Utility of aerosol-based detection of Mycobacterium tuberculosis in predicting household transmission | Social medicine, infectious diseases and migration (SIM)
Detecting aerosolised tuberculosis in clinical practice has been difficult due to the complexity, size and cost of available detection devices. Understanding the role of aerosolization in the transmission of TB is important to better direct limited resources towards contacts at the highest risk of exposure and developing disease.
This project will evaluate a novel, handheld electrostatic air-sampling device developed at KI. Performance of the device will be compared with other equivalent devices in dedicated research settings while clinical studies in Sweden, South Africa and Mozambique will investigate the association between index case aerosol detection and household contact infection.
The project will be implemented in collaboration with Karolinska University Hospital, Stellenbosch University, Barcelona Institute of Global Health (ISGlobal), and Manhiça Heatlh Research Centre (CISM). Funding has been provided by the Swedish Research Council for Health.