Maria Kasper

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JCI INSIGHT. 2024;9(6):e165226

Stimulation of skeletal stem cells in the growth plate promotes linear bone growth

Trompet D; Kurenkova AD; Zhou B; Li L; Dregval O; Usanova AP; Chu TL; Are A; Nedorubov AA; Kasper M; Chagin AS
Article: SCIENCE ADVANCES. 2024;10(3):eadi5791

Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages

Nguyen MB; Flora P; Branch MC; Weber M; Zheng XY; Sivan U; Joost S; Annusver K; Zheng D; Kasper M; Ezhkova E
Article: AUTOPHAGY. 2023;19(11):2958-2971

Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation

Van Hove L; Toniolo A; Ghiasloo M; Lecomte K; Boone F; Ciers M; Raaijmakers K; Vandamme N; Roels J; Maschalidi S; Ravichandran KS; Kasper M; van Loo G; Hoste E
Article: DEVELOPMENTAL CELL. 2023;58(10):2140-2162.e5

Molecular and spatial landmarks of early mouse skin development

Jacob T; Annusver K; Czarnewski P; Dalessandri T; Kalk C; Levron CL; Campamasanz N; Kastriti ME; Mikkola ML; Rendl M; Lichtenberger BM; Donati G; Bjorklund AK; Kasper M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(10):e20220953

Skin mesenchymal niches maintain and protect AML-initiating stem cells

Sandhow L; Cai H; Leonard E; Xiao P; Tomaipitinca L; Mansson A; Kondo M; Sun X; Johansson A-S; Tryggvason K; Kasper M; Jaras M; Qian H
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(9):1227-1239

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Matsuoka K; Bakiri L; Bilban M; Toegel S; Haschemi A; Yuan H; Kasper M; Windhager R; Wagner EF
Article: NATURE. 2023;619(7968):167-175

Injury prevents Ras mutant cell expansion in mosaic skin

Gallini S; Annusver K; Rahman N-T; Gonzalez DG; Yun S; Matte-Martone C; Xin T; Lathrop E; Suozzi KC; Kasper M; Greco V
Article: JOURNAL OF CELL BIOLOGY. 2023;222(7):e202302095

Cell cycle controls long-range calcium signaling in the regenerating epidermis

Moore JL; Bhaskar D; Gao F; Matte-Martone C; Du S; Lathrop E; Ganesan S; Shao L; Norris R; Campama Sanz N; Annusver K; Kasper M; Cox A; Hendry C; Rieck B; Krishnaswamy S; Greco V
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2023;15(5):a041232

Plasticity of Epithelial Cells during Skin Wound Healing

Sun X; Joost S; Kasper M
Article: NATURE COMMUNICATIONS. 2023;14(1):1221

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

Mainwaring OJ; Weishaupt H; Zhao M; Rosen G; Borgenvik A; Breinschmid L; Verbaan AD; Richardson S; Thompson D; Clifford SC; Hill RM; Annusver K; Sundstrom A; Holmberg KO; Kasper M; Hutter S; Swartling FJ
Article: NATURE CELL BIOLOGY. 2022;24(12):1692-1700

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer

Cockburn K; Annusver K; Gonzalez DG; Ganesan S; Mesa KR; Kawaguchi K; Kasper M; Greco V
Article: NATURE. 2022;607(7919):548-554

Retrograde movements determine effective stem cell numbers in the intestine

Azkanaz M; Corominas-Murtra B; Ellenbroek SIJ; Bruens L; Webb AT; Laskaris D; Oost KC; Lafirenze SJA; Annusver K; Messal HA; Iqbal S; Flanagan DJ; Huels DJ; Rojas-Rodriguez F; Vizoso M; Kasper M; Sansom OJ; Snippert HJ; Liberali P; Simons BD; Katajisto P; Hannezo E; van Rheenen J
Article: NATURE COMMUNICATIONS. 2021;12(1):5913

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Hoste E; Lecomte K; Annusver K; Vandamme N; Roels J; Maschalidi S; Verboom L; Vikkula H-K; Sze M; Van Hove L; Verstaen K; Martens A; Hochepied T; Saeys Y; Ravichandran K; Kasper M; van Loo G
Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(5):614-628

Cellular heterogeneity and microenvironmental control of skin cancer

Lichtenberger BM; Kasper M
Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(3):e1008772

Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance

Larsson AJM; Ziegenhain C; Hagemann-Jensen M; Reinius B; Jacob T; Dalessandri T; Hendriks G-J; Kasper M; Sandberg R
Article: DEVELOPMENTAL DYNAMICS. 2020;249(6):711-722

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Zhang Y; Kameneva P; Annusver K; Kasper M; Chagin AS; Adameyko I; Xie M
Article: ELIFE. 2020;9:e46756

Coordinated hedgehog signaling induces new hair follicles in adult skin

Sun X; Are A; Annusver K; Sivan U; Jacob T; Dalessandri T; Joost S; Fullgrabe A; Gerling M; Kasper M
Article: CELL STEM CELL. 2020;26(3):441-457.e7

The Molecular Anatomy of Mouse Skin during Hair Growth and Rest

Joost S; Annusver K; Jacob T; Sun X; Dalessandri T; Sivan U; Sequeira I; Sandberg R; Kasper M
Article: INTERNATIONAL JOURNAL OF CANCER. 2020;146(4):1125-1138

GLI1-induced mammary gland tumours are transplantable and maintain major molecular features

Norum JH; Frings O; Kasper M; Bergholtz H; Thime HZ; Bergstrom A; Andersson A; Kuiper R; Fredlund E; Sorlie T; Toftgard R
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:122

Epiphyseal Cartilage Formation Involves Differential Dynamics of Various Cellular Populations During Embryogenesis

Zhang Y; Annusver K; Sunadome K; Kameneva P; Edwards S; Lei G; Kasper M; Chagin AS; Adameyko I; Xie M
Article: NATURE. 2019;567(7747):234-238

A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate

Newton PT; Li L; Zhou B; Schweingruber C; Hovorakova M; Xie M; Sun X; Sandhow L; Artemov AV; Ivashkin E; Suter S; Dyachuk V; El Shahawy M; Gritli-Linde A; Bouderlique T; Petersen J; Mollbrink A; Lundeberg J; Enikolopov G; Qian H; Fried K; Kasper M; Hedlund E; Adameyko I; Savendahl L; Chagin AS
Article: DEVELOPMENTAL CELL. 2019;48(1):32-48.e5

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

Mok K-W; Saxena N; Heitman N; Grisanti L; Srivastava D; Muraro MJ; Jacob T; Sennett R; Wang Z; Su Y; Yang LM; Ma'ayan A; Ornitz DM; Kasper M; Rendl M
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(11):2943-2954

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

Sternberg C; Gruber W; Eberl M; Tesanovic S; Stadler M; Elmer DP; Schlederer M; Grund S; Roos S; Wolff F; Kaur S; Mangelberger D; Lehrach H; Hache H; Wierling C; Laimer J; Lackner P; Wiederstein M; Kasper M; Risch A; Petzelbauer P; Moriggl R; Kenner L; Aberger F
Article: CELL REPORTS. 2018;25(3):585-597.e7

Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing

Joost S; Jacob T; Sun X; Annusver K; La Manno G; Sur I; Kasper M
Article: ELIFE. 2018;7:e34465

Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage

Kaucka M; Petersen J; Tesarova M; Szarowska B; Kastriti ME; Xie M; Kicheva A; Annusver K; Kasper M; Symmons O; Pan L; Spitz F; Kaiser J; Hovorakova M; Zikmund T; Sunadome K; Matise MP; Wang H; Marklund U; Abdo H; Ernfors P; Maire P; Wurmser M; Chagin AS; Fried K; Adameyko I
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638

MicroRNA-132 with Therapeutic Potential in Chronic Wounds

Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
Article: STEM CELL RESEARCH & THERAPY. 2017;8(1):250

Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population

Acosta JR; Joost S; Karlsson K; Ehrlund A; Li X; Aouadi M; Kasper M; Arner P; Ryden M; Laurencikiene J
Article: CELL METABOLISM. 2016;24(4):593-607

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

Segerstolpe A; Palasantza A; Eliasson P; Andersson E-M; Andreasson A-C; Sun X; Picelli S; Sabirsh A; Clausen M; Bjursell MK; Smith DM; Kasper M; Ammala C; Sandberg R
Article: CELL SYSTEMS. 2016;3(3):221-237.e9

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

Joost S; Zeisel A; Jacob T; Sun X; La Manno G; Lonnerberg P; Linnarsson S; Kasper M
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1453:123-136

Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase.

Kasper M; Toftgård R; Jaks V
Article: STEM CELL REPORTS. 2015;5(5):843-855

Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

Fullgrabe A; Joost S; Are A; Jacob T; Sivan U; Haegebarth A; Linnarsson S; Simons BD; Clevers H; Toftgard R; Kasper M
Article: STEM CELLS AND DEVELOPMENT. 2015;24(21):2547-2560

Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo

Hoelzl MA; Heby-Henricson K; Bilousova G; Rozell B; Kuiper RV; Kasper M; Toftgard R; Teglund S
Article: NATURE METHODS. 2014;11(2):163-166

Quantitative single-cell RNA-seq with unique molecular identifiers

Islam S; Zeisel A; Joost S; La Manno G; Zajac P; Kasper M; Lonnerberg P; Linnarsson S
Article: GUT. 2013;62(3):348-357

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus

van Dop WA; Rosekrans SL; Uhmann A; Jaks V; Offerhaus GJA; Weerman MAVDB; Kasper M; Heijmans J; Hardwick JCH; Verspaget HW; Hommes DW; Toftgard R; Hahn H; van den Brink GR
Article: ONCOGENESIS. 2012;1(3):e3

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma

Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4099-4104

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes

Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Barker N; Toftgard R
Article: SCIENCE. 2010;327(5971):1385-1389

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

Snippert HJ; Haegebarth A; Kasper M; Jaks V; van Es JH; Barker N; van de Wetering M; van den Born M; Begthel H; Vries RG; Stange DE; Toftgard R; Clevers H
Article: JOURNAL OF PATHOLOGY. 2009;219(1):61-68

Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?

Gore SM; Kasper M; Williams T; Regl G; Aberger F; Cerio R; Neill GW; Philpott MP
Article: CANCER RESEARCH. 2009;69(4):1284-1292

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

Schnidar H; Eberl M; Klingler S; Mangelberger D; Kasper M; Hauser-Kronberger C; Regl G; Kroismayr R; Moriggl R; Sibilia M; Aberger F
Article: NATURE GENETICS. 2008;40(11):1291-1299

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

Jaks V; Barker N; Kasper M; Van Es JH; Snippert HJ; Clevers H; Toftgard R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14345-14354

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal

Shimokawa T; Tostar U; Lauth M; Palaniswamy R; Kasper M; Toftgard R; Zaphiropoulos PG
Article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2008;73:351-356

Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.

Barker N; van Es JH; Jaks V; Kasper M; Snippert H; Toftgård R; Clevers H
Article: METHODS IN MOLECULAR BIOLOGY. 2007;397:67-78

Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems.

Kasper M; Regl G; Eichberger T; Frischauf A-M; Aberger F
Article: GENOME RESEARCH. 2006;16(8):1041-1045

RNA expression profiling at the single molecule level

Hesse J; Jacak J; Kasper M; Regl G; Eichberger T; Winklmayr M; Aberger F; Sonnleitner M; Schlapak R; Howorka S; Muresan L; Frischauf A-M; Schuetz GJ
Article: GENOMICS. 2006;87(5):616-632

Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes

Eichberger T; Sander V; Schnidar H; Regl G; Kasper M; Schmid C; Plamberger S; Kaser A; Aberger F; Frischauf A-M
Article: CANCER RESEARCH. 2004;64(21):7724-7731

Activation of the BCL2 promoter in response to hedgehog/GLI signal transduction is predominantly mediated by GLI2

Regl G; Kasper M; Schnidar H; Eichberger T; Neill GW; Philpott MP; Esterbauer H; Hauser-Kronberger C; Frischauf AM; Aberger F
Article: ONCOGENE. 2004;23(6):1263-1274

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells

Regl G; Kasper M; Schnidar H; Eichberger T; Neill GW; Ikram MS; Quinn AG; Philpott MP; Frischauf AM; Aberger F
Article: ONCOGENE. 2002;21(36):5529-5539

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

Regl G; Neill GW; Eichberger T; Kasper M; Ikram MS; Koller J; Hintner H; Quinn AG; Frischauf AM; Aberger F
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Preprint: BIORXIV. 2023

A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

Gopee NH; Huang N; Olabi B; Admane C; Botting RA; Foster AR; Torabi F; Winheim E; Sumanaweera D; Goh I; Miah M; Stephenson E; Tun WM; Moghimi P; Rumney B; He P; Lawrence S; Roberts K; Sidhpura K; Englebert J; Jardine L; Reynolds G; Rose A; Ganier C; Rowe V; Pritchard S; Mulas I; Fletcher J; Popescu D-M; Poyner E; Dubois A; Filby A; Lisgo S; Barker RA; Park J-E; Vento-Tormo R; Le PA; Serdy S; Kim J; Deakin C; Lee J; Nikolova M; Rajan N; Ballereau S; Li T; Moore J; Horsfall D; Lozada DB; O’Toole EA; Treutlein B; Bayraktar O; Kasper M; Mazin P; Gambardella L; Koehler K; Teichmann SA; Haniffa M
Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(9):1667-1677

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization

Almet AA; Yuan H; Annusver K; Ramos R; Liu Y; Wiedemann J; Sorkin DH; Landen NX; Sonkoly E; Haniffa M; Nie Q; Lichtenberger BM; Luecken MD; Andersen B; Tsoi LC; Watt FM; Gudjonsson JE; Plikus MV; Kasper M
Preprint: BIORXIV. 2023

CAF variants control the tumor-immune microenvironment and predict skin cancer malignancy

Forsthuber A; Korosec A; Jacob T; Aschenbrenner B; Annusver K; Frech S; Purkhauser K; Krajic N; Lipp K; Werner F; Nguyen V; Griss J; Bauer W; Cardona AS; Weber B; Weninger W; Gesslbauer B; Staud C; Nedomansky J; Radtke C; Wagner SN; Petzelbauer P; Kasper M; Lichtenberger BM
Preprint: BIORXIV. 2022

Rare Gli1+ perivascular fibroblasts promote skin wound repair

Sun X; Annusver K; Dalessandri T; Kasper M
Editorial comment: CELL STEM CELL. 2019;24(4):501-502

TREMendous Macrophages Inhibit Hair Growth

Dalessandri T; Kasper M
Letter: ACTA ONCOLOGICA. 2013;52(4):862-U221

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma

Asklund T; Henriksson R; Axelsson J; Bergstrom A; Kasper M; Ogren M; Toftgard R; Riklund KA
Editorial comment: CANCER CELL. 2013;23(1):3-5

Smoothing Out Drug Resistance

Kasper M; Toftgard R
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5548

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes (vol 108, pg 4099, 2011)

Kasper M; Jaks V; Are A; Bergstrom A; Schwager A; Svard J; Teglund S; Barker N; Toftgard R
Review: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):455-463

Basal cell carcinoma - molecular biology and potential new therapies

Kasper M; Jaks V; Hohl D; Toftgard R
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):219

Long-term GLI1 expression induces mammary gland tumour formation in nulliparous transgenic mice

Norum JH; Kasper M; Jaks V; Toftgard R
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1422-1428

The hair follicle-a stem cell zoo

Jaks V; Kasper M; Toftgard R
Review: CARCINOGENESIS. 2009;30(6):903-911

Hedgehog signalling in breast cancer

Kasper M; Jaks V; Fiaschi M; Toftgard R
Review: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(16):6283-6298

Selective modulation of hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes

Kasper M; Schnidar H; Neill GW; Hanneder M; Klingler S; Blaas L; Schmid C; Hauser-Kronberger C; Regl G; Philpott MP; Aberger F
Review: EUROPEAN JOURNAL OF CANCER. 2006;42(4):437-445

GLI transcription factors: Mediators of oncogenic Hedgehog signalling

Kasper M; Regi G; Frischauf AM; Aberger F

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