Department of Oncology-Pathology
The Department of Oncology-Pathology conducts basic, translational and clinical research and educational activities related to cancer.
Lars Holmgren on X
Follow the chair of the department of Oncology-Pathology Lars Holmgren on X.
Thuy Tran receives grant from Erling-Persson Foundation to develop method for hard-to-treat cancer
Thuy Tran’s research group has been awarded 8 million SEK over three years from the Erling-Persson Foundation to develop a precision-focused, theranostic method that integrates both diagnostics and treatment of advanced solid tumors. Thuy Tran’s research focuses on creating an innovative, targeted platform that aims to provide less invasive, personalized, and targeted treatment options. The goal is to improve both patient well-being and treatment outcomes.
New study reveals how mitochondria change during egg cell maturation
In a study published in Biomarkers Research, Kenny Rodriguez-Wallberg, Xia Hao and Jian Zhao explores how mitochondria, the energy powerhouses of cells, behave during the maturation of mouse oocytes. The researchers found that as oocytes mature from the germinal vesicle (GV) stage to metaphase II (MII), mitochondria shift from being evenly distributed to forming clusters. This clustering increases as the oocytes progress through their stages. The study provides the first comprehensive profiles of these mitochondrial changes, offering a new, standardized method to evaluate oocyte health based on mitochondrial dynamics. This could help in better monitoring and understanding oocyte conditions during maturation.
Pembrolizumab improves survival in early triple-negative breast cancer
Theodoros Foukakis is co-author of a newly published article in New England Journal of Medicine. In this phase 3 trial, the addition of pembrolizumab to preoperative chemotherapy in patients with early-stage triple-negative breast cancer was investigated. The study found that this combination significantly improved both pathological complete response and event-free survival. Final results showed that overall survival at 60 months was higher in the pembrolizumab-chemotherapy group compared to the placebo-chemotherapy group. Adverse events were consistent with known safety profiles of the treatments.