Maria Johansson project
Our work aims at developing and using mouse models where antileukemic reactivity can be improved by employing natural killer (NK) cells.
Research and contact
Our work aims at developing and using mouse models where antileukemic reactivity can be improved by employing natural killer (NK) cells. NK cells are lymphocytes in the innate immune system and their activity is regulated by activating and inhibitory receptors. We study well characterized inhibitory receptors for self MHC class I on NK cells. By blocking these receptors, one can induce NK cell rejection of leukemia cells in mice. We found that this anti-tumor reactivity can be potentiated by exogenous IL-2.
Publications
Selected publications from Maria Johansson Project.
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