Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related deaths worldwide. Helicobacter pylori infection is the single most important risk factor for stomach cancer.

Although theoretically population-based widespread eradication of the bacterium can reduce stomach cancer incidence and mortality, the concerns of inducing multidrug resistance problems and iatrogenic diseases related to Helicobacter pylori eradication, have hampered the implementation of this approach. We aim to develop a cost-effective and safe program for stomach cancer prevention through identification of high-risk groups, on which chemoprevention or endoscopic screening can be targeted.

Prinicipal Investigator 

Weimin Ye

Project Acronym

PreventStoCan (project number 682663)

Funder

ERC consolidator grant

Team Members

Weimin Ye

Principal Investigator, Professor

Amir Sohrabi

Senior research specialist

Joar Franzen

PhD student

Yun Du

PhD student

Former team members

  • Huan Song
  • Justine Debelius
  • Ulrika Zagai
  • Nikolaos Tertipis
  • Isabella Ekheden

Publications

Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population-based case-control study in China.
Zhang T, Yang X, Yin X, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W
J Periodontol 2022 07;93(7):988-1002

Changes of Body Mass Index and Body Shape in relation to risk of Gastric Cancer: A population-based case-control study.
Yin X, Yang X, Zhang T, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W
J Cancer 2021 ;12(10):3089-3097

Efficacy of Loop-Mediated Isothermal Amplification for H. pylori Detection as Point-of-Care Testing by Noninvasive Sampling.
Sohrabi A, Franzen J, Tertipis N, Zagai U, Li W, Zheng Z, Ye W
Diagnostics (Basel) 2021 Aug;11(9):

Healthy Lifestyle Factors, Cancer Family History, and Gastric Cancer Risk: A Population-Based Case-Control Study in China.
Man J, Ni Y, Yang X, Zhang T, Yuan Z, Chen H, Chen X, Lu M, Ye W
Front Nutr 2021 ;8():774530

Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study.
Song H, Ekheden IG, Ploner A, Ericsson J, Nyren O, Ye W
Int J Epidemiol 2018 04;47(2):440-449