Publications 2022

Cellular shape reinforces niche to stem cell signaling in the small intestine.
Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund JI, Castillo-Azofeifa D, Gallagher A, Broberg M, Song KY, Sola Carvajal A, Speidel AT, Sundstrom M, Allbritton N, Stevens MM, Klein OD, Teixeira A, Katajisto P
Sci Adv 2022 Oct;8(41):eabm1847

Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit.
Abbasi M, Julner A, Lim YT, Zhao T, Sobota RM, Menéndez-Benito V
Biol Open 2022 Nov;11(11):

Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation.
Petrus-Reurer S, Lederer AR, Baqué-Vidal L, Douagi I, Pannagel B, Khven I, Aronsson M, Bartuma H, Wagner M, Wrona A, Efstathopoulos P, Jaberi E, Willenbrock H, Shimizu Y, Villaescusa JC, André H, Sundstrӧm E, Bhaduri A, Kriegstein A, Kvanta A, La Manno G, Lanner F
Stem Cell Reports 2022 06;17(6):1458-1475

Retrograde movements determine effective stem cell numbers in the intestine.
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J
Nature 2022 Jul;():

Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation.
Kumar B, Navarro C, Winblad N, Schell JP, Zhao C, Weltner J, Baqué-Vidal L, Salazar Mantero A, Petropoulos S, Lanner F, Elsässer SJ
Nat Cell Biol 2022 May;():

Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice.
Whisenant D, Lim K, Revêchon G, Yao H, Bergo MO, Machtel P, Kim JS, Eriksson M
Nat Commun 2022 Jun;13(1):3068

Lack of N-glycosylation increases Amyloidogenic processing of the amyloid precursor protein.
Lin T, van Husen LS, Yu Y, Tjernberg LO, Schedin-Weiss S
Glycobiology 2022 Mar;():

Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions.
Hu J, Gong X, Strömblad S
Sci Adv 2022 Mar;8(12):eabl3667

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.
Maqdasy S, Lecoutre S, Renzi G, Frendo-Cumbo S, Rizo-Roca D, Moritz T, Juvany M, Hodek O, Gao H, Couchet M, Witting M, Kerr A, Bergo MO, Choudhury RP, Aouadi M, Zierath JR, Krook A, Mejhert N, Rydén M
Nat Metab 2022 Feb;4(2):190-202

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.
Bost JP, Ojansivu M, Munson MJ, Wesén E, Gallud A, Gupta D, Gustafsson O, Saher O, Rädler J, Higgins SG, Lehto T, Holme MN, Dahlén A, Engkvist O, Strömstedt PE, Andersson S, Edvard Smith CI, Stevens MM, Esbjörner EK, Collén A, El Andaloussi S
Commun Biol 2022 Mar;5(1):185

The microtubule plus-end tracking protein Bik1 is required for chromosome congression.
Julner A, Abbasi M, Menéndez-Benito V
Mol Biol Cell 2022 Mar;():mbcE21100500

Metabolic determination of cell fate through selective inheritance of mitochondria.
Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI, Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES, Torregrosa Muñumer R, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R, Hietakangas V, Tyynismaa H, Ori A, Katajisto P
Nat Cell Biol 2022 02;24(2):148-154

Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3.
Balleza-Tapia H, Arroyo-García LE, Isla AG, Loera-Valencia R, Fisahn A
Prog Neurobiol 2022 Mar;210():102213

Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling.
Akusjärvi SS, Ambikan AT, Krishnan S, Gupta S, Sperk M, Végvári Á, Mikaeloff F, Healy K, Vesterbacka J, Nowak P, Sönnerborg A, Neogi U
iScience 2022 Jan;25(1):103607

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles.
Bost JP, Saher O, Hagey D, Mamand DR, Liang X, Zheng W, Corso G, Gustafsson O, Görgens A, Smith CE, Zain R, El Andaloussi S, Gupta D
Adv Healthc Mater 2022 Mar;11(5):e2101658