Matthew James Gagne
Biträdande Lektor
E-postadress: matthew.gagne@ki.se
Telefon: +46852482628
Besöksadress: Entrévägen 2, 18257 Danderyd
Postadress: D1 Kliniska vetenskaper, Danderyds sjukhus, D1 Medicin Klinisk immunologi, 171 77 Stockholm
Del av:
Om mig
Jag är biträdande universitetslektor och mukosal immunolog vid institutionen för kliniska vetenskaper, Danderyds sjukhus, Karolinska Institutet. Min forskning fokuserar på optimering av intranasala vacciner för att förebygga luftvägsvirusinfektioner.
RNA-virus som infekterar de övre luftvägarna omfattar vanligt förekommande patogener som utgör en betydande folkhälsobörda, däribland rhinovirus, respiratoriskt syncytialvirus (RSV) och säsongsinfluensastammar, samt patogener som ger större anledning till oro, såsom högpatogen aviär influensa och nya coronavirus. Nästan alla vacciner mot luftvägsvirus ges intramuskulärt, trots att dessa virus initialt infekterar och replikerar i luftvägarnas slemhinnor. Att leverera vacciner till de platser där luftvägsvirusen replikerar, tillsammans med en bättre förståelse av de unika mekanismer som ligger bakom immunförsvaret i de övre luftvägarna, skulle vara fördelaktigt inte bara mot de virus som cirkulerar idag, utan också avgörande för att förebygga framtida pandemier.
Artiklar
- Journal article: ISCIENCE. 2026;29(4):115433Kim B; Roenicke R; Roeder PM; Steinberg I; Patamawenu A; Harrison M; Veer FV; Koory E; Xie J; Shofner T; Matsuda K; Wettstein E; Ober E; Cooney C; Kim T; Webber JD; Meeks T; Park C; Burdette T; Georgia S; Readler JM; Vostal AC; Hostal A; Cohen JI; Gagne M; Ziff Z; Richard K; Burnett MR; Maule E; Callier V; Liang J; Kovacikova G; Souter SC; Weiner JA; Douek D; Ackerman ME; Wright PF; Johnson RF; Connors M
- Journal article: NATURE IMMUNOLOGY. 2025;26(6):814-816Gagne M; Douek DC; Seder RA
- Journal article: TOXICOLOGICAL SCIENCES. 2025;205(1):74-105Friedman KP; Thomas RS; Wambaugh JF; Harrill JA; Judson RS; Shafer TJ; Williams AJ; Lee J-YJ; Loo L-H; Gagne M; Long AS; Barton-Maclaren TS; Whelan M; Bouhifd M; Rasenberg M; Simanainen U; Sobanski T
- Journal article: PLOS PATHOGENS. 2025;21(1):e1012456Edwards CT; Karunakaran KA; Garcia E; Beutler N; Gagne M; Golden N; Aoued H; Pellegrini KL; Burnett MR; Honeycutt CC; Lapp SA; Ton T; Lin MC; Metz A; Bombin A; Goff K; Scheuermann SE; Wilkes A; Wood JS; Ehnert S; Weissman S; Curran EH; Roy M; Dessasau E; Paiardini M; Upadhyay AA; Moore IN; Maness NJ; Douek DC; Piantadosi A; Andrabi R; Rogers TR; Burton DR; Bosinger SE
- Journal article: ENVIRONMENTAL POLLUTION. 2024;361:124827Beal MA; Coughlan MC; Nunnikhoven A; Gagne M; Barton-Maclaren TS; Bradford LM; Rowan-Carroll A; Williams A; Meier MJ
- Journal article: NATURE IMMUNOLOGY. 2024;25(10):1913-1927Gagne M; Flynn BJ; Andrew SF; Marquez J; Flebbe DR; Mychalowych A; Lamb E; Davis-Gardner ME; Burnett MR; Serebryannyy LA; Lin BC; Ziff ZE; Maule E; Carroll R; Naisan M; Jethmalani Y; Pessaint L; Todd J-PM; Doria-Rose NA; Case JB; Dmitriev IP; Kashentseva EA; Ying B; Dodson A; Kouneski K; O'Dell S; Wali B; Ellis M; Godbole S; Laboune F; Henry AR; Teng I-T; Wang D; Wang L; Zhou Q; Zouantchangadou S; Van Ry A; Lewis MG; Andersen H; Kwong PD; Curiel DT; Roederer M; Nason MC; Foulds KE; Suthar MS; Diamond MS; Douek DC; Seder RA
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):6894Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airwaysGagne M; Flynn BJ; Honeycutt CC; Flebbe DR; Andrew SF; Provost SJ; Mccormick L; Van Ry A; Mccarthy E; Todd J-PM; Bao S; Teng I-T; Marciano S; Rudich Y; Li C; Jain S; Wali B; Pessaint L; Dodson A; Cook A; Lewis MG; Andersen H; Zahradnik J; Suthar MS; Nason MC; Foulds KE; Kwong PD; Roederer M; Schreiber G; Seder RA; Douek DC
- Journal article: NATURE. 2024;630(8018):950-960Liang C-Y; Raju S; Liu Z; Li Y; Arunkumar GA; Case JB; Scheaffer SM; Zost SJ; Acreman CM; Gagne M; Andrew SF; dos Anjos DCC; Foulds KE; McLellan JS; Crowe Jr JE; Douek DC; Whelan SPJ; Elbashir SM; Edwards DK; Diamond MS
- Journal article: CELL REPORTS. 2024;43(2):113706Ratnasiri K; Zheng H; Toh J; Yao Z; Duran V; Donato M; Roederer M; Kamath M; Todd J-PM; Gagne M; Foulds KE; Francica JR; Corbett KS; Douek DC; Seder RA; Einav S; Blish CA; Khatri P
- Journal article: FRONTIERS IN PHARMACOLOGY. 2024;15:1307905Collins SP; Mailloux B; Kulkarni S; Gagne M; Long AS; Barton-Maclaren TS
- Article: NPJ VACCINES. 2024;9(1):17Lenart K; Cerveira RA; Hellgren F; Ols S; Sheward DJ; Kim C; Cagigi A; Gagne M; Davis B; Germosen D; Roy V; Alter G; Letscher H; Van Wassenhove J; Gros W; Gallouet A-S; Le Grand R; Kleanthous H; Guebre-Xabier M; Murrell B; Patel N; Glenn G; Smith G; Lore K
- Journal article: SCIENCE IMMUNOLOGY. 2023;8(85):eadg0033Viox EG; Hoang TN; Upadhyay AA; Nchioua R; Hirschenberger M; Strongin Z; Tharp GK; Pino M; Nguyen K; Harper JL; Gagne M; Marciano S; Boddapati AK; Pellegrini KL; Pradhan A; Tisoncik-Go J; Whitmore LS; Karunakaran KA; Roy M; Kirejczyk S; Curran EH; Wallace C; Wood JS; Connor-Stroud F; Voigt EA; Monaco CM; Gordon DE; Kasturi SP; Levit RD; Gale M; Vanderford TH; Silvestri G; Busman-Sahay K; Estes JD; Vaccari M; Douek DC; Sparrer KMJ; Johnson RP; Kirchhoff F; Schreiber G; Bosinger SE; Paiardini M
- Journal article: FRONTIERS IN VETERINARY SCIENCE. 2023;10:1182197Shin T-H; Zhou Y; Lee B-C; Hong SG; Andrew SFF; Flynn BJJ; Gagne M; Todd J-PM; Moore INN; Cook A; Lewis MGG; Foulds KEE; Seder RAA; Douek DCC; Roederer M; Dunbar CEE
- Journal article: COMMUNICATIONS BIOLOGY. 2023;6(1):277Yogev O; Weissbrod O; Battistoni G; Bressan D; Naamati A; Falciatori I; Berkyurek AC; Rasnic R; Izuagbe R; Hosmillo M; Ilan S; Grossman I; McCormick L; Honeycutt CC; Johnston T; Gagne M; Douek DC; Goodfellow I; Hannon GJ; Erlich Y
- Journal article: TOXICOLOGICAL SCIENCES. 2023;191(2):266-275Matteo G; Leingartner K; Rowan-Carroll A; Meier M; Williams A; Beal MA; Gagne M; Farmahin R; Wickramasuriya S; Reardon AJF; Barton-Maclaren T; Christopher Corton J; Yauk CL; Atlas E
- Journal article: NATURE COMMUNICATIONS. 2022;13(1):6309Li D; Martinez DR; Schafer A; Chen H; Barr M; Sutherland LL; Lee E; Parks R; Mielke D; Edwards W; Newman A; Bock KW; Minai M; Nagata BM; Gagne M; Douek D; DeMarco CT; Denny TN; Oguin THIII; Brown A; Rountree W; Wang Y; Mansouri K; Edwards RJ; Ferrari G; Sempowski GD; Eaton A; Tang J; Cain DW; Santra S; Pardi N; Weissman D; Tomai M; Fox C; Moore IN; Andersen H; Lewis MG; Golding H; Khurana S; Seder R; Baric RS; Montefiori DC; Saunders KO; Haynes BF
- Journal article: CLINICAL INFECTIOUS DISEASES. 2022;75(1):e350-e353Sexton ME; Waggoner JJ; Carmola LR; Nguyen P-V; Wang E; Khosravi D; Taz A; Arthur RA; Patel M; Edara V-V; Foster SL; Moore KM; Gagne M; Roberts-Torres J; Henry AR; Godbole S; Douek DC; Rouphael N; Suthar MS; Piantadosi A
- Journal article: CELL. 2022;185(9):1556-1571.e18Gagne M; Moliva JI; Foulds KE; Andrew SF; Flynn BJ; Werner AP; Wagner DA; Teng I-T; Lin BC; Moore C; Jean-Baptiste N; Carroll R; Foster SL; Patel M; Ellis M; Edara V-V; Maldonado NV; Minai M; McCormick L; Honeycutt CC; Nagata BM; Bock KW; Dulan CNM; Cordon J; Flebbe DR; Todd J-PM; McCarthy E; Pessaint L; Van Ry A; Narvaez B; Valentin D; Cook A; Dodson A; Steingrebe K; Nurmukhambetova ST; Godbole S; Henry AR; Laboune F; Roberts-Torres J; Lorang CG; Amin S; Trost J; Naisan M; Basappa M; Willis J; Wang L; Shi W; Doria-Rose NA; Zhang Y; Yang ES; Leung K; O'Dell S; Schmidt SD; Olia AS; Liu C; Harris DR; Chuang G-Y; Stewart-Jones G; Renzi I; Lai Y-T; Malinowski A; Wu K; Mascola JR; Carfi A; Kwong PD; Edwards DK; Lewis MG; Andersen H; Corbett KS; Nason MC; McDermott AB; Suthar MS; Moore IN; Roederer M; Sullivan NJ; Douek DC; Seder RA
- Journal article: NATURE. 2022;603(7902):687-692Halfmann PJ; Iida S; Iwatsuki-Horimoto K; Maemura T; Kiso M; Scheaffer SM; Darling TL; Joshi A; Loeber S; Singh G; Foster SL; Ying B; Case JB; Chong Z; Whitener B; Moliva J; Floyd K; Ujie M; Nakajima N; Ito M; Wright R; Uraki R; Warang P; Gagne M; Li R; Sakai-Tagawa Y; Liu Y; Larson D; Osorio JE; Hernandez-Ortiz JP; Henry AR; Ciuoderis K; Florek KR; Patel M; Odle A; Wong L-YR; Bateman AC; Wang Z; Edara V-V; Chong Z; Franks J; Jeevan T; Fabrizio T; DeBeauchamp J; Kercher L; Seiler P; Gonzalez-Reiche AS; Sordillo EM; Chang LA; van Baker H; Simon V; Douek DC; Sullivan NJ; Thackray LB; Ueki H; Yamayoshi S; Imai M; Perlman S; Webby RJ; Seder RA; Suthar MS; Garcia-Sastre A; Schotsaert M; Suzuki T; Boon ACM; Diamond MS; Kawaoka Y
- Journal article: CELL REPORTS MEDICINE. 2022;3(2):100529Edara V-V; Manning KE; Ellis M; Lai L; Moore KM; Foster SL; Floyd K; Davis-Gardner ME; Mantus G; Nyhoff LE; Bechnak S; Alaaeddine G; Naji A; Samaha H; Lee M; Bristow L; Gagne M; Roberts-Torres J; Henry AR; Godbole S; Grakoui A; Saxton M; Piantadosi A; Waggoner JJ; Douek DC; Rouphael N; Wrammert J; Suthar MS
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Alla övriga publikationer
- Preprint: BIORXIV. 2026;BIORXIVKim B; Roenicke R; Roeder PM; Steinberg I; Patamawenu A; Harrison M; Van't Veer F; Koory E; Xie J; Shofner T; Matsuda K; Wettstein E; Ober E; Cooney C; Kim T; Webber JD; Meeks T; Burdette T; Clark SG; Vostal AC; Hostal A; Cohen JI; Gagne M; Ziff Z; Richard K; Burnett MR; Maule E; Callier V; Liang J; Kovacikova G; Souter SC; Weiner JA; Douek D; Ackerman ME; Wright PF; Johnson RF; Connors M
- Preprint: RES SQ. 2025;RES SQSalinas TRW; Freeman S; Richardson R; Weng W; Ali M; van Schoor A; Viox E; Nguyen K; Auger J; Ketan R; Gagne M; Picou B; Golden NA; Vaccari M; Jean S; Wood JS; Cohen J; Johnson RP; Douek DC; Niclou BA; Levit RD; Moore IN; Paiardini M; Raper J
- Conference publication: JOURNAL OF IMMUNOLOGY. 2025;214Intranasal replicating adenovirus type 4-SARS-CoV-2 recombinants induce durable immunity in hamstersRoeder PM; Kim B; Roenicke R; Steinberg I; Ober E; Cooney C; Patamawenu A; Gagne M; Wright P; Johnson R; Connors M
- Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2025;66:106Buick JK; Rowan-Carroll A; Bradford LM; Williams A; Yauk CL; Gagne M; Long AS; Barton-Maclaren T; Meier M
- Preprint: BIORXIV. 2023;BIORXIVMoliva JI; Andrew SF; Flynn BJ; Wagner DA; Foulds KE; Gagne M; Flebbe DR; Lamb E; Provost S; Marquez J; Mychalowych A; Lorag CG; Honeycutt CC; Burnett MR; McCormick L; Henry AR; Godbole S; Davis-Gardner ME; Minai M; Bock KW; Nagata BM; Todd J-PM; McCarthy E; Dodson A; Kouneski K; Cook A; Pessaint L; Ry AV; Valentin D; Young S; Littman Y; Boon ACM; Suthar MS; Lewis MG; Andersen H; Alves DA; Woodward R; Leuzzi A; Vitelli A; Colloca S; Folgori A; Raggiolli A; Capone S; Nason MC; Douek DC; Roederer M; Seder RA; Sullivan NJ
- Preprint: BIORXIV. 2023;BIORXIVGagne M; Flynn BJ; Andrew SF; Flebbe DR; Mychalowych A; Lamb E; Davis-Gardner ME; Burnett MR; Serebryannyy LA; Lin BC; Pessaint L; Todd J-PM; Ziff ZE; Maule E; Carroll R; Naisan M; Jethmalani Y; Case JB; Dmitriev IP; Kashentseva EA; Ying B; Dodson A; Kouneski K; Doria-Rose NA; O'Dell S; Godbole S; Laboune F; Henry AR; Marquez J; Teng I-T; Wang L; Zhou Q; Wali B; Ellis M; Zouantchangadou S; Ry AV; Lewis MG; Andersen H; Kwong PD; Curiel DT; Foulds KE; Nason MC; Suthar MS; Roederer M; Diamond MS; Douek DC; Seder RA
- Conference publication: JOURNAL OF MEDICAL PRIMATOLOGY. 2023;52(5):310Viox EG; Hoang TN; Upadhyay AA; Strongin Z; Tharp GK; Pino M; Nchioua R; Hirschenberger M; Gagne M; Nguyen K; Harper JL; Estes J; Vanderford TH; Vaccari M; Douek DC; Sparrer K; Kirchhoff F; Johnson RP; Schreiber G; Bosinger SE; Paiardini M
- Preprint: BIORXIV. 2023Ratnasiri K; Zheng H; Toh J; Yao Z; Duran V; Donato M; Roederer M; Kamath M; Todd J-PM; Gagne M; Foulds KE; Francica JR; Corbett KS; Douek DC; Seder RA; Einav S; Blish CA; Khatri P
- Preprint: BIORXIV. 2023;BIORXIVGagne M; Flynn BJ; Honeycutt CC; Flebbe DR; Andrew SF; Provost SJ; McCormick L; Van Ry A; McCarthy E; Todd J-PM; Bao S; Teng I-T; Marciano S; Rudich Y; Li C; Pessaint L; Dodson A; Cook A; Lewis MG; Andersen H; Zahradník J; Nason MC; Foulds KE; Kwong PD; Roederer M; Schreiber G; Seder RA; Douek DC
- Preprint: BIORXIV. 2023;BIORXIVShin T-H; Zhou Y; Lee B-C; Hong SG; Andrew SF; Flynn BJ; Gagne M; Todd J-PM; Moore IN; Cook A; Lewis MG; Foulds KE; Seder RA; Douek DC; Roederer M; Dunbar CE
- Preprint: BIORXIV. 2022;BIORXIVHoang TN; Viox EG; Upadhyay AA; Strongin Z; Tharp GK; Pino M; Nchioua R; Hirschenberger M; Gagne M; Nguyen K; Harper JL; Marciano S; Boddapati AK; Pellegrini KL; Tisoncik-Go J; Whitmore LS; Karunakaran KA; Roy M; Kirejczyk S; Curran EH; Wallace C; Wood JS; Connor-Stroud F; Kasturi SP; Levit RD; Gale M; Vanderford TH; Silvestri G; Busman-Sahay K; Estes JD; Vaccari M; Douek DC; Sparrer KMJ; Kirchhoff F; Johnson RP; Schreiber G; Bosinger SE; Paiardini M
- Conference publication: TOXICOLOGY LETTERS. 2022;368:S56Barton-Maclaren T; Collins S; Kulkarni S; Reardon A; Wickramasuriya S; Gagne M
- Preprint: BIORXIV. 2022;BIORXIVYogev O; Weissbrod O; Battistoni G; Bressan D; Naamti A; Falciatori I; Berkyurek AC; Rasnic R; Hosmillo M; Ilan S; Grossman I; McCormick L; Honeycutt CC; Johnston T; Gagne M; Douek DC; Goodfellow I; Hannon GJ; Erlich Y
- Preprint: BIORXIV. 2022;BIORXIVLi D; Martinez DR; Schäfer A; Chen H; Barr M; Sutherland LL; Lee E; Parks R; Mielke D; Edwards W; Newman A; Bock KW; Minai M; Nagata BM; Gagne M; Douek DC; DeMarco CT; Denny TN; Oguin TH; Brown A; Rountree W; Wang Y; Mansouri K; Edwards RJ; Ferrari G; Sempowski GD; Eaton A; Tang J; Cain DW; Santra S; Pardi N; Weissman D; Tomai MA; Fox CB; Moore IN; Andersen H; Lewis MG; Golding H; Seder R; Khurana S; Baric RS; Montefiori DC; Saunders KO; Haynes BF
- Preprint: BIORXIV. 2022Gagne M; Moliva JI; Foulds KE; Andrew SF; Flynn BJ; Werner AP; Wagner DA; Teng I-T; Lin BC; Moore C; Jean-Baptiste N; Carroll R; Foster SL; Patel M; Ellis M; Edara V-V; Maldonado NV; Minai M; McCormick L; Honeycutt CC; Nagata BM; Bock KW; Dulan CNM; Cordon J; Todd J-PM; McCarthy E; Pessaint L; Van Ry A; Narvaez B; Valentin D; Cook A; Dodson A; Steingrebe K; Flebbe DR; Nurmukhambetova ST; Godbole S; Henry AR; Laboune F; Roberts-Torres J; Lorang CG; Amin S; Trost J; Naisan M; Basappa M; Willis J; Wang L; Shi W; Doria-Rose NA; Olia AS; Liu C; Harris DR; Carfi A; Mascola JR; Kwong PD; Edwards DK; Andersen H; Lewis MG; Corbett KS; Nason MC; McDermott AB; Suthar MS; Moore IN; Roederer M; Sullivan NJ; Douek DC; Seder RA
- Preprint: RES SQ. 2021;RES SQThe SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamsters.Diamond M; Halfmann P; Maemura T; Iwatsuki-Horimoto K; Iida S; Kiso M; Scheaffer S; Darling T; Joshi A; Loeber S; Foster S; Ying B; Whitener B; Floyd K; Ujie M; Nakajima N; Ito M; Wright R; Uraki R; Li R; Sakai Y; Liu Y; Larson D; Osorio J; Hernandez-Ortiz J; Čiuoderis K; Florek K; Patel M; Bateman A; Odle A; Wong L-Y; Wang Z; Edara VV; Chong Z; Thackray L; Ueki H; Yamayoshi S; Imai M; Perlman S; Webby R; Seder R; Suthar M; Garcia-Sastre A; Schotsaert M; Suzuki T; Boon A; Kawaoka Y; Douek D; Moliva J; Sullivan N; Gagne M; Ransier A; Case J; Jeevan T; Franks J; Fabrizio T; DeBeauchamp J; Kercher L; Seiler P; Singh G; Warang P; Gonzalez-Reiche AS; Sordillo E; van Bakel H; Simon V
- Preprint: BIORXIV. 2021;BIORXIVEdara V-V; Manning KE; Ellis M; Lai L; Moore KM; Foster SL; Floyd K; Davis-Gardner ME; Mantus G; Nyhoff LE; Bechnak S; Alaaeddine G; Naji A; Samaha H; Lee M; Bristow L; Hussaini L; Ciric CR; Nguyen P-V; Gagne M; Roberts-Torres J; Henry AR; Godbole S; Grakoui A; Sexton M; Piantadosi A; Waggoner JJ; Douek DC; Anderson EJ; Rouphael N; Wrammert J; Suthar MS
- Preprint: BIORXIV. 2021;BIORXIVGagne M; Corbett KS; Flynn BJ; Foulds KE; Wagner DA; Andrew SF; Todd J-PM; Honeycutt CC; McCormick L; Nurmukhambetova ST; Davis-Gardner ME; Pessaint L; Bock KW; Nagata BM; Minai M; Werner AP; Moliva JI; Tucker C; Lorang CG; Zhao B; McCarthy E; Cook A; Dodson A; Mudvari P; Roberts-Torres J; Laboune F; Wang L; Goode A; Kar S; Boyoglu-Barnum S; Yang ES; Shi W; Ploquin A; Doria-Rose N; Carfi A; Mascola JR; Boritz EA; Edwards DK; Andersen H; Lewis MG; Suthar MS; Graham BS; Roederer M; Moore IN; Nason MC; Sullivan NJ; Douek DC; Seder RA
- Conference publication: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2021;62:77Matteo G; Leingartner K; Rowan-Carroll A; Meier M; Williams A; Beal M; Gagne M; Farmahin R; Wickramasuriya S; Barton-Maclaren T; Corton C; Atlas E; Yauk C
- Preprint: BIORXIV. 2021;BIORXIVEdara V-V; Lai L; Sahoo MK; Floyd K; Sibai M; Solis D; Flowers MW; Hussaini L; Ciric CR; Bechnack S; Stephens K; Mokhtari EB; Mudvari P; Creanga A; Pegu A; Derrien-Colemyn A; Henry AR; Gagne M; Graham BS; Wrammert J; Douek DC; Boritz E; Pinsky BA; Suthar MS
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Forskningsbidrag
- National Institute of Allergy and Infectious Diseases1 september 2017 - 31 maj 2019