Toppublikationer från FyFa

2023

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.
Grätz L, Kowalski-Jahn M, Scharf MM, Kozielewicz P, Jahn M, Bous J, Lambert NA, Gloriam DE, Schulte G.Nat Commun. 2023 Jul 29;14(1):4573. doi: 10.1038/s41467-023-40213-0.PMID: 37516754

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model.
Grätz L, Sajkowska-Kozielewicz JJ, Wesslowski J, Kinsolving J, Bridge LJ, Petzold K, Davidson G, Schulte G, Kozielewicz P.Br J Pharmacol. 2023 Apr 13. doi: 10.1111/bph.16090. Online ahead of print.PMID: 37055379

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.
Bowin CF, Kozielewicz P, Grätz L, Kowalski-Jahn M, Schihada H, Schulte G.Sci Signal. 2023 Apr 4;16(779):eabo4974. doi: 10.1126/scisignal.abo4974. Epub 2023 Apr 4.PMID: 37014927

Direct electrical stimulation impacts on neuromuscular junction morphology on both stimulated and unstimulated contralateral soleus.
Lee YI, Cacciani N, Wen Y, Zhang X, Hedström Y, Thompson W, Larsson L
J Cachexia Sarcopenia Muscle 2023 Apr;():

Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization.
Lund LH, Hage C, Pironti G, Thorvaldsen T, Ljung-Faxén U, Zabarovskaja S, Shahgaldi K, Webb DL, Hellström PM, Andersson DC, Ståhlberg M
Eur Heart J 2023 Mar;():

2022

A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.
Cacciani N, Skärlén Å, Wen Y, Zhang X, Addinsall AB, Llano-Diez M, Li M, Gransberg L, Hedström Y, Bellander BM, Nelson D, Bergquist J, Larsson L
J Cachexia Sarcopenia Muscle 2022 Oct;():

Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis.
Jarach CM, Lugo A, Scala M, van den Brandt PA, Cederroth CR, Odone A, Garavello W, Schlee W, Langguth B, Gallus S
JAMA Neurol 2022 

Alterations in auditory brain stem response distinguish occasional and constant tinnitus.
Edvall NK, Mehraei G, Claeson M, Lazar A, Bulla J, Leineweber C, Uhlén I, Canlon B, Cederroth CR
J Clin Invest 2022 

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.
T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal CL, Schweinfurth JM, Seshadri S, Shiroma E, Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP et.al.
Am J Hum Genet 2022 

Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting
Addinsall A B, Cacciani N, Backéus A, Hedström Y, Shevchenko G, Bergquist J, Larsson L.
J Cachexia Sarcopenia Muscle 2022 

2021

A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.
Milon B, Shulman ED, So KS, Cederroth CR, Lipford EL, Sperber M, Sellon JB, Sarlus H, Pregernig G, Shuster B, Song Y, Mitra S, Orvis J, Margulies Z, Ogawa Y, Shults C, Depireux DA, Palermo AT, Canlon B, Burns J, Elkon R, Hertzano R
Cell Rep 2021 

Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies.
Himori K, Ashida Y, Tatebayashi D, Abe M, Saito Y, Chikenji T, Westerblad H, Andersson DC, Yamada T
Arthritis Rheumatol 2021 May;73(5):848-857

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.
Amanat S, Gallego-Martinez A, Sollini J, Perez-Carpena P, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Batuecas-Caletrio A, Canlon B, May P, Cederroth CR, Lopez-Escamez JA
EBioMedicine 2021

Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019.
Lancet 2021 

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.
Kowalski-Jahn M, Schihada H, Turku A, Huber T, Sakmar TP, Schulte G.
Science Advances. 2021

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs. 
Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han G-W, Kowalski-Jahn M, Kozielewicz P, Bowin C-F, Bouvier M, Schulte G^¤, Xu F.
Cell Research. 2021

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.
Zhou Y, Arribas GH, Turku A, Jürgenson T, Mkrtchian S, Krebs K, Wang Y, Svobodova B, Milani L, Schulte G, Korabecny J, Gastaldello S, Lauschke VM.
Science Advances. 2021 

Residue 6.43 defines receptor function in Class F GPCRs.
Turku A, Schihada H, Kozielewicz P, Bowin C-F, Schulte G. 
Nature Communications 2021

Perturbed BMP signaling and denervation contributes to muscle wasting in cancer cachexia.
Sartori R., Hagg A., Winbanks C.E., Armani A., Penna F., Zampieri S., Qian H.,  Larsson A.,  Zanchettin G., Pierobon S.E., Da Dalt G., Sperti C., Kustermann M., Thomson R.E., Larsson L., Loveland K., Costelli P., Megighian A., Merigliano S. Gregorevic P., Sandri M. 2021.
Science Translational Medicine. 04  Aug. 13. 

Time trajectories in the transcriptomic response to exercise - a meta-analysis 
David Amar, Malene E. Lindholm, Jessica Norrbom, Matthew T. Wheeler, Manuel A. Rivas & Euan A. Ashley
Nature Communications volume 12, Article number: 3471 (2021)

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky et al.
Autophagy 2021 Feb 8;1-382. doi: 10.1080/15548627.2020.1797280. Online ahead of print

Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting.
Kacal M, Zhang B, Hao Y, Norberg E, Vakifahmetoglu-Norberg H
Autophagy 2021 

2020

A New Buzz for Tinnitus-It's in the Genes!
Cederroth CR, Trpchevska N, Langguth B
JAMA Otolaryngol Head Neck Surg 2020 

Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors.
Schihada H, Kowalski-Jahn M, Turku A, Schulte G
Biosens Bioelectron 2020 

Eccentric resistance training ameliorates muscle weakness in a mouse model of idiopathic inflammatory myopathies.
Himori K, Ashida Y, Tatebayashi D, Abe M, Saito Y, Chikenji T, Westerblad H, Andersson DC, Yamada T.
Arthritis Rheumatol 2020 

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E, Vakifahmetoglu-Norberg H, Norberg E.
Cell Death Differ 2020 

Fast skeletal muscle troponin activator CK-2066260 mitigates skeletal muscle weakness independently of the underlying cause.
Cheng AJ, Ström J, Hwee DT, Malik FI, Westerblad H
J Cachexia Sarcopenia Muscle 2020 

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.
Swist S, Unger A, Li Y, Vöge A, von Frieling-Salewsky M, Skärlén Å, Cacciani N, Braun T, Larsson L, Linke WA
Nat Commun 2020 

Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients.
Stebbing J, Krishnan V, de Bono S, Ottaviani S, Casalini G, Richardson PJ, Monteil V, Lauschke VM, Mirazimi A, Youhanna S, Tan YJ, Baldanti F, Sarasini A, Terres JAR, Nickoloff BJ, Higgs RE, Rocha G, Byers NL, Schlichting DE, Nirula A, Cardoso A, Corbellino M; Sacco Baricitinib Study Group
EMBO Mol Med 2020 

A 3D Cell Culture Model Identifies Wnt/β-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration.
Oliva-Vilarnau N, Vorrink SU, Ingelman-Sundberg M, Lauschke VM
Adv Sci (Weinh) 2020 

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V, Jager J, Chen P, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M
Sci Transl Med 2020

Can CYP Inhibition Overcome Chemotherapy Resistance?
Ingelman-Sundberg M, Lauschke VM
Trends Pharmacol. Sci. 2020 

Structural insight into small molecule action on Frizzleds.
Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G. Nat Commun, 21 January 2020

Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome.
Chen YH, Grigelioniene G, Newton PT, Gullander J, Elfving M, Hammarsjö A, Batkovskyte D, Alsaif HS, Kurdi WIY, Abdulwahab F, Shanmugasundaram V, Devey L, Bacrot S, Brodszki J, Huber C, Hamel B, Gisselsson D, Papadogiannakis N, Jedrycha K, Gürtl-Lackner B, Chagin AS, Nishimura G, Aschenbrenner D, Alkuraya FS, Laurence A, Cormier-Daire V, Uhlig HH
J. Exp. Med. 8 January 2020

2019

Medicine in the Fourth Dimension.
Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch JB, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B
Cell Metab 2019 

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids.
Cederroth CR, Park JS, Basinou V, Weger BD, Tserga E, Sarlus H, Magnusson AK, Kadri N, Gachon F, Canlon B
Curr Biol 2019 

Sex-Specific Association of Tinnitus With Suicide Attempts.
Lugo A, Trpchevska N, Liu X, Biswas R, Magnusson C, Gallus S, Cederroth CR
JAMA Otolaryngol Head Neck Surg 2019 

Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus.
Cederroth CR, PirouziFard M, Trpchevska N, Idrizbegovic E, Canlon B, Sundquist J, Sundquist K, Zöller B
JAMA Otolaryngol Head Neck Surg 2019 

Therapeutic Approaches to the Treatment of Tinnitus.
Langguth B, Elgoyhen AB, Cederroth CR
Annu Rev Pharmacol Toxicol 2019 

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.
Lauschke VM, Zhou Y, Ingelman-Sundberg M
Pharmacol. Ther. 2019 

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.
Risal S, Pei Y, Lu H, Manti M, Fornes R, Pui HP, et al
Nat. Med. 2019 

Life expectancy and disease burden in the Nordic countries: results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017.
Nordic Burden Disease Collaborators
Lancet Public Health 2019 

Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish.
Xie M, Kamenev D, Kaucka M, Kastriti ME, Zhou B, Artemov AV, et al
Proc. Natl. Acad. Sci. U.S.A. 2019 

Targetome analysis of chaperone-mediated autophagy in cancer cells.
Hao Y, Kacal M, Ouchida AT, Zhang B, Norberg E, Vakifahmetoglu-Norberg H
Autophagy 2019 

Medicine in the Fourth Dimension
Cederroth c, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch J, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B.
Cell Metabolism 6 August 2019, Volume 30 (p. 238-250), https://doi.org/10.1016/j.cmet.2019.06.019

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring.
Manti M, Fornes R, Pironti G, McCann Haworth S, Zhengbing Z, Benrick A, et al
Cardiovasc. Res. 2019 

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Cederroth C, Park J-S, Basinou V, Weger B, Tserga E, Sarlus H, Magnusson A, Kadri N, Gachon F, Canlon B
Current Biology, 25 July 2019

Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, et al
J. Exp. Med. 2019 

Spatiotemporal structure of cell fate decisions in murine neural crest.
Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, et al
Science 2019 

Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.
Sun CW, Yang J, Kleschyov AL, Zhuge Z, Carlström M, Pernow J, et al
Circulation 2019

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.
Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, et al
Nat Commun 2019 

Days at Home after Surgery: An Integrated and Efficient Outcome Measure for Clinical Trials and Quality Assurance
Max Bell, Lars I. Eriksson, Tobias Svensson, Linn Hallqvist, Fredrik Granath, Jennifer Reilly, Paul S. Myles
The Lancet, 26 April 2019

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study
Marin Jukic, Robert L Smith, Tore Haslemo, Espen Molden, and Magnus Ingelman-Sundberg.
The Lancet Psychiatry, online April 15, 2019

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M, Xie M, et al
Nature 2019 

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, et al
Nat. Neurosci. 2019 

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.
Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, et al
Nat Commun 2019 

2018

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.
Lauschke VM, Barragan I, Ingelman-Sundberg M
Annu. Rev. Pharmacol. Toxicol. 2018

Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I.
Zhou Z, Mahdi A, Tratsiakovich Y, Zahorán S, Kövamees O, Nordin F, Uribe Gonzalez AE, Alvarsson M, Östenson CG, Andersson DC, Hedin U, Hermesz E, Lundberg JO, Yang J, Pernow J
J Am Coll Cardiol 2018 Aug;72(7):769-780

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, et al
Annu. Rev. Pharmacol. Toxicol. 2018 

Frizzleds as GPCRs - More Conventional Than We Thought!
Schulte G, Wright SC
Trends Pharmacol Sci 2018 

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
Larsson L, Degens H, Li M, Salviati L, Lee YI, Thompson W, et al
Physiol. Rev. 2019 

Nanothermometry Reveals Calcium-Induced Remodeling of Myosin
Kuhn E, Naik A, Lewis B, Kokovich K, Li M, Stemmler T, Larsson L, Jena B
ACS Nano Letters October 22 2018, DOI: 10.1021/acs.nanolett.8b02989

Therapeutic Approaches to the Treatment of Tinnitus.
Langguth B, Elgoyhen AB, Cederroth CR
Annu. Rev. Pharmacol. Toxicol. 2019 

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability.
Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, et al
Circulation 2018 

Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis.
Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, et al
Cell Metab. 2018 

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.
Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M
Am J Psychiatry 2018 

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.
Lauschke VM, Barragan I, Ingelman-Sundberg M
Annu. Rev. Pharmacol. Toxicol. 2018 

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, et al
Annu. Rev. Pharmacol. Toxicol. 2018 

2017

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.
Yao N, Skiteva O, Zhang X, Svenningsson P, Chergui K
Mol. Psychiatry 2018 

Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.
Maas IL, Brüggemann P, Requena T, Bulla J, Edvall NK, Hjelmborg JVB, et al
Genet. Med. 2017 

Differential Phase Arrangement of Cellular Clocks along the Tonotopic Axis of the Mouse Cochlea Ex Vivo.
Park JS, Cederroth CR, Basinou V, Sweetapple L, Buijink R, Lundkvist GB, et al
Curr. Biol. 2017

Regenerative medicine: Cartilage stem cells identified, but can they heal?
Chagin A, Medvedeva E
Nat Rev Rheumatol 2017

Mechanical isolation, and measurement of force and myoplasmic free [Ca2+] in fully intact single skeletal muscle fibers.
Cheng AJ, Westerblad H
Nat Protoc 2017 

Adiponectin protects against development of metabolic disturbances in a PCOS mouse model.
Benrick A, Chanclón B, Micallef P, Wu Y, Hadi L, Shelton JM, et al
Proc. Natl. Acad. Sci. U.S.A. 2017

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.
Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, et al
Nat Commun 2017 

The immune response of the human brain to abdominal surgery.
Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, et al
Ann. Neurol. 2017 

Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, et al
JAMA 2017 

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury.
Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, et al
Hepatology 2017

Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
Glatz P, Sandin RH, Pedersen NL, Bonamy AK, Eriksson LI, Granath F
JAMA Pediatr 2017 

2016

Precision Medicine and Rare Genetic Variants.
Lauschke VM, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016 

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, et al
Hepatology 2016 

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, et al, . Molecular Psychiatry, 29 november 2016

Association of Anesthesia and Surgery During Childhood With Academic Performance. Pia Glatz, Rolf H Sandin, Nancy L Pedersen, Anna-Karin Bonamy, Lars I Eriksson, et al. JAMA Pediatrics, 7 november 2016

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.
Lauschke VM, Vorrink SU, Moro SM, Rezayee F, Nordling Å, Hendriks DF, et al
Hepatology 2016 

Dietary nitrate improves cardiac contractility via enhanced cellular Ca²⁺ signaling.
Pironti G, Ivarsson N, Yang J, Farinotti AB, Jonsson W, Zhang SJ, Bas D, Svensson CI, Westerblad H, Weitzberg E, Lundberg JO, Pernow J, Lanner J, Andersson DC
Basic Res Cardiol 2016 May;111(3):34

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.
Ivanov M, Kals M, Lauschke V, Barragan I, Ewels P, Käller M, et al
Nucleic Acids Res. 2016 

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Cervenka I, Valnohova J, Bernatik O, Harnos J, Radsetoulal M, Sedova K, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, et al
Sci Transl Med 2016 

Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.
Bouderlique T, Vuppalapati KK, Newton PT, Li L, Barenius B, Chagin AS
Ann. Rheum. Dis. 2016 

Precision Medicine and Rare Genetic Variants.
Lauschke VM, Ingelman-Sundberg M
Trends Pharmacol. Sci. 2016