Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention
Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related deaths worldwide. Helicobacter pylori infection is the single most important risk factor for stomach cancer.
Although theoretically population-based widespread eradication of the bacterium can reduce stomach cancer incidence and mortality, the concerns of inducing multidrug resistance problems and iatrogenic diseases related to Helicobacter pylori eradication, have hampered the implementation of this approach. We aim to develop a cost-effective and safe program for stomach cancer prevention through identification of high-risk groups, on which chemoprevention or endoscopic screening can be targeted.
Prinicipal Investigator
Project Acronym
PreventStoCan (project number 682663)
Funder
ERC consolidator grant
Team Members
Weimin Ye
Principal Investigator, ProfessorAmir Sohrabi
Senior Research SpecialistJoar Franzén
Phd StudentYun Du
Affiliated to ResearchFormer team members
- Huan Song
- Justine Debelius
- Ulrika Zagai
- Nikolaos Tertipis
- Isabella Ekheden
Publications
Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population-based case-control study in China.
Zhang T, Yang X, Yin X, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W
J Periodontol 2022 07;93(7):988-1002
Changes of Body Mass Index and Body Shape in relation to risk of Gastric Cancer: A population-based case-control study.
Yin X, Yang X, Zhang T, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W
J Cancer 2021 ;12(10):3089-3097
Efficacy of Loop-Mediated Isothermal Amplification for H. pylori Detection as Point-of-Care Testing by Noninvasive Sampling.
Sohrabi A, Franzen J, Tertipis N, Zagai U, Li W, Zheng Z, Ye W
Diagnostics (Basel) 2021 Aug;11(9):
Healthy Lifestyle Factors, Cancer Family History, and Gastric Cancer Risk: A Population-Based Case-Control Study in China.
Man J, Ni Y, Yang X, Zhang T, Yuan Z, Chen H, Chen X, Lu M, Ye W
Front Nutr 2021 ;8():774530
Family history of gastric mucosal abnormality and the risk of gastric cancer: a population-based observational study.
Song H, Ekheden IG, Ploner A, Ericsson J, Nyren O, Ye W
Int J Epidemiol 2018 04;47(2):440-449