Collaborations

At Karolinska Institutet

Within our Department, we are collaborating with the groups of Rikard Holmdahl and Roman Zubarev in projects where we are studying redox control of inflammation and the redox biology of cancer, for which we also received funding from the Knut and Alice Wallenberg Foundation (for more information, click here and here).

With Rolf Kiessling and Stina Wickström we are studying the redox biology of antitumoral immunity, with a special focus on how to strengthen the resistance of T and NK cells towards high levels of exogenous oxidative stress.

Elsewhere in Sweden

Together with Volkan Sayin and his group in Gothenburg we are studying the redox biology of cancer, with an aim of developing more efficient therapeutic protocols.

International Collaborators

A long-standing collaborator of ours is Edward “Ed" Schmidt, who is an outstanding expert in genetic mouse models and with whom we have had and continue to have many joint projects. Ed has a laboratory in Montana and, similarly to us, a second laboratory in Budapest, which he runs together with Peter Nagy. We are also collaborating with Peter Nagy, an expert in hydrogen sulfide and protein persulfidation.

We have close collaborations on trace element research and glutathione peroxidases with Anna Kipp in Jena, Germany, with several joint publications and ongoing collaborative projects.

Another close collaboration is with Matthew Hall at NCATS, NIH, with whom we are discovering and characterizing novel inhibitors of selenoproteins, with possible applications for cancer treatment. Drs. Hall and Arnér are also jointly supervising PhD students in the KI-NIH joint PhD program (more information here and here), from where Dorian Cheff graduated in June 2023 (her Ph.D. dissertation is available here) and into which Madeleine Barrett was admitted in the fall of 2023.

Together with Juan Sastre, Valencia, Spain, we are studying the in vivo roles of TRP14 (TXNDC17). Several other groups are also involved in those studies, and among them also Antonio Miranda Vizuete, Sevilla, Spain, who is a colleague and collaborator of ours that we have worked with for many years, and also now in different collaborative projects.

The group of Oliver Thorn-Seshold, Munich, Germany, is a fantastic group of talented chemical biologists that we are very happy to work with, which is a collaboration that also led to development and validation of RX1, which is a remarkably useful tool for assessment of TrxR1 activity in live cells.