Thomas Gustafsson
Professor/Senior Physician | Docent
E-mail: thomas.gustafsson@ki.se
Visiting address: Alfred Nobels allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klinisk Fysiologi Gustafsson, 141 52 Huddinge
About me
- I graduated with a medical degree from KI in 1994 and obtained a Swedish medical licence in 1997. In 2005 I received PhD degree from KI after defending my doctoral thesis on angiogenic growth factors in skeletal muscle. I became Associate Professor at KI in 2010, and since 2014 acting as the Head of the Division of Clinical Physiology at the Department of Laboratory Medicine.
Since 2000, I have been active as a clinician at Karolinska University Hospital, currently as senior consultant at Department of Clinical Physiology. I was appointed Professor of Clinical Physiology at Karolinska Institutet on 1 January 2019.
Research
- My research focuses on combating the increase in morbidity and mortality caused by common non-communicable diseases in humans by combining clinical parameters with physiological measurements and molecular findings from various human tissues. I try to bring preclinical and clinical researchers together when it comes to relevant scientific questions and to translate our findings from the laboratory into practice.
One of my main research topics is the importance of skeletal muscle and the cardiovascular system for physical work capacity in health and disease, especially in situations where it has been shown to be important for function/QoL, disease progression or side effects of treatment, e.g. in aging and heart failure This may not only lead to a better understanding of the underlying processes, but also pave the way for different types of interventions
Teaching
- I teach physiology and clinical physiology in most of Karolinska Institutet's study programs, such as for occupational therapists, biomedical analysts (with focus on physiology and laboratory medicine), physicians, physiotherapists, nurses with focus on BMA (with focus on clinical physiology) and the medical study program. I have also participated in and been responsible for various independent courses in clinical physiology. I work with student-centred learning, using elements of flipped classroom, problem-based learning and team-based learning, among others.
Articles
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2024;:dgae745
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(5):2143-2155
- Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2024;47(9):2249-2260
- Article: PHYSIOLOGICAL REPORTS. 2024;12(7):e15995
- Article: JAMA NETWORK OPEN. 2024;7(4):e244386
- Article: NATURE AGING. 2024;4(1):80-94
- Article: JOURNAL OF PHYSIOLOGY. 2023;601(12):2359-2370
- Article: NATURE METABOLISM. 2023;5(3):495-515
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2023;134(3):753-765
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2023;134(2):264-275
- Article: ISCIENCE. 2023;26(1):105811
- Journal article: ISCIENCE. 2023;26(1):1-20
- Article: COMMUNICATIONS BIOLOGY. 2022;5(1):1121
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2022;13(5):2551-2561
- Article: PHYSIOLOGICAL REPORTS. 2022;10(14):e15398
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(6):944-952
- Article: BRITISH JOURNAL OF RADIOLOGY. 2022;95(1133):20211094
- Article: EXPERIMENTAL GERONTOLOGY. 2022;157:111631
- Article: PHYSIOLOGICAL REPORTS. 2021;9(7):e14841
- Article: CLINICAL RESEARCH IN CARDIOLOGY. 2020;109(6):655-672
- Article: THE FASEB JOURNAL. 2020;34(6):7958-7969
- Article: ACTA PHYSIOLOGICA. 2020;229(1):e13449
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2020;40(3):165-172
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(4):654-663
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(3):dgz247-E813
- Article: SCIENTIFIC REPORTS. 2020;10(1):2239
- Article: JOURNAL OF PHYSIOLOGY. 2020;598(4):773-787
- Article: THE JOURNAL OF FRAILTY & AGING. 2020;9(1):57-63
- Article: LUPUS SCIENCE AND MEDICINE. 2020;7(1):e000362
- Article: ENDOCRINE CONNECTIONS. 2019;8(7):1070-1081
- Article: SCIENTIFIC REPORTS. 2019;9(1):10762
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2019;317(1):R83-R92
- Article: JCI INSIGHT. 2019;4(9):126347
- Article: ANGIOGENESIS. 2019;22(1):103-115
- Article: BMC GERIATRICS. 2018;18(1):286
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2018;315(4):R799-R809
- Journal article: CLINICAL NUTRITION. 2018;37:s56-s57
- Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2018;118(9):1903-1909
- Article: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 2018;10:148-153
- Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5S):548
- Article: NATURE COMMUNICATIONS. 2018;9(1):800
- Article: ACTA PHYSIOLOGICA. 2018;222(2)
- Article: PLOS ONE. 2018;13(2):e0192384
- Article: JOURNAL OF NUTRITION, HEALTH AND AGING. 2018;22(4):541-548
- Article: JOURNAL OF NUTRITION, HEALTH AND AGING. 2018;22(1):1-7
- Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;73(1):95-101
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2017;122(5):1145-1154
- Journal article: THE FASEB JOURNAL. 2017;31(S1):460.3
- Article: SCIENTIFIC REPORTS. 2017;7:41926
- Article: FRONTIERS IN ENDOCRINOLOGY. 2017;8:229
- Article: FRONTIERS IN PHYSIOLOGY. 2017;8:1074
- Article: JOURNAL OF NUTRITION, HEALTH AND AGING. 2017;21(9):936-942
- Article: THE FASEB JOURNAL. 2017;31(1):96-108
- Article: LUPUS. 2016;25(14):1602-1609
- Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2016;13(5):361-366
- Article: THE FASEB JOURNAL. 2016;30(9):3039-3052
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2016;44(11):e109
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2016;310(11):R1279-R1287
- Article: THE FASEB JOURNAL. 2016;30(3):1120-1134
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2016;310(3):R297-R304
- Article: ENDOCRINOLOGY. 2016;157(1):98-111
- Article: PLOS ONE. 2016;11(4):e0153036
- Article: GENOME BIOLOGY. 2015;16(1):185
- Article: CONTEMPORARY CLINICAL TRIALS. 2015;43:164-171
- Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):84
- Article: CALCIFIED TISSUE INTERNATIONAL. 2015;96(3):256-263
- Article: SKELETAL MUSCLE. 2015;5:26
- Article: ACTA PHYSIOLOGICA. 2014;212(2):142-151
- Journal article: EUROPEAN GERIATRIC MEDICINE. 2014;5:s202
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):R248-R255
- Article: AVIATION SPACE AND ENVIRONMENTAL MEDICINE. 2014;85(7):694-699
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2014;34(4):322-326
- Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2014;114(2):221-234
- Article: BIOMED RESEARCH INTERNATIONAL. 2014;2014:519310-11
- Article: PHARMACOLOGY. 2014;93(3-4):178-184
- Article: PHYSIOLOGICAL REPORTS. 2013;1(6):e00140
- Article: JOURNAL OF RHEUMATOLOGY. 2013;40(11):1856-1864
- Article: ANGIOGENESIS. 2013;16(4):759-772
- Article: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2013;32(9):925-929
- Article: DIABETES. 2013;62(8):2717-2727
- Journal article: PHYSIOLOGICAL REPORTS. 2013;1(2):e00028
- Article: SKELETAL MUSCLE. 2013;3(1):12
- Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2013;113(5):1249-1255
- Article: PLOS GENETICS. 2013;9(3):e1003389
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2013;33(1):38-44
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2013;114(1):81-89
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2013;114(1):3-10
- Article: PLOS ONE. 2013;8(7):e67579
- Article: LUPUS. 2012;21(13):1405-1411
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2012;44(9):1680-1688
- Article: LUPUS. 2012;21(8):815-820
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2012;42(3):260-265
- Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2012;112(3):1059-1065
- Article: CLINICAL SCIENCE. 2012;122(3-4):133-142
- Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2011;39(6):1628-1632
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2011;301(6):E1092-E1098
- Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(8):1214-1221
- Article: DIABETES. 2011;60(8):2061-2067
- Article: ACTA PHYSIOLOGICA. 2011;202(1):91-98
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;651(1-3):146-151
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(1):46-59
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2010;109(3):721-727
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2010;108(6):1625-1630
- Article: CORONARY ARTERY DISEASE. 2010;21(2):65-71
- Article: AGING CLINICAL AND EXPERIMENTAL RESEARCH. 2010;22(1):85-94
- Article: ARTHRITIS RESEARCH & THERAPY. 2010;12(6):R214
- Article: ACTA PHYSIOLOGICA. 2010;198(1):71-79
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2009;161(3):427-434
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(3):804-812
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2008;105(3):902-906
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2008;294(1):E43-E51
- Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY (EJE). 2007;157(4):427-435
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2007;103(3):1012-1020
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2007;102(6):2346-2351
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2007;102(2):781-786
- Article: ACTA PHYSIOLOGICA. 2006;188(3-4):207-216
- Article: GROWTH HORMONE AND IGF RESEARCH. 2006;16(4):217-223
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;346(1):125-130
- Article: AMERICAN JOURNAL OF HYPERTENSION. 2005;18(10):1347-1352
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2005;98(6):2137-2146
- Article: ACTA PHYSIOLOGICA. 2005;184(2):105-112
- Article: THE FASEB JOURNAL. 2005;19(6):1009-1011
- Article: THE FASEB JOURNAL. 2005;19(7):750-760
- Article: EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY. 2005;6(2):127-133
- Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2004;37(6):1235-1244
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;322(1):287-291
- Journal article: CARDIOVASCULAR PATHOLOGY. 2004;13(3):26
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;315(4):1058-1063
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2004;96(1):189-194
- Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;444(6):752-759
- Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2001;443(1):61-66
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2001;31(4):362-366
- Article: ACTA PHYSIOLOGICA. 1999;165(3):335-336
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;276(2):H679-H685
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;274(2):e377-e380
- Article: JOURNAL OF CLINICAL INVESTIGATION. 1998;101(1):79-85
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All other publications
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(20):10932
- Letter: JOURNAL OF PHYSIOLOGY. 2024;602(20):5397-5399
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10S):790-791
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):777-778
- Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2024;26:565
- Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2024;26:547
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2022;60:1105
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(9S):389
- Preprint: BIORXIV. 2022
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(9):389
- Preprint: BIORXIV. 2021
- Review: FRONTIERS IN GENETICS. 2021;12:688526
- Conference publication: LUPUS SCIENCE AND MEDICINE. 2020;7(Suppl 1):a107
- Editorial comment: ACTA PHYSIOLOGICA. 2019;227(1):e13287
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:1165-1166
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2019;51(6):493
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2019;51(6):146
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:794-795
- Conference publication: JOURNAL OF VASCULAR RESEARCH. 2019;56:86
- Review: INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY. 2019;346:157-200
- Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;128:S106
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5S):488
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5S):112-113
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5S):600
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5):548
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5):488
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5):600
- Letter: ARCHIVES OF DISEASE IN CHILDHOOD. 2018;103(1):113-114
- Editorial comment: ACTA PHYSIOLOGICA. 2018;222(1)
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2018;50(5):112-113
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2017;49(5):329
- Conference publication: THE FASEB JOURNAL. 2017;31
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2016;48(5):16
- Conference publication: THE FASEB JOURNAL. 2016;30
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:1105-1106
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: THE FASEB JOURNAL. 2015;29
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:595
- Conference publication: ANGIOGENESIS. 2014;17(4):952
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;71:528
- Meeting abstract: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2013;32(4):S248
- Conference publication: THE FASEB JOURNAL. 2013;27:688.1
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2013;45(5):522
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2013;45(5):519
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2013;45(5):518
- Conference publication: THE FEBS JOURNAL. 2013;280:229
- Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(4):680-684
- Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(4):683-684
- Book chapter: ENCYCLOPEDIA OF EXERCISE MEDICINE IN HEALTH AND DISEASE. 2012;p. 83-86
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2011;43(5):42
- Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2011;43(5):151
- Conference publication: EUROPEAN HEART JOURNAL. 2010;31:541
- Conference publication: DIABETOLOGIA. 2010;53:S80
- Corrigendum: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(2):749
- Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:610
- Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2008;105(4):1382-1383
- Conference publication: THE FASEB JOURNAL. 2008;22:753.10
- Conference publication: THE FASEB JOURNAL. 2008;22:753.11
- Conference publication: THE FASEB JOURNAL. 2008;22:753.9
- Conference publication: THE FASEB JOURNAL. 2008;22:754.12
- Conference publication: THE FASEB JOURNAL. 2008;22:753.12
- Conference publication: EUROPEAN HEART JOURNAL. 2008;29:419
- Conference publication: THE FASEB JOURNAL. 2007;21(5):A576
- Conference publication: THE FASEB JOURNAL. 2007;21(5):A576
- Conference publication: THE FASEB JOURNAL. 2007;21(5):A575
- Conference publication: EUROPEAN HEART JOURNAL. 2007;28:876-877
- Conference publication: THE FASEB JOURNAL. 2007;21(6):A938
- Thesis / dissertation: 2005
- Conference publication: THE FASEB JOURNAL. 2005;19(5):A1273
- Conference publication: EUROPEAN HEART JOURNAL. 2005;26:66
- Letter: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(6):2636-2637
- Conference publication: THE FASEB JOURNAL. 2003;17(4):A440
- Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 2001;6:D75-D89
- Conference publication: THE FASEB JOURNAL. 2001;15(5):A763
- Conference publication: THE FASEB JOURNAL. 2001;15(5):A763
- Letter: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2000;279(6):H3144-H3145
- Conference publication: JOURNAL OF PHYSIOLOGY. 1998;506P:25P
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Grants
- A longitudinal approach to characterize loss of muscle mass and function in aging humansSwedish Research Council for Sport Science1 January 2024 - 31 December 2023
- longitudinal approach to characterize loss of muscle mass and function in aging humans – the importance of peripheral nerve integrity- part 2Swedish Research Council1 January 2024 - 31 December 2023
- A longitudinal approach to characterize loss of muscle mass and function in aging humansSwedish Research Council for Sport Science1 January 2023 - 31 December 2023
- Deciphering the roles of pericytes within ischemic muscleCanadian Institutes of Health Research1 October 2022 - 30 September 2027
- Swedish Research Council1 January 2021 - 31 December 2023
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2013 - 31 December 2018
Employments
- Professor/Senior Physician, Department of Laboratory Medicine, Karolinska Institutet, 2019-
Degrees and Education
- Docent, Karolinska Institutet, 2010
- Doctor Of Philosophy, Karolinska Institutet, 2005
- University Medical Degree, Karolinska Institutet, 1994
Supervisor
- Seher Alam, 2024
- Lisa Eriksson, 2023
- Alen Lovric, 2021
- Maria Joao Pires, 2020
- Michael Melin, Physical capacity, physical activity and skeletal muscle in heart failure : studies of pathophysiology
- Eric Rullman, Skeletal Muscle Metalloproteinase and Exercise in Humans
- Anna Strömberg, Recruitment of circulating cells into skeletal muscle - occurrence and possible mechanisms
- Karl Olsson, Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
- Elisabeth Skoglund, Muscle aging and its relation to physical activity and function – longitudinal and cross sectional analysis
- Karin Pernold, Home-cage monitoring of activity patterns of laboratory mice
- Mirko Mandic, Blood volume expansion following supramaximal exercise : occurrence and contribution to maximal oxygen uptake
- Mats Lilja, Effects of anti-inflammatory drugs on human skeletal muscle adaptations to resistance training
- Helene Rundqvist, Skeletal muscle HIF-1 and exercise
- Jessica Norrbom, Exercise and regulation of mitochondrial biogenesis factors in human skeletal muscle