Diabetes and Metabolism Breakout, KI-Mayo Meeting 2023

• 16:00pm /9:00am: Plenary Session - Muscle and metabolism
  Jorge Ruas, Ph.D. (KI)
• 16:20 pm/9:20 am: Divergent skeletal metabolomics signatures of different exercise modes independently predict cardiometabolic parameters
  Mark Pataky, Ph.D. (MC)
• 16:35 pm/9:35 am: Cacng1 as a potential biomarker of skeletal muscle-derived extracellular vesicles
  Gerard Baiges Gaya (KI) (Presenting virtually)
• 16:20pm/9:20am: What makes a good introduction to the clinical learning environment? - A Study of Physiotherapy Students’ Experiences of early stages of clinical training -Malin Sellberg (KI)
• 16:50pm/9:50am: ATF4-mediated activation of Cdkn1a (p21) promotes muscle atrophy
  Matt Miller (MC)
• 16:40pm/9:40am: Adipose macrophage and senescent cell numbers are elevated in older adults and are associated with markers of inflammation and metabolic health
  Hawley Kunz (MC)
• 16:55pm/9:55am: Skeletal muscle creatine metabolism is altered in Type 2 Diabetes
  David Riza-Roca (KI)
• 17:05pm/10:05 am: Regulation of muscle function by E3 ubiquitin ligase HECTD1
  Igor Cervenka (KI)
• 17:20 pm/ 10:20am: Sarcomeric mitochondrial creatine kinase 2 modulates mitochondrial homeostasis and is downregulated in men with type 2 diabetes
  David Rizo-Roca, Ph.D. (KI) Presenting virtually
• 17:35pm/10:35am: Gadd45a is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle
  George Marcotte (MC)
• 17:50 pm/10:50 am: Calcitonin gene-related peptide (CGRP) suppresses adipocyte differentiation and induces fibrotic collagen expression
  Kyle Dumont (KI) Presenting virtually
• 18:05 pm/11:05 am: Insulin regulation of lysine and α-aminoadipic acid dynamics and amino metabolites in insulin-resistant and control women
  Aneesh Kumar Asokan, Ph.D. (MC)
• 18:20pm/11:20 am: Lunch
• 19:00pm/12:00am: David Murdock Lecture 
  How does loss of CFTR cause cystic fibrosis lung disease?
• 18:00 pm Poster Session

Chairs: Ian Lanza, Ph.D. (MC), Paul Petrus, Ph.D. (KI)

• 15:00 pm/8:00 am: Keynote speaker – Metabolism / Obesity
  Ian Lanza, Ph.D. (MC)
   
• 15:25 pm/8:25 am: Evidence of pro-inflammatory profiles in multiple tissue in healthy older adults and relationships to metabolic and functional phenotypes
  Hawley Kunz, Ph.D. (MC)
   
• 15:40pm/8:40am: Uncovering a potential novel target in non-alcoholic fatty liver disease
  Stine Marie Praestholm (KI) -Presenting virtually
   
• 15:55pm/8:55am: Diabetes-associated variation in TCF7L2 is associated with a longitudinal decline in glucose tolerance accompanied by impaired suppression of postprandial glucagon secretion
  Sneha Mohan, MBBS (MC)
   
• 16:10pm/9:10am: The differential effect of glucagon-like peptide-1 receptor blockage on glucose metabolism in people with and without type 2 diabetes
  Hannah Christie, PhD (MC)
   
• 16:25pm/9:25am: Break
   
• 16:40pm/9:40am: Keynote speaker - Circadian metabolic coordination by tissue specific clocks 
  Paul Petrus, Ph.D. (KI)
• 17:05pm/10:05am: Obesity impairs the effect of exercise timing on glucose metabolism and adipose tissue lipolysis
  Logan Pendergrast (KI)
• 17:20pm/10:20 am: Oxygen modulation improves the differentiation of stem cell-derived pancreatic beta cells
  Lauren Jennings (MC) 
   
• 17:35pm/10:35 am: Ablation of intracellular lipolytic inhibitor GOS2 promotes vascular lipolysis and alleviates diet-induced atherosclerosis
  Yongbin Chen, M.D., Ph.D. (MC)
• 17:50pm/10:50 am: PNPLA3 selectively mobilizes PUFAs for ER membrane desaturation and VLDL secretion during lipogenesis
  Scott Johnson (MC)
• 18:05pm/11:05am: Lunch
• 19:00 pm/12:00am: Plenary session