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Om mig

Currently holds a position as Assistant Professor at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet. I received my Ph.D. degree from the Department of Oncology-Pathology, Karolinska Institutet in 2012 followed by postdoctoral training at Harvard University. In 2016, I joined The Centre for Translational Microbiome Research (CTMR) at Karolinska Institutet. My research interests focus on host-microbiota interactions.

Forskningsbeskrivning

Project 1: Cohort study: Microbiota interaction with Human Papillomavirus (HPV) related diseases

The goal for this project is to evaluate the microbiome from HPV infected individuals, pre-cancer and cancer patients before and after treatments. By comparing the data of HPV infected individuals with healthy controls, the probiotics that impact HPV clearance or cancer development will be selected for further investigation.

 

Project 2: In vitro microbiota culture and the usage of bacteriophage as a potential treatment for dysbiosis

In this project, we are developing a culture system of whole gut and vaginal microbiota in vitro. Meanwhile we are also isolating bacteriophages from pathogens in gut and vaginal microbiota. Using the in vitro culture microbiota model, we are testing and comparing potential treatments for dysbiosis such as bacteriophages and probiotic. Bacteriophage therapy is highly pathogen specific and suggested to have a more efficient impact on infections.

 

Project 3: Mechanism study for bacteria-bacteria and bacteria-host interaction

We have a large collection of commensal human gut and vaginal bacteria strains. We are testing the potential inhibition mechanism of commensal bacteria or probiotic on pathogens e.g. metabolism. We are also investigating the potential immune system response to different bacteria.

 

Project 4: Gut/Vagina-microbiota 3D model for host-microbiota interaction study

We aim to build up an in vitro 3D co-culture platform using a hydrogel system, which mimics the morphology of human small intestine and vagina, as a foundation for co-culturing human small intestine cell lines or vaginal cell lines with human microbiota in order to evaluate the interactions between host and microbiota.

 

Lab members:

Juan Du, Ph.D. Assistant Professor
Liqin Cheng, PhD student, Karolinska Institutet
Unnur Guðnadóttir, Master student, 2019, Uppsala University
Sebastian-Alexandru Radu, Bachelor student, 2018-2019, Karolinska Institutet

 

Alumni:

Yue Hu, PostDoc fellow, 2017-2018, Karolinska Institutet
Tabusi Mahebali, Master student, 2018, Karolinska Institutet
IngTsyr Beh, Bachelor exchange student, 2017, Karolinska Institutet
Gloria Natalia Loko, Master, 2017-2018, Uppsala University
Daniel Scheiner, Bachelor exchange student, 2018, Karolinska Institutet
Arlisa Alisjahbana, Master, 2017, Karolinska Institutet, Summer project
Julia Foyer, Bachelor, 2017, Karolinska Institutet, Summer project
Mikaela Svensson, Bachelor, 2017-2018, Imperial College London, Summer project
Andreas Ährlund-Richter, Master student, 2017, University of Skövde.

 

Funding

Current:

Stiftelsens för Strategisk Forskning (SSF)-Ingvar Carlsson Award
Åke Wibergs stiftelse
Harald Jeanssons Stiftelse
Extra satsning juniora forskare KI Forskningsbidrag
Föreningen för Klinisk Mikrobiologi
Clas Groschinskys minnesfonds (CGM)
Svenska Läkaresällskapet (SLS)

 

Past:

Åke Wibergs stiftelse
Harald Jeanssons Stiftelse
Stiftelsen Längmanska kulturfonden
Stiftelsen Lars Hiertas Minne
Fredrik och Ingrid Thurings Stiftelse
Svenska Sällskapet för Medicinsk Forskning (SSMF)

 

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