Susanna Brighenti
Principal Researcher | Docent
E-mail: susanna.brighenti@ki.se
Visiting address: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postal address: H7 Medicin, Huddinge, H7 CIM Brighenti, 171 77 Stockholm
About me
- Immunologist with a research focus on tuberculosis (TB) infection and disease who has a large interest in basic and clinical research.
Research
- My group study immunopathogenesis in TB and how immune responses that are suppressed by M. tuberculosis can be restored to support antibiotic treatment and prevent the mergence of antimicrobial resistance.
Teaching
- Extensive experience of teaching and education including supervision of PhD students at Karolinska Institutet.
Articles
- Article: BIOMOLECULES. 2025;15(4):550Kalsum S; Xu R; Akber M; Huang S; Lerm M; Chen Y; Lourda M; Zhou Y; Brighenti S
- Article: GENES AND IMMUNITY. 2025;26(1):70-74Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
- Article: SCIENTIFIC REPORTS. 2024;14(1):28150Kalsum S; Akber M; Loreti MG; Andersson B; Danielson E; Lerm M; Brighenti S
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1296501Ashenafi S; Loreti MG; Bekele A; Aseffa G; Amogne W; Kassa E; Aderaye G; Brighenti S
- Article: IMMUNOBIOLOGY. 2023;228(2):152350Akhtar E; Mily A; Sarker P; Chanda BC; Haque F; Kuddusi RU; Haq MA; Lourda M; Brighenti S; Raqib R
- Article: RESPIRATORY RESEARCH. 2023;24(1):62Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
- Article: MBIO. 2022;13(5):e0108622-e01022Teran G; Li H; Catrina S-B; Liu R; Brighenti S; Zheng X; Grunler J; Nylen S; Carow B; Rottenberg ME
- Article: NUTRIENTS. 2022;14(16):3318Ashenafi S; Bekele A; Aseffa G; Amogne W; Kassa E; Aderaye G; Worku A; Bergman P; Brighenti S
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2022;192(4):653-670Ashenafi S; Muvva JR; Mily A; Snall J; Zewdie M; Chanyalew M; Rehn A; Rahman S; Aseffa G; Bekele A; Aderaye G; Lema B; Svensson M; Brighenti S
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
- Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(2):332-344Muvva JR; Ahmed S; Rekha RS; Kalsum S; Groenheit R; Schon T; Agerberth B; Bergman P; Brighenti S
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
- Article: BMC INFECTIOUS DISEASES. 2020;20(1):933Mily A; Sarker P; Taznin I; Hossain D; Haq MA; Kamal SMM; Agerberth B; Brighenti S; Raqib R
- Article: CELL. 2020;183(1):158-168.e14Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
- Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(163)Mily A; Kalsum S; Loreti MG; Rekha RS; Muvva JR; Lourda M; Brighenti S
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(163)Mily A; Kalsum S; Loreti MG; Rekha RS; Muvva JR; Lourda M; Brighenti S
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
- Article: FRONTIERS IN IMMUNOLOGY. 2020;10:3157Rao Muvva J; Parasa VR; Lerm M; Svensson M; Brighenti S
- Article: NUTRIENTS. 2019;11(7):E1675-1675Missailidis C; Sorensen N; Ashenafi S; Amogne W; Kassa E; Bekele A; Getachew M; Gebreselassie N; Aseffa A; Aderaye G; Andersson J; Brighenti S; Bergman P
- Article: NUTRIENTS. 2019;11(1):E133-133Ashenafi S; Amogne W; Kassa E; Gebreselassie N; Bekele A; Aseffa G; Getachew M; Aseffa A; Worku A; Hammar U; Bergman P; Aderaye G; Andersson J; Brighenti S
- Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(3):292-306Bekele A; Gebreselassie N; Ashenafi S; Kassa E; Aseffa G; Amogne W; Getachew M; Aseffa A; Worku A; Raqib R; Agerberth B; Hammar U; Bergman P; Aderaye G; Andersson J; Brighenti S
- Article: NUTRIENTS. 2018;10(6):E721-721Ashenafi S; Mazurek J; Rehn A; Lemma B; Aderaye G; Bekele A; Assefa G; Chanyalew M; Aseffa A; Andersson J; Bergman P; Brighenti S
- Article: RESPIRATORY MEDICINE. 2018;138:S38-S44Parasa VR; Forsslund H; Enger T; Lorenz D; Kullberg S; Eklund A; Skold M; Wahlstrom J; Grunewald J; Brighenti S
- Article: FASEB JOURNAL. 2018;32(5):2827-2840Wan M; Tang X; Rekha RS; Muvva SSVJR; Brighenti S; Agerberth B; Haeggstrom JZ
- Article: FRONTIERS IN MICROBIOLOGY. 2017;8:2370Parasa VR; Muvva JR; Rose JF; Braian C; Brighenti S; Lerm M
- Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;59:29-36Rane L; Rahman S; Magalhaes I; Ambati A; Andersson J; Zumla A; Brighenti S; Maeurer MJ
- Article: VACCINE. 2017;35(12):1652-1661Norrby M; Vesikari T; Lindqvist L; Maeurer M; Ahmed R; Mandavifar S; Bennett S; McClain JB; Shepherd BM; Li D; Hokey DA; Kromann I; Hoff ST; Andersen P; de Visser AW; Joosten SA; Ottenhoff THM; Andersson J; Brighenti S
- Article: MICROBIOLOGY SPECTRUM. 2016;4(6):10.1128/microbiolspec.tbtBrighenti S; Ordway DJ
- Article: ETHIOPIAN MEDICAL JOURNAL. 2016;54(4):181-188Bekele A; Ashenafi S; Aderay G; Assefa G; Aseffa A; Anderssen J; Brighenti S
- Article: CLINICAL INFECTIOUS DISEASES. 2015;61(Suppl 3):S225-S234Rao M; Valentini D; Poiret T; Dodoo E; Parida S; Zumla A; Brighenti S; Maeurer M
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2015;(104):53084Braian C; Svensson M; Brighenti S; Lerm M; Parasa VR
- Article: PLOS ONE. 2015;10(9):e0138340Mily A; Rekha RS; Kamal SMM; Arifuzzaman ASM; Rahim Z; Khan L; Haq MA; Zaman K; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B; Raqib R
- Article: AUTOPHAGY. 2015;11(9):1688-1699Rekha RS; Muvva SSVJR; Wan M; Raqib R; Bergman P; Brighenti S; Gudmundsson GH; Agerberth B
- Article: CLINICAL IMMUNOLOGY. 2015;156(2):85-97Rahman S; Rehn A; Rahman J; Andersson J; Svensson M; Brighenti S
- Article: CLINICAL IMMUNOLOGY. 2014;151(2):84-99Ashenafi S; Aderaye G; Bekele A; Zewdie M; Aseffa G; Anh TNH; Carow B; Habtamu M; Wijkander M; Rottenberg M; Aseffa A; Andersson J; Svensson M; Brighenti S
- Article: DISEASE MODELS & MECHANISMS. 2014;7(2):281-288Parasa VR; Rahman MJ; Anh TNH; Svensson M; Brighenti S; Lerm M
- Article: THORAX. 2013;68(3):269-276Ashenafi S; Aderaye G; Zewdie M; Raqib R; Bekele A; Magalhaes I; Lema B; Habtamu M; Rekha RS; Aseffa G; Maeurer M; Aseffa A; Svensson M; Andersson J; Brighenti S
- Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205:S316-S324Brighenti S; Andersson J
- Article: MOLECULAR MEDICINE. 2012;18(4):647-658Rahman S; Magalhaes I; Rahman J; Ahmed RK; Sizemore DR; Scanga CA; Weichold F; Verreck F; Kondova I; Sadoff J; Thorstensson R; Spangberg M; Svensson M; Andersson J; Maeurer M; Brighenti S
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(1):114-123Bond E; Liang F; Sandgren KJ; Smed-Sorensen A; Bergman P; Brighenti S; Adams WC; Betemariam SA; Rangaka MX; Lange C; Wilkinson RJ; Andersson J; Lore K
- Article: GENES AND IMMUNITY. 2011;12(7):513-522Rane L; Rahman S; Magalhaes I; Ahmed R; Spangberg M; Kondova I; Verreck F; Andersson J; Brighenti S; Maeurer MJ
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):50-57Brighenti S; Andersson J
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2009;174(6):2211-2224Rahman S; Gudetta B; Fink J; Granath A; Ashenafi S; Aseffa A; Derbew M; Svensson M; Andersson J; Brighenti SG
- Article: INFECTION AND IMMUNITY. 2007;75(11):5210-5222Andersson J; Samarina A; Fink J; Rahman S; Grundstroem S
- Article: MICROBES AND INFECTION. 2006;8(8):1985-1993Toro JC; Hoffner S; Linde C; Andersson M; Andersson J; Grundstrom S
- Article: INFECTION AND IMMUNITY. 2005;73(10):6332-6339Linde CMA; Grundström S; Nordling E; Refai E; Brennan PJ; Andersson M
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2005;302(1-2):13-25Zuber B; Levitsky V; Jönsson G; Paulie S; Samarina A; Grundström S; Metkar S; Norell H; Callender GG; Froelich C; Ahlborg N
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(9):8460-8468Grundström S; Anderson P; Scheipers P; Sundstedt A
- Article: JOURNAL OF IMMUNOLOGY. 2003;170(10):5008-5017Grundström S; Cederbom L; Sundstedt A; Scheipers P; Ivars F
- Article: JOURNAL OF IMMUNOLOGY. 2000;164(3):1175-1184Grundström S; Dohlsten M; Sundstedt A
- Article: IMMUNOLOGY. 1998;95(1):76-82Sundstedt A; Grundström S; Dohlsten M
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All other publications
- Editorial comment: LANCET GLOBAL HEALTH. 2024;12(8):e1225-e1226Cirillo D; Anthony R; Gagneux S; Horsburgh Jr CR; Hasan R; Darboe S; Laniado-Laborin R; Probandari A; Tukvadze N; Arcencio RA; Bimba JS; Brighenti S; Chesov D; Chiang C-Y; Kalmambetova G; Knight G; Konstantynovska O; Kruse A; Lange C; Mayanja-Kizza H; Mcbryde E; Min J; Sanchez-Montalva A; Sulis G; Tsogt B; van der Walt M; Yeboah-Manu D; Hauser J
- Review: FRONTIERS IN IMMUNOLOGY. 2022;13:1059725Ashenafi S; Brighenti S
- Corrigendum: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(164)Mily A; Kalsum S; Loreti MG; Rekha RS; Muvva JR; Lourda M; Brighenti S
- Review: FRONTIERS IN MEDICINE. 2020;7:537Berry SB; Haack AJ; Theberge AB; Brighenti S; Svensson M
- Editorial comment: NUTRIENTS. 2020;12(6):E1682-1682Bergman P; Brighenti S
- Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2018;284(2):113-115Brighenti S; Lerm M
- Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(2):163-188Lange C; Alghamdi WA; Al-Shaer MH; Brighenti S; Diacon AH; DiNardo AR; Grobbel HP; Groschel MI; von Groote-Bidlingmaier F; Hauptmann M; Heyckendorf J; Kohler N; Kohl TA; Merker M; Niemann S; Peloquin CA; Reimann M; Schaible UE; Schaub D; Schleusener V; Thye T; Schon T
- Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(2):145-162Brighenti S; Bergman P; Martineau AR
- Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(2):125-144Brighenti S; Joosten SA
- Book chapter: TUBERCULOSIS AND THE TUBERCLE BACILLUS. 2017;p. 73-93Brighenti S; Ordway DJ
- Review: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;56:140-154Valentini D; Rao M; Rane L; Rahman S; Axelsson-Robertson R; Heuchel R; Lohr M; Hoft D; Brighenti S; Zumla A; Maeurer M
- Review: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;56:167-175Ferrara G; Valentini D; Rao M; Wahlstrom J; Grunewald J; Larsson L-O; Brighenti S; Dodoo E; Zumla A; Maeurer M
- Letter: THORAX. 2011;66(8):727-729Thomas T; Brighenti S; Andersson J; Sack D; Raqib R
- Review: CURRENT HIV/AIDS REPORTS. 2006;3(1):32-38Grundström S; Andersson J
Grants
- Swedish Research Council1 January 2023 - 31 December 2026Multidrug-resistant tuberculosis (MDR-TB) is a serious threat to global elimination of TB and a difficult challenge in treatment and management of disease. This 4-year project aims to explore how immune checkpoint molecules are modulated in MDR-TB patients depending on clinical disease severity and bacterial strain virulence. Our original findings from TB patients show that antimicrobial macrophage and T cell responses are severely impaired, while myeloid-derived suppressor cells and regulatory T cells expand in the TB lesions. To advance our understanding of immunoregulation in MDR-TB compared to drug-susceptible TB, we will examine stimulatory and inhibitory checkpoint molecules in a well-defined patient cohort in Addis Ababa, Ethiopia. We will model disease progression and quantify disease severity at enrolment and after chemotherapy using a composite clinical TB score and chest X-ray grading. Drug susceptibility testing will determine the level of resistance and genotyping of patient´s strains will signify bacterial virulence. Longitudinal assessment of checkpoint molecules in peripheral blood and induced sputum samples involves deep profiling with RNA-sequencing, multicolor flow cytometry and in vitro suppression assays. We will also exploit in situ imaging of resected lung tissue from MDR-TB patients. This collaborative project offers untapped opportunities for translating new advances on checkpoint molecules in chronic infections into clinical applications for MDR-TB.
- Swedish Research Council1 December 2022 - 30 November 2025Immune enhancing therapies represent an underexplored opportunity to meet the challenges of treatment failure in tuberculosis (TB). My group has generated a platform for epigenetic modulation in chronic TB using histone deacetylase (HDAC) inhibitors that can alter immune cell differentiation and function. We have shown that phenylbutyrate (PBA) can restore Mycobacterium tuberculosis (Mtb)-induced impairment of antimicrobial responses in macrophages and enhance clinical recovery of pulmonary TB. Now, we advance our concept and recently discovered several HDAC inhibitors that can inhibit intracellular Mtb more effectively than PBA. Next, we plan to exploit computer-aided methods including structure- and artificial intelligence-based design of potent HDAC modulators that can control the level of gene inhibition or activation in immune cells more precisely. This work will focus on HDAC inhibition to restore antimicrobial genes, while HDAC activation repress excess activity of immunosuppressive genes. Our panel of de novo HDAC modulators will be explored using a bioassay for high-content imaging and methods for cell-specific transcriptional regulation. The effects of selected compounds on the function of innate and adaptive immune cells and stromal cells will be evaluated in relevant in vitro and in vivo infection models. This project will promote personalized medicine in TB based on endotype-specific therapies for different groups of TB patients including multidrug-resistant TB.
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Heart-Lung Foundation1 January 2020 - 31 December 2022
- Swedish Research Council1 November 2016 - 30 November 2016
- Swedish Research Council1 January 2015 - 31 December 2017
- Swedish Research Council1 January 2015 - 31 December 2017
- Swedish Research Council1 January 2015 - 31 December 2018
- Swedish Research Council1 January 2013 - 31 December 2014
- Swedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2012 - 31 December 2014
- Swedish Research Council1 July 2010 - 31 December 2010
- Swedish Research Council1 January 2010 - 31 December 2012
Employments
- Principal Researcher, Immunology of tuberculosis (TB), Department of Medicine, Huddinge, Karolinska Institutet, 2014-
Degrees and Education
- Docent, Karolinska Institutet, 2014