Catharina Lavebratt
About me
I was born in 1967, grew up in Värmland Sweden, started studying in
Stockholm in 1986, am since 2003 an Associate Professor of medical genetics
at the Department of Molecular Medicine and Surgery, Karolinska Institutet
and lead the research group Translational Psychiatry with activities in the
Center for Molecular Medicine (CMM) at Karolinska University Hospital, Solna.
My research focus is on early risk factors and treatment effects in
psychiatric disorder. We have a particular focus on the connection between
psychiatric disorder, immune activity and metabolic factors. Both epidemiological, clinical
and experimental studies are used. I have been the main supervisor of 12 PhD
students now graduated, most of have embarked on a research career, and I
have authored ~185 international original peer-reviewed articles, being first
or senior author on more than half of those (h-index 41 [Web of science]).
The research group Translational Psychiatry has 22 members. I am currently
supervising 7 PhD students (main supervisor of 2) and 2 postdoctoral
fellows.In parallell I am Director of doctoral education at MMK, KI since 2016 with ~165 doctoral students.
I am member of the Steering groups of Center for Molecular Medicine (CMM) and
Department of Molecular Medicine and Surgery, as well as Director of
postgraduate studies [1] at the Department of Molecular Medicine and
Surgery.
Catharina, with a MSc degree in Biochemistry and Biotechnology from the Royal
Institute of Technology (KTH), Stockholm, received her PhD degree in
Biochemistry and Biotechnology from KTH in 1996. She was a Swedish Research
Council Medicine-postdoctoral fellow at McGill University, Canada, and
thereafter a Swedish Research Council Medicine-Junior researcher
(Forskarassistent) at Karolinska Institutet until 2006, and has since then a
senior researcher position at the Department of Molecular Medicine and
Surgery, Karolinska Institutet. She became docent (Associate professor) at
Karolinska Institutet in 2003.
Research
Research group leader for Translational Psychiatry [1]
My research is focused on early risk factors of, and treatment response
in, psychiatric disorders particularly studying the links to immune activity, the gut microbiome and metabolic
risk using clinical and population-based naturalistic cohorts and
experimental models. In nation-wide registries we study pre- and perinatal
metabolic and inflammatory risk factors, and possible protective factors, for
neurodevelopmental and psychiatric disorders. In clinical studies we test
adjuvant treatments, i.e. probiotics and physical exercise, to improve
symptoms and reduce comorbidity in ADHD and psychosis. For example, I led a
large RCT in ADHD with 182 patients fulfilling 9 weeks daily intake of a
probiotic. We also look for early biomarkers of lithium response, and
lithium’s longterm effects on metabolic comorbidity, and plasma markers of
metabolic risk in relation to psychiatric profile, pharmacological treatment
and metabolic comorbidity in psychosis. We collaborate within large
international consortia for genome-wide genetic association studies.
I am also responsible for molecular studies in clinical or naturalistic
population-based studies of primarily mood and anxiety (www.REGASSA.se,
www.kupolstudien.se, PART).
[1] https://ki.se/en/mmk/translational-psychiatry
Teaching
Organization of and lecturer in KI-courses at advanced and research level: Several week-long
courses on master and doctoral levels run annually in- psychiatric
genetics.
Supervisorship of PhD students: Main supervisor of 12 graduated and
2 current. Co-supervisor of 7 graduated and 5 current.
Supervision of 25 master student theses.
Own education in teaching in higher education, corresponding to 10 full-time
weeks.
Director of postgraduate studies at the Department of Molecular Medicine and
Surgery.
Articles
- Article: CLINICAL NUTRITION ESPEN. 2024;63:74-83
- Journal article: JAMA NETWORK OPEN. 2024;7(10):e2440517
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2024;87:49
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;120:360-371
- Article: SCIENTIFIC REPORTS. 2024;14(1):17566
- Article: EUROPEAN CHILD AND ADOLESCENT PSYCHIATRY. 2024;:1-13
- Article: INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS. 2024;12(1):20
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;117:298-309
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):109
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):37
- Journal article: NEUROSCIENCE APPLIED. 2024;3:104030
- Article: INTERNATIONAL JOURNAL OF EATING DISORDERS. 2023;56(12):2232-2249
- Article: MOLECULAR PSYCHIATRY. 2023;28(12):5251-5261
- Article: HUMAN REPRODUCTION OPEN. 2023;2023(4):hoad048
- Article: BIPOLAR DISORDERS. 2023;25(5):391-401
- Journal article: BIOLOGICAL PSYCHIATRY. 2023;93(9):s146
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;110:310-321
- Article: PSYCHONEUROENDOCRINOLOGY. 2023;148:106001
- Article: FRONTIERS IN ONCOLOGY. 2023;13:928008
- Article: NUTRIENTS. 2022;14(24):5247
- Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2022;272(8):1611-1620
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2022;156:36-43
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e32-e33
- Article: THE LANCET PSYCHIATRY. 2022;9(6):447-457
- Article: HUMAN REPRODUCTION. 2022;37(6):1311-1323
- Article: ACTA NEUROPSYCHIATRICA. 2022;34(2):86-92
- Article: SCIENTIFIC REPORTS. 2022;12(1):4963
- Article: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;220(4):1-10
- Article: JOURNAL OF CLINICAL MEDICINE. 2022;11(5):1291
- Article: BIOLOGICAL PSYCHIATRY. 2022;91(3):313-327
- Article: JAMA NETWORK OPEN. 2022;5(1):e2145719
- Article: PLOS ONE. 2022;17(12):e0275999
- Article: PLOS ONE. 2022;17(2):e0263173
- Article: BIOLOGICAL PSYCHIATRY. 2022;91(1):102-117
- Article: COMPLEX PSYCHIATRY. 2021;7(3-4):80-89
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):606
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):477
- Article: SCIENTIFIC REPORTS. 2021;11(1):17823
- Article: MOLECULAR PSYCHIATRY. 2021;26(8):4179-4190
- Article: HUMAN REPRODUCTION. 2021;36(8):2345-2357
- Article: PSYCHIATRY RESEARCH. 2021;301:113968
- Article: NATURE GENETICS. 2021;53(6):817-829
- Article: MOLECULAR PSYCHIATRY. 2021;26(6):2457-2470
- Article: JOURNAL OF ADOLESCENT HEALTH. 2021;68(4):758-764
- Article: MOLECULAR PSYCHIATRY. 2021;26(4):1286-1298
- Article: SCIENTIFIC REPORTS. 2021;11(1):1155
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2021;132:38-43
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;41:118-131
- Article: HUMAN REPRODUCTION. 2020;35(10):2336-2347
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2020;89:9-19
- Article: JOURNAL OF NEUROCHEMISTRY. 2020;154(6):635-646
- Article: BIOLOGICAL PSYCHIATRY. 2020;88(2):169-184
- Article: BIPOLAR DISORDERS. 2020;22(3):255-265
- Article: PSYCHIATRY RESEARCH. 2020;286:112865
- Article: JAMA NETWORK OPEN. 2020;3(2):e1920787
- Article: PSYCHIATRY RESEARCH. 2020;284:112677
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2020;260:597-603
- Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):340
- Article: CELL. 2019;179(7):1469-1482.e11
- Article: SCIENTIFIC REPORTS. 2019;9(1):18142
- Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):317
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2019;117:45-54
- Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):150
- Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):149
- Article: NATURE GENETICS. 2019;51(5):793-803
- Article: JAMA PSYCHIATRY. 2019;76(5):516-525
- Journal article: MOLECULAR PSYCHIATRY. 2019;24(4):484-490
- Article: JAMA PEDIATRICS. 2019;173(4):371-378
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2019;245:597-601
- Article: BIPOLAR DISORDERS. 2019;21(1):68-75
- Article: COMPLEX PSYCHIATRY. 2019;4(4):196-203
- Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:s848-s849
- Article: FRONTIERS IN NEUROSCIENCE. 2019;13:220
- Article: PEDIATRICS. 2018;142(3):e20180776
- Article: SCIENTIFIC REPORTS. 2018;8(1):12743
- Article: BMC MEDICAL GENETICS. 2018;19(1):126
- Article: TRANSLATIONAL PSYCHIATRY. 2018;8(1):121
- Article: PSYCHIATRY RESEARCH. 2018;263:48-53
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2018;75(1):52-58
- Article: CLINICAL EPIDEMIOLOGY. 2018;10:729-738
- Article: FRONTIERS IN PSYCHIATRY. 2018;9:207
- Article: PSYCHIATRIC GENETICS. 2017;27(6):210-218
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2017;222:138-145
- Article: PSYCHIATRY RESEARCH. 2017;257:322-326
- Article: SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE. 2017;12(10):1658-1667
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2017;93:50-58
- Article: SCIENTIFIC REPORTS. 2017;7(1):7906
- Journal article: NEURO-ONCOLOGY. 2017;19(suppl_4):iv19-iv20
- Article: PSYCHIATRY RESEARCH. 2017;252:270-276
- Article: PSYCHIATRY RESEARCH. 2017;250:217-220
- Article: FRONTIERS IN NEUROSCIENCE. 2017;11:244
- Article: NEUROPSYCHIATRIC DISEASE AND TREATMENT. 2017;13:967-972
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(12):pyw069
- Article: ANNALS OF HEMATOLOGY. 2016;95(11):1825-1832
- Article: ONCOTARGET. 2016;7(39):63640-63650
- Article: TRANSLATIONAL PSYCHIATRY. 2016;6(8):e869
- Article: HUMAN MOLECULAR GENETICS. 2016;25(15):3383-3394
- Article: BMC PSYCHIATRY. 2016;16:243
- Article: NORDIC JOURNAL OF PSYCHIATRY. 2016;70(5):380-391
- Article: PSYCHIATRIC GENETICS. 2016;26(3):136-139
- Article: PSYCHIATRY RESEARCH. 2016;237:55-59
- Article: THE LANCET. 2016;387(10023):1085-1093
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2016;189:62-69
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2016;8:34
- Article: TRIALS. 2015;16:553
- Journal article: EUROPEAN JOURNAL OF CANCER. 2015;51:s163
- Article: BIPOLAR DISORDERS. 2015;17(6):645-652
- Article: CARCINOGENESIS. 2015;36(8):876-882
- Article: COMPLEX PSYCHIATRY. 2015;1(2):76-81
- Article: CHRONOBIOLOGY INTERNATIONAL. 2015;32(4):579-584
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(7):pyv002
- Article: THE PRIMARY CARE COMPANION FOR CNS DISORDERS. 2015;17(1)
- Article: PLOS ONE. 2015;10(8):e0136436
- Article: ANNALS OF MEDICINE. 2014;46(7):539-546
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(2):pyu032
- Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2014;370(19):1859-1860
- Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2014;370(19):1855-1856
- Article: MOLECULAR PSYCHIATRY. 2014;19(3):334-341
- Article: OBESITY. 2014;22(3):895-900
- Article: NEUROBIOLOGY OF LEARNING AND MEMORY. 2013;106:274-282
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2013;151(2):652-659
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(7):1513-1528
- Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e261
- Article: TRANSLATIONAL PSYCHIATRY. 2013;3(5):e255
- Article: NEURON. 2013;77(5):899-914
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2013;144(3):216-224
- Article: PLOS ONE. 2013;8(11):e79015
- Article: PLOS ONE. 2013;8(7):e67450
- Article: PLOS ONE. 2013;8(6):e65636
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15(5):669-679
- Article: THE FASEB JOURNAL. 2012;26(6):2712-2718
- Journal article: EUROPEAN PSYCHIATRY. 2012;27:1
- Article: PLOS ONE. 2012;7(8):e43057
- Article: PLOS ONE. 2012;7(7):e41652
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(7):1121-1130
- Article: PLOS ONE. 2011;6(4):e18213
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2011;129(1-3):158-166
- Journal article: JOURNAL OF BEHAVIORAL AND BRAIN SCIENCE. 2011;01(04):210-228
- Article: PLOS ONE. 2010;5(9):e12632
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2010;125(1-3):249-255
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS, PART B: NEUROPSYCHIATRIC GENETICS. 2010;153B(2):570-581
- Article: PLOS ONE. 2010;5(2):e9407
- Article: JOURNAL OF MEDICAL ETHICS. 2010;36(2):93-98
- Article: JOURNAL OF CIRCADIAN RHYTHMS. 2010;8:1
- Article: SEIZURE. 2009;18(10):672-675
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2009;118(1-3):124-130
- Article: JOURNAL OF AFFECTIVE DISORDERS. 2009;113(1-2):66-76
- Article: NEUROBIOLOGY OF DISEASE. 2008;32(3):364-376
- Journal article: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. 2007;11:15
- Article: CLINICAL LIPIDOLOGY. 2007;2(2):147-151
- Article: NEUROBIOLOGY OF DISEASE. 2007;26(1):221-228
- Article: BMC NEUROSCIENCE. 2007;8:10
- Article: HIPPOCAMPUS. 2007;17(4):292-304
- Article: NEUROBIOLOGY OF DISEASE. 2006;24(2):374-383
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2006;30(3):453-459
- Article: NATURE PROTOCOLS. 2006;1(6):2573-2582
- Article: INTERNATIONAL JOURNAL OF OBESITY. 2005;29(12):1422-1428
- Article: BMC NEUROSCIENCE. 2005;6:65
- Article: JOURNAL OF LIPID RESEARCH. 2005;46(10):2278-2281
- Article: GENES AND IMMUNITY. 2005;6(7):620-627
- Article: HUMAN GENETICS. 2005;117(1):54-60
- Article: HUMAN MUTATION. 2004;23(1):92-97
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3231-3240
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;18(12):3218-3230
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;103(2):244-252
- Article: TWIN RESEARCH AND HUMAN GENETICS. 2003;6(2):162-169
- Article: INFECTION AND IMMUNITY. 2003;71(1):126-131
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2002;32(12):938-942
- Article: HUMAN MUTATION. 2002;19(4):395-401
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2002;34(8):583-590
- Article: DIABETES. 2001;50(10):2410-2413
- Article: BRAIN RESEARCH. 2000;84(1-2):97-105
- Article: TUBERCLE AND LUNG DISEASE. 2000;80(1):15-25
- Article: NEUROLOGY. 1999;53(6):1254-1259
- Article: BRAIN RESEARCH. 1999;72(1):80-88
- Article: JOURNAL OF INFECTIOUS DISEASES. 1999;180(1):150-155
- Article: SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE. 1998;25(2):53-58
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1997;29(1):65-70
- Article: ACTA TROPICA. 1997;63(1):15-31
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1996;28(1):75-81
- Journal article: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 1994;88(3):303-306
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All other publications
- Review: BIOESSAYS. 2024;46(10):e2300246
- Corrigendum: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;121:404-405
- Preprint: RES SQ. 2023;RES SQ
- Preprint: MEDRXIV. 2023
- Preprint: RESEARCH SQUARE. 2023
- Preprint: RES SQ. 2023;RES SQ
- Corrigendum: THE BRITISH JOURNAL OF PSYCHIATRY. SUPPLEMENT. 2022;221(2):494
- Corrigendum: TRANSLATIONAL PSYCHIATRY. 2022;12(1):278
- Preprint: RESEARCH SQUARE. 2022
- Letter: HUMAN REPRODUCTION. 2021;37(1):193-194
- Letter: SCHIZOPHRENIA RESEARCH. 2021;228:316-318
- Review: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(10):1981-2000
- Review: FRONTIERS IN PSYCHIATRY. 2020;11:586083
- Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):16377
- Letter: JAMA PEDIATRICS. 2019;173(9):889-890
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S776
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S969-S970
- Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S908-S909
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:1045
- Meeting abstract: BIOLOGICAL PSYCHIATRY. 2018;83(9):S351-S352
- Preprint: BIORXIV. 2017
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S502
- Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S387
- Corrigendum: PLOS ONE. 2016;11(10):e0165249
- Corrigendum: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(6):pyv026
- Letter: PSYCHIATRY RESEARCH. 2015;226(1):405-406
- Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2014;370(19):1857-1859
- Editorial comment: EPIGENOMICS. 2012;4(4):359-362
- Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(6):757-765
- Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S48-S49
- Review: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. 2008;12(6):438-445
- Conference publication: BIOPHYSICAL JOURNAL. 2005;88(1):282A
- Review: NEUROSCIENCE. 2000;100(2):297-317
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Grants
- Blodkärls-inflammation hos barn med ADHD? Skyddar probiotika?Swedish Brain Foundation1 November 2024 - 30 October 2025
- Swedish Brain Foundation23 September 2023 - 30 October 2024
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 December 2020 - 31 October 2021
- Swedish Research Council1 January 2020 - 31 December 2022
- Swedish Research Council for Health Working Life and Welfare1 December 2019 - 30 November 2022
- Swedish Brain Foundation3 July 2017 - 30 June 2023
- Swedish Research Council1 January 2017 - 31 December 2019
- Swedish Research Council1 January 2015 - 31 December 2017
- Swedish Research Council1 January 2012 - 31 December 2015
- Swedish Research Council1 January 2011 - 31 December 2013
- VINNOVA1 June 2009 - 30 December 2012
Employments
- Principal Researcher, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2003