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Vascular Surgery

Our research is focused on basic mechanisms both in the development of vascular disease as well as in the response of the vessel wall to vascular interventions for limb ischemia, carotid disease and stroke and aneurysms.

Research group leader:


Ulf Hedin

Telefon: 08-517 721 75
Enhet: Kärlkirurgi
Vascular Surgery, Department of Molecular Medicine and Surgery
Karolinska Institutet
Karolinska University Hospital, Solna, L8:03
SE-171 76 Stockholm

Research Area

Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our group utilizes a translational platform with advanced cell- and molecular biology, animal models in combination with patient centred research to resolve target processes in peripheral vascular disease such as mechanisms related to thromboembolic carotid disease and stroke, pathogenesis of abdominal aortic aneurysms, vascular repair processes and inflammation in association with interventional procedures and pulmonary hypertension. The close proximity between clinical vascular surgery and advanced molecular research creates a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.

The group is the main research team at the clinical department of vascular surgery at the Karolinska University Hospital and belongs to the Department of Molecular Medicine and Surgery at the Karolinska Institutet. It contains several principal investigators, each with a specific target project, an administrative and technical staff, post-docs, and PhD students. Collaborations are established with the cardiovascular research groups at CMM, the Departments of Clinical Physiology, Neurology, Cardiology, Nuclear Medicine, Clinical Chemistry, and Clinical Pharmacology at the hospital as well as the Departments of Cell and Molecular Biology, Molecular Biochemistry and Biology and SciLifeLab, researchers at Royal School of Technology and at Uppsala University.

Research Projects

Research project Project leader
Abdominal Aortic Aneurysms Joy Roy and Rebecka Hultgren
Aortic Aneurysms - riskfactors for development, growth and rupture Rebecka Hultgren
Carotid atherosclerosis - from molecule to man Ulf Hedin
Cellular and Molecular Mechanisms in Pulmonary Hypertension Karin Tran Lundmark
Complications in Vascular Surgery Carl-Magnus Wahlgren
Epidemiology, diagnosis and treatment of chronic venous disease Lena Blomgren
Novel mechanisms of atherosclerotic plaque (in)stability governed by smooth muscle cells Ljubica Perisic
Riskminimering vid carotiskirurgi (only in Swedish) David Lindström
Studies of the natural course of the vein graft disease Anton Razuvaev
The role of Proprotein Convertase Subtilisins Kexins (PCSKs) in vascular disease Ljubica Perisic
Vessel Wall Healing Ulf Hedin
Vessel Wall Signaling Joy Roy