This page in English
Laddar profil information

Om mig

Jag är läkare, professor och enhetschef för Integrativ toxikologi, på IMM.

Jag är studierektor för forskarutbildningen vid IMM, ordförande i disputationskommittén vid Karolinska Institutet och lärarrepersentant i Kommittén för forskarutbildningen vid Karolinska Instittutet.

Utbildning

Forskningsbeskrivning

Målet med min forskning är att skapa en grund för effektiv framtida behandling genom ökad kunskap om bakomliggande mekanismer vid utvecklandet av kronisk bronkit och kroniskt obstruktiv lungsjukdom (KOL). 

Pedagogiska meriter

  • Handleder doktorander och masterstudenter
  • Undervisar på läkarprogrammet och masterutbildningen i toxikologi
  • Föreläser  på olika nivåer inom 3R och avancerade lungmodeller

Länkar

Publikationer

Osteopontin protects against lung injury caused by extracellular histones
Kasetty G, Papareddy P, Bhongir Rkv, Ali Mn, Mori M, Wygrecka M, et al
Mucosal immunology 2019;12(1):39-50

Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity
Upadhyay S, Palmberg L
Toxicological sciences : an official journal of the Society of Toxicology 2018;164(1):21-30

Cadmium in tobacco smokers: a neglected link to lung disease?
Ganguly K, Levänen B, Palmberg L, Åkesson A, Lindén A
European respiratory review : an official journal of the European Respiratory Society 2018;27(147):-

Cholinergic mechanisms in an organic dust model simulating an acute exacerbation in patients with COPD
Palmberg L, Sundblad Bm, Ji J, Karén J, Larsson K
International journal of chronic obstructive pulmonary disease 2018;13():3611-3624

Inflammatory effects of acrolein, crotonaldehyde and hexanal vapors on human primary bronchial epithelial cells cultured at air-liquid interface
Dwivedi Am, Upadhyay S, Johanson G, Ernstgård L, Palmberg L
Toxicology in vitro : an international journal published in association with BIBRA 2018;46():219-228

Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization
Ji J, Upadhyay S, Xiong X, Malmlöf M, Sandström T, Gerde P, et al
Particle and fibre toxicology 2018;15(1):19-

Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population
Vishweswaraiah S, Thimraj Ta, George L, Krishnarao Cs, Lokesh Ks, Siddaiah Jb, et al
Disease markers 2018;2018():4949175-

Development of Combining of Human Bronchial Mucosa Models with XposeALI® for Exposure of Air Pollution Nanoparticles
Ji J, Hedelin A, Malmlöf M, Kessler V, Seisenbaeva G, Gerde P, et al
PloS one 2017;12(1):e0170428-

Interleukin-26 Production in Human Primary Bronchial Epithelial Cells in Response to Viral Stimulation: Modulation by Th17 cytokines
Che Kf, Kaarteenaho R, Lappi-blanco E, Levänen B, Sun J, Wheelock Å, et al
Molecular medicine (Cambridge, Mass.) 2017;23():247-257

Comparing human respiratory adverse effects after acute exposure to particulate matter in conventional and particle-reduced swine building environments
Hedelin As, Sundblad Bm, Sahlander K, Wilkinson K, Seisenbaeva G, Kessler V, et al
Occupational and environmental medicine 2016;73(10):648-55

Effects of budesonide on toll-like receptor expression in alveolar macrophages from smokers with and without COPD
Ji J, Von Schéele I, Billing B, Dahlén B, Lantz As, Larsson K, et al
International journal of chronic obstructive pulmonary disease 2016;11():1035-43

Extracellular cadmium in the bronchoalveolar space of long-term tobacco smokers with and without COPD and its association with inflammation
Sundblad Bm, Ji J, Levänen B, Midander K, Julander A, Larsson K, et al
International journal of chronic obstructive pulmonary disease 2016;11():1005-13

Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways
Levänen B, Glader P, Dahlén B, Billing B, Qvarfordt I, Palmberg L, et al
International journal of chronic obstructive pulmonary disease 2016;11():2109-2116

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD
Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, et al
The European respiratory journal 2016;47(6):1645-56

Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4
Lukic A, Ji J, Idborg H, Samuelsson B, Palmberg L, Gabrielsson S, et al
Journal of lipid research 2016;57(9):1659-69

Acute effects of acrolein in human volunteers during controlled exposure
Dwivedi Am, Johanson G, Lorentzen Jc, Palmberg L, Sjögren B, Ernstgård L
Inhalation toxicology 2015;27(14):810-21

Long term effect and allergic sensitization in newly employed workers in laboratory animal facilities
Palmberg L, Sundblad Bm, Lindberg A, Kupczyk M, Sahlander K, Larsson K
Respiratory medicine 2015;109(9):1164-73

Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells
Feliu N, Kohonen P, Ji J, Zhang Y, Karlsson Hl, Palmberg L, et al
ACS nano 2015;9(1):146-63

Compartment differences of inflammatory activity in chronic obstructive pulmonary disease
Ji J, Von Schéele I, Bergström J, Billing B, Dahlén B, Lantz As, et al
Respiratory research 2014;15():104-

Interactions between alveolar epithelial cells and neutrophils under pro-inflammatory conditions
Von Schéele I, Larsson K, Palmberg L
European clinical respiratory journal 2014;1():-

Interleukin-26 in Antibacterial Host Defense of Human Lungs Effects on Neutrophil Mobilization
Che Kf, Tengvall S, Levanen B, Silverpil E, Smith Me, Awad M, et al
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2014;190(9):1022-31

Adhesion molecules in subjects with COPD and healthy non-smokers: a cross sectional parallel group study
Blidberg K, Palmberg L, James A, Billing B, Henriksson E, Lantz As, et al
Respiratory research 2013;14():47-

Dental health in smokers with and without COPD
Bergström J, Cederlund K, Dahlén B, Lantz As, Skedinger M, Palmberg L, et al
PloS one 2013;8(3):e59492-

Chemokine release by neutrophils in chronic obstructive pulmonary disease
Blidberg K, Palmberg L, Dahlén B, Lantz As, Larsson K
Innate immunity 2012;18(3):503-10

Daily exposure to dust alters innate immunity
Sahlander K, Larsson K, Palmberg L
PloS one 2012;7(2):e31646-

Increased neutrophil migration in smokers with or without chronic obstructive pulmonary disease
Blidberg K, Palmberg L, Dahlén B, Lantz As, Larsson K
Respirology (Carlton, Vic.) 2012;17(5):854-60

Solution-Engineered Palladium Nanoparticles: Model for Health Effect Studies of Automotive Particulate Pollution
Wilkinson Ke, Palmberg L, Witasp E, Kupczyk M, Feliu N, Gerde P, et al
ACS NANO 2011;5(7):5312-24

Toll-like receptor expression in smokers with and without COPD
Von Scheele I, Larsson K, Dahlen B, Billing B, Skedinger M, Lantz As, et al
RESPIRATORY MEDICINE 2011;105(8):1222-30

Altered innate immune response in farmers and smokers
Sahlander K, Larsson K, Palmberg L
INNATE IMMUNITY 2010;16(1):27-38

Budesonide enhances Toll-like receptor 2 expression in activated bronchial epithelial cells
Von Scheele I, Larsson K, Palmberg L
INHALATION TOXICOLOGY 2010;22(6):493-9

Effect of formoterol and budesonide on chemokine release, chemokine receptor expression and chemotaxis in human neutrophils
Strandberg K, Blidberg K, Sahlander K, Palmberg L, Larsson K
PULMONARY PHARMACOLOGY & THERAPEUTICS 2010;23(4):316-23

Increased Serum Levels of Soluble ST2 in Birch Pollen Atopics and Individuals Working in Laboratory Animal Facilities
Sahlander K, Larsson K, Palmberg L
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 2010;52(2):214-8

Evaluation of respiratory effects related to high-pressure cleaning in a piggery with and without robot pre-cleaning
Hiel D, Von Scheele I, Sundblad Bm, Larsson K, Palmberg L
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH 2009;35(5):376-83

Repeated exposure to organic material alters inflammatory and physiological airway responses
Sundblad Bm, Von Scheele I, Palmberg L, Olsson M, Larsson K
EUROPEAN RESPIRATORY JOURNAL 2009;34(1):80-8

Effect of budesonide and formoterol on Il-6 and Il-8 release from primary bronchial epithelial cells
Strandberg K, Palmberg L, Larsson K
JOURNAL OF ASTHMA 2008;45(3):201-3

Fluticasone and ibuprofen do not add to the effect of salmeterol on organic dust-induced airway inflammation and bronchial hyper-responsiveness
Strandberg K, Ek A, Palmberg L, Larsson K
JOURNAL OF INTERNAL MEDICINE 2008;264(1):83-94

Differential pattern of human blood neutrophil activation after stimulation with organic dust in vitro and in vivo
Jonsson Ew, Palmberg L
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 2007;49(2):131-8

Effect of formoterol and salmeterol on IL-6 and IL-8 release in airway epithelial cells
Strandberg K, Palmberg L, Larsson K
RESPIRATORY MEDICINE 2007;101(6):1132-9

Organic dust-induced activation, adhesion to substrate and expression of intercellular adhesion molecules in THP-1 monocytes
Burvall K, Palmberg L, Larsson K
LIFE SCIENCES 2007;80(17):1598-607

Effect of respirators equipped with particle or particle-and-gas filters during exposure in a pig confinement building
Sundblad Bm, Sahlander K, Ek A, Kumlin M, Olsson M, Larsson K, et al
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH 2006;32(2):145-53

Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects
Larsson Bm, Kumlin M, Sundblad Bm, Larsson K, Dahlen Se, Palmberg L
RESPIRATORY MEDICINE 2006;100(2):226-37

Prostaglandin D2 release from mast cells after anti-IgE and/or IL-1 beta stimulation
Gulliksson M, Palmberg L, Nilsson G, Kumlin M
PROSTAGLANDINS & OTHER LIPID MEDIATORS 2006;79(1-2):174-174

Release of prostaglandin D-2 and leukotriene C-4 in response to hyperosmolar stimulation of mast cells
Gulliksson M, Palmberg L, Nilsson G, Ahlstedt S, Kumlin M
ALLERGY 2006;61(12):1473-9

Saliva is one likely source of leukotriene B-4 in exhaled breath condensate
Gaber F, Acevedo F, Delin I, Sundblad Bm, Palmberg L, Larsson K, et al
EUROPEAN RESPIRATORY JOURNAL 2006;28(6):1229-35

Exposure to organic dust causes activation of human plasma complement factors C3 and B and the synthesis of factor C3 by lung epithelial cells in vitro
Acevedo F, Palmberg L, Larsson K
INFLAMMATION 2005;29(1):39-45

Expression of TNFalpha and its receptors R1 and R2 in human alveolar epithelial cells exposed to organic dust and the effects of 8-bromo-cAMP and protein kinase A modulation
Burvall K, Palmberg L, Larsson K
INFLAMMATION RESEARCH 2005;54(7):281-8

Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust
Ivanov S, Palmberg L, Venge P, Larsson K, Linden A
RESPIRATORY RESEARCH 2005;:44-

Salmeterol does not alter increased bronchial responsiveness caused by organic dust exposure
Ek A, Palmberg L, Sundblad Bm, Larsson K
CHEST 2005;128(4):3038-47

Acute respiratory effects of exposure to ammonia on healthy persons
Sundblad Bm, Larsson Bm, Acevedo F, Ernstgard L, Johanson G, Larsson K, et al
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH 2004;30(4):313-21

Influence of 8-bromo-cyclicAMP on interleukin-6 and-8 mRNA levels in A549 human lung epithelial cells exposed to organic dust: A time-kinetic study
Burvall K, Palmberg L, Larsson K
LIFE SCIENCES 2004;75(23):2733-49

Partial protection by respirators on airways responses following exposure in a swine house
Palmberg L, Larsson Bm, Sundblad Bm, Larsson K
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 2004;46(4):363-70

The effect of fluticasone on the airway inflammatory response to organic dust
Ek A, Palmberg L, Larsson K
EUROPEAN RESPIRATORY JOURNAL 2004;24(4):587-93

Working group report 1: Tools for the diagnosis of organic dusts-induced disease
Wouters Im, Sigsgaard T, Gora A, Nowak D, Palmberg L, Sundblad Bm, et al
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 2004;46(4):410-3

De novo synthesis of IL-17 in human airways following exposure to organic dust
Ivanov S, Prause O, Palmberg L, Larsson K, Linden A
EUROPEAN RESPIRATORY JOURNAL 2003;:42S-42S

Effects by 8-bromo-cyclicAMP on basal and organic dust-induced release of interleukin-6 and interleukin-8 in A549 human airway epithelial cells
Burvall K, Palmberg L, Larsson K
RESPIRATORY MEDICINE 2003;97(1):46-50

Organic dust activates NF-kappa B in lung epithelial cells
Liden J, Ek A, Palmberg L, Okret S, Larsson K
RESPIRATORY MEDICINE 2003;97(8):882-92

Red blood cells stimulate human lung fibroblasts to secrete interleukin-8
Fredriksson K, Lundahl J, Palmberg L, Romberger Dj, Liu Xd, Rennard Si, et al
INFLAMMATION 2003;27(2):71-8

Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building
Palmberg L, Larssson Bm, Malmberg P, Larsson K
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH 2002;28(4):256-63

Airways inflammation after exposure in a swine confinement building during cleaning procedure
Larsson Bm, Larsson K, Malmberg P, Palmberg L
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 2002;41(4):250-8

Bronchial responsiveness to eucapnic hyperventilation and methacholine following exposure to organic dust
Sundblad Bm, Palmberg L, Larsson K
CHEST 2002;122(1):363-8

Exhaled nitric oxide and bronchial responsiveness in healthy subjects exposed to organic dust
Sundblad Bm, Larsson Bm, Palmberg L, Larsson K
EUROPEAN RESPIRATORY JOURNAL 2002;20(2):426-31

Free, soluble interleukin-17 protein during severe inflammation in human airways
Laan M, Palmberg L, Larsson K, Linden A
EUROPEAN RESPIRATORY JOURNAL 2002;19(3):534-7

Metabolic activation of A549 human airway epithelial cells by organic dust: A study based on microphysiometry
Burvall K, Palmberg L, Larsson K
LIFE SCIENCES 2002;71(3):299-309

Modulation of plasma levels of soluble adhesion molecules and nitric oxide in healthy volunteers by exposure to swine dust
Kolbeck Kg, Sardh E, Gyllenhammar H, Palmberg L, Larsson K, Palmblad J
INFLAMMATION 2002;26(6):291-6

The tyrosine kinase inhibitor genistein increases basal cAMP and potentiates forskolin-induced cAMP accumulation in A549 human airway epithelial cells
Burvall Km, Palmberg L, Larsson K
MOLECULAR AND CELLULAR BIOCHEMISTRY 2002;240(1-2):131-3

Albumin, transferrin and alpha(2)-macroglobulin in bronchoalveolar lavage fluid following exposure to organic dust in healthy subjects
Vesterberg O, Palmberg L, Larsson K
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 2001;74(4):249-54

Sodium cromoglycate attenuates pulmonary inflammation without influencing bronchial responsiveness in healthy subjects exposed to organic dust
Larsson K, Larsson Bm, Sandstrom T, Sundblad Bm, Palmberg L
CLINICAL AND EXPERIMENTAL ALLERGY 2001;31(9):1356-68

Airway reactivity and exhaled NO following swine dust exposure in healthy volunteers
Kolbeck Kg, Ehnhage A, Juto Je, Forsberg S, Gyllenhammar H, Palmberg L, et al
RESPIRATORY MEDICINE 2000;94(11):1065-72

Influence of fluticasone and salmeterol on airway effects of inhaled organic dust; an in vivo and ex vivo study
Ek A, Palmberg L, Larsson K
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2000;121(1):11-6

Airway responses in naive subjects to exposure in poultry houses: Comparison between cage rearing system and alternative rearing system for laying hens
Larsson Bm, Larsson K, Malmberg P, Martensson L, Palmberg L
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 1999;35(2):142-9

Fluticasone and budesonide inhibit cytokine release in human lung epithelial cells and alveolar macrophages
Ek A, Larsson K, Siljerud S, Palmberg L
ALLERGY 1999;54(7):691-9

Gram positive bacteria induce IL-6 and IL-8 production in human alveolar macrophages and epithelial cells
Larsson Bm, Larsson K, Malmberg P, Palmberg L
INFLAMMATION 1999;23(3):217-30

House dust induces IL-6 and IL-8 response in A549 epithelial cells
Saraf A, Larsson L, Larsson Bm, Larsson K, Palmberg L
INDOOR AIR 1999;9(4):219-25

Swine dust induces cytokine secretion from human epithelial cells and alveolar macrophages
Wang Z, Malmberg P, Ek A, Larsson K, Palmberg L
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 1999;115(1):6-12

Budesonide but not terbutaline decreases phagocytosis in alveolar macrophages
Zetterlund A, Larsson Ph, Muller-suur C, Palmberg L, Larsson K
RESPIRATORY MEDICINE 1998;92(2):162-6

Exposure of healthy volunteers to swine house dust increases formation of leukotrienes, prostaglandin D-2, and bronchial responsiveness to methacholine
O'sullivan S, Dahlen Se, Larsson K, Larsson Bm, Malmberg P, Kumlin M, et al
THORAX 1998;53(12):1041-6

Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro by swine dust
Palmberg L, Larsson Bm, Malmberg P, Larsson K
THORAX 1998;53(4):260-4

Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects
Larsson K, Tornling G, Gavhed D, Muller-suur C, Palmberg L
EUROPEAN RESPIRATORY JOURNAL 1998;12(4):825-30

DNA adducts in human nasal mucosa and white blood cells from smokers and non-smokers
Zhao Cy, Georgellis A, Flato S, Palmberg L, Thunberg E, Hemminki K
CARCINOGENESIS 1997;18(11):2205-8

Effect of exposure to swine dust on levels of IL-8 in airway lavage fluid
Larsson Bm, Palmberg L, Malmberg Po, Larsson K
THORAX 1997;52(7):638-42

Inhalation of swine dust induces cytokine release in the upper and lower airways
Wang Z, Larsson K, Palmberg L, Malmberg P, Larsson P, Larsson L
EUROPEAN RESPIRATORY JOURNAL 1997;10(2):381-7

Reaction of human alveolar macrophages to exposure to Aspergillus fumigatus and inert particles
Nessa K, Palmberg L, Johard U, Malmberg P, Jarstrand C, Camner P
ENVIRONMENTAL RESEARCH 1997;75(2):141-8

Acute effects of exposure to air contaminants in a sawmill on healthy volunteers
Dahlqvist M, Palmberg L, Malmberg P, Sundblad Bm, Ulfvarson U, Zhiping W
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 1996;53(9):586-90

Visa alla publikationer

Filmer