About the Gastroenterology and Nutrition Unit (GUT)

Gene Regulation and Epigenetics

In this field, our research aims to understand the molecular mechanisms that regulate gene expression and how these are disrupted in diseases, particularly in inflammation-related conditions. Using genome-wide sequencing of human patient samples and advanced bioinformatics, we identify alterations of regulatory elements linked to disease phenotypes. Additionally, in translational cancer epigenetics projects, we apply genome-wide approaches to understand and target cancer-associated regulatory pathways.

Cancer Biology and Precision Medicine

We are also engaged in cancer research, aiming to unravel key molecular mechanisms involved in cancer development and progression. We integrate large-scale omics approaches with focused mechanistic studies and in vivo experiments. Our work supports the development of novel diagnostics, personalized treatments, and preventive strategies. By understanding critical signaling pathways in cancer, we hope to contribute to reduced mortality and more effective clinical interventions, including biomarker discovery.

Metabolic Diseases and Inflammation

Our research investigates on how metabolic stress reprograms hepatocytes and immune cells, contributes to disease progression. We study tissue remodelling in the liver, monocytes, and immune cells within adipose tissue to understand the molecular mechanisms of the metabolic syndrome, liver steatosis, insulin resistance and type 2 diabetes.

Clinical and Epidemiology Research in Hepatology and Pancreatology

In hepatology, we conduct clinical, epidemiological, and translational studies with a focus on metabolic and autoimmune liver and pancreatic diseases. We conduct large-scale observational studies and randomized controlled trials to identify risk factors and develop strategies for disease prevention and health promotion. The research include biomarker discovery, prognostic models and aim to identify at-risk patients, discover new treatment strategies, and prevent severe liver disease. In pancreatology, we focus on the connection between the endocrine and exocrine axes.

Nutrition

In the field of nutrition, we conduct research to develop and evaluate digital technologies – such as apps, wearable sensors, and AI-based approaches – to support the prevention, treatment, and management of obesity and cardiometabolic diseases. Our studies include both large-scale observational studies and randomized controlled trials. GUT also encompasses the Centre for Nutrition, which is organized around four research tracks: molecular, preventive, sustainable, and clinical nutrition. The centre aims to deepen the understanding of how non-communicable diseases (NCDs) can be prevented and treated while promoting healthy and sustainable dietary habits. It serves as a strong foundation for translational research, including precision nutrition for the prevention and treatment of various NCDs.

Reproductive Health

Research in reproductive health focuses on preeclampsia with the aim to develop diagnostic biomarkers and therapeutic strategies to predict and manage the condition. Studies also delve into early embryonic development, fertility and estrogen signaling.