Publications LCI

Publications 2025

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Liang X, Gupta D, Xie J, Van Wonterghem E, Van Hoecke L, Hean J, Niu Z, Ghaeidamini M, Wiklander OPB, Zheng W, Wiklander RJ, He R, Mamand DR, Bost J, Zhou G, Zhou H, Roudi S, Estupiñán HY, Rädler J, Zickler AM, Görgens A, Hou VWQ, Slovak R, Hagey DW, de Jong OG, Uy AG, Zong Y, Mäger I, Perez CM, Roberts TC, Carter D, Vader P, Esbjörner EK, de Fougerolles A, Wood MJA, Vandenbroucke RE, Nordin JZ, El Andaloussi S
Nat Commun 2025 Apr;16(1):4028

Publications 2024

Impaired branched-chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux.
Green CR, Alaeddine LM, Wessendorf-Rodriguez KA, Turner R, Elmastas M, Hover JD, Murphy AN, Ryden M, Mejhert N, Metallo CM, Wallace M
J Biol Chem 2024 Dec;300(12):108004

Anti-gene oligonucleotide clamps invade dsDNA and downregulate huntingtin expression.
Umek T, Lundin KE, Mowoe MO, Hao Y, Roudi S, Žura L, Jørgensen PT, Lou C, Hagey DW, Wengel J, Smith CIE, Zain R
Mol Ther Nucleic Acids 2024 Dec;35(4):102348

In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity.
Rooda I, Hassan J, Hao J, Wagner M, Moussaud-Lamodière E, Jääger K, Otala M, Knuus K, Lindskog C, Papaikonomou K, Gidlöf S, Langenskiöld C, Vogt H, Frisk P, Malmros J, Tuuri T, Salumets A, Jahnukainen K, Velthut-Meikas A, Damdimopoulou P
Nat Commun 2024 Aug;15(1):6989

Tuneable Recombinant Spider Silk Protein Hydrogels for Drug Release and 3D Cell Culture.
Arndt T, Chatterjee U, Shilkova O, Francis J, Lundkvist J, Johansson D, Schmuck B, Greco G, Nordberg ÅE, Li Y, Wahlberg LU, Langton M, Johansson J, Götherström C, Rising A
Adv Funct Mater 2024 Aug;34(35):2303622

Effects of chemical in vitro activation versus fragmentation on human ovarian tissue and follicle growth in culture.
Hao J, Li T, Heinzelmann M, Moussaud-Lamodière E, Lebre F, Krjutškov K, Damdimopoulos A, Arnelo C, Pettersson K, Alfaro-Moreno E, Lindskog C, van Duursen M, Damdimopoulou P
Hum Reprod Open 2024 ;2024(3):hoae028

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol.
Spanos F, Gerenu G, Goikolea J, Latorre-Leal M, Balleza-Tapia H, Gomez K, Álvarez-Jiménez L, Piras A, Gómez-Galán M, Fisahn A, Cedazo-Minguez A, Maioli S, Loera-Valencia R
Front Cell Neurosci 2024 ;18():1347535

Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro.
Panagiotou EM, Damdimopoulos A, Li T, Moussaud-Lamodière E, Pedersen M, Lebre F, Pettersson K, Arnelo C, Papaikonomou K, Alfaro-Moreno E, Lindskog C, Svingen T, Damdimopoulou P
Toxicology 2024 Apr;505():153815

Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro.
Li T, Björvang RD, Hao J, Di Nisio V, Damdimopoulos A, Lindskog C, Papaikonomou K, Damdimopoulou P
Environ Int 2024 Apr;187():108710

Antibody-displaying extracellular vesicles for targeted cancer therapy.
Wiklander OPB, Mamand DR, Mohammad DK, Zheng W, Jawad Wiklander R, Sych T, Zickler AM, Liang X, Sharma H, Lavado A, Bost J, Roudi S, Corso G, Lennaárd AJ, Abedi-Valugerdi M, Mäger I, Alici E, Sezgin E, Nordin JZ, Gupta D, Görgens A, El Andaloussi S
Nat Biomed Eng 2024 May;():

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
ElBeck Z, Hossain MB, Siga H, Oskolkov N, Karlsson F, Lindgren J, Walentinsson A, Koppenhöfer D, Jarvis R, Bürli R, Jamier T, Franssen E, Firth M, Degasperi A, Bendtsen C, Menzies RI, Streckfuss-Bömeke K, Kohlhaas M, Nickel AG, Lund LH, Maack C, Végvári Á, Betsholtz C
Nat Commun 2024 Mar;15(1):2358.

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway.
Coschiera A, Yoshihara M, Lauter G, Ezer S, Pucci M, Li H, Kavšek A, Riedel CG, Kere J, Swoboda P
BMC Biol 2024 Feb;22(1):48

A system for inducible mitochondria-specific protein degradation in vivo.
Sanyal S, Kouznetsova A, Ström L, Björkegren C
Nat Commun 2024 Feb;15(1):1454

Transcriptional determinants of lipid mobilization in human adipocytes.
Ludzki AC, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, Renzi G, Klingelhuber F, Boland S, Ambaw YA, Wang N, Damdimopoulos A, Liu J, Jernberg T, Petrus P, Arner P, Krahmer N, Fan R, Treuter E, Gao H, Rydén M, Mejhert N
Sci Adv 2024 Jan;10(1):eadi2689