Vesna Munic Kos

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Main focus of my research are chemicals (pharmaceuticals and environmental
toxins) which accumulate in organisms, and the effects they have on cells.
During 13 years of my career in the research of pharmaceutical industry large
part of my research was dealing with highly accumulating pharmaceuticals,
especially of macrolide class. Now I am studying endocrine disrupting
chemicals and the mechanisms of their impact on metabolic disorders as well
as their toxicokinetic properties.
Read more about my research on this link [1].
[1] https://ki.se/en/people/vesmun

Artiklar

Journal article: CHEMOSPHERE. 2024;349:140852
Environmental chemicals change extracellular lipidome of mature human white adipocytes.
Burkhardt P; Palma-Duran SA; Tuck ARR; Norgren K; Li X; Nikiforova V; Griffin JL; Munic Kos V
Journal article: TOXICOLOGY LETTERS. 2023;384:s72-S74
OS04-07 Environmental chemicals change extracellular lipidome of mature human white adipocytes
Burkhardt P; Duran SAP; Tuck A; Norgren K; Li X; Nikiforova V; Griffin JL; Kos VM
Article: FOOD AND CHEMICAL TOXICOLOGY. 2022;161:112842
High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs)
Norgren K; Tuck A; Silva AV; Burkhardt P; Oberg M; Kos VM
Article: ARCHIVES OF TOXICOLOGY. 2021;95(2):591-615
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
Delp J; Cediel-Ulloa A; Suciu I; Kranaster P; van Vugt-Lussenburg BMA; Munic Kos V; van der Stel W; Carta G; Bennekou SH; Jennings P; van de Water B; Forsby A; Leist M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(2):363-377
A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides
Peric M; Pesic D; Alihodzic S; Fajdetic A; Herreros E; Gamo FJ; Angulo-Barturen I; Jimenez-Diaz MB; Ferrer-Bazaga S; Martinez MS; Gargallo-Viola D; Mathis A; Kessler A; Banjanac M; Padovan J; Bencetic Mihaljevic V; Munic Kos V; Bukvic M; Erakovic Haber V; Spaventi R
Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;130:110582
Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19
Norinder U; Tuck A; Norgren K; Kos VM
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(23):E5938-5938
QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles
Norinder U; Munic Kos V
Article: JOURNAL OF PHARMACEUTICAL SCIENCES. 2019;108(1):652-660
Quantification of Intracellular Accumulation and Retention of Lysosomotropic Macrocyclic Compounds by High-Throughput Imaging of Lysosomal Changes
Easwaranathan A; Inci B; Ulrich S; Brunken L; Nikiforova V; Norinder U; Swanson S; Kos VM
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2018;829:44-53
Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy
Kagebeck P; Nikiforova V; Brunken L; Easwaranathan A; Ruegg J; Cotgreave I; Kos VM
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2018;281:1-10
Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs
Garcia DS; Sjodin M; Hellstrandh M; Norinder U; Nikiforova V; Lindberg J; Wincent E; Bergman A; Cotgreave I; Kos VM
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017;133:351-364
Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation
Kostrun S; Kos VM; Skugor MM; Jakopovic IP; Malnar I; Dragojevic S; Ralic J; Alihodzic S
Article: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 2014;39(4):263-276
A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents
Milic A; Mihaljevic VB; Ralic J; Bokulic A; Nozinic D; Tavcar B; Mildner B; Munic V; Malnar I; Padovan J
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2013;49(2):206-219
Structure-property relationship for cellular accumulation of macrolones in human polymorphonuclear leukocytes (PMNs)
Kos VM; Kostrun S; Fajdetic A; Bosnar M; Kelneric Z; Stepanic V; Haber VE
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2013;21(1):321-332
Macrolactonolides: A novel class of anti-inflammatory compounds
Tomaskovic L; Komac M; Stegic OM; Munic V; Ralic J; Stanic B; Banjanac M; Markovic S; Hrvacic B; Paljetak HC; Padovan J; Glojnaric I; Haber VE; Mesic M; Mercep M
Article: PHARMACOLOGICAL RESEARCH. 2012;66(4):357-362
Anti-inflammatory mechanism of action of azithromycin in LPS-stimulated J774A.1 cells
Banjanac M; Kos VM; Nujic K; Vrancic M; Belamaric D; Crnkovic S; Hlevnjak M; Haber VE
Article: PHARMACOLOGICAL RESEARCH. 2012;66(4):332-342
Fluorescently labeled macrolides as a tool for monitoring cellular and tissue distribution of azithromycin
Matijasic M; Kos VM; Nujic K; Cuzic S; Padovan J; Kragol G; Alihodzic S; Mildner B; Verbanac D; Haber VE
Article: CELLULAR IMMUNOLOGY. 2012;279(1):78-86
Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype
Nujic K; Banjanac M; Munic V; Polancec D; Haber VE
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2012;165(5):1348-1360
Azithromycin distinctively modulates classical activation of human monocytes in vitro
Vrancic M; Banjanac M; Nujic K; Bosnar M; Murati T; Munic V; Polancec DS; Belamaric D; Parnham MJ; Haber VE
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;91(2):229-243
Azithromycin drives in vitro GM-CSF/IL-4-induced differentiation of human blood monocytes toward dendritic-like cells with regulatory properties
Polancec DS; Kos VM; Banjanac M; Vrancic M; Cuzic S; Belamaric D; Parnham MJ; Polancec D; Haber VE
Article: PHARMACOLOGICAL RESEARCH. 2011;64(3):298-307
Intensity of macrolide anti-inflammatory activity in J774A.1 cells positively correlates with cellular accumulation and phospholipidosis
Munic V; Banjanac M; Kostrun S; Nujic K; Bosnar M; Marjanovic N; Ralic J; Matijasic M; Hlevnjak M; Haber VE
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2011;43(5):359-369
Characterization of rhodamine-123, calcein and 5(6)-carboxy-2′,7′-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells
Munic V; Hlevnjak M; Haber VE
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2011;54(3):719-733
Modeling Cellular Pharmacokinetics of 14-and 15-Membered Macrolides with Physicochemical Properties
Stepanic V; Kostrun S; Malnar I; Hlevnjak M; Butkovic K; Caleta I; Duksi M; Kragol G; Makaruha-Stegic O; Mikac L; Ralic J; Tatic I; Tavcar B; Valko K; Zulfikari S; Munic V
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010;41(1):86-95
Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays
Munic V; Kelneric Z; Mikac L; Haber VE
Article: AQUATIC TOXICOLOGY. 2008;90(4):322-332
Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes
Zaja R; Munic V; Klobucar RS; Ambriovic-Ristov A; Smital T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;517(1-2):132-143
Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment
Parnham MJ; Culic O; Erakovic V; Munic V; Popovic-Grle S; Barisic K; Bosnar M; Brajsa K; Cepelak I; Cuzic S; Glojnaric I; Manojlovic Z; Novak-Mircetic R; Oreskovic K; Pavicic-Beljak V; Radosevic S; Sucic M
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2005;49(6):2372-2377
Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin
Bosnar M; Kelneric Z; Munic V; Erakovic V; Parnham MJ
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2002;450(3):277-289
Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects
Culic O; Erakovic V; Cepelak I; Barisic K; Brajsa K; Ferencic Z; Galovic R; Glojnaric I; Manojlovic Z; Munic V; Novak-Mircetic R; Pavicic-Beljak V; Sucic M; Veljaca M; Zanic-Grubisic T; Parnham MJ
Article: NEUROPEPTIDES. 2000;34(2):121-128
The link between met-enkephalin-induced down regulation of APN activity and the release of superoxide anion
Marotti T; Balog T; Munic V; Sobocanec S; Abramic M
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Alla övriga publikationer

Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2022;202:115145
Corrigendum to "Obesity III: Obesogen assays: Limitations, strengths, and new directions" [Biochem. Pharmacol. 199 (2022) 115014].
Kassotis CD; Vom Saal FS; Babin PJ; Lagadic-Gossmann D; Le Mentec H; Blumberg B; Mohajer N; Legrand A; Munic Kos V; Martin-Chouly C; Podechard N; Langouët S; Touma C; Barouki R; Kim MJ; Audouze K; Choudhury M; Shree N; Bansal A; Howard S; Heindel JJ
Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2022;202:115144
Obesity II: Establishing causal links between chemical exposures and obesity (vol 199, 115015, 2022)
Heindel JJ; Howard S; Agay-Shay K; Arrebola JP; Audouze K; Babin PJ; Barouki R; Bansal A; Blanc E; Cave MC; Chatterjee S; Chevalier N; Choudhury M; Collier D; Connolly L; Coumoul X; Garruti G; Gilbertson M; Hoepner LA; Holloway AC; Howell GIII; Kassotis CD; Kay MK; Kim MJ; Lagadic-Gossmann D; Langouet S; Legrand A; Li Z; Le Mentec H; Lind L; Lind PM; Lustig RH; Martin-Chouly C; Kos VM; Podechard N; Roepke TA; Sargis RM; Starling A; Tomlinson CR; Touma C; Vondracek J; vom Saal F; Blumberg B
Review: BIOCHEMICAL PHARMACOLOGY. 2022;199:115014
Obesity III: Obesogen assays: Limitations, strengths, and new directions.
Kassotis CD; Vom Saal FS; Babin PJ; Lagadic-Gossmann D; Le Mentec H; Blumberg B; Mohajer N; Legrand A; Munic Kos V; Martin-Chouly C; Podechard N; Langouët S; Touma C; Barouki R; Kim MJ; Audouze K; Choudhury M; Shree N; Bansal A; Howard S; Heindel JJ
Review: BIOCHEMICAL PHARMACOLOGY. 2022;199:115015
Obesity II: Establishing causal links between chemical exposures and obesity
Heindel JJ; Howard S; Agay-Shay K; Arrebola JP; Audouze K; Babin PJ; Barouki R; Bansal A; Blanc E; Cave MC; Chatterjee S; Chevalier N; Choudhury M; Collier D; Connolly L; Coumoul X; Garruti G; Gilbertson M; Hoepner LA; Holloway AC; Howell GIII; Kassotis CD; Kay MK; Kim MJ; Lagadic-Gossmann D; Langouet S; Legrand A; Li Z; Le Mentec H; Lind L; Lind PM; Lustig RH; Martin-Chouly C; Kos VM; Podechard N; Roepke TA; Sargis R; Starling A; Tomlinson CR; Touma C; Vondracek J; vom Saal F; Blumberg B
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(10):E3480-3480
The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds
Legler J; Zalko D; Jourdan F; Jacobs M; Fromenty B; Balaguer P; Bourguet W; Kos VM; Nadal A; Beausoleil C; Cristobal S; Remy S; Ermler S; Margiotta-Casaluci L; Griffin JL; Blumberg B; Chesne C; Hoffmann S; Andersson PL; Kamstra JH
Published conference paper: MARINE ENVIRONMENTAL RESEARCH. 2008;66(1):77-79
Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes
Zaja R; Munic V; Smital T

Anställningar

Anknuten till Forskning, Fysiologi och farmakologi, Karolinska Institutet, 2024-2024
Anknuten till Forskning, Fysiologi och farmakologi, Karolinska Institutet, 2024-2024

Om mig

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Alla övriga publikationer

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