Amir Sohrabi

Amir Sohrabi

Affiliated to Research | Senior Research Specialist | Postdoctoral Researcher
Visiting address: Nobels väg 12a, 17165 Solna
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB Weimin, 171 77 Stockholm
Part of:

Selected publications

  • Patent: 2014
    Candidate of Molecular Diagnostic Kit for Human Papillomavirus Genotyping as Cervical Cancer Agent by In-House Multiplex Real Time PCR
    Sohrabi A
  • Patent: 2009
    Application of Novel Method for Preparation and Transfer of Stool Specimen on the Dried Paper Due to Diagnosis and Molecular Survey of Viral Gastroenteritis
    Mirshahabi H; Sohrabi A; Azadmanesh K

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2024 - 31 December 2026
    The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer and its precursor lesions. To achieve this aim, first we will use stored serum samples to perform metabolomics profiling among 12,599 twin subjects, among whom 1034 were deemed to have chronic atrophic gastritis based on measured pepsinogen I and II levels. Logistic regression will be used to search for metabolites related to the risk of chronic atrophic gastritis. Second, we will further measure serum proteome by using two quantitatively precise proteomics assays, among the above-mentioned twin subjects. Identified protein biomarkers will be combined with metabolomics biomarkers to create a prediction model for chronic atrophic gastritis. Last, we have created a cohort of subjects who were histopathologically diagnosed with chronic atrophic gastritis or more severe precursor lesions. They were followed for stomach cancer occurrence, and a nested case-control study will be performed. Baseline formalin-fixed paraffin-embedded tissue blocks will be retrieved for both stomach cancer cases and their matched controls, and patterns of tissue proteome and transcriptome will be compared, to identify driving factors associated with progression of precursor lesions to malignancy. The results will hopefully improve our understanding of the etiological factors and provide promising early detection biomarkers for stomach cancer and its precursor lesions.

Employments

  • Affiliated to Research, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2024-2025
  • Senior Research Specialist, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020-2024
  • Postdoctoral Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2018-2020
  • Assistant Professor, Health Reference Laboratory, Ministry of Health and Medical Education, Tehran, Iran, 2014-2018
  • Head of Molecular Diagnostic Section, Pathobiology Laboratories, Tehran, Iran, 2012-2018
  • Researcher and Auditor Member, Health Reference Laboratory, Ministry of Health and Medical Education, Tehran, Iran, 2009-2018
  • Research Assistant, Department of Molecular Virology, Pasteur Institute of Iran, 2007-2013

Degrees and Education

  • Postdoctoral Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2020
  • Ph.D. in Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Iran, 2014
  • MSc. in Medical Virology, Department of Virology, Jundishapur University of Medical Sciencest, Ahvaz, Iran, 2006
  • BSc. in Medical Laboratory Sciences, Kerman University of Medical Sciences, Iran, 2003

Supervision

  • Supervision to doctoral degree

    • Yun Du, Ph.D., Karolinska Institute, Sweden, 2023
    • Sara Zamani, Ph.D., Shahid Beheshti University of Sciences, Iran, 2018
  • Other researchers who have defended a thesis

    • Fatemeh Sadeghi, MSc., Karolinska Institutet, Sweden, 2021
    • Manijheh Vazifehdoost, MSc., East Tehran Branch, Islamic Azad University , Iran, 2018
    • Elham Golshekan, MSc., East Tehran Branch, Islamic Azad University , Iran, 2018
    • Moharreri Mona, MSc., East Tehran Branch, Islamic Azad University , Iran, 2018
    • Masoumeh Abdolmaleki, MSc., East Tehran Branch, Islamic Azad University , Iran, 2017
    • Fatemeh Bassam-Tolami, MSc., Tehran Shargh Branch, Payame Noor University , Iran, 2017

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