Vascular Surgery, research area
Our research is focused on basic mechanisms both in the development of vascular disease as well as in the response of the vessel wall to vascular interventions for limb ischemia, carotid disease and stroke and aneurysms. The advanced molecular research conducted in the group and the close proximity to clinical vascular surgery, create a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.
The group is headed by Professor Ulf Hedin and belongs to the Department of molecular medicine and surgery, and is also the main research team at the clinical department of vascular surgery at the Karolinska University Hospital. We have established collaborations with the cardiovascular research groups at CMM and the departments of Clinical Physiology, Neurology, Cardiology, Nuclear Medicine, Clinical Chemistry, and Clinical Pharmacology at the hospital. The group also collaborate with CMB, MBB and SciLifeLab at Karolinska Institutet, as well as with researchers at the Royal School of Technology and Uppsala University, and research groups in Sweden and in Norway, Germany, Netherlands, England, USA and Canada.
Vascular Surgery, Department of Molecular Medicine and Surgery
Karolinska University Hospital, Solna
171 76 Stockholm
Group leader Professor Ulf Hedin
Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our group utilizes a translational platform with advanced cell- and molecular biology, animal models in combination with patient centred research to resolve target processes in peripheral vascular disease such as mechanisms related to thromboembolic carotid disease and stroke, pathogenesis of abdominal aortic aneurysms, vascular repair processes and inflammation in association with interventional procedures and pulmonary hypertension. The close proximity between clinical vascular surgery and advanced molecular research creates a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.
Translational Vascular Medicine
The Translational Vascular Medicine team is a translational Team composed of basic researchers with expertise in molecular biology and pharmacology, and clinically active vascular surgeons. The team applies integrative analyses combining bioinformatic and clinical data studies with murine models of vascular injury and disease, while in vitro systems based on primary cells and tissue explants are utilized for functional and mechanistic investigations.
Lack of surgical healthcare costs lives and money. Five billion people do not have access to quality surgical services at an affordable cost when needed. Still, surgical conditions account for 30% of the global burden of disease and causes the loss of 16.9 million lives every year. This is more than the number of deaths from tuberculosis, HIV/AIDS and malaria combined. The burden of surgical disease is highest in sub-Saharan Africa where access to surgery is most limited.