Bertrand Joseph Research group
Life and death decisions at the cellular level
We are interested in the molecular signaling that regulates the decision between life and death at the cellular level, as well as how its deregulation is involved in various disease processes in humans. Examinations are performed in various disease models, ranging from cancer to neurodegenerative diseases. The group has a well-established national and international network of colleagues and employees, which provides access to additional expertise and scientific expertise.
Research group leader
- Mathilde Cheray, Postdoc
- Pinelopi Engskog Vlachos, Senior lab manager
- Lara Friess, PhD student
- Patricia González Rodriguez, PhD student
- Kathleen Grabert, Postdoc
- Bertrand Joseph, Professor, Group leader
- Ioulia Vardaki, PhD student
- Guillermo Vázquez Cabrera, student
- Vassilis Stratoulias, Postdoc
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, et al
Nat Immunol 2016 Nov;17(11):1282-1290
Neuroinflammation in Alzheimer's disease.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al
Lancet Neurol 2015 Apr;14(4):388-405
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
Burguillos MA, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, Kavanagh E, et al
Cell Rep 2015 Mar;10(9):1626-1638
The return of the nucleus: transcriptional and epigenetic control of autophagy.
Füllgrabe J, Klionsky DJ, Joseph B
Nat Rev Mol Cell Biol 2014 01;15(1):65-74
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, et al
Nature 2013 Aug;500(7463):468-71
Caspase signalling controls microglia activation and neurotoxicity.
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, et al
Nature 2011 Apr;472(7343):319-24