PublicationsSelected publications Article: CELL. 2025;188(19):5142-5156.e23 GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandström A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Grätz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T Article: CELL REPORTS MEDICINE. 2024;5(1):101348 Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A Article: SCIENCE ADVANCES. 2022;8(36):eabo3192 Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; de ten Ryen SVD; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR Article: NATURE GENETICS. 2022;54(9):1332-1344 Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention Wang Z; Emmerich A; Pillon NJ; Moore T; Hemerich D; Cornelis MC; Mazzaferro E; Broos S; Ahluwalia TS; Bartz TM; Bentley AR; Bielak LF; Chong M; Chu AY; Berry D; Dorajoo R; Dueker ND; Kasbohm E; Feenstra B; Feitosa MF; Gieger C; Graff M; Hall LM; Haller T; Hartwig FP; Hillis DA; Huikari V; Heard-Costa N; Holzapfel C; Jackson AU; Johansson A; Jorgensen AM; Kaakinen MA; Karlsson R; Kerr KF; Kim B; Koolhaas CM; Kutalik Z; Lagou V; Lind PA; Lorentzon M; Lyytikainen L-P; Mangino M; Metzendorf C; Monroe KR; Pacolet A; Perusse L; Pool R; Richmond RC; Rivera NV; Robiou-Du-Pont S; Schraut KE; Schulz C-A; Stringham HM; Tanaka T; Teumer A; Turman C; Van der Most PJ; Vanmunster M; Van Rooij FJA; Van Vliet-Ostaptchouk JV; Zhang X; Zhao J-H; Zhao W; Balkhiyarova Z; Balslev-Harder MN; Baumeister SE; Beilby J; Blangero J; Boomsma DI; Brage S; Braund PS; Brody JA; Bruinenberg M; Ekelund U; Liu C-T; Cole JW; Collins FS; Cupples LA; Esko T; Enroth S; Faul JD; Fernandez-Rhodes L; Fohner AE; Franco OH; Galesloot TE; Gordon SD; Grarup N; Hartman CA; Heiss G; Hui J; Illig T; Jago R; James A; Joshi PK; Jung T; Kahonen M; Kilpelainen TO; Koh W-P; Kolcic I; Kraft PP; Kuusisto J; Launer LJ; Li A; Linneberg A; Luan J; Vidal PM; Medland SE; Milaneschi Y; Moscati A; Musk B; Nelson CP; Nolte IM; Pedersen NL; Peters A; Peyser PA; Power C; Raitakari OT; Reedik M; Reiner AP; Ridker PM; Rudan I; Ryan K; Sarzynski MA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Smith AV; Smith JA; Sonestedt E; Strom M; Tai ES; Teo KK; Thorand B; Toenjes A; Tremblay A; Uitterlinden AG; Vangipurapu J; Van Schoor N; Volker U; Willemsen G; Williams K; Wong Q; Xu H; Young KL; Yuan JM; Zillikens MC; Zonderman AB; Ameur A; Bandinelli S; Bis JC; Boehnke M; Bouchard C; Chasman DI; Smith GD; De Geus EJC; Deldicque L; Dorr M; Evans MK; Ferrucci L; Fornage M; Fox C; Garland TJ; Gudnason V; Gyllensten U; Hansen T; Hayward C; Horta BL; Hypponen E; Jarvelin M-R; Johnson WC; Kardia SLR; Kiemeney LA; Laakso M; Langenberg C; Lehtimaki T; Le Marchand L; Magnusson PKE; Martin NG; Melbye M; Metspalu A; Meyre D; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pare G; Park T; Pedersen O; Penninx BWJH; Pers TH; Polasek O; Prokopenko I; Rotimi CN; Samani NJ; Sim X; Snieder H; Sorensen TIA; Spector TD; Timpson NJ; Van Dam RM; Van der Velde N; Van Duijn CM; Vollenweider P; Volzke H; Voortman T; Waeber G; Wareham NJ; Weir DR; Wichmann H-E; Wilson JF; Hevener AL; Krook A; Zierath JR; Thomis MAI; Loos RJF; Den Hoed M Article: NATURE COMMUNICATIONS. 2020;11(1):470 Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity Pillon NJ; Gabriel BM; Dollet L; Smith JAB; Puig LS; Botella J; Bishop DJ; Krook A; Zierath JRAll publications from group members Journal article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2026;331(2):C425-C440 miR-339-5p impairs myogenic proliferation and differentiation by repressing contractile gene programs in skeletal muscle. Yu X; Caria E; Guimarães DSPSF; Jollet M; Rizo-Roca D; Marica AA; Mkrtchian S; Gómez-Galán M; Krook A; Pillon NJ Article: DIABETOLOGIA. 2026;69(6):1643-1658 Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle Abdelmoez AM; Jollet M; Yu X; Rizo-Roca D; Marica AA; De Zevallos JO; Dollet L; Borg ML; Bjornholm M; Checa A; Olsson T; Otten J; Zierath JR; Krook A; Schwartz TW; Chibalin AV; Pillon NJ Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2026;111(2):366-374 Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism Bjornsdotter-Oberg S; Koman A; Skorpil M; Ryden H; Lanner JT; Krook A; Nilsson I-L; Pillon NJ; Nylen C Article: JOURNAL OF SPORT AND HEALTH SCIENCE. 2025;15:101098 Human development and gender inequality are associated with cardiorespiratory fitness: A global systematic review of VO2peak Pillon NJ; de Zevallos JO; Zierath JR; Ainsworth BE Article: CELL. 2025;188(19):5142-5156.e23 GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandström A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Grätz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T Corrigendum: CELL. 2025;188(19):5429-5431 GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity (vol. 188, pg. 5142, 2025) Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandstrom A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Gratz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T Article: DIABETOLOGIA. 2025;68(9):2023-2035 Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes Keller MJ; Brady AJ; Smith JAB; Savikj M; MacGregor K; Jollet M; Oberg SB; Nylen C; Bjornholm M; Rickenlund A; Carlsson M; Caidahl K; Krook A; Pillon NJ; Zierath JR; Wallberg-Henriksson H Article: MOLECULAR METABOLISM. 2025;99:102200 Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation: Insights from in vitro analysis Smith JAB; Gabriel BM; Brady AJ; Abdelmoez AM; Savikj M; Wright SC; Koutsilieri S; Barres R; Lauschke VM; Krook A; Zierath JR; Pillon NJ Conference publication: DIABETOLOGIA. 2025;68:S118 Dysregulated inflammatory response to exercise in type 2 diabetes: a role of CXCL12 in hypoxia-induced signalling de Zevallos JO; Jollet M; Marica AA; Lehtonen L; Jude B; Lanner JT; Krook A; Zierath JR; Pillon N Conference publication: DIABETOLOGIA. 2025;68:S157 Differential response of extracellular vesicle miRNA to acute exercise in men with type 2 diabetes Pinto-Hernandez P; Sen I; Pillon N; Zierath JR; Krook A Review: NATURE REVIEWS ENDOCRINOLOGY. 2025;21(3):166-179 Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus Macgregor K; Ellefsen S; Pillon NJ; Hammarstroem D; Krook A Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;158:155939 Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity Jollet M; Tramontana F; Jiang LQ; Borg ML; Savikj M; Kuefner MS; Massart J; Barbosa TDC; Manneras-Holm L; Checa A; Pillon NJ; Chibalin AV; Bjornholm M; Zierath JR Conference publication: DIABETOLOGIA. 2024;67:S252 The oxidized linoleic acid metabolite 9-hydroxyoctadecadienoic acid promotes metabolic adaptions in skeletal muscle Yu X; Krook A; Zierath JR; Pillon NJ Preprint: BIORXIV. 2024 Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle Smith JAB; Gabriel B; Abdelmoez A; Savikj M; Wright S; Koutsilieri S; Barrès R; Lauschke V; Krook A; Zierath J; Pillon N Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;151:155716 Adiponectin stimulates Sca1+CD34--adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue Bauza-Thorbrugge M; Vujicic M; Chanclon B; Palsdottir V; Pillon NJ; Benrick A; Asterholm IW Article: CELL REPORTS MEDICINE. 2024;5(1):101348 Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2023;324(4):E289-E298 Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle Abdelmoez AM; Dmytriyeva O; Zurke Y-X; Trauelsen M; Marica AA; Savikj M; Smith JAB; Monaco C; Schwartz TW; Krook A; Pillon NJ Editorial: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2023;123(2):243-245 Mitochondrial response to inactivity-induced muscle disuse and exercise training Pillon NJ Corrigendum: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2023;123(2):247 Mitochondrial response to inactivity-induced muscle disuse and exercise training (vol 123, pg 243, 2023) Pillon NJ Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598 Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers Pillon NJ; Puig LS; Altintas A; Kamble PG; Casani-Galdon S; Gabriel BM; Barres R; Conesa A; Chibalin AV; Naslund E; Krook A; Zierath JR Show more
Staff and contactGroup leader Nicolas Pillon Assistant Senior Lecturer | Research team leader | Docent E-mail nicolas.pillon@ki.seAll members of the group Sofia Björnsdotter Öberg Phd Student E-mail sofia.bjornsdotter.oberg@ki.se Alesandra Marica Phd Student E-mail alesandra.marica.2@ki.se Joaquin Ortiz de Zevallos Muñoz Postdoctoral Researcher E-mail joaquin.ortiz.de.zevallos@ki.se Xue Yu Phd Student E-mail xue.yu@ki.seOther people connected to the group May, GabrielaVisiting addressKarolinska Institutet, Physiology and Pharmacology, Biomedicum C4, Stockholm, 171 11, Sweden