Urban Lendahl

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Professor i genetik.

Forskningsbeskrivning

Notch-signalering, cancerbiologi, vaskulärbiologi, utvecklingsbiologi

Artiklar

Article: CIRCULATION RESEARCH. 2024;134(11):1405-1423
Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis
Mocci G; Sukhavasi K; Ord T; Bankier S; Singha P; Arasu UT; Agbabiaje OO; Makinen P; Ma L; Hodonsky CJ; Aherrahrou R; Muhl L; Liu J; Gustafsson S; Byandelger B; Wang Y; Koplev S; Lendahl U; Owens GK; Leeper NJ; Pasterkamp G; Vanlandewijck M; Michoel T; Ruusalepp A; Hao K; Yla-Herttuala S; Vali M; Jarve H; Mokry M; Civelek M; Miller CJ; Kovacic JC; Kaikkonen MU; Betsholtz C; Bjorkegren JLM
Article: BREAST CANCER RESEARCH. 2024;26(1):4
Identification of a Notch transcriptomic signature for breast cancer
Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D'Assoro AB; Ingle JN; Goetz MP; Kreis J; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Article: NEURON. 2023;111(23):3745-3764.e7
Molecular anatomy of adult mouse leptomeninges
Pietila R; Del Gaudio F; He L; Vazquez-Liebanas E; Vanlandewijck M; Muhl L; Mocci G; Bjornholm KD; Lindblad C; Fletcher-Sandersjoo A; Svensson M; Thelin EP; Liu J; van Voorden AJ; Torres M; Antila S; Xin L; Karlstrom H; Storm-Mathisen J; Bergersen LH; Moggio A; Hansson EM; Ulvmar MH; Nilsson P; Makinen T; Mae MA; Alitalo K; Proulx ST; Engelhardt B; McDonald DM; Lendahl U; Andrae J; Betsholtz C
Journal article: MOLECULAR CANCER THERAPEUTICS. 2023;22(12_Supplement):b013
Abstract B013: Identification of a Notch transcriptomic signature for breast cancer
Braune E-B; Geist F; Tang X; Kalari K; Boughey J; Wang L; Leon-Ferre RA; D’Assoro AB; Ingle JN; Goetz MP; Wang K; Foukakis T; Seshire A; Wienke D; Lendahl U
Article: SCIENTIFIC REPORTS. 2023;13(1):15022
Left ventricular hypertrophy and metabolic resetting in the Notch3-deficient adult mouse heart
Del Gaudio F; Liu D; Andaloussi Mae M; Braune E-B; Hansson EM; Wang Q-D; Betsholtz C; Lendahl U
Article: CELL REPORTS: METHODS. 2023;3(3):100431
A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature
Bjornholm KD; Del Gaudio F; Li H; Li W; Vazquez-Liebanas E; Mae MA; Lendahl U; Betsholtz C; Nilsson P; Karlstrom H; Vanlandewijck M
Article: EMBO MOLECULAR MEDICINE. 2023;15(2):e16556
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira DV; Coupland KG; Shao W; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Zetterberg H; Lundkvist J; Oberstein SAL; Lendahl U; Karlstrom H
Article: EMBO MOLECULAR MEDICINE. 2022;14(12):e15809
Sex differences and risk factors for bleeding in Alagille syndrome
Hankeova S; Van Hul N; Laznovsky J; Verboven E; Mangold K; Hensens N; Adori C; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Sjoqvist M; Johansson BR; Hassan MG; Fredriksson L; Baumgartel K; Bryja V; Lendahl U; Jheon A; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Article: DEVELOPMENTAL CELL. 2022;57(20):2426-2443.e6
A single-cell transcriptomic inventory of murine smooth muscle cells
Muhl L; Mocci G; Pietila R; Liu J; He L; Genove G; Leptidis S; Gustafsson S; Buyandelger B; Raschperger E; Hansson EM; Bjorkegren JLM; Vanlandewijck M; Lendahl U; Betsholtz C
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):3351
Abstract 3351: Identification of a NOTCH transcriptomic signature for basal-like breast cancer
Braune E-B; Geist F; Wienke D; Seshire A; Lendahl U
Article: STEM CELL REPORTS. 2022;17(6):1248-1267
100 plus years of stem cell research-20 years of ISSCR
Lendahl U
Article: STEM CELL REPORTS. 2022;17(5):1089-1104
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research
Muhl L; He L; Sun Y; Mae MA; Pietila R; Liu J; Genove G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Rasanen M; Hansson EM; Bjorkegren J; Vanlandewijck M; Blomgren K; Makinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
Article: NATURE. 2022;604(7907):740-748
Specification of CNS macrophage subsets occurs postnatally in defined niches
Masuda T; Amann L; Monaco G; Sankowski R; Staszewski O; Krueger M; Del Gaudio F; He L; Paterson N; Nent E; Fernandez-Klett F; Yamasaki A; Frosch M; Fliegauf M; Bosch LFP; Ulupinar H; Hagemeyer N; Schreiner D; Dorrier C; Tsuda M; Grothe C; Joutel A; Daneman R; Betsholtz C; Lendahl U; Knobeloch K-P; Laemmermann T; Priller J; Kierdorf K; Prinz M
Article: EBIOMEDICINE. 2021;74:103689
Biliary Atresia-emerging diagnostic and therapy opportunities
Lendahl U; Lui VCH; Chung PHY; Tam PKH
Article: BMC BIOLOGY. 2021;19(1):229
MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries
Yu R; Liu T; Jin S-B; Ankarcrona M; Lendahl U; Nister M; Zhao J
Article: CELL REPORTS: METHODS. 2021;1(4):100043
Highly efficient manipulation of nervous system gene expression with NEPTUNE
Mangold K; Masek J; He J; Lendahl U; Fuchs E; Andersson ER
Article: NEUROLOGY: GENETICS. 2021;7(3):e584
Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions
Arnardottir S; Del Gaudio F; Klironomos S; Braune E-B; Lombrana AA; Oliveira DV; Jin S; Karlstrom H; Lendahl U; Sjostrand C
Article: ELIFE. 2021;10:e60916
DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Dawit F; Jaros J; Bryja V; Lendahl U; Ellis E; Nemeth A; Fischler B; Hannezo E; Kaiser J; Andersson ER
Article: DISEASE MODELS & MECHANISMS. 2021;14(2):dmm046300
The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
Wu D; Wang S; Oliveira DV; Del Gaudio F; Vanlandewijck M; Lebouvier T; Betsholtz C; Zhao J; Jin S; Lendahl U; Karlstrom H
Journal article: STEM CELL REPORTS. 2021;16(1):1-2
Mentorship in Science: Response to AlShebli et al., Nature Communications 2020.
Mummery C; Little M; Lin H; Clark A; Zaret K; ISSCR Board 2020–2021; Srivastava D; Fuchs E; Watt F; Temple S
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:706687
The Molecular Assembly State of Drp1 Controls its Association With the Mitochondrial Recruitment Receptors Mff and MIEF1/2
Yu R; Jin S-B; Ankarcrona M; Lendahl U; Nister M; Zhao J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100593
PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion
Landor SKJ; Santio NM; Eccleshall WB; Paramonov VM; Gagliani EK; Hall D; Jin S-B; Dahlstrom KM; Salminen TA; Rivero-Muller A; Lendahl U; Kovall RA; Koskinen PJ; Sahlgren C
Article: JOURNAL OF HEPATOLOGY. 2020;73(6):1391-1403
Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia
Babu RO; Lui VCH; Chen Y; Yiu RSW; Ye Y; Niu B; Wu Z; Zhang R; Yu MON; Chung PHY; Wong KKY; Xia H; Zhang MQ; Wang B; Lendahl U; Tam PKH
Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156
Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes
Phoon YP; Chivukula IV; Tsoi YL; Kanatani S; Uhlen P; Kuiper R; Lendahl U
Article: NATURE COMMUNICATIONS. 2020;11(1):3953
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
Muhl L; Genove G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe A; Raschperger E; Hansson EM; Bjorkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s542
FRI286 Cracking the notch code in alagille syndrome: single-cell receptor-ligand interactions and outcomes in vivo, and an emerging role of immune cells
Mašek J; Hankeova S; Jin S-B; Lendahl U; Andersson E
Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s43
AS058 Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Article: DEVELOPMENT. 2020;147(4):dev183665
Notch signalling regulates epibranchial placode patterning and segregation
Wang L; Xie J; Zhang H; Tsang LH; Tsang SL; Braune E-B; Lendahl U; Sham MH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(46):17262-17277
The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria
Yu R; Liu T; Ning C; Tan F; Jin S-B; Lendahl U; Zhao J; Nister M
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
Article: MATRIX BIOLOGY. 2019;81:107-121
Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling
Papadakos KS; Bartoschek M; Rodriguez C; Gialeli C; Jin S-B; Lendahl U; Pietras K; Blom AM
Article: EMBO JOURNAL. 2019;38(8):embj201899748
Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery
Yu R; Jin S-B; Lendahl U; Nister M; Zhao J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(14):6985-6994
Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
Zheng X; Narayanan S; Sunkari VG; Eliasson S; Botusan IR; Grunler J; Catrina AI; Radtke F; Xu C; Zhao A; Ekberg NR; Lendahl U; Catrina S-B
Article: DEVELOPMENT. 2019;146(2):dev165589
Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling
Ando K; Wang W; Peng D; Chiba A; Lagendijk AK; Barske L; Crump JG; Stainier DYR; Lendahl U; Koltowska K; Hogan BM; Fukuhara S; Mochizuki N; Betsholtz C
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1981:203-236
Mouse Models for Diseases in the Cholangiocyte Lineage.
Van Hul N; Lendahl U; Andersson ER
Article: ONCOGENE. 2018;37(46):6083-6095
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types
Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
Article: SCIENTIFIC DATA. 2018;5:180160
Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
He L; Vanlandewijck M; Mae MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Segerstolpe A; Liu J; Gustafsson S; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: BLOOD. 2018;131(15):1712-1719
Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis
Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luis TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson ER; Chivukula IV; Hankeova S; Sjoqvist M; Tsoi YL; Ramskold D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netusilova J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: NATURE. 2018;554(7693):475-480
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck M; He L; Mae MAA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: ELIFE. 2017;6:e30126
An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis
Zhang H; Wang L; Wong EYM; Tsang SL; Xu P-X; Lendahl U; Sham MH
Journal article: EXPERIMENTAL CELL RESEARCH. 2017;360(1):1
Introduction.
Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2017;356(2):146-151
The interplay between the cellular hypoxic response and Notch signaling
Landor SK-J; Lendahl U
Article: SCIENTIFIC REPORTS. 2017;7(1):880
MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff
Yu R; Liu T; Jin S-B; Ning C; Lendahl U; Nister M; Zhao J
Article: NEUROSCIENCE RESEARCH. 2016;109:9-15
Endogenous APP accumulates in synapses after BACE1 inhibition
Nigam SM; Xu S; Ackermann F; Gregory JA; Lundkvist J; Lendahl U; Brodin L
Article: ONCOTARGET. 2016;7(28):43220-43238
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells
Santio NM; Landor SK-J; Vahtera L; Yla-Pelto J; Paloniemi E; Imanishi SY; Corthals G; Varjosalo M; Manoharan GB; Uri A; Lendahl U; Sahlgren C; Koskinen PJ
Article: STEM CELL REPORTS. 2016;6(5):643-651
Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells
Braune E-B; Tsoi YL; Phoon YP; Landor S; Cascales HS; Ramskold D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
Article: DISCOVERY MEDICINE. 2016;21(115):189-196
Notch -- a Goldilocks Signaling Pathway in Disease and Cancer Therapy
Braune E-B; Lendahl U
Journal article: LAKARTIDNINGEN. 2015;112:DRCD
[2015 Nobel Prize in Physiology or Medicine. Better health for millions of people thanks to drugs against parasites].
Andersson J; Lendahl U; Forssberg H
Journal article: EXPERIMENTAL CELL RESEARCH. 2015;337(2):v
Cell Biology at High Resolution
Lendahl U
Article: BREAST CANCER RESEARCH. 2015;17(1):109
Decoding breast cancer tissue-stroma interactions using species-specific sequencing
Chivukula IV; Ramskold D; Storvall H; Anderberg C; Jin S; Mamaeva V; Sahlgren C; Pietras K; Sandberg R; Lendahl U
Article: BMC CANCER. 2015;15:311
Frequency and distribution of Notch mutations in tumor cell lines
Mutvei AP; Fredlund E; Lendahl U
Article: JOURNAL OF NEUROCHEMISTRY. 2015;132(4):477-486
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS
Georgievska B; Gustavsson S; Lundkvist J; Neelissen J; Eketjall S; Ramberg V; Bueters T; Agerman K; Jureus A; Svensson S; Berg S; Falting J; Lendahl U
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(2):409-420
Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System
Henshall TL; Keller A; He L; Johansson BR; Wallgard E; Raschperger E; Mae MA; Jin S; Betsholtz C; Lendahl U
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2014;71(19):3841-3857
Cell surface antigen profiling using a novel type of antibody array immobilised to plasma ion-implanted polycarbonate
Main H; Radenkovic J; Kosobrodova E; McKenzie D; Bilek M; Lendahl U
Article: CELL RESEARCH. 2014;24(4):433-450
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Sjoqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(3):1540-1550
Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions
Olsson F; Schmidt S; Althoff V; Munter LM; Jin S; Rosqvist S; Lendahl U; Multhaup G; Lundkvist J
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(18):2893-2904
The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics
Liu T; Yu R; Jin S-B; Han L; Lendahl U; Zhao J; Nister M
Article: ONCOGENE. 2013;32(41):4892-4902
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKb
Jin S; Mutvei AP; Chivukula IV; Andersson ER; Ramskold D; Sandberg R; Lee KL; Kronqvist P; Mamaeva V; Ostling P; Mpindi J-P; Kallioniemi O; Screpanti I; Poellinger L; Sahlgren C; Lendahl U
Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369
Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Lanner F; Lee KL; Ortega GC; Sohl M; Li X; Jin S; Hansson EM; Claesson-Welsh L; Poellinger L; Lendahl U; Farnebo F
Article: STEM CELLS. 2013;31(4):741-751
A Critical Role for Sox9 in Notch-Induced Astrogliogenesis and Stem Cell Maintenance
Martini S; Bernoth K; Main H; Ortega GDC; Lendahl U; Just U; Schwanbeck R
Article: PLOS ONE. 2013;8(5):e62959
Notch Signaling Maintains Neural Rosette Polarity
Main H; Radenkovic J; Jin S-B; Lendahl U; Andersson ER
Article: JOURNAL OF NEUROSCIENCE. 2012;32(48):17297-17305
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
Borgegard T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg A-L; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlstrom H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
Journal article: ALZHEIMER'S AND DEMENTIA. 2012;8(4S_Part_19):p703-p704
P4‐192: Mechanism of gamma‐secretase‐mediated APP processing and modulation
Lundkvist J; Olsson F; Schmidt S; Althoff V; Jin S; Lendahl U; Multhaup G; Arvidsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(46):18814-18819
Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
Landor SK-J; Mutvei AP; Mamaeva V; Jin S; Busk M; Borra R; Gronroos TJ; Kronqvist P; Lendahl U; Sahlgren CM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;413(3):426-431
Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling
Liu L; Lanner F; Lendahl U; Das D
Article: EMBO JOURNAL. 2011;30(14):2762-2778
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
Zhao J; Liu T; Jin S; Wang X; Qu M; Uhlen P; Tomilin N; Shupliakov O; Lendahl U; Nister M
Article: JOURNAL OF THEORETICAL BIOLOGY. 2011;268(1):62-76
Modelling cell lineage using a meta-Boolean tree model with a relation to gene regulatory networks
Larsson J-A; Wadstromer N; Hermanson O; Lendahl U; Forchheimer R
Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166
Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
Das D; Lanner F; Main H; Andersson ER; Bergmann O; Sahlgren C; Heldring N; Hermanson O; Hansson EM; Lendahl U
Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(9):1610-1624
Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells
Main H; Lee KL; Yang H; Haapa-Paananen S; Edgren H; Jin S; Sahlgren C; Kallioniemi O; Poellinger L; Lim B; Lendahl U
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;393(1):21-27
Evidence for dimeric BACE-mediated APP processing
Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Falting J; Berg S; Lundkvist J; Lendahl U
Article: DEVELOPMENT. 2010;137(3):437-445
Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression
Marklund U; Hansson EM; Sundstrom E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):88
Notch1 signaling promotes neuro-ectodermal differentiation of embryonic stem cells via the Notch target gene Sox9.
Martini S; Schwanbeck R; Main H; Lendahl U; Just U
Article: JOURNAL OF INTERNAL MEDICINE. 2009;266(4):303-310
Regenerative medicine: a 2009 overview
Andersson ER; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(39):26928-26940
YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation
Rauen T; Raffetseder U; Frye BC; Djudjaj S; Muehlenberg PJT; Eitner F; Lendahl U; Bernhagen J; Dooley S; Mertens PR
Article: JOURNAL OF CELL SCIENCE. 2009;122(13):2252-2262
The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation
Zhao J; Liu T; Jin S-B; Tomilin N; Castro J; Shupliakov O; Lendahl U; Nister M
Article: ONCOGENE. 2008;27(44):5833-5844
Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells
Song LL; Peng Y; Yun J; Rizzo P; Chaturvedi V; Weijzen S; Kast WM; Stone PJB; Santos L; Loredo A; Lendahl U; Sonenshein G; Osborne B; Qin J-Z; Pannuti A; Nickoloff BJ; Miele L
Article: CANCER RESEARCH. 2008;68(13):5226-5235
Cross-talk between Notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
Rizzo P; Miao H; D'Souza G; Osipo C; Yun J; Zhao H; Mascarenhas J; Wyatt D; Antico G; Hao L; Yao K; Rajan P; Hicks C; Siziopikou K; Selvaggi S; Bashir A; Bhandari D; Marchese A; Lendahl U; Qin J-Z; Tonetti DA; Albain K; Nickoloff BJ; Miele L
Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491
Notch signaling regulates platelet-derived growth factor receptor-β expression in vascular smooth muscle cells
Jin S; Hansson EM; Tikka S; Lanner F; Sahlgren C; Farnebo F; Baumann M; Kalimo H; Lendahl U
Article: DEVELOPMENT. 2008;135(10):1843-1851
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(17):6392-6397
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
Sahlgren C; Gustafsson MV; Jin S; Poellinger L; Lendahl U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(14):3141-3152
Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines
Dohda T; Maljukova A; Liu L; Heyman M; Grander D; Brodin D; Sangfelt O; Lendahl U
Article: CANCER RESEARCH. 2007;67(12):5611-5616
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling
Malyukova A; Dohda T; von der Lehr N; Akhondi S; Corcoran M; Heyman M; Spruck C; Grander D; Lendahl U; Sangfelt O
Journal article: EXPERIMENTAL CELL RESEARCH. 2007;313(10):1979-1980
Special issue: Intermediate filaments
Omary MB; Herrmann H; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 2006;175(4):535-540
High levels of Notch signaling down-regulate Numb and Numblike.
Chapman G; Liu L; Sahlgren C; Dahlqvist C; Lendahl U
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127
Recording Notch signaling in real time
Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF NEUROCHEMISTRY. 2005;95(3):880-890
γ-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal γ-secretase activity
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(42):35352-35360
A nine-transmembrane domain topology for presenilin 1
Laudon H; Hansson EM; Melén K; Bergman A; Farmery MR; Winblad B; Lendahl U; von Heijne G; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(5):1010-1020
Aph-1 interacts at the cell surface with proteins in the active γ-secretase complex and membrane-tethered Notch
Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
Article: GENESIS (UNITED STATES). 2005;41(1):13-22
Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
Lundkvist J; Zhu SW; Hansson EM; Schweinhardt P; Miao Q; Beatus P; Dannaeus K; Karlström H; Johansson CB; Viitanen M; Rozell B; Spenger C; Mohammed A; Kalimo H; Lendahl U
Article: NATURE GENETICS. 2004;36(9):925-927
The European dimension for the mouse genome mutagenesis program
Auwerx J; Avner P; Baldock R; Ballabio A; Balling R; Barbacid M; Berns A; Bradley A; Brown S; Carmeliet P; Chambon P; Cox R; Davidson D; Davies K; Duboule D; Forejt J; Granucci F; Hastie N; de Angelis MH; Jackson I; Kioussis D; Kollias G; Lathrop M; Lendahl U; Malumbres M; von Melchner H; Müller W; Partanen J; Ricciardi-Castagnoli P; Rigby P; Rosen B; Rosenthal N; Skarnes B; Stewart AF; Thornton J; Tocchini-Valentini G; Wagner E; Wahli W; Wurst W
Article: DEVELOPMENTAL BRAIN RESEARCH. 2004;151(1-2):13-23
Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling
Mellodew K; Suhr R; Uwanogho DA; Reuter I; Lendahl U; Hodges H; Price J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23925-23932
Functional domains in presenilin 1 -: The TYR-288 residue controls γ-secretase activity and endoproteolysis
Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(16):16744-16753
Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin
Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; Lendahl U; Lundkvist J; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2004;89(1):44-53
Co-expressed presenilin 1 NTF and CTF form functional γ-secretase complexes in cells devoid of full-length protein
Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
Article: EXPERIMENTAL CELL RESEARCH. 2004;292(1):21-28
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors
Enlund F; Behboudi A; Andrén Y; Öberg C; Lendahl U; Mark J; Stenman G
Article: DEVELOPMENT. 2003;130(24):6089-6099
Functional notch signaling is required for BMP4-induced inhibition of myogenic differentiation
Dahlqvist C; Blokzijl A; Chapman G; Falk A; Dannaeus K; Ibâñez CF; Lendahl U
Article: JOURNAL OF CELL BIOLOGY. 2003;163(4):723-728
Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
Blokzijl A; Dahlqvist C; Reissmann E; Falk A; Moliner A; Lendahl U; Ibáñez CF
Article: JOURNAL OF IMMUNOLOGY. 2003;171(9):4504-4511
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
Anastasi E; Campese AF; Bellavia D; Bulotta A; Balestri A; Pascucci M; Checquolo S; Gradini R; Lendahl U; Frati L; Gulino A; Di Mario U; Screpanti I
Article: GENESIS (UNITED STATES). 2003;37(3):139-143
Characterization of Notch3-deficient mice:: Normal embryonic development and absence of genetic interactions with a Notch1 mutation
Krebs LT; Xue YZ; Norton CR; Sundberg JP; Beatus P; Lendahl U; Joutel A; Gridley T
Article: DEVELOPMENT. 2003;130(18):4451-4460
Role of Islet1 in the patterning of murine dentition
Mitsiadis TA; Angeli I; James C; Lendahl U; Sharpe PT
Article: EXPERIMENTAL CELL RESEARCH. 2003;282(2):101-109
Notch2 protein distribution in human teeth under normal and pathological conditions
Mitsiadis TA; Roméas A; Lendahl U; Sharpe PT; Farges JC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):17119-17124
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling
Karlström H; Beatus P; Dannaeus K; Chapman G; Lendahl U; Lundkvist J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(22):7812-7819
p300 and PCA act cooperatively to mediate transcriptional activation from chromatin templates by Notch intracellular domains in vitro
Wallberg AE; Pedersen K; Lendahl U; Roeder RG
Article: LAKARTIDNINGEN. 2002;99(41):4026-4032
[Sydney Brenner, Robert Horvitz and John Sulston. Winners of the 2002 Nobel Prize in medicine or physiology. Genetic regulation of organ development and programmed cell death].
Lendahl U; Orrenius S
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(6):784-794
Nestin enhancer requirements for expression in normal and injured adult CNS
Johansson CB; Lothian C; Molin M; Okano H; Lendahl U
Journal article: EXPERIMENTAL CELL RESEARCH. 2002;278(2):123-124
Nils Ringertz
Lendahl U
Article: EXPERIMENTAL CELL RESEARCH. 2002;278(1):31-44
Mouse notch 3 expression in the pre- and postnatal brain: Relationship to the stroke and dementia syndrome CADASIL
Prakash N; Hansson E; Betsholtz C; Mitsiadis T; Lendahl U
Article: APMIS. 2002;110(6):499-507
Patterns of nestin and other intermediate filament expression distinguish between gastrointestinal stromal tumors, leiomyomas and schwannomas
Sarlomo-Rikala M; Tsujimura T; Lendahl U; Miettinen M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;160(6):2123-2133
E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions
Heymann R; About I; Lendahl U; Franquin JC; Öbrink B; Mitsiadis TA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):3788-3793
Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
Bellavia D; Campese AF; Checquolo S; Balestri A; Biondi A; Cazzaniga G; Lendahl U; Fehling HJ; Hayday AC; Frati L; von Boehmer H; Gulino A; Screpanti I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):4014-4019
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi Y; Karlström H; Lundkvist J; Mizutani T; Otaka A; Vestling M; Bernstein A; Donoviel D; Lendahl U; Honjo T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(9):6763-6766
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Article: JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY. 2002;50(2):147-158
Immunohistochemical detection of nestin in pediatric brain tumors
Almqvist PM; Mah R; Lendahl U; Jacobsson B; Hendson G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(24):14006-14011
Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin
Kokaia M; Holmberg K; Nanobashvili A; Xu ZQD; Kokaia Z; Lendahl U; Hilke S; Theodorsson E; Kahl U; Bartfai T; Lindvall O; Hökfelt T
Article: NEUROSCIENCE LETTERS. 2001;314(3):151-155
Induction of astrocytic nestin expression by depolarization in rats
Holmin S; von Gertten C; Sandberg-Nordqvist AC; Lendahl U; Mathiesen T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(38):35847-35853
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian sel-10 homolog
Öberg C; Li JH; Pauley A; Wolf E; Gurney M; Lendahl U
Journal article: EXPERIMENTAL CELL RESEARCH. 2001;269(1):1
Accelerated Publication in Experimental Cell Research
Lendahl U
Article: MECHANISMS OF DEVELOPMENT. 2001;107(1-2):181-185
A 1.8 kb GFAP-promoter fragment is active in specific regions of the embryonic CNS
Andræ J; Bongcam-Rudloff E; Hansson I; Lendahl U; Westermark B; Nistér M
Article: MECHANISMS OF DEVELOPMENT. 2001;104(1-2):3-20
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
Beatus P; Lundkvist J; Öberg C; Pedersen K; Lendahl U
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2001;60(6):588-597
The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle
Vaittinen S; Lukka R; Sahlgren C; Hurme T; Rantanen J; Lendahl U; Eriksson JE; Kalimo H
Article: JOURNAL OF IMMUNOLOGY. 2001;166(11):6585-6592
MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells
Fahlén L; Lendahl U; Sentman CL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):16456-16463
Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase
Sahlgren CM; Mikhailov A; Hellman J; Chou YH; Lendahl U; Goldman RD; Eriksson JE
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(3):817-823
Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal
Tsujimura T; Makiishi-Shimobayashi C; Lundkvist J; Lendahl U; Nakasho K; Sugihara A; Iwasaki T; Mano M; Yamada N; Yamashita K; Toyosaka A; Terada N
Article: NEUROREPORT. 2001;12(2):423-425
Mice over-expressing galanin have elevated heat nociceptive threshold
Blakeman KH; Holmberg K; Hao JX; Xu XJ; Kahl U; Lendahl U; Bartfai T; Wiesenfeld-Hallin Z; Hökfelt T
Article: BIOESSAYS. 2001;23(1):3-7
Oh no, Notch again!
Frisén J; Lendahl U
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2001;11:s116-s117
Monoamine—neuropeptide interactions
Hökfelt T; Xu Z-QD; Holmberg K; Kehr J; Schött P; Ögren SO; Wang FH; Yoshitaki T; Bartfai T; Lendahl U; Kokaia M; Nanobashvili A; Kokaia Z; Lindvall O; Kahl U; Yamaguchi M
Article: EMBO JOURNAL. 2000;19(13):3337-3348
Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice
Bellavia D; Campese AF; Alesse E; Vacca A; Felli MP; Balestri A; Stoppacciaro A; Tiveron C; Tatangelo L; Giovarelli M; Gaetano C; Ruco L; Hoffman ES; Hayday AC; Lendahl U; Frati L; Gulino A; Screpanti I
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(1):287-295
Nestin expression in embryonic and adult human teeth under normal and pathological conditions
About I; Laurent-Maquin D; Lendahl U; Mitsiadis TA
Article: SCIENCE. 2000;288(5471):1660-1663
Generalized potential of adult neural stem cells
Clarke DL; Johansson CB; Wilbertz J; Veress B; Nilsson E; Karlström H; Lendahl U; Frisén J
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(2):215-222
Ly49A expression on T cells alters T cell selection
Fahlén L; Öberg L; Brännström T; Khoo NKS; Lendahl U; Sentman CL
Article: DEVELOPMENT. 1999;126(17):3925-3935
The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
Beatus P; Lundkvist J; Öberg C; Lendahl U
Article: NATURE. 1999;400(6747):877-881
Notch signalling controls pancreatic cell differentiation
Apelqvist Å; Li H; Sommer L; Beatus P; Anderson DJ; Honjo T; de Angelis MH; Lendahl U; Edlund H
Article: INTERNATIONAL IMMUNOLOGY. 1999;11(7):1017-1025
Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development
Felli MP; Maroder M; Mitsiadis TA; Campese AF; Bellavia D; Vacca A; Mann RS; Frati L; Lendahl U; Gulino A; Screpanti I
Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén Å; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 1999;248(2):509-519
Identification of both general and region-specific embryonic CNS enhancer elements in the nestin promoter
Lothian C; Prakash N; Lendahl U; Wahlström GM
Article: AMERICAN JOURNAL OF PATHOLOGY. 1999;154(2):591-600
Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle
Vaittinen S; Lukka R; Sahlgren C; Rantanen J; Hurme T; Lendahl U; Eriksson JE; Kalimo H
Article: CELL. 1999;96(1):25-34
Identification of a neural stem cell in the adult mammalian central nervous system
Johansson CB; Momma S; Clarke DL; Risling M; Lendahl U; Frisén J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(2):1078-1084
Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element
Timmusk T; Palm K; Lendahl U; Metsis M
Article: DEVELOPMENTAL BIOLOGY. 1998;204(2):420-431
Delta-Notch signaling in odontogenesis: Correlation with cytodifferentiation and evidence for feedback regulation
Mitsiadis TA; Hirsinger E; Lendahl U; Goridis C
Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479
MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells
Andersson M; Freland S; Johansson MH; Wallin R; Sandberg JK; Chambers BJ; Christensson B; Lendahl U; Lemieux S; Salcedo M; Ljunggren HG
Article: NATURE. 1998;395(6700):398-402
Retinoid-X receptor signalling in the developing spinal cord
Solomin L; Johansson CB; Zetterström RH; Bissonnette RP; Heyman RA; Olson L; Lendahl U; Frisén J; Perlmann T
Article: NEURON. 1998;21(2):305-315
BDNF regulates Reelin expression and Cajal-Retzius cell development in the cerebral cortex
Ringstedt T; Linnarsson S; Wagner J; Lendahl U; Kokaia Z; Arenas E; Ernfors P; Ibáñez CF
Article: JOURNAL OF CELL SCIENCE. 1998;111:1951-1961
A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice
Marvin NJ; Dahlstrand J; Lendahl U; McKay RDG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(9):5269-5274
Targeted expression of a multifunctional chimeric neurotrophin in the lesioned sciatic nerve accelerates regeneration of sensory and motor axons
Funakoshi H; Risling M; Carlstedt T; Lendahl U; Timmusk T; Metsis M; Yamamoto Y; Ibáñez CF
Article: PEDIATRIC RESEARCH. 1998;43(3):386-392
Pediatric rhabdomyosarcomas express the intermediate filament nestin
Kobayashi M; Sjöberg G; Söderhäll S; Lendahl U; Sandstedt B; Sejersen T
Article: BIOESSAYS. 1998;20(2):103-107
A growing family of Notch ligands
Lendahl U
Article: DEVELOPMENT. 1997;124(13):2603-2613
Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system
Ringstedt T; Kucera J; Lendahl U; Ernfors P; Ibanez CF
Journal article: EXPERIMENTAL CELL RESEARCH. 1997;232(2):193
EDITORIAL COMMENT
Ringertz N; Lendahl U; Baserga R
Article: DIFFERENTIATION. 1997;61(4):243-249
The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse
Frojdman K; Pelliniemi LJ; Lendahl U; Virtanen I; Eriksson JE
Article: DEVELOPMENT. 1997;124(8):1473-1483
Mouse Serrate-1 (Jagged-1): Expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
Mitsiadis TA; Henrique D; Thesleff I; Lendahl U
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(3):452-462
An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells
Lothian C; Lendahl U
Article: DIFFERENTIATION. 1997;61(3):151-159
Distribution of nestin in the developing mouse limb bud in vivo and in micro-mass cultures of cells isolated from limb buds
Wroblewski J; Engstrom M; EdwallArvidsson C; Sjoberg G; Sejersen T; Lendahl U
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA, SUPPLEMENT. 1997;110:116-118
Transgenic analysis of central nervous system development and regeneration.
Lendahl U
Journal article: DIFFERENTIATION. 1997;61(4):243
The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse
Fröjdman K; Pelliniemi LJ; Lendahl U; Virtanen I; Eriksson JE
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 1997;9(4):264-275
Structural and functional characterization of the rat neurotrophin-4 gene
Salin T; Timmusk T; Lendahl U; Metsis M
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(1):65-75
Adult nestin-expressing subependymal cells differentiate to astrocytes in response to brain injury
Holmin S; Almqvist P; Lendahl U; Mathiesen T
Article: PEDIATRIC RESEARCH. 1996;40(6):809-814
Cerebrospinal fluid of newborn infants contains a deglycosylated form of the intermediate filament nestin
Grigelioniene G; Blennow M; Torok C; Fried G; Dahlin I; Lendahl U; Lagercrantz H
Article: EXPERIMENTAL BRAIN RESEARCH. 1996;112(1):47-57
Fetal ventral mesencephalon of human and rat origin maintained in vitro and transplanted to 6-hydroxydopamine-lesioned rats gives rise to grafts rich in dopaminergic neurons
Spenger C; Haque NSK; Studer L; Evtouchenko L; Wagner B; Buhler B; Lendahl U; Dunnett SB; Seiler RW
Article: MECHANISMS OF DEVELOPMENT. 1996;59(2):177-190
Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
Lardelli M; Williams R; Mitsiadis T; Lendahl U
Journal article: PEDIATRIC RESEARCH. 1996;40(3):531
Intermediate Filament Nestin is Present in the Cerebrospinal Fluid of Children. 97
Grigelioniené G; Blennow M; Marchini G; Wahlquist Y; Lendahl U
Journal article: PEDIATRIC RESEARCH. 1996;40(3):554
The Second Intron of the Human Nestin Gene Directs Gene Expression To Cns Progenitor Cells 236
Török C; Lagercrantz H; Lendahl U
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(9):2127-2132
Influence of glycosylphosphatidylinositol-linked H-2D(d) molecules on target cell protection and natural killer cell specificity in transgenic mice
Sentman CL; OlssonAlheim MY; Lendahl U; Karre K
Article: INTERNATIONAL IMMUNOLOGY. 1996;8(7):1149-1157
Elevated expression levels of an Ig transgene in mice links the IgH 3' enhancer to the regulation of IgH expression
Arulampalam V; Furebring C; Samuelsson A; Lendahl U; Borrebaeck C; Lundkvist I; Pettersson S
Journal article: PEDIATRIC RESEARCH. 1996;39(Suppl 4):373
THE EMBRYONIC INTERMEDIATE FILAMENT PROTEIN NESTIN IS PRESENT IN THE CEREBROSPINAL FLUID OF NICU INFANTS. † 2223
Blennow M; Grigelioniené G; Török C; Lendahl U; Lagercrantz H
Article: JOURNAL OF IMMUNOLOGY. 1996;156(7):2423-2429
H-2D(p) transgene alters natural killer cell specificity at the target and effector cell levels - Comparison with an H-2D(d) transgene
Sentman CL; OlssonAlheim MY; Lendahl U; Karre K
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1996;Suppl 1:113S-114S
Mouse Serrate-1 and Notch genes differ in their response to signaling molecules during odontogenesis.
Mitsiadis TA; Thesleff I; Lendahl U
Article: LABORATORY INVESTIGATION. 1996;74(1):188-198
Coexpression of platelet-derived growth factor cu and beta receptors on medulloblastomas and other primitive neuroectodermal tumors is consistent with an immature stem cell and neuronal derivation
Smits A; vanGrieken D; Hartman M; Lendahl U; Funa K; Nister M
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(6):947-956
Expression of the intermediate filament nestin during rodent tooth development
Terling C; Rass A; Mitsiadis TA; Fried K; Lendahl U; Wroblewski J
Article: TRANSGENIC RESEARCH. 1995;4(6):378-387
ALTERED EXPRESSION AFTER EXPANSION OF A V-ERBA TRANSGENE IN TRANSGENIC MICE
BARLOW C; MEISTER B; LENDAHL U; VENNSTROM B
Article: MECHANISMS OF DEVELOPMENT. 1995;53(3):357-368
COMPLEMENTARY AND COMBINATORIAL PATTERNS OF NOTCH GENE FAMILY EXPRESSION DURING EARLY MOUSE DEVELOPMENT
WILLIAMS R; LENDAHL U; LARDELLI M
Article: JOURNAL OF CELL BIOLOGY. 1995;131(2):453-464
RAPID, WIDESPREAD, AND LONG-LASTING INDUCTION OF NESTIN CONTRIBUTES TO THE GENERATION OF GLIAL SCAR TISSUE AFTER CNS INJURY
FRISEN J; JOHANSSON CB; TOROK C; RISLING M; LENDAHL U
Article: JOURNAL OF CELL BIOLOGY. 1995;130(2):407-418
EXPRESSION OF NOTCH-1, NOTCH-2, AND NOTCH-3 IS REGULATED BY EPITHELIAL-MESENCHYMAL INTERACTIONS AND RETINOIC ACID IN THE DEVELOPING MOUSE TOOTH AND ASSOCIATED WITH DETERMINATION OF AMELOBLAST CELL FATE
MITSIADIS TA; LARDELLI M; LENDAHL U; THESLEFF I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(9):4046-4050
REGULATORY REGION IN CHOLINE-ACETYLTRANSFERASE GENE DIRECTS DEVELOPMENTAL AND TISSUE-SPECIFIC EXPRESSION IN TRANSGENIC MICE
LONNERBERG P; LENDAHL U; FUNAKOSHI H; ARHLUNDRICHTER L; PERSSON H; IBANEZ CF
Article: DEVELOPMENTAL BRAIN RESEARCH. 1995;84(1):109-129
NESTIN MESSENGER-RNA EXPRESSION CORRELATES WITH THE CENTRAL-NERVOUS-SYSTEM PROGENITOR-CELL STATE IN MANY, BUT NOT ALL, REGIONS OF DEVELOPING CENTRAL-NERVOUS-SYSTEM
DAHLSTRAND J; LARDELLI M; LENDAHL U
Article: PEDIATRIC RESEARCH. 1995;37(1):15-20
EXPRESSION OF C-FOS, TYROSINE-HYDROXYLASE, AND NEUROPEPTIDE MESSENGER-RNA IN THE RAT-BRAIN AROUND BIRTH - EFFECTS OF HYPOXIA AND HYPOTHERMIA
RINGSTEDT T; TANG LQ; PERSSON H; LENDAHL U; LAGERCRANTZ H
Article: JOURNAL OF CELL BIOLOGY. 1995;128(1-2):185-199
IDENTIFICATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR PROMOTER REGIONS MEDIATING TISSUE-SPECIFIC, AXOTOMY-INDUCED, AND NEURONAL ACTIVITY-INDUCED EXPRESSION IN TRANSGENIC MICE
TIMMUSK T; LENDAHL U; FUNAKOSHI H; ARENAS E; PERSSON H; METSIS M
Journal article: JOURNAL OF IMMUNOLOGY. 1994;153(12):5482-5490
H-2 ALLELE-SPECIFIC PROTECTION FROM NK CELL-LYSIS IN-VITRO FOR LYMPHOBLASTS BUT NOT TUMOR TARGETS - PROTECTION MEDIATED BY ALPHA-1/ALPHA-2 DOMAINS
SENTMAN CL; OLSSON MY; SALCEDO M; HOGLUND P; LENDAHL U; KARRE K
Journal article: GENOMICS. 1994;24(2):253-258
THE HUMAN NOTCH1, NOTCH2, AND NOTCH3 GENES ARE LOCATED AT CHROMOSOME POSITIONS 9Q34, 1P13-P11, AND 19P13.2-P13.1 IN REGIONS OF NEOPLASIA-ASSOCIATED TRANSLOCATION
LARSSON C; LARDELLI M; WHITE I; LENDAHL U
Journal article: EXPERIMENTAL CELL RESEARCH. 1994;214(2):447-458
COLOCALIZATION OF NESTIN AND VIMENTIN/DESMIN IN SKELETAL-MUSCLE CELLS DEMONSTRATED BY 3-DIMENSIONAL FLUORESCENCE DIGITAL IMAGING MICROSCOPY
SJOBERG G; JIANG WQ; RINGERTZ NR; LENDAHL U; SEJERSEN T
Journal article: EMBO JOURNAL. 1994;13(18):4241-4250
THYROID ABNORMALITIES AND HEPATOCELLULAR-CARCINOMA IN MICE TRANSGENIC FOR V-ERBA
BARLOW C; MEISTER B; LARDELLI M; LENDAHL U; VENNSTROM B
Journal article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 1994;53(4):416-423
MYOFIBERS FROM DUCHENNE/BECKER MUSCULAR-DYSTROPHY AND MYOSITIS EXPRESS THE INTERMEDIATE FILAMENT NESTIN
SJOBERG G; EDSTROM L; LENDAHL U; SEJERSEN T
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1994;24(7):1671-1677
LIPOPOLYSACCHARIDE-DEPENDENT TRANSACTIVATION OF THE TEMPORALLY REGULATED IMMUNOGLOBULIN HEAVY-CHAIN 3' ENHANCER
ARULAMPALAM V; GRANT PA; SAMUELSSON A; LENDAHL U; PETTERSSON S
Journal article: MECHANISMS OF DEVELOPMENT. 1994;46(2):123-136
THE NOVEL NOTCH HOMOLOG MOUSE NOTCH-3 LACKS SPECIFIC EPIDERMAL GROWTH FACTOR-REPEATS AND IS EXPRESSED IN PROLIFERATING NEUROEPITHELIUM
LARDELLI M; DAHLSTRAND J; LENDAHL U
Journal article: LAKARTIDNINGEN. 1994;91(17):1711-1717
[Transgenic animals. Animals with designed genetic changes].
Lendahl U; Törnell J
Journal article: BIOTECHNIQUES. 1994;16(3):420-422
GENERATING BACTERIOPHAGE-LAMBDA SUBLIBRARIES ENRICHED FOR RARE CLONES
LARDELLI M; LENDAHL U
Journal article: CANCER RESEARCH. 1994;54(2):354-356
EXPRESSION OF THE NEUROECTODERMAL INTERMEDIATE FILAMENT NESTIN IN HUMAN MELANOMAS
FLORENES VA; HOLM R; MYKLEBOST O; LENDAHL U; FODSTAD O
Journal article: NEURON. 1994;12(1):11-24
Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors.
Zimmerman L; Parr B; Lendahl U; Cunningham M; McKay R; Gavin B; Mann J; Vassileva G; McMahon A
Journal article: CELL. 1990;60(4):585-595
CNS STEM-CELLS EXPRESS A NEW CLASS OF INTERMEDIATE FILAMENT PROTEIN
LENDAHL U; ZIMMERMAN LB; MCKAY RDG
Journal article: JOURNAL OF MOLECULAR BIOLOGY. 1990;211(2):331-349
THE BALBIANI RING-3 GENE IN CHIRONOMUS-TENTANS HAS A DIVERGED REPETITIVE STRUCTURE SPLIT BY MANY INTRONS
PAULSSON G; LENDAHL U; GALLI J; ERICSSON C; WIESLANDER L
Journal article: GENETICS. 1987;117(1):43-49
RAPID AND CONCERTED EVOLUTION OF REPEAT UNITS IN A BALBIANI RING GENE
LENDAHL U; SAIGA H; HOOG C; EDSTROM JE; WIESLANDER L
Journal article: DEVELOPMENTAL BIOLOGY. 1987;121(1):130-138
BALBIANI RING (BR) GENES EXHIBIT DIFFERENT PATTERNS OF EXPRESSION DURING DEVELOPMENT
LENDAHL U; WIESLANDER L
Journal article: CHEMICA SCRIPTA. 1986;26B:159-163
THE BALBIANI RING GENE FAMILY - AN EXAMPLE OF SATELLITE-LIKE EVOLUTION OF CODING SEQUENCES
WIESLANDER L; HOOG C; LENDAHL U; DANEHOLT B
Journal article: JOURNAL OF MOLECULAR EVOLUTION. 1985;22(1):63-68
ABRUPT EVOLUTIONARY CHANGE IN THE BALBIANI RING GENE FAMILY IN 2 SIBLING SPECIES OF CHIRONOMUS
LENDAHL U; WIESLANDER L
Journal article: CELL. 1984;36(4):1027-1034
BALBIANI RING 6-GENE IN CHIRONOMUS TENTANS - A DIVERGED MEMBER OF THE BALBIANI RING GENE FAMILY
LENDAHL U; WIESLANDER L
Journal article: JOURNAL OF MOLECULAR EVOLUTION. 1984;20(3-4):304-312
CONSERVED AND NONCONSERVED STRUCTURES IN THE SECRETORY PROTEINS ENCODED IN THE BALBIANI RING GENES OF CHIRONOMUS-TENTANS
WIESLANDER L; HOOG C; HOOG JO; JORNVALL H; LENDAHL U; DANEHOLT B
Journal article: EMBO JOURNAL. 1983;2(7):1169-1175
THE BALBIANI RING-2 GENE IN CHIRONOMUS-TENTANS IS BUILT FROM 2 TYPES OF TANDEMLY ARRANGED MAJOR REPEAT UNITS WITH A COMMON EVOLUTIONARY ORIGIN
WIESLANDER L; LENDAHL U
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Alla övriga publikationer

Editorial comment: NATURE METABOLISM. 2023;5(12):2037-2038
The thyroid gland under Notch control
Lendahl U
Book chapter: ENCYCLOPEDIA OF CELL BIOLOGY. 2023;p. 125-133
The Notch Signaling Pathway
Braune E-B; Del Gaudio F; Lendahl U
Corrigendum: NATURE. 2022;610(7930):E1
Specification of CNS macrophage subsets occurs postnatally in defined niches (vol 604, pg 740, 2022)
Masuda T; Amann L; Monaco G; Sankowski R; Staszewski O; Krueger M; Del Gaudio F; He L; Paterson N; Nent E; Fernandez-Klett F; Yamasaki A; Frosch M; Fliegauf M; Bosch LFP; Ulupinar H; Hagemeyer N; Schreiner D; Dorrier C; Tsuda M; Grothe C; Joutel A; Daneman R; Betsholtz C; Lendahl U; Knobeloch K-P; Lammermann T; Priller J; Kierdorf K; Prinz M
Preprint: BIORXIV. 2022
NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira DV; Coupland KG; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Lundkvist J; Oberstein SAJL; Lendahl U; Karlström H
Review: NATURE COMMUNICATIONS. 2022;13(1):3409
Identification, discrimination and heterogeneity of fibroblasts
Lendahl U; Muhl L; Betsholtz C
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(11):6241
Roles of Notch Signaling in the Tumor Microenvironment
D'Assoro AB; Leon-Ferre R; Braune E-B; Lendahl U
Review: OPEN BIOLOGY. 2022;12(4):220004
Notch signalling in healthy and diseased vasculature
Del Gaudio F; Liu D; Lendahl U
Corrigendum: NATURE GENETICS. 2022;54(3):358-360
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome (vol 37, pg 1155, 2005)
Janier M; Almadjub M; Beuf O; Billotey C; Bolbos R; Canaple L; Chereul E; Grenier D; Hiba B; Odet C; Langlois J-B; Lartizien C; Magnier L; Ma W; Zouagui T; Lathrop M; Gut I; Puech A; Herault Y; Blanquet V; Brault V; Samarut J; Aubert D; Plateroti M; Rosenthal N; Al Banchaabouchi M; Carter J; Ermakova O; Gale K; Gonzalez J; Perlas E; Rientjes J; Spanner A; Trillat A-C; Tocchini-Valentini G; Mandillo S; Golini E; Marazziti D; Deidda G; Rossi N; Matteoni R; Raspa M; Scavizzi F; Barbacid M; Campuzano MV; Dubus P; Perez Gallego L; Guerra Gonzalez C; Balling R; Frischmann U; Hauser H; Lengeling A; Muller W; Pasche B; Hrabe de Angelis M; Wurst W; Abe K; Beckers J; Busch DH; Dalke C; Gailus Durner V; Elvert R; Franz TJ; Fuchs H; Graw J; Holter SM; Jakob T; Kalaydjiev S; Kallnik M; Klempt M; Klingenspor M; Klopstock T; Lengger C; Quintanilla Martinez L; Pedersen V; Puk O; Schneider I; Vogt Weisenhorn D; Wagner S; Wolf E; Chambon P; Auwerx J; Ali-Hadji D; Champy M-F; Frossard N; Helwig J-J; Mark M; Monassier L; Antal MC; Barthelmebs M; Bloch-Zupan A; Constantinesco A; Doll P; El Fertak L; Gofflot F; Juillard L; Krezel W; Meziane H; Ouagazzal A-M; Pons F; Romand R; Selloum M; Sorg T; Teletin M; Vasseur L; Wendling O; Avner P; Chantalat S; Lendahl U; Wilbertz J; Davies K; Oliver P; Brown S; Cheeseman M; Coghill E; Cox R; Bentley L; Ferguson S; Gates H; Gkoutos G; Green E; Hancock J; Hough T; Johnson R; Lad H; Mallon A-M; Nolan P; Parker A; Quarterman J; Smith A; Studley M; Shukla A; Tateossian H; Tucci V; Weekes J; Jackson I; Cross S; Davidson D; Hart A; Murray A; Berns A; Breuer M; van Garderen E; Jonkers J; Song JY; van der Valk M; Neyses L; Cartwright E; Oceandy D; Emerson M; Wahli W; Delgado MB; Desvergne B; Michalik L; Bedu E; Duboule D; Kmita M; Zakany J; Animage; Bradley A; Warren M
Conference publication: CANCER RESEARCH. 2022;82(12)
Identification of a NOTCH transcriptomic signature for basal-like breast cancer
Braune E-B; Geist F; Wienke D; Seshire A; Lendahl U
Preprint: SSRN ELECTRONIC JOURNAL. 2022
Distinct Fibroblast Subtypes Populate Specific Brain Barriers
Del Gaudio F; He L; Pietilä R; Vanlandewijck M; Muhl L; Mocci G; Bjørnholm KD; Liu J; van Voorden J; Torres M; Moggio A; Antilla S; Storm-Mathisen J; Bergersen LH; Nilsson P; Hansson E; Alitalo K; Lendahl U; Andrae J; Betsholtz C
Preprint: SSRN ELECTRONIC JOURNAL. 2022
A Robust and Efficient Microvascular Isolation Method for Multimodal Characterization of the Mouse Brain Vasculature
Bjørnholm KD; Del Gaudio F; Li H; Li W; Vázquez Liébanas E; Mäe MA; Lendahl U; Betsholtz C; Nilsson P; Karlström H; Vanlandewijck M
Preprint: BIORXIV. 2021
Multimodal characterization of the murine neurovascular niche using a novel microvascular isolation protocol
Bjørnholm KD; Vanlandewijck M; Del Gaudio F; Lendahl U; Nilsson P; Karlström H; Betsholtz C
Preprint: BIORXIV. 2021
Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors
Hankeova S; Van Hul N; Laznovsky J; Hensen N; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Li L; Sjöqvist M; Johansson BR; Hassan M; Bryja V; Lendahl U; Jheon A; Wang JS; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Letter: CIRCULATION. 2021;143(8):865-868
Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells
McCracken IR; Saginc G; He L; Huseynov A; Daniels A; Fletcher S; Peghaire C; Kalna V; Andaloussi-Mae M; Muhl L; Craig NM; Griffiths SJ; Haas JG; Tait-Burkard C; Lendahl U; Birdsey GM; Betsholtz C; Noseda M; Baker AH; Randi AM
Corrigendum: MOLECULAR THERAPY. 2021;29(1):409
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Preprint: BIORXIV. 2020
Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells
McCracken I; Saginc G; He L; Huseynov A; Daniels A; Fletcher S; Peghaire C; Kalna V; Andaloussi-Mäe M; Muhl L; Craig NM; Griffiths SJ; Haas JG; Tait-Burkard C; Lendahl U; Birdsey GM; Betsholtz C; Noseda M; Baker A; Randi AM
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):4493
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination (Aug, 10.1038/s41467-020-17740-1, 2020)
Muhl L; Genove G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe A; Raschperger E; Hansson EM; Bjoerkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Preprint: BIORXIV. 2020
Neural plate targeting by in utero nanoinjection (NEPTUNE) reveals a role forSptbn2in neurulation and abdominal wall closure
Mangold K; Mašek J; He J; Lendahl U; Fuchs E; Andersson E
Preprint: BIORXIV. 2020
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19
He L; Mäe MA; Muhl L; Sun Y; Pietilä R; Nahar K; Liébanas EV; Fagerlund MJ; Oldner A; Oldner A; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Mirabeau O; Hansson E; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Arnold T; Alitalo K; Eriksson L; Lendahl U; Betsholtz C
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S542
Cracking the notch code in alagille syndrome: single-cell receptor-ligand interactions and outcomes in vivo, and an emerging role of immune cells
Masek J; Hankeova S; Jin S-B; Lendahl U; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S43
Double resin casting micro computed tomography (CT) reveals biliary and vascular pathology in tandem in a mouse model for alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul NKM; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson E
Review: FRONTIERS IN ENDOCRINOLOGY. 2020;11:374
Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges
Yu R; Lendahl U; Nister M; Zhao J
Preprint: BIORXIV. 2019
DoUble resin casting micro computed tomography (DUCT) reveals biliary and vascular pathology in a mouse model of Alagille syndrome
Hankeova S; Salplachta J; Zikmund T; Kavkova M; Van Hul N; Brinek A; Smekalova V; Laznovsky J; Jaros J; Bryja V; Lendahl U; Ellis E; Hannezo E; Kaiser J; Andersson ER
Review: EMBO REPORTS. 2019;20(11):e48070
Emerging links between cerebrovascular and neurodegenerative diseases-a special role for pericytes
Lendahl U; Nilsson P; Betsholtz C
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2019;56:87
Characterization of a Novel CADASIL-Like Mutation in the NOTCH3 Receptor
Arnardottir S; Del Gaudio F; Lombrana AA; Oliveira DV; Karlstrom H; Lendahl U; Sjostrand C
Review: BIOMEDICINES. 2018;6(4):E101-101
Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation
Braune E-B; Seshire A; Lendahl U
Review: STROKE. 2018;49(11):2793-2800
Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Coupland K; Lendahl U; Karlstrom H
Corrigendum: EBIOMEDICINE. 2018;36:564
Cholangiopathies - Towards a molecular understanding (vol 35, pg 381, 2018)
Tam PKH; Yiu RS; Lendahl U; Andersson ER
Editorial comment: EXPERIMENTAL CELL RESEARCH. 2018;370(2):189
Changing master regulator without reprogramming
Lendahl U; Simon A
Review: EBIOMEDICINE. 2018;35:381-393
Cholangiopathies - Towards a molecular understanding
Tam PKH; Yiu RS; Lendahl U; Andersson ER
Corrigendum: NATURE. 2018;560(7716):E3
A molecular atlas of cell types and zonation in the brain vasculature (vol 554, pg 475, 2018)
Vanlandewijck M; He L; Mae MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Conference publication: JOURNAL OF HEPATOLOGY. 2018;68:S141-S142
Uncovering the liver Notch code using high-throughput reporter imaging on micropatterns
Masek J; Vervuurt C; Hankeova S; Lendahl U; Lindqvist A; Andersson E
Conference publication: JOURNAL OF HEPATOLOGY. 2018;68:S414-S415
Double resin casting micro computed tomography (DUCT) of biliary and vascular system
Hankeova S; Zikmund T; Kavkova M; Brinek A; Lendahl U; Kaiser J; Bryja V; Andersson E
Review: PHYSIOLOGICAL REVIEWS. 2017;97(4):1235-1294
NOTCH SIGNALING IN DEVELOPMENT, TISSUE HOMEOSTASIS, AND DISEASE
Siebel C; Lendahl U
Other: CELL DEATH AND DIFFERENTIATION. 2017;24(4):571
Lorenz Poellinger MD, PhD (1957-2016) Obituary
Lendahl U
Conference publication: HAEMATOLOGICA. 2017;102:456
BONE MARROW MYELOPOIESIS INDEPENDENTLY OF CANONICAL NOTCH SIGNALING
Duarte S; Woll PS; Natalija B-V; Boukarabila H; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Thongjuea S; Jin S; Clark S-A; Chin D; Lu-S T; Repapi E; Gray N; Taylor S; Mutvei A; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
Editorial comment: TRANSLATIONAL CANCER RESEARCH. 2016;5:S831-S835
A new angle on Notch combination therapies
Lendahl U
Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2016;280(3):232-235
At the interface of stem cell research and new technologies Introduction
Lendahl U
Meeting abstract: CANCER RESEARCH. 2016;76:b41
Cell-contact dependent epithelial-stromal cross talk, including a modulation of stromal PDGFR expression, drives the progression of early-stage breast cancer lesions
Strell C; Paulsson J; Mezheyeuski A; Jin S-B; Roswall P; Andrea J; Frings O; Warnberg F; Johansson H; Jirstrom K; Pietras K; Hall P; Lendahl U; Betsholtz C; Radisky DC; Ostman A
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2016;27
MIEF1/2 functions in coordination with Mff to regulate the balance of mitochondrial dynamics in mammals.
Yu R; Liu T; Jin S; Ning C; Lendahl U; Nister M; Zhao J
Review: NATURE REVIEWS DRUG DISCOVERY. 2014;13(5):357-378
Therapeutic modulation of Notch signalling - are we there yet?
Andersson ER; Lendahl U
Review: JOURNAL OF INTERNAL MEDICINE. 2013;273(3):235-245
Regenerative medicine for the treatment of heart disease
Hansson EM; Lendahl U
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(6):951-976
Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates
Zhao J; Lendahl U; Nister M
Conference publication: TRANSGENIC RESEARCH. 2013;22(1):224
EMMA: The European Mouse Mutant Archive
Fernandez J; Hong Y; Montoliu L; Tocchini-Valentini G; Herault Y; Brown S; Lendahl U; Demengeot J; Flicek P; Ramirez-Solis R; Kollias G; Sedlacek R; Soininen R; Ruelicke T; Iraqi F; Jonkers J; De Angelis MH
Review: DEVELOPMENT. 2011;138(17):3593-3612
Notch signaling: simplicity in design, versatility in function
Andersson ER; Sandberg R; Lendahl U
Conference publication: TRANSGENIC RESEARCH. 2011;20(5):1179
EMMA: The European mouse mutant archive
Fernandez J; Fessele S; Montoliu L; Tocchini-Valentini G; Herault Y; Brown S; Lendahl U; Demengeot J; Birney E; Ramirez-Solis R; Kollias G; Sedlacek R; Soininen R; Ruelicke T; De Angelis MH
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2011;22
Human MIEF1 Recruits Drp1 to Mitochondrial Outer Membranes and Promotes Mitochondrial Fusion Rather than Fission
Zhao J; Liu T; Jin S; Wang X; Qu M; Tomilin N; Shupliakov O; Lendahl U; Nister M
Book chapter: ASPARTIC ACID PROTEASES AS THERAPEUTIC TARGETS: METHODS AND PRINCIPLES IN MEDICINAL CHEMISTRY. 2010;p. 325-351
γ‐Secretase: An Unusual Enzyme with Many Possible Disease Targets, Including Alzheimer's Disease
Lundkvist J; Lendahl U
Book chapter: THE NEWBORN BRAIN. 2010;p. 23-36
The molecular basis of central nervous system development
Hermanson O; Lendahl U
Conference publication: TRANSGENIC RESEARCH. 2010;19(2):327-328
EMMA: The European mouse mutant archive
Fernandez J; Hagn M; Fessele S; Marschall S; Jesus del Hierro M; Montoliu L; Matteoni R; Raspa M; Scavizzi F; Tocchini-Valentini G; Larrigaldie V; Paturance S; Herault Y; Fray M; Pickard A; Brown S; Wilbertz J; Lendahl U; Demengeot J; Smedley D; Wilkinson P; Birney E; Bottomley J; Houghton R; Ramirez-Solis R; Ayadi A; Selloum M; Mandel JL; Kontoyiannis D; Kollias G; De Angelis MH
Review: NATURE REVIEWS GENETICS. 2009;10(12):821-832
Generating specificity and diversity in the transcriptional response to hypoxia
Lendahl U; Lee KL; Yang H; Poellinger L
Review: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2008;18(5):449-454
Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms
Poellinger L; Lendahl U
Review: CURRENT OPINION IN NEUROBIOLOGY. 2008;18(3):232-236
Ion fluxes and neurotransmitters signaling in neural development
Andang M; Lendahl U
Review: LAKARTIDNINGEN. 2008;105(20):1492-1494
[Dedifferentiation of specialized cells. New way open for cell therapy and regenerative medicine].
Lendahl U
Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514
Modular of vascular gene expression by hypoxia
Ruas JL; Lendahl U; Poellinger L
Review: REGENERATIVE MEDICINE. 2006;1(2):195-205
Notch signaling and its integration with other signaling mechanisms
Sahlgren C; Lendahl U
Conference publication: EXPERIMENTAL HEMATOLOGY. 2005;33(7):55
Notch activation promotes conversion of B cell to T cell fate at the earliest stages of B cell committed progenitors
Taneera J; Smith E; Sigvarhsson M; Bryder D; Hansson E; Lendahl U; Jacobsen SE
Review: NEUROSCIENCE. 2005;133(1):59-77
Generation and phenotypic characterization of a galanin overexpressing mouse
Holmberg K; Kuteeva E; Brumovsky P; Kahl U; Karlström H; Lucas GA; Rodriguez J; Westerblad H; Hilke S; Theodorsson E; Berge OG; Lendahl U; Bartfai T; Hökfelt T
Review: SEMINARS IN CANCER BIOLOGY. 2004;14(5):320-328
Notch signaling in development and disease
Hansson EM; Lendahl U; Chapman G
Conference publication: NEUROBIOLOGY OF AGING. 2004;25:S559-S560
Functional domains in presenilin 1:: The TYR-288 residue controls gamma-secretas activity and endoproteolysis
Laudon H; Karlstöm H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Conference publication: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;73(5):229
Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas.
Enlund F; Behboudi A; Andren Y; Öberg C; Lendahl U; Mark J; Stenman G
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2002;12:S169-S170
Peptide receptors:: Anything different from targeting amine systems?
Hökfelt T; Xu ZQD; Holmberg K; Kehr J; Schött PA; Ögren SO; Wang FH; Yoshitaki T; Bartfai T; Lendahl U; Kokaia M; Nanobashvili A; Kokaia Z; Lindvall O; Kahl U; Yamaguchi M
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S206-S207
PS1-controlled γ-secretase activity:: Definition of am minimal structural motif in the N-terminal fragment
Laudon H; Bergman A; Farmery MR; Winblad B; Naslund J; Karlstrom H; Lundkvist J; Lendahl U; Mathews P; Gandy SE
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S11
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S174
Measurement of total gamma-cleavage of C99 with mutations in the transmembrane domain by a luciferase assay
Bergman A; Religa D; Laudon H; Lannfelt L; Nüslund J; Karlström H; Lendahl U; Lundqvist J
Review: TRENDS IN NEUROSCIENCES. 2001;24(9):492-494
Notch and the birth of glial cells
Lundkvist J; Lendahl U
Published conference paper: JOURNAL OF NEUROSCIENCE METHODS. 2001;109(1):71-80
Microdialysis in freely moving mice:: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice
Kehr J; Yoshitake T; Wang FH; Wynick D; Holmberg H; Lendahl U; Bartfai T; Yamaguchi M; Hökfelt T; Ögren SO
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA. 2000;102:34
Characterization of neural stem cells in the adult CNS
Johansson CB; Momma S; Clarke DL; Lendahl U; Frisen J
Review: JOURNAL OF NEUROSCIENCE RESEARCH. 1998;54(2):125-136
Notch and neurogenesis
Beatus P; Lendahl U
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 1998;54(9):935-945
Central nervous system stem cells in the embryo and adult
Frisén J; Johansson CB; Lothian C; Lendahl U
Review: LAKARTIDNINGEN. 1997;94(51-52):4908-4913
[Genetic breakthrough within neuroresearch. Notch 3-gene reveals hereditary multiinfarction dementia].
Lendahl U; Wålinder J
Published conference paper: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS, SUPPLEMENT. 1997;86:8-11
Gene regulation in the formation of the central nervous system
Lendahl U
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;785:353-355
Nestin distribution in the developing limb bud in vivo and in vitro
Wroblewski J; Engstrom M; EdwallArvidsson C; Sjoberg G; Sejersen T; Lendahl U
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1996;785:298-300
Expression of Trk receptors during cartilage differentiation
Mitsiadis TA; Wroblewski J; Urdiales JL; Becker E; MartinZanca D; Rudkin BB; Lendahl U
Conference publication: PEDIATRIC RESEARCH. 1996;39(4):2223
The embryonic intermediate filament protein nestin is present in the cerebrospinal fluid of NICU infants.
Blennow M; Grigelioniene G; Torok C; Lendahl U; Lagercrantz F
Review: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):769-780
Notch-related genes in animal development
Lardelli M; Williams R; Lendahl U
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1995;6:2202
MORPHOLOGICAL-CHANGES IN THE INTERMEDIATE FILAMENT (IF) NESTIN NETWORK DURING MITOSIS CORRELATE WITH INCREASED PHOSPHORYLATION OF NESTIN
SAHLGREN C; ERIKSSON JE; LENDAHL U
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1995;:98
COEXISTENCE OF TRANSGENE POSITIVE AND NEGATIVE CELLS IN A H-I TRANSGENIC STRAIN WITH A CHIMERIC PHENOTYPE LEADS TO NK TOLERANCE AGAINST MISSING SELF
JOHANSSON M; BIEBERICH C; JAY G; LENDAHL U; KARRE K; HOGLUND P
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1994;:511
INTERMEDIATE FILAMENT NESTIN EXPRESSION DURING MYOGENESIS AND IN MUSCLE DISORDERS
SEJERSEN T; LENDAHL U; SJOBERG G; EDSTROM L
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Forskningsbidrag

Establishing how cerebral small vessel disease affects brain vasculature and fluid transport
Swedish Research Council
1 January 2018 - 31 December 2022
Consequences of misregulated Notch signaling in breast cancer
Swedish Cancer Society
1 January 2015
The Karolinska-China-Hong Kong Regenerative Medicine Initiative.
Swedish Research Council
1 January 2014 - 31 December 2018
Dysregulation of Notch signaling in vascular disease
Swedish Research Council
1 January 2014 - 31 December 2018
Consequences of misregulated Notch signaling in breast cancer
Swedish Cancer Society
1 January 2014
Karolinska CardioVascular Initiative
Knut and Alice Wallenberg Foundation
1 January 2013 - 1 January 2016
Decoding mitochondrial fusion/fission dynamics - elucidating the role of MIEF proteins
Swedish Research Council
1 January 2013 - 31 December 2015
Notch signaling in vascular differentiation and disease
Swedish Research Council
1 January 2011 - 31 December 2013
Set-up for high-resolution studies of rapid cellular events
Swedish Research Council
1 July 2009 - 30 June 2014

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