Bertrand Joseph Research group

Life and death decisions at the cellular level

We are interested in the molecular signaling that regulates the decision between life and death at the cellular level, as well as how its deregulation is involved in various disease processes in humans. Examinations are performed in various disease models, ranging from cancer to neurodegenerative diseases. The group has a well-established national and international network of colleagues and employees, which provides access to additional expertise and scientific expertise.

Research group leader

Group members

Selected publications

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, et al
Nat Immunol 2016 Nov;17(11):1282-1290

Neuroinflammation in Alzheimer's disease.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, et al
Lancet Neurol 2015 Apr;14(4):388-405

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
Burguillos MA, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, Kavanagh E, et al
Cell Rep 2015 Mar;10(9):1626-1638

The return of the nucleus: transcriptional and epigenetic control of autophagy.
Füllgrabe J, Klionsky DJ, Joseph B
Nat Rev Mol Cell Biol 2014 01;15(1):65-74

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, et al
Nature 2013 Aug;500(7463):468-71

Caspase signalling controls microglia activation and neurotoxicity.
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, et al
Nature 2011 Apr;472(7343):319-24