Publications LCI

Publications 2025

An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer.
Söderqvist S, Viljamaa A, Geyer N, Keller AL, Ruksha K, Strell C, Hekmati N, Niculae A, Engstrand J, Sparrelid E, Salmén C, Costa TDF, Zhao M, Strömblad S, Zacharouli A, Ghorbani P, Harrizi S, Hamidi Y, Khorosjutina O, Milanova S, Schmierer B, Bozóky B, Fernández Moro C, Gerling M
Nat Commun 2025 Sep;16(1):8307

Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue.
Couchet M, Gao H, Klingelhuber F, Jalkanen J, De Castro Barbosa T, Omar-Hmeadi M, Massier L, Krahmer N, Mejhert N, Rydén M
Adipocyte 2025 Dec;14(1):2283213

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength.
Vrtačnik P, Merino LG, Subhash S, Helgadóttir HT, Bardin M, Stefani F, Wang D, Chen P, Franco I, Revêchon G, Eriksson M
Nat Aging 2025 Sep;5(9):1739-1749

Silk-Ovarioids: establishment and characterization of a human ovarian primary cell 3D-model system.
Di Nisio V, Li T, Xiao Z, Papaikonomou K, Damdimopoulos A, Végvári Á, Lebre F, Alfaro-Moreno E, Pedersen M, Svingen T, Zubarev R, Acharya G, Damdimopoulou P, Salumets A
Hum Reprod Open 2025 ;2025(3):hoaf042

Matrix stiffness-induced IKBKE and MAPK8 signaling drives a phenotypic switch from DCIS to invasive breast cancer.
Yan F, Göransson S, Olofsson H, Vogiatzakis C, Acharekar A, Strömblad S
Cell Commun Signal 2025 Jun;23(1):269

Mechanical control of breast cancer malignancy by promotion of mevalonate pathway enzyme synthesis.
Göransson S, Olofsson H, Johansson HJ, Yan F, Vogiatzakis C, Liang S, Bellato HM, Masvidal L, Aksoylu I, Hartman J, Hajj GNM, Larsson O, Lehtiö J, Strömblad S
Matrix Biol 2025 Jun;():

Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease.
Revêchon G, Witasp A, Viceconte N, Helgadottir HT, Machtel P, Stefani F, Whisenant D, Sola-Carvajal A, McGuinness D, Abutaleb NO, Artiach G, Arzt EW, Soveri I, Babler A, Ziegler S, Kramann R, Bäck M, Thorell A, Truskey GA, Wennberg L, Shiels PG, Wernerson A, Stenvinkel P, Eriksson M
Nat Aging 2025 Jun;5(6):1046-1062

Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles.
Niu Z, Zhou H, Zheng W, Hayes OG, Hou VWQ, Görgens A, Roudi S, Zhou G, Wiklander RJ, Sych T, Sezgin E, Nordin JZ, Zhao Y, Liang X, Andaloussi SEL
J Control Release 2025 May;384():113882

Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids.
Tajpara P, Sobkowiak MJ, Healy K, Naud S, Gündel B, Halimi A, Khan ZA, Gabarrini G, Le Guyader S, Imreh G, Reisz JA, Del Chiaro M, D'Alessandro A, Heuchel R, Löhr JM, Özenci V, Sällberg Chen M
Front Immunol 2025 ;16():1553034

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Liang X, Gupta D, Xie J, Van Wonterghem E, Van Hoecke L, Hean J, Niu Z, Ghaeidamini M, Wiklander OPB, Zheng W, Wiklander RJ, He R, Mamand DR, Bost J, Zhou G, Zhou H, Roudi S, Estupiñán HY, Rädler J, Zickler AM, Görgens A, Hou VWQ, Slovak R, Hagey DW, de Jong OG, Uy AG, Zong Y, Mäger I, Perez CM, Roberts TC, Carter D, Vader P, Esbjörner EK, de Fougerolles A, Wood MJA, Vandenbroucke RE, Nordin JZ, El Andaloussi S
Nat Commun 2025 Apr;16(1):4028