall S, McGrath BA, Mosier JM, Perin D, Roca O, Rollé A, Russotto V, Sakles JC, Shrestha GS, Smischney NJ, Sorbello M, Tung A, Jabaley CS, Myatra SN; Society of Critical Care Anesthesiologists (SOCCA) Physiologically Difficult Airway Task Force.

Intensive Care Med. 2024 Oct;50(10):1563-1579. doi: 10.1007/s00134-024-07578-2. Epub 2024 Aug 20.

PMID: 39162823
 

Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach.

He Q, Li M, Ji P, Zheng A, Yao L, Zhu X, Shin JG, Lauschke VM, Han B, Xiang X.

Toxicol Appl Pharmacol. 2024 Oct;491:117064. doi: 10.1016/j.taap.2024.117064. Epub 2024 Aug 8.

PMID: 39122118
 

New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.

Espinosa-Bustos C, Bertrand J, Villegas-Menares A, Guerrero S, Di Marcotullio L, Navacci S, Schulte G, Kozielewicz P, Bloch N, Villela V, Paulino M, Kogan MJ, Cantero J, Salas CO.

Bioorg Chem. 2024 Oct;151:107681. doi: 10.1016/j.bioorg.2024.107681. Epub 2024 Jul 28.

PMID: 39106711
 

Validation of a Novel Method for Noninvasive Mixed Venous Oxygen Saturation Monitoring in Anesthetized Children.

Svedmyr A, Steiner K, Andersson A, Sjöberg G, Hallbäck M, Wallin M, Lönnqvist PA, Karlsson J.

Anesth Analg. 2024 Oct 1;139(4):781-788. doi: 10.1213/ANE.0000000000007083. Epub 2024 Aug 2.

PMID: 39093817

Quantitative trait locus mapping in placenta: A comparative study of chorionic villus and birth placenta.

Dieckmann L, Lahti-Pulkkinen M, Cruceanu C, Räikkönen K, Binder EB, Czamara D.

HGG Adv. 2024 Oct 10;5(4):100326. doi: 10.1016/j.xhgg.2024.100326. Epub 2024 Jul 10.

PMID: 38993113 

Free PMC article.

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model.

Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P.

Br J Pharmacol. 2024 Oct;181(20):3819-3835. doi: 10.1111/bph.16090. Epub 2023 May 6.

PMID: 37055379