Julian Walfridsson

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: LEUKEMIA. 2023;37(3):593-605

The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes.

Trempenau ML; Schuster MB; Pundhir S; Pereira MA; Kalvisa A; Tapia M; Su J; Ge Y; de Boer B; Balhuizen A; Bagger FO; Shliaha P; Sroczynska P; Walfridsson J; Grønbæk K; Theilgaard-Mönch K; Jensen ON; Helin K; Porse BT
Article: BLOOD. 2022;139(20):3040-3057

Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression.

Cai H; Kondo M; Sandhow L; Xiao P; Johansson A-S; Sasaki T; Zawacka-Pankau J; Tryggvason K; Ungerstedt J; Walfridsson J; Ekblom M; Qian H
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:880668

FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors.

Peña-Pérez L; Kharazi S; Frengen N; Krstic A; Bouderlique T; Hauenstein J; He M; Somuncular E; Li Wang X; Dahlberg C; Gustafsson C; Johansson A-S; Walfridsson J; Kadri N; Woll P; Kierczak M; Qian H; Westerberg L; Luc S; Månsson R
Article: CANCER RESEARCH. 2021;81(22):5733-5744

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.

Sanjiv K; Calderón-Montaño JM; Pham TM; Erkers T; Tsuber V; Almlöf I; Höglund A; Heshmati Y; Seashore-Ludlow B; Nagesh Danda A; Gad H; Wiita E; Göktürk C; Rasti A; Friedrich S; Centio A; Estruch M; Våtsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Mönch K; Garnett MJ; Östling P; Walfridsson J; Helleday T; Warpman Berglund U
Article: MOLECULAR CANCER RESEARCH. 2020;18(10):1522-1533

HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment.

Johard H; Omelyanenko A; Fei G; Zilberter M; Dave Z; Abu-Youssef R; Schmidt L; Harisankar A; Vincent CT; Walfridsson J; Nelander S; Harkany T; Blomgren K; Andäng M
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.

Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CB; Sandhow L; Kutzner J; Hed Myrberg I; Bunten SS; Axelsson H; Zhang SM; Rasti A; Mäkelä P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtiö J; Rassidakis GZ; Pokrovskaja Tamm K; Warpman-Berglund U; Heyman M; Grandér D; Lehmann S; Lundbäck T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: SCIENTIFIC REPORTS. 2018;8(1):11202

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation.

Heshmati Y; Kharazi S; Türköz G; Chang D; Kamali Dolatabadi E; Boström J; Krstic A; Boukoura T; Wagner E; Kadri N; Månsson R; Altun M; Qian H; Walfridsson J
Article: HAEMATOLOGICA. 2018;103(7):1169-1181

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia.

Heshmati Y; Türköz G; Harisankar A; Kharazi S; Boström J; Dolatabadi EK; Krstic A; Chang D; Månsson R; Altun M; Qian H; Walfridsson J
Article: BLOOD ADVANCES. 2018;2(12):1480-1494

Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice.

Xiao P; Sandhow L; Heshmati Y; Kondo M; Bouderlique T; Dolinska M; Johansson A-S; Sigvardsson M; Ekblom M; Walfridsson J; Qian H
Article: BLOOD ADVANCES. 2018;2(5):534-548

Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.

Xiao P; Dolinska M; Sandhow L; Kondo M; Johansson A-S; Bouderlique T; Zhao Y; Li X; Dimitriou M; Rassidakis GZ; Hellström-Lindberg E; Minato N; Walfridsson J; Scadden DT; Sigvardsson M; Qian H
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2018;117:247-257

Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis.

Khalkar P; Ali HA; Codó P; Argelich ND; Martikainen A; Arzenani MK; Lehmann S; Walfridsson J; Ungerstedt J; Fernandes AP
Article: NATURE MEDICINE. 2017;23(2):256-263

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Page BDG; Calderón-Montaño JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Höglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grandér D; Lundbäck T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: DRUG DESIGN DEVELOPMENT AND THERAPY. 2016;10:2881-2897

Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design.

Masoumi S; Harisankar A; Gracias A; Bachinger F; Fufa T; Chandrasekar G; Gaunitz F; Walfridsson J; Kitambi SS
Article: CYTOTHERAPY. 2015;17(12):1732-1745

Xeno-immunosuppressive properties of human decidual stromal cells in mouse models of alloreactivity in vitro and in vivo.

Sadeghi B; Heshmati Y; Khoein B; Kaipe H; Uzunel M; Walfridsson J; Ringdén O
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;171(4):478-490

Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts.

Conte S; Katayama S; Vesterlund L; Karimi M; Dimitriou M; Jansson M; Mortera-Blanco T; Unneberg P; Papaemmanuil E; Sander B; Skoog T; Campbell P; Walfridsson J; Kere J; Hellström-Lindberg E
Article: STEM CELL REPORTS. 2014;3(3):502-515

Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases.

Castelo-Branco G; Lilja T; Wallenborg K; Falcão AM; Marques SC; Gracias A; Solum D; Paap R; Walfridsson J; Teixeira AI; Rosenfeld MG; Jepsen K; Hermanson O
Article: BLOOD. 2014;123(12):1870-1882

shRNA screening identifies JMJD1C as being required for leukemia maintenance.

Sroczynska P; Cruickshank VA; Bukowski J-P; Miyagi S; Bagger FO; Walfridsson J; Schuster MB; Porse B; Helin K
Article: PLOS GENETICS. 2011;7(3):e1001334

The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation.

Strålfors A; Walfridsson J; Bhuiyan H; Ekwall K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(39):29729-29737

A chromatin-remodeling protein is a component of fission yeast mediator.

Khorosjutina O; Wanrooij PH; Walfridsson J; Szilagyi Z; Zhu X; Baraznenok V; Ekwall K; Gustafsson CM
Article: NUCLEIC ACIDS RESEARCH. 2010;38(15):4958-4969

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.

Pasini D; Malatesta M; Jung HR; Walfridsson J; Willer A; Olsson L; Skotte J; Wutz A; Porse B; Jensen ON; Helin K
Article: NATURE. 2010;464(7286):306-310

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

Pasini D; Cloos PAC; Walfridsson J; Olsson L; Bukowski J-P; Johansen JV; Bak M; Tommerup N; Rappsilber J; Helin K
Article: CANCER RESEARCH. 2009;69(21):8491-8498

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.

Ciró M; Prosperini E; Quarto M; Grazini U; Walfridsson J; McBlane F; Nucifero P; Pacchiana G; Capra M; Christensen J; Helin K
Article: EMBO JOURNAL. 2007;26(12):2868-2879

A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly.

Walfridsson J; Khorosjutina O; Matikainen P; Gustafsson CM; Ekwall K
Article: PLOS ONE. 2007;2(4):e386

Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1.

Opel M; Lando D; Bonilla C; Trewick SC; Boukaba A; Walfridsson J; Cauwood J; Werler PJH; Carr AM; Kouzarides T; Murzina NV; Allshire RC; Ekwall K; Laue ED
Article: GENETICS. 2007;175(4):1549-1560

Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.

Isaac S; Walfridsson J; Zohar T; Lazar D; Kahan T; Ekwall K; Cohen A
Article: EMBO JOURNAL. 2005;24(16):2906-2918

Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast.

Wirén M; Silverstein RA; Sinha I; Walfridsson J; Lee H-M; Laurenson P; Pillus L; Robyr D; Grunstein M; Ekwall K
Article: NUCLEIC ACIDS RESEARCH. 2005;33(9):2868-2879

The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres.

Walfridsson J; Bjerling P; Thalen M; Yoo E-J; Park SD; Ekwall K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):16648-16653

Dicer is required for chromosome segregation and gene silencing in fission yeast cells.

Provost P; Silverstein RA; Dishart D; Walfridsson J; Djupedal I; Kniola B; Wright A; Samuelsson B; Radmark O; Ekwall K
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Corrigendum: NUCLEIC ACIDS RESEARCH. 2021;49(15):gkab625--9001

Correction to 'Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes'.

Pasini D; Malatesta M; Jung HR; Walfridsson J; Willer A; Olsson L; Skotte J; Wutz A; Porse B; Jensen ON; Helin K
Other: CELL. 2017;170(2):407

Retraction Notice to: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule.

Kitambi SS; Toledo EM; Usoskin D; Wee S; Harisankar A; Svensson R; Sigmundsson K; Kalderén C; Niklasson M; Kundu S; Aranda S; Westermark B; Uhrbom L; Andäng M; Damberg P; Nelander S; Arenas E; Artursson P; Walfridsson J; Nilsson KF; Hammarström LGJ; Ernfors P

Anställningar

Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-2025

Examina och utbildning

Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2021
FILOSOFIE DOKTOR, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2007

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Anställningar

Examina och utbildning

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