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Psychiatric disorders affect more than one in three people during their lifetime. Pharmacological treatments are commonly used but, to date, most treatment are based on findings from clinical trials. However, clinical trials may have limitations in that they often study selected, relatively small study populations, with short follow-up time. This means that it is not always clear what is the effect of drugs in clinical practice in unselected clinical populations and with longer follow-up. Safety issues need to be investigated also in study designs using large study populations.

In Sweden it is possible to identify all patients who have filled prescriptions of drugs in pharmacies and link these data to other population based registers. This enables us to investigate a broad range of research questions regarding drug utilization, adherence, safety and effectiveness of drugs. Taking into account confounding factors which are related to the drug use and outcome is a high priority.

We perform pharmacoepidemiological register based studies in the field of psychiatry, using descriptive and analytical methods. We are engaged in both academic studies and commissioned research projects, often in collaboration with research groups abroad. Some of our completed and ongoing research projects concern the study of adherence to drugs in schizophrenia and bipolar disorder, safety of quetiapine use, comparative effectiveness of drugs used in bipolar disorder, and treatment resistant depression.


The research area is led by Johan Reutfors (Publications on PubMed)