Lars Larsson

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Lars Larsson är professor i neurofysiologi och gruppledare för Basal och klinisk muskelbiologi på institutionen för fysiologi och farmakologi.

Artiklar

Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;222:493-504

The role of zinc and matrix metalloproteinases in myofibrillar protein degradation in critical illness myopathy.

Ribeiro F; Zhang X; Wen Y; Cacciani N; Hedström Y; Xia Z; Schulz R; Larsson L
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;209(11):1304-1313

Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.

Palakshappa JA; Batt JAE; Bodine SC; Connolly BA; Doles J; Falvey JR; Ferrante LE; Files DC; Harhay MO; Harrell K; Hippensteel JA; Iwashyna TJ; Jackson JC; Lane-Fall MB; Monje M; Moss M; Needham DM; Semler MW; Lahiri S; Larsson L; Sevin CM; Sharshar T; Singer B; Stevens T; Taylor SP; Gomez CR; Zhou G; Girard TD; Hough CL
Article: ACTA PHYSIOLOGICA. 2024;240(5):e14128

Ruxolitinib: A new hope for ventilator-induced diaphragm dysfunction.

Addinsall AB; Cacciani N; Moruzzi N; Akkad H; Maestri A; Berggren P-O; Widegren A; Bergquist J; Tchkonia T; Kirkland JL; Larsson L
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2023;14(3):1533-1545

Direct electrical stimulation impacts on neuromuscular junction morphology on both stimulated and unstimulated contralateral soleus.

Lee YI; Cacciani N; Wen Y; Zhang X; Hedström Y; Thompson W; Larsson L
Article: FRONTIERS IN PHYSIOLOGY. 2023;14:1207802

Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment.

Mnuskina S; Bauer J; Wirth-Hücking A; Schneidereit D; Nübler S; Ritter P; Cacciani N; Li M; Larsson L; Friedrich O
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(6):2669-2682

A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.

Cacciani N; Skärlén Å; Wen Y; Zhang X; Addinsall AB; Llano-Diez M; Li M; Gransberg L; Hedström Y; Bellander B-M; Nelson D; Bergquist J; Larsson L
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(4):2162-2174

Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting.

Addinsall AB; Cacciani N; Backéus A; Hedström Y; Shevchenko G; Bergquist J; Larsson L
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2022;722:109212

The optimized quantum dot mediated thermometry reveals isoform specific differences in efficiency of myosin extracted from muscle mini bundles.

Li M; Coppo L; Jena BP; Larsson L
Article: JOURNAL OF ORTHOPAEDIC RESEARCH. 2022;40(6):1293-1300

Acute and severe trabecular bone loss in a rat model of critical illness myopathy.

Gugala Z; Cacciani N; Klein GL; Larsson L
Journal article: FASEB JOURNAL. 2022;36(S1)

The Optimized Quantum Dots Mediated Thermometry Reveals the Efficiency of Myosin Extracted from Muscle Mini Bundles

Li M; Coppo L; Jena BP; Larsson L
Journal article: FASEB JOURNAL. 2022;36(S1)

Non‐acidotic hypercapnia limits the loss of diaphragm force at single fiber level in mechanically ventilated rats for 5 days

Cacciani N; Addinsall AB; Larsson L
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:849973

Metabolomic Profiling of Respiratory Muscles and Lung in Response to Long-Term Controlled Mechanical Ventilation.

Wen Y; Zhang X; Larsson L
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(605):eaay9592

Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.

Sartori R; Hagg A; Zampieri S; Armani A; Winbanks CE; Viana LR; Haidar M; Watt KI; Qian H; Pezzini C; Zanganeh P; Turner BJ; Larsson A; Zanchettin G; Pierobon ES; Moletta L; Valmasoni M; Ponzoni A; Attar S; Da Dalt G; Sperti C; Kustermann M; Thomson RE; Larsson L; Loveland KL; Costelli P; Megighian A; Merigliano S; Penna F; Gregorevic P; Sandri M
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2021;599(11):2869-2886

JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R.

Addinsall AB; Cacciani N; Akkad H; Salah H; Tchkonia T; Kirkland JL; Larsson L
Article: SKELETAL MUSCLE. 2021;11(1):11

Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.

Lyu Q; Wen Y; Zhang X; Addinsall AB; Cacciani N; Larsson L
Article: FRONTIERS IN MEDICINE. 2021;8:672370

Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Stanculescu D; Larsson L; Bergquist J
Article: FRONTIERS IN MEDICINE. 2021;8:628029

Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Stanculescu D; Larsson L; Bergquist J
Article: MACHINE LEARNING-SCIENCE AND TECHNOLOGY. 2020;1(4):045004

Res-CR-Net, a residual network with a novel architecture optimized for the semantic segmentation of microscopy images

Abdallah H; Formosa B; Liyanaarachchi A; Saigh M; Silvers S; Arslanturk S; Taatjes DJ; Larsson L; Jena BP; Gatti DL
Article: DIAGNOSTICS. 2020;10(11):E966-966

Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.

Marrero HDJG; Stålberg EV; Cooray G; Corpeno Kalamgi R; Hedström Y; Bellander B-M; Nennesmo I; Larsson L
Article: NATURE COMMUNICATIONS. 2020;11(1):4479

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin.

Swist S; Unger A; Li Y; Vöge A; von Frieling-Salewsky M; Skärlén Å; Cacciani N; Braun T; Larsson L; Linke WA
Article: ACTA PHYSIOLOGICA. 2020;229(1):e13425

Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model.

Cacciani N; Salah H; Li M; Akkad H; Backeus A; Hedstrom Y; Jena BP; Bergquist J; Larsson L
Article: SKELETAL MUSCLE. 2019;9(1):9

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy.

Llano-Diez M; Fury W; Okamoto H; Bai Y; Gromada J; Larsson L
Article: ACTA PHYSIOLOGICA. 2019;225(2):e13172

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model.

Akkad H; Cacciani N; Llano-Diez M; Corpeno Kalamgi R; Tchkonia T; Kirkland JL; Larsson L
Article: NANO LETTERS. 2018;18(11):7021-7029

Nanothermometry Reveals Calcium-Induced Remodeling of Myosin.

Kuhn ER; Naik AR; Lewis BE; Kokotovich KM; Li M; Stemmler TL; Larsson L; Jena BP
Article: ACTA PHYSIOLOGICA. 2018;222(3)

Muscle-specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long-term mechanical ventilation and immobilization in rats.

Salah H; Fury W; Gromada J; Bai Y; Tchkonia T; Kirkland JL; Larsson L
Article: MOLECULAR & CELLULAR PROTEOMICS. 2017;16(6):1081-1097

A Proteomic Approach to Identify Alterations in the Small Ubiquitin-like Modifier (SUMO) Network during Controlled Mechanical Ventilation in Rat Diaphragm Muscle.

Namuduri AV; Heras G; Mi J; Cacciani N; Hörnaeus K; Konzer A; Lind SB; Larsson L; Gastaldello S
Article: COMPREHENSIVE PHYSIOLOGY. 2016;7(1):105-112

Critical Illness Myopathy (CIM) and Ventilator-Induced Diaphragm Muscle Dysfunction (VIDD): Acquired Myopathies Affecting Contractile Proteins.

Larsson L; Friedrich O
Article: CRITICAL CARE. 2016;20(1):254

Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.

Llano-Diez M; Cheng AJ; Jonsson W; Ivarsson N; Westerblad H; Sun V; Cacciani N; Larsson L; Bruton J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.

Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedström Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388

Mechano-signalling pathways in an experimental intensive critical illness myopathy model.

Corpeno Kalamgi R; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2016;37(1-2):41-52

Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics.

Jin Y; Peng Y; Lin Z; Chen Y-C; Wei L; Hacker TA; Larsson L; Ge Y
Article: FRONTIERS IN PHYSIOLOGY. 2016;7:417

Targeting Heat Shock Proteins Mitigates Ventilator Induced Diaphragm Muscle Dysfunction in an Age-Dependent Manner.

Ogilvie H; Cacciani N; Akkad H; Larsson L
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2015;583:1-8

Nanometric features of myosin filaments extracted from a single muscle fiber to uncover the mechanisms underlying organized motility.

Li M; Deguchi T; Näreoja T; Jena BP; Hänninen P; Larsson L
Article: ANALYTICAL CHEMISTRY. 2015;87(16):8399-8406

Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker.

Chen Y-C; Ayaz-Guner S; Peng Y; Lane NM; Locher M; Kohmoto T; Larsson L; Moss RL; Ge Y
Article: REDOX BIOLOGY. 2015;5:267-274

Oxidative proteome alterations during skeletal muscle ageing.

Lourenço Dos Santos S; Baraibar MA; Lundberg S; Eeg-Olofsson O; Larsson L; Friguet B
Article: AGING CELL. 2015;14(2):228-235

Aberrant post-translational modifications compromise human myosin motor function in old age.

Li M; Ogilvie H; Ochala J; Artemenko K; Iwamoto H; Yagi N; Bergquist J; Larsson L
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2015;36(2):169-181

Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry.

Chen Y-C; Sumandea MP; Larsson L; Moss RL; Ge Y
Journal article: CRITICAL CARE. 2015;19(Suppl 1):p250

Structural and functional effects of mechanical ventilation and aging on single rat diaphragm muscle fibers

Cacciani N; Ogilvie H; Larsson L
Article: EXPERIMENTAL GERONTOLOGY. 2014;59:28-33

Age related differences in diaphragm muscle fiber response to mid/long term controlled mechanical ventilation.

Cacciani N; Ogilvie H; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2014;592(17):3859-3880

Time course analysis of mechanical ventilation-induced diaphragm contractile muscle dysfunction in the rat.

Corpeno R; Dworkin B; Cacciani N; Salah H; Bergman H-M; Ravara B; Vitadello M; Gorza L; Gustafson A-M; Hedström Y; Petersson J; Feng H-Z; Jin J-P; Iwamoto H; Yagi N; Artemenko K; Bergquist J; Larsson L
Article: JOURNAL OF PROTEOMICS. 2014;108:55-64

Alterations in muscle proteome of patients diagnosed with amyotrophic lateral sclerosis.

Elf K; Shevchenko G; Nygren I; Larsson L; Bergquist J; Askmark H; Artemenko K
Article: BIOLOGY-BASEL. 2014;3(2):368-382

The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).

Ogilvie H; Larsson L
Article: PLOS ONE. 2014;9(4):e92622

Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model.

Akkad H; Corpeno R; Larsson L
Article: JOURNAL OF CELL BIOLOGY. 2013;203(2):345-357

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass.

Winbanks CE; Chen JL; Qian H; Liu Y; Bernardo BC; Beyer C; Watt KI; Thomson RE; Connor T; Turner BJ; McMullen JR; Larsson L; McGee SL; Harrison CA; Gregorevic P
Article: PHYSIOLOGICAL GENOMICS. 2013;45(12):477-486

Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle.

Banduseela VC; Chen Y-W; Kultima HG; Norman HS; Aare S; Radell P; Eriksson LI; Hoffman EP; Larsson L
Article: BIOGERONTOLOGY. 2013;14(3):303-323

Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.

Sandri M; Barberi L; Bijlsma AY; Blaauw B; Dyar KA; Milan G; Mammucari C; Meskers CGM; Pallafacchina G; Paoli A; Pion D; Roceri M; Romanello V; Serrano AL; Toniolo L; Larsson L; Maier AB; Muñoz-Cánoves P; Musarò A; Pende M; Reggiani C; Rizzuto R; Schiaffino S
Article: BIOGERONTOLOGY. 2013;14(3):293-301

Detection of an aging-related increase in advanced glycation end products in fast- and slow-twitch skeletal muscles in the rat.

Ramamurthy B; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(9):2333-2344

Hormone replacement therapy improves contractile function and myonuclear organization of single muscle fibres from postmenopausal monozygotic female twin pairs.

Qaisar R; Renaud G; Hedstrom Y; Pöllänen E; Ronkainen P; Kaprio J; Alen M; Sipilä S; Artemenko K; Bergquist J; Kovanen V; Larsson L
Article: PHYSIOLOGICAL GENOMICS. 2013;45(8):312-320

Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model.

Aare S; Radell P; Eriksson LI; Akkad H; Chen Y-W; Hoffman EP; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(5):1385-1402

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model.

Renaud G; Llano-Diez M; Ravara B; Gorza L; Feng H-Z; Jin J-P; Cacciani N; Gustafson A-M; Ochala J; Corpeno R; Li M; Hedström Y; Ford GC; Nair KS; Larsson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2012;303(10):R1090-R1099

Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness.

Alamdari N; Toraldo G; Aversa Z; Smith I; Castillero E; Renaud G; Qaisar R; Larsson L; Jasuja R; Hasselgren P-O
Article: CRITICAL CARE. 2012;16(5):R209

Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading.

Llano-Diez M; Renaud G; Andersson M; Marrero HG; Cacciani N; Engquist H; Corpeño R; Artemenko K; Bergquist J; Larsson L
Article: PHYSIOLOGICAL GENOMICS. 2012;44(18):865-877

Role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model.

Aare S; Radell P; Eriksson LI; Chen Y-W; Hoffman EP; Larsson L
Article: ENDOCRINOLOGY. 2012;153(5):2267-2276

Early parenteral nutrition evokes a phenotype of autophagy deficiency in liver and skeletal muscle of critically ill rabbits.

Derde S; Vanhorebeek I; Güiza F; Derese I; Gunst J; Fahrenkrog B; Martinet W; Vervenne H; Ververs E-J; Larsson L; Van den Berghe G
Article: FASEB JOURNAL. 2012;26(3):1077-1085

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

Qaisar R; Renaud G; Morine K; Barton ER; Sweeney HL; Larsson L
Article: CRITICAL CARE MEDICINE. 2012;40(1):79-89

Muscle atrophy and preferential loss of myosin in prolonged critically ill patients.

Derde S; Hermans G; Derese I; Güiza F; Hedström Y; Wouters PJ; Bruyninckx F; D'Hoore A; Larsson L; Van den Berghe G; Vanhorebeek I
Article: PHYSIOLOGICAL GENOMICS. 2011;43(24):1334-1350

Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model.

Aare S; Ochala J; Norman HS; Radell P; Eriksson LI; Göransson H; Chen Y-W; Hoffman EP; Larsson L
Article: BMC GENOMICS. 2011;12:602

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model.

Llano-Diez M; Gustafson A-M; Olsson C; Goransson H; Larsson L
Article: ACTA PHYSIOLOGICA. 2011;202(4):671-681

There is no slowing of motility speed with increased body size in rat, human, horse and rhinoceros independent on temperature and skeletal muscle myosin isoform.

Li M; Li M; Marx JO; Larsson L
Article: FASEB JOURNAL. 2011;25(6):1903-1913

Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.

Ochala J; Lehtokari V-L; Iwamoto H; Li M; Feng H-Z; Jin J-P; Yagi N; Wallgren-Pettersson C; Pénisson-Besnier I; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2011;589(Pt 8):2007-2026

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms.

Ochala J; Gustafson A-M; Diez ML; Renaud G; Li M; Aare S; Qaisar R; Banduseela VC; Hedström Y; Tang X; Dworkin B; Ford GC; Nair KS; Perera S; Gautel M; Larsson L
Journal article: BIOPHYSICAL JOURNAL. 2011;100(3):287a

Time Resolved Analyses of Gene Expression in a Rodent Icu Model

Llano-Diez M; Gustafson A-M; Goransson H; Olsson C; Larsson L
Article: PLOS ONE. 2011;6(6):e20558

Diaphragm muscle weakness in an experimental porcine intensive care unit model.

Ochala J; Renaud G; Llano Diez M; Banduseela VC; Aare S; Ahlbeck K; Radell PJ; Eriksson LI; Larsson L
Article: PLOS ONE. 2011;6(6):e20876

Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model.

Ochala J; Ahlbeck K; Radell PJ; Eriksson LI; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(Pt 24):5105-5114

Force-generating capacity of human myosin isoforms extracted from single muscle fibre segments.

Li M; Larsson L
Article: AGING CELL. 2010;9(5):685-697

Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells.

Cristea A; Qaisar R; Edlund PK; Lindblad J; Bengtsson E; Larsson L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(21):9807-9812

A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation.

Ochala J; Iwamoto H; Larsson L; Yagi N
Journal article: FASEB JOURNAL. 2010;24(S1):1046.3

Myosin loss and muscle wasting in an experimental ICU model: Underlying mechanisms

Larsson L; Ochala J; Diaz ML; Gustafson A; Dworkin BR; Nair SK; Gautel M
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2010;459(3):475-483

EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation.

Ochala J; Radell PJ; Eriksson LI; Larsson L
Article: CRITICAL CARE MEDICINE. 2010;38(2):602-611

Increasing intravenous glucose load in the presence of normoglycemia: effect on outcome and metabolism in critically ill rabbits.

Derde S; Vanhorebeek I; Ververs E-J; Vanhees I; Darras VM; Van Herck E; Larsson L; Van den Berghe G
Article: PHYSIOLOGICAL GENOMICS. 2009;39(3):141-159

Gene expression and muscle fiber function in a porcine ICU model.

Banduseela VC; Ochala J; Chen Y-W; Göransson H; Norman H; Radell P; Eriksson LI; Hoffman EP; Larsson L
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2009;285(1-2):28-38

Myofibrillar protein and gene expression in acute quadriplegic myopathy.

Norman H; Zackrisson H; Hedström Y; Andersson P; Nordquist J; Eriksson LI; Libelius R; Larsson L
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2009;24(9):1608-1617

Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age.

Lang DH; Conroy DE; Lionikas A; Mack HA; Larsson L; Vogler GP; Vandenbergh DJ; Blizard DA; McClearn GE; Sharkey NA
Journal article: NEUROMUSCULAR DISORDERS. 2009;19(8-9):559

G.P.2.01 Acute Quadriplegic Myopathy: Underlying mechanisms, improved diagnostic methods and specific intervention strategies

Larsson L; Gustafson AM; Ochala J; Banduseela V; Li M; Aare S; Hedström Y; Qaisar R; Diaz ML; Tang X; Dworkin BR
Journal article: NEUROMUSCULAR DISORDERS. 2009;19(8-9):551

EM.P.1.07 Effects of muscle hypertrophy on individual myonuclear domain sizes in single muscle fibers from myostatin deficient or IGF-1 over-expressing mice

Qaiasr R; Morine K; Barton ER; Sweeney HL; Larsson L
Journal article: NEUROMUSCULAR DISORDERS. 2009;19(8-9):560

G.P.2.03 Partial reversal of ventilator-induced diaphragm muscle cell dysfunction

Ochala J; Larsson L
Journal article: NEUROMUSCULAR DISORDERS. 2009;19(8-9):559-560

G.P.2.02 Aspiration muscle biopsy for monitoring and diagnosis of Acute Quadriplegic Myopathy

Hedström Y; Banduseela V; Larsson L
Article: JOURNAL OF APPLIED MICROBIOLOGY. 2009;106(5):1494-1501

Impact of temperature on growth and metabolic efficiency of Penicillium roqueforti--correlations between produced heat, ergosterol content and biomass.

Li Y; Wadsö L; Larsson L
Article: PHYSIOLOGICAL GENOMICS. 2009;36(3):158-166

Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.

Blizard DA; Lionikas A; Vandenbergh DJ; Vasilopoulos T; Gerhard GS; Griffith JW; Klein LC; Stout JT; Mack HA; Lakoski JM; Larsson L; Spicer JM; Vogler GP; McClearn GE
Article: UPSALA JOURNAL OF MEDICAL SCIENCES. 2009;114(4):235-241

Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin.

Ochala J; Carpén O; Larsson L
Article: EXPERIMENTAL PHYSIOLOGY. 2009;94(1):117-129

Myonuclear domain size and myosin isoform expression in muscle fibres from mammals representing a 100,000-fold difference in body size.

Liu J-X; Höglund A-S; Karlsson P; Lindblad J; Qaisar R; Aare S; Bengtsson E; Larsson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2008;295(3):C722-C731

Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.

Larsson L; Wang X; Yu F; Höök P; Borg K; Chong SM; Jin J-P
Article: ACTA PHYSIOLOGICA. 2008;193(3):275-289

Effects of combined strength and sprint training on regulation of muscle contraction at the whole-muscle and single-fibre levels in elite master sprinters.

Cristea A; Korhonen MT; Häkkinen K; Mero A; Alén M; Sipilä S; Viitasalo JT; Koljonen MJ; Suominen H; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2008;586(12):2993-3004

Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation.

Ochala J; Li M; Ohlsson M; Oldfors A; Larsson L
Article: EXPERIMENTAL PHYSIOLOGY. 2008;93(4):486-495

Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.

Ochala J; Larsson L
Article: JOURNAL OF NEUROSCIENCE. 2008;28(8):1904-1915

Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha1.

Wallis K; Sjögren M; van Hogerlinden M; Silberberg G; Fisahn A; Nordström K; Larsson L; Westerblad H; Morreale de Escobar G; Shupliakov O; Vennström B
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2008;642:92-98

Acute quadriplegic myopathy: an acquired "myosinopathy".

Larsson L
Article: ACTA MYOLOGICA. 2007;26(3):136-144

Muscle paralysis and myosin loss in a patient with cancer cachexia.

Banduseela V; Ochala J; Lamberg K; Kalimo H; Larsson L
Article: MOLECULAR MEDICINE. 2007;13(9-10):461-470

Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats.

Nordquist J; Höglund A-S; Norman H; Tang X; Dworkin B; Larsson L
Article: CRITICAL CARE MEDICINE. 2007;35(9 Suppl):S484-S487

Experimental animal models of muscle wasting in intensive care unit patients.

Larsson L
Article: ACTA PHYSIOLOGICA. 2007;190(3):229-241

Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres.

Yu F; Hedström M; Cristea A; Dalén N; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2007;581(Pt 3):1283-1292

Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres.

Ochala J; Li M; Tajsharghi H; Kimber E; Tulinius M; Oldfors A; Larsson L
Journal article: ACTA PHYSIOLOGICA. 2007;0(0):070405174852003-???

Effects of ageing and gender on contractile properties in human skeletal muscle and single fibres

Yu F; Hedström M; Cristea A; Dalén N; Larsson L
Journal article: JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS. 2007;7(1):56-61

Application of skinned single muscle fibres to determine myofilament function in ageing and disease.

Degens H; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2006;577(Pt 1):339-352

Fibre type-specific increase in passive muscle tension in spinal cord-injured subjects with spasticity.

Olsson MC; Krüger M; Meyer L-H; Ahnlund L; Gransberg L; Linke WA; Larsson L
Article: NEUROMUSCULAR DISORDERS. 2006;16(11):782-791

Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).

Li M; Lionikas A; Yu F; Tajsharghi H; Oldfors A; Larsson L
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2006;47(10):4188-4193

Uncoordinated expression of myosin heavy chains and myosin-binding protein C isoforms in human extraocular muscles.

Kjellgren D; Stål P; Larsson L; Fürst D; Pedrosa-Domellöf F
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2006;50(9):1058-1067

A porcine model of acute quadriplegic myopathy: a feasibility study.

Norman H; Kandala K; Kolluri R; Zackrisson H; Nordquist J; Walther S; Eriksson LI; Larsson L
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2006;453(1):53-66

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression.

Norman H; Nordquist J; Andersson P; Ansved T; Tang X; Dworkin B; Larsson L
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2006;101(3):906-917

Aging, muscle fiber type, and contractile function in sprint-trained athletes.

Korhonen MT; Cristea A; Alén M; Häkkinen K; Sipilä S; Mero A; Viitasalo JT; Larsson L; Suominen H
Article: MAMMALIAN GENOME. 2006;17(6):615-628

Genetic determinants of weight of fast- and slow-twitch skeletal muscles in old mice.

Lionikas A; Blizard DA; Vandenbergh DJ; Stout JT; Vogler GP; McClearn GE; Larsson L
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2006;452(2):222-230

Scaling of skeletal muscle shortening velocity in mammals representing a 100,000-fold difference in body size.

Marx JO; Olsson MC; Larsson L
Article: ANATOMICAL SCIENCE INTERNATIONAL. 2006;81(1):47-49

Anomaly of anatomical origin of soleus muscle: a mouse model.

Lionikas A; Glover MG; Yu F; Larsson L; Vogler GP; McClearn GE; Blizard DA
Article: ACTA PHYSIOLOGICA. 2006;186(2):151-158

Human skeletal muscle myosin function at physiological and non-physiological temperatures.

Lionikas A; Li M; Larsson L
Article: JOURNAL OF GENERAL PHYSIOLOGY. 2006;127(2):95-107

Activation dependence of stretch activation in mouse skinned myocardium: implications for ventricular function.

Stelzer JE; Larsson L; Fitzsimons DP; Moss RL
Journal article: JOURNAL OF BONE AND MINERAL RESEARCH. 2005;20(5):748-757

Adjusting data to body size: a comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes.

Lang DH; Sharkey NA; Lionikas A; Mack HA; Larsson L; Vogler GP; Vandenbergh DJ; Blizard DA; Stout JT; Stitt JP; McClearn GE
Article: PHYSIOLOGICAL GENOMICS. 2005;21(2):184-192

Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage.

Lionikas A; Blizard DA; Gerhard GS; Vandenbergh DJ; Stout JT; Vogler GP; McClearn GE; Larsson L
Journal article: BEHAVIOURAL BRAIN RESEARCH. 2005;158(2):301-310

Coherence of EMG activity and single motor unit discharge patterns in human rhythmical force production.

Sosnoff JJ; Vaillancourt DE; Larsson L; Newell KM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2005;288(2):R482-R490

Aberrant expression of myosin isoforms in skeletal muscles from mice lacking the rev-erbAalpha orphan receptor gene.

Pircher P; Chomez P; Yu F; Vennström B; Larsson L
Journal article: PHYSIOLOGICAL GENOMICS. 2003;16(1):141-152

Genetic architecture of fast- and slow-twitch skeletal muscle weight in 200-day-old mice of the C57BL/6J and DBA/2J lineage.

Lionikas A; Blizard DA; Vandenbergh DJ; Glover MG; Stout JT; Vogler GP; McClearn GE; Larsson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2003;285(2):C419-C424

Glutathione reverses early effects of glycation on myosin function.

Ramamurthy B; Jones AD; Larsson L
Journal article: NEUROBIOLOGY OF AGING. 2003;24(1):25-35

Effects of aging on force variability, single motor unit discharge patterns, and the structure of 10, 20, and 40 Hz EMG activity.

Vaillancourt DE; Larsson L; Newell KM
Journal article: CLINICAL NEUROPHYSIOLOGY. 2002;113(8):1325-1338

Time-dependent structure in the discharge rate of human motor units.

Vaillancourt DE; Larsson L; Newell KM
Journal article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2002;57(6):B232-B238

Effects of aging on human skeletal muscle myosin heavy-chain mRNA content and protein isoform expression.

Marx JO; Kraemer WJ; Nindl BC; Larsson L
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2002;23(4):317-326

Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms.

Yu F; Stål P; Thornell LE; Larsson L
Article: INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM. 2001;11 Suppl:S28-S43

Effects of aging on regulation of muscle contraction at the motor unit, muscle cell, and molecular levels.

Larsson L; Yu F; Höök P; Ramamurthy B; Marx JO; Pircher P
Article: FASEB JOURNAL. 2001;15(13):2415-2422

Changes in myosin structure and function in response to glycation.

Ramamurthy B; Höök P; Jones AD; Larsson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2001;280(4):C782-C788

Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans.

Höök P; Sriramoju V; Larsson L
Journal article: DRUGS & AGING. 2000;17(4):303-316

Aging-related changes in skeletal muscle. Mechanisms and interventions.

Larsson L; Ramamurthy B
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;278(6):R1545-R1554

Effects of thyroid hormone receptor gene disruption on myosin isoform expression in mouse skeletal muscles.

Yu F; Göthe S; Wikström L; Forrest D; Vennström B; Larsson L
Journal article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2000;21(4):357-365

Actomyosin interactions in a novel single muscle fiber in vitro motility assay.

Hook P; Larsson L
Article: DEVELOPMENT. 2000;127(7):1489-1498

Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor.

Chomez P; Neveu I; Mansén A; Kiesler E; Larsson L; Vennström B; Arenas E
Article: CRITICAL CARE MEDICINE. 2000;28(1):34-45

Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: mechanisms at the cellular and molecular levels.

Larsson L; Li X; Edström L; Eriksson LI; Zackrisson H; Argentini C; Schiaffino S
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1999;520 Pt 2(Pt 2):463-471

In vitro motility speed of slow myosin extracted from single soleus fibres from young and old rats.

Höök P; Li X; Sleep J; Hughes S; Larsson L
Article: CLINICAL SCIENCE. 1999;97(4):449-455

Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres.

Degens H; Soop M; Höök P; Ljungqvist O; Larsson L
Article: BONE MARROW TRANSPLANTATION. 1999;23(8):835-837

Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer.

Samuelsson J; Zackrisson H; Tokics L; Ljungman P; Lidbrink E; Pircher P; Larsson L
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1998;437(1):21-30

Gender- and age-related differences in the regulatory influence of thyroid hormone on the contractility and myosin composition of single rat soleus muscle fibres.

Yu F; Degens H; Li X; Larsson L
Article: ACTA PHYSIOLOGICA. 1998;163(1):33-40

Effects of age and gender on shortening velocity and myosin isoforms in single rat muscle fibres.

Degens H; Yu F; Li X; Larsson L
Article: MUSCLE & NERVE. 1997;20(8):948-952

Contractile studies of single human skeletal muscle fibers: a comparison of different muscles, permeabilization procedures, and storage techniques.

Frontera WR; Larsson L
Article: MUSCLE & NERVE. 1997;20(8):938-947

Firing rate of the lower motoneuron and contractile properties of its muscle fibers after upper motoneuron lesion in man.

Frontera WR; Grimby L; Larsson L
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1997;18(3):335-344

Contractility and myosin isoform compositions of skeletal muscles and muscle cells from rats treated with thyroid hormone for 0, 4 and 8 weeks.

Li X; Larsson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;272(2 Pt 1):C638-C649

Effects of aging on shortening velocity and myosin isoform composition in single human skeletal muscle cells.

Larsson L; Li X; Frontera WR
Article: ACTA PHYSIOLOGICA. 1997;159(1):81-89

Gender-related differences in the regulatory influence of thyroid hormone on the expression of myosin isoforms in young and old rats.

Larsson L; Yu F
Article: JOURNAL OF APPLIED PHYSIOLOGY. 1997;82(1):182-188

Lower limb skeletal muscle function after 6 wk of bed rest.

Berg HE; Larsson L; Tesch PA
Article: JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE. 1997;46(1):5-6

Effects of aging on contractile properties of single skeletal muscle cells and motor units from humans and rodents

Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1996;494 ( Pt 2)(Pt 2):555-567

Thyroid hormone effects on contractility and myosin composition of soleus muscle and single fibres from young and old rats.

Li X; Hughes SM; Salviati G; Teresi A; Larsson L
Article: LAKARTIDNINGEN. 1996;93(23):2249-2254

[Drug induced tetraparesis and loss of myosin. Mild types are probably overlooked].

Larsson L; Roland A
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1996;432(2):320-328

Effects of removal of weight-bearing function on contractility and myosin isoform composition in single human skeletal muscle cells.

Larsson L; Li X; Berg HE; Frontera WR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;270(1 Pt 1):C352-C360

Maximum shortening velocity and myosin isoforms in single muscle fibers from young and old rats.

Li X; Larsson L
Article: CELL CALCIUM. 1996;19(1):15-27

Age-related abnormalities in regulation of the ryanodine receptor in rat fast-twitch muscle.

Damiani E; Larsson L; Margreth A
Article: FISH PHYSIOLOGY AND BIOCHEMISTRY. 1995;14(6):439-448

Spawning induces a shift in energy metabolism from glucose to lipid in rainbow trout white muscle.

Kiessling A; Larsson L; Kiessling KH; Lutes PB; Storebakken T; Hung SS
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 1995;132(2):182-192

Contractile properties in single muscle fibres from chronically overused motor units in relation to motoneuron firing properties in prior polio patients.

Larsson L; Li X; Tollbäck A; Grimby L
Article: ACTA PHYSIOLOGICA. 1995;154(1):59-64

Effects of age on sarcoplasmic reticulum properties and histochemical composition of fast- and slow-twitch rat muscles.

Danieli-Betto D; Betto R; Megighian A; Midrio M; Salviati G; Larsson L
Article: ACTA PHYSIOLOGICA. 1995;153(2):109-116

Thyroid hormone regulation of myosin heavy chain isoform composition in young and old rats, with special reference to IIX myosin.

Larsson L; Müller U; Li X; Schiaffino S
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 1994;481 ( Pt 1)(Pt 1):149-161

Effects of thyroid hormone on fast- and slow-twitch skeletal muscles in young and old rats.

Larsson L; Li X; Teresi A; Salviati G
Journal article: ACTA PHYSIOLOGICA. 1993;147(2):227-234

An age-related type IIB to IIX myosin heavy chain switching in rat skeletal muscle.

Larsson L; Biral D; Campione M; Schiaffino S
Journal article: ACTA NEUROLOGICA SCANDINAVICA. 1993;87(1):37-42

Paramyotonia congenita (Eulenburg): clinical, neurophysiological and muscle biopsy observations in a Swedish family.

Borg K; Hovmöller M; Larsson L; Edström L
Journal article: ACTA PHYSIOLOGICA. 1992;146(4):485-495

A technique for studies of the contractile apparatus in single human muscle fibre segments obtained by percutaneous biopsy.

Larsson L; Salviati G
Journal article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 1992;55(10):916-920

Neurogenic effects on the palatopharyngeal muscle in patients with obstructive sleep apnoea: a muscle biopsy study.

Edström L; Larsson H; Larsson L
Journal article: JOURNAL OF BIOMECHANICS. 1992;25(7):747

Spatial distribution of motor unit fibres in fast- and slow-switch muscles of young and old rats

Ansved T; Wallner P; Larsson L
Journal article: ACTA PHYSIOLOGICA. 1991;143(4):445-446

Regional differences in the influence of the interval between removal and freezing of muscle samples on muscle fibre size.

Gür H; Larsson L
Journal article: ACTA PHYSIOLOGICA. 1991;143(3):345-354

Spatial distribution of motor unit fibres in fast- and slow-twitch rat muscles with special reference to age.

Ansved T; Wallner P; Larsson L
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 1991;443:257-275

Effects of age on physiological, immunohistochemical and biochemical properties of fast-twitch single motor units in the rat.

Larsson L; Ansved T; Edström L; Gorza L; Schiaffino S
Journal article: AMERICAN JOURNAL OF PHYSIOLOGY. 1991;261(1 Pt 1):C93-101

MHC composition and enzyme-histochemical and physiological properties of a novel fast-twitch motor unit type.

Larsson L; Edström L; Lindegren B; Gorza L; Schiaffino S
Journal article: BRITISH JOURNAL OF SURGERY. 1991;157(5):347-354

The effect of excessive weight loss on skeletal muscle in man. A study of obese patients following gastroplasty.

Wadström C; Larsson L; Knutsson E; Edström L
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 1989;93(1):105-124

Effects of ageing on enzyme-histochemical, morphometrical and contractile properties of the soleus muscle in the rat.

Ansved T; Larsson L
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 1989;412:267-276

A novel type of delayed tension reduction observed in rat motor units after intense activity.

Lännergren J; Larsson L; Westerblad H
Journal article: SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY. 1989;23(3):181-186

An electrophysiological method for monitoring blood flow in skeletal muscle. An experimental study in the rat.

Larsson L
Journal article: JOURNAL OF BIOMECHANICS. 1989;22(10):1096

A new computer-assisted model to assess the randomness of the muscle fiber arrangement in single motor units

Wallner P; Ansved T; Larsson L
Journal article: JOURNAL OF BIOMECHANICS. 1989;22(10):981

The effects of age on contractile, morphometrical and enzyme-histochemical properties of the rat soleus muscle

Ansved T; Larsson L
Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1988;515:303-313

Effects of age on the motor unit. A study on single motor units in the rat.

Larsson L; Ansved T
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 1987;392:129-145

Effects of age on contractile and enzyme-histochemical properties of fast- and slow-twitch single motor units in the rat.

Edström L; Larsson L
Journal article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY. 1986;55(2):130-136

Motor unit fibre density in extremely hypertrophied skeletal muscles in man. Electrophysiological signs of muscle fibre hyperplasia.

Larsson L; Tesch PA
Journal article: ACTA PHYSIOLOGICA. 1985;125(2):235-243

Contractile properties, fatiguability and glycolytic metabolism in fast- and slow-twitch rat skeletal muscles of various temperatures.

Blomstrand E; Larsson L; Edström L
Journal article: MUSCLE & NERVE. 1985;8(8):714-722

Effects of long-term physical training and detraining on enzyme histochemical and functional skeletal muscle characteristic in man.

Larsson L; Ansved T
Journal article: ACTA PHYSIOLOGICA. 1985;123(4):515-518

Torque-velocity relations in the quadriceps muscle of smoking-discordant twins with different fibre type proportions.

Larsson L; Gransberg L; Knutsson E
Journal article: ACTA PHYSIOLOGICA. 1983;117(3):469-471

Histochemical characteristics of human skeletal muscle during aging.

Larsson L
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 1982;14(3):203-206

Physical training effects on muscle morphology in sedentary males at different ages.

Larsson L
Journal article: ACTA PHYSIOLOGICA. 1979;107(1):39-46

Skeletal muscle metabolism, morphology and function in sedentary smokers and nonsmokers.

Orlander J; Kiessling KH; Larsson L
Journal article: JOURNAL OF APPLIED PHYSIOLOGY. 1979;46(3):451-456

Muscle strength and speed of movement in relation to age and muscle morphology.

Larsson L; Grimby G; Karlsson J
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 1977;9(1):26-30

Muscle strength and fiber composition in athletes and sedentary men.

Thorstensson A; Larsson L; Tesch P; Karlsson J
Visa fler

Alla övriga publikationer

Preprint: RESEARCH SQUARE. 2024

Non-acidotic hypercapnia limits atrophy and loss of specific force in rat diaphragm after 5 days of controlled mechanical ventilation in parallel with increased local inflammation

Cacciani N; Addinsall AB; Larsson L
Conference publication: FASEB JOURNAL. 2022;36

Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction

Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
Review: JOURNAL OF NUTRITION. 2022;152(4):926-938

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.

Ebert SM; Rasmussen BB; Judge AR; Judge SM; Larsson L; Wek RC; Anthony TG; Marcotte GR; Miller MJ; Yorek MA; Vella A; Volpi E; Stern JI; Strub MD; Ryan Z; Talley JJ; Adams CM
Review: CURRENT TREATMENT OPTIONS IN NEUROLOGY. 2022;24(4):173-182

Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications.

Rodriguez B; Larsson L; Z'Graggen WJ
Review: DISCOVERIES (CRAIOVA). 2022;10(1):e144

Understanding Brain-Skeletal Muscle Crosstalk Impacting Metabolism and Movement.

Jena BP; Larsson L; Gatti DL; Ghiran I; Cho WJ
Book chapter: ACQUIRED NEUROMUSCULAR DISORDERS. 2022;p. 189-212

Intensive Care Unit-Acquired Weakness

Meznaric M; Larsson L; Angelini C
Preprint: BIORXIV. 2021

Electrical Stimulated GLUT4 Signaling Attenuates Critical Illness-Associated Muscle Wasting

Addinsall AB; Cacciani N; Backéus A; Hedström Y; Shevchenko G; Bergquist J; Larsson L
Review: BRITISH JOURNAL OF CANCER. 2021;124(10):1623-1636

Pancreatic cancer cachexia: three dimensions of a complex syndrome.

Kordes M; Larsson L; Engstrand L; Löhr J-M
Letter: BRITISH JOURNAL OF ANAESTHESIA. 2020;125(3):e334-e336

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?

Lönnqvist P-A; Bell M; Karlsson T; Wiklund L; Höglund A-S; Larsson L
Review: PHYSIOLOGICAL REVIEWS. 2019;99(1):427-511

Sarcopenia: Aging-Related Loss of Muscle Mass and Function.

Larsson L; Degens H; Li M; Salviati L; Lee YI; Thompson W; Kirkland JL; Sandri M
Editorial comment: NEUROMUSCULAR DISORDERS. 2018;28(12):1022-1030

234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017.

Weihl CC; Udd B; Hanna M; ENMC workshop study group
Review: ACTA PHYSIOLOGICA. 2018;222(1)

Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment.

Friedrich O; Diermeier S; Larsson L
Conference publication: FASEB JOURNAL. 2017;31

Resonance Raman spectroscopy probes the effects of BGP-15 treatment on Ventilator Induced Diaphragm Dysfunction Myopathy in Rat ICU animal model

Sriramoju V; Salah H; Cacciani N; Akkad H; Larsson L; Alfano R
Conference publication: ACTA PHYSIOLOGICA. 2017;219:6-7

Bench to bedside research on critical illness myopathy (CIM) and ventilator-induced diaphragm muscle dysfunction (VIDD): mechanisms and intervention strategies

Larsson L
Review: FRONTIERS IN PHYSIOLOGY. 2016;7:23

Mechanical Signaling in the Pathophysiology of Critical Illness Myopathy.

Kalamgi RC; Larsson L
Letter: JOURNAL OF PHYSIOLOGY-LONDON. 2015;593(15):3391-3392

Reply from Lars Larsson, Nicola Cacciani and Barry Dworkin.

Larsson L; Cacciani N; Dworkin B
Review: PHYSIOLOGICAL REVIEWS. 2015;95(3):1025-1109

The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.

Friedrich O; Reid MB; Van den Berghe G; Vanhorebeek I; Hermans G; Rich MM; Larsson L
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2013;65:s36-s37

Myosin in aging skeletal muscle: post-translational modifications and actomyosin interactions

Li M; Renaud G; Artemenko K; Bergquist J; Larsson L
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2013;65:S50-S51

Determining the impact of oxidation on the motility of single muscle-fibres expressing different myosin isoforms

Spanos D; Li M; Baron CP; Larsson L
Meeting abstract: EXPERIMENTAL GERONTOLOGY. 2013;48(7):687-688

Optimization of a proteomic approach for evidencing and identifying oxidized proteins during human skeletal muscle aging

Santos S; Baraibar M; Le Boulch M; Larsson L; Friguet B
Editorial comment: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2012;2012:257812-3

Muscle contractility and cell motility.

Jin J-P; Bloch RJ; Huang X; Larsson L
Book chapter: SARCOPENIA – AGE-RELATED MUSCLE WASTING AND WEAKNESS. 2011;p. 55-74

Aging-Related Changes Motor Unit Structure and Function

Cristea A; Vaillancourt DE; Larsson L
Meeting abstract: NEUROMUSCULAR DISORDERS. 2009;19(8-9):560-561

Expression profile and functional analysis of masticatory muscle in porcine AQM-ICU model

Aare S; Banduseela V; Ochala J; Goransson H; Norman H; Radell P; Eriksson LI; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 2007;:488A

Effects of risk factors on skeletal muscle fiber function and mRNA expression of AQM porcine animal model

Banduseela VC; Ochala J; Norman H; Radell P; Eriksson LI; Larsson L
Book chapter: GERIATRIC REHABILITATION MANUAL. 2007;p. 9-11

Chapter 2 Skeletal muscle function in older people

dos Santos MHH; Frontera WR; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 2005;88(1):316A

Up-regulation of alternatively spliced low molecular weight isoform of slow skeletal muscle troponin T in Charcot-Marie-Tooth disease

Wang X; Larsson L; Borg K; Jin JP
Conference publication: BIOPHYSICAL JOURNAL. 2005;88(1):635A

Down-regulation of actin and myosin mRNA in animal models of acute quadriplegic myopathy

Norman H; Nordquist J; Kandala K; Kolluri R; Zackrisson H; Walther S; Radell P; Eriksson LI; Dworkin B; Larsson L
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2004;15:270A

Down-regulation of actin and myosin mRNA in animal models of acute quadriplegic myopathy

Norman H; Kandala K; Kolluri R; Zackrisson H; Walther S; Larsson L; Nordquist J; Dworkin B; Eriksson L
Book chapter: HANDBOOK OF CLINICAL NEUROPHYSIOLOGY. 2003;p. 119-144

Chapter 8 Effects of aging on motor unit structure and function

Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 2001;80(1):89A

Acute quadriplegic myopathy and loss of myosin in icu patients. Underlying cellular and molecular mechanisms.

Kolluri R; Zackrisson H; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 2001;80(1):70A

Expression of myosin isoforms in skeletal muscles from mice lacking the Rev-erbAα orphan receptor

Pircher P; Chomez P; Vennstrom B; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 2001;80(1):260A-261A

Cardiac myosin expression in heart of mice lacking thyroid hormone receptor(s)

Yu FS; Mansen A; Vennström B; Larsson LG
Published conference paper: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. 1999;20(6):413-422

Regulation of human muscle contraction at the cellular and molecular levels.

Larsson L; Höök P; Pircher P
Published conference paper: ACTA PHYSIOLOGICA. 1999;167(4):327-329

An overview of carbohydrate-protein interactions with specific reference to myosin and ageing.

Ramamurthy B; Höök P; Larsson L
Published conference paper: ACTA PHYSIOLOGICA. 1999;167(4):325-326

The effect of age on in vitro motility speed of slow myosin extracted from single rat soleus fibres.

Höök P; Li X; Sleep J; Hughes S; Larsson L
Published conference paper: ACTA PHYSIOLOGICA. 1999;167(4):317-323

Gender- and thyroid hormone-related transitions of essential myosin light chain isoform expression in rat soleus muscle during ageing.

Biral D; Ballarin F; Toscano I; Salviati G; Yu F; Larsson L; Betto R
Published conference paper: ACTA PHYSIOLOGICA. 1999;167(4):313-316

The influence of thyroid hormone on myosin isoform composition and shortening velocity of single skeletal muscle fibres with special reference to ageing and gender.

Yu F; Degens H; Larsson L
Editorial comment: ACTA PHYSIOLOGICA. 1999;167(4):299

Symposium: 'The age-related motor handicap. Basic and clinical studies of skeletal muscle' - an introduction

Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 1999;76(1):A36

Motility speed of myosin extracted from single soleus fibres expressing slow myosin isoforms from young and old rats

Li X; Hook P; Sleep J; Hughes SM; Larsson L
Conference publication: ANESTHESIOLOGY. 1999;91(3A):U427

The critical-illness myopathies. A new animal model to clarify underlying cellular mechanisms.

Zackrisson H; Eriksson LI; Walther S; Larsson L
Conference publication: FASEB JOURNAL. 1999;13(4):A415

Effects of disruption of thyroid hormone receptor gene on the expression of myosin isoform composition of mouse skeletal muscles

Yu F; Pircher P; Gothe S; Vennstrom B; Larsson L
Conference publication: FASEB JOURNAL. 1999;13(4):A85

A novel in vitro motility assay to study different myosin isoforms extracted from single muscle fiber segments

Höök P; Larsson L
Conference publication: FASEB JOURNAL. 1999;13(4):A85

Expresion of myosin isoforms in skeletal muscles from mice lacking Rev-erbA alpha orphan receptors

Pircher P; Yu F; Chomez P; Vennstrom B; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 1999;76(1):A52

Expression of myosin isoforms in skeletal muscles from mice lacking Rev-erbA alpha orphan receptors

Pircher P; Chomez P; Vennstrom B; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 1999;76(1):A51

A novel in vitro motility assay to study different myosin isoforms extracted from single muscle fiber segments

Höök P; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 1999;76(1):A156

Effects of disruption of thyroid hormone receptor gene on the expression of myosin isoform composition of mouse skeletal muscles

Yu F; Gothe S; Venström B; Larsson L
Published conference paper: ACTA PHYSIOLOGICA. 1998;163(3):27-29

The age-related motor disability: underlying mechanisms in skeletal muscle at the motor unit, cellular and molecular level.

Larsson L
Published conference paper: MUSCLE & NERVE. 1997;5:S74-S78

Age-related changes in contractile properties and expression of myosin isoforms in single skeletal muscle cells.

Larsson L; Li X; Yu F; Degens H
Conference publication: BIOPHYSICAL JOURNAL. 1997;72(2):TH200

Effects of age and gender on contractility at the whole and single fibre level in the rate soleus and extensor digitorum longus muscles

Yu F; Degens H; Li X; Gur H; Larsson L
Conference publication: BIOPHYSICAL JOURNAL. 1997;72(2):WAMA8

Acute quadriplegia and loss of thick filament proteins after treatment with non-depolarizing neuromuscular blocking agents (NMB) and high doses of corticosteroids in intensive care

Larsson L; Li X; Edstrom L; Eriksson LI; Zachrisson H; Schiaffino S
Conference publication: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1996;17(1):129

Effects of six weeks bed-rest on contractile properties and myosin isoform composition in single muscle fibres from man

Frontera WR; Li X; Berg H; Larsson L
Published conference paper: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 1995;50 Spec No:91-95

Motor units: remodeling in aged animals.

Larsson L
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1995;753:335-342

Motoneuron and muscle fiber properties of remaining motor units in weak tibialis anterior muscles in prior polio.

Borg J; Borg K; Edström L; Grimby L; Henriksson J; Larsson L; Tollbäck A
Review: PROGRESS IN NEUROBIOLOGY. 1995;45(5):397-458

Effects of ageing on the motor unit.

Larsson L; Ansved T
Conference publication: BIOPHYSICAL JOURNAL. 1993;64(2):A253

EXTRACTION OF C-PROTEIN ELIMINATES THE DELAYED OVERSHOOT OF ISOMETRIC TENSION DUE TO STRETCH OF MAMMALIAN SKELETAL-MUSCLES

LARSSON L; GREASER ML; MOSS RL
Conference publication: BIOPHYSICAL JOURNAL. 1993;64(2):A250

MAXIMUM VELOCITY OF SHORTENING IN RELATION TO MYOSIN HEAVY AND LIGHT CHAIN COMPOSITIONS IN SINGLE FIBERS FROM HUMAN SKELETAL-MUSCLES

LARSSON L; MOSS RL
Conference publication: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1989;10(2):157

EFFECTS OF AGE ON PHYSIOLOGICAL-PROPERTIES OF FAST-TWITCH AND SLOW-TWITCH SINGLE MOTOR UNITS IN THE RAT

LARSSON L; EDSTROM L
Conference publication: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1989;10(2):156

EFFECTS OF AGING ON ENZYME HISTOCHEMICAL, MORPHOMETRICAL AND CONTRACTILE PROPERTIES OF THE SOLEUS MUSCLE IN THE RAT

ANSVED T; LARSSON L
Conference publication: MUSCLE & NERVE. 1986;9(5):169

EFFECT OF AGING ON ENZYME HISTOCHEMICAL AND CONTRACTILE PROPERTIES OF FAST-TWITCHED AND SLOW-TWITCH SKELETAL-MUSCLES AND SINGLE MOTOR UNITS IN THE RAT

LARSSON L; EDSTROM L
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 1983;15(2):160

FORCE VELOCITY RELATION IN RUNNERS AS DETERMINED IN ACCELERATION CONTROLLED ISOKINETIC MOVEMENTS

FORSYTHE K; GRANSBERG L; KNUTSSON E; LARSSON L
Conference publication: ACTA PHYSIOLOGICA. 1980;108(2):A48

A COMPARISON OF SKELETAL-MUSCLE MORPHOLOGY, METABOLISM AND FUNCTION IN SMOKERS AND NON-SMOKERS

LARSSON L; ORLANDER J; KIESSLING KH
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Professor Emeritus/Emerita, Fysiologi och farmakologi, Karolinska Institutet, 2024-2024
Professor, Fysiologi och farmakologi, Karolinska Institutet, 2020-2024

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