Gefei Chen
Senior Forskare
E-postadress: gefei.chen@ki.se
Besöksadress: Blickagången 16, 14152 Flemingsberg
Postadress: H2 Biovetenskaper och näringslära, H2 BioNut Johansson Chen, 171 77 Stockholm
Om mig
- *Honours*
Biträdande Lektor position at KI (Stockholm, Sweden), 2019
*Commissions of trust*
/Grant review/
1) Austrian Science Fund (FWF) in the frame of the programme for funding
patient oriented clinical research (KLIF).
/Journal editorial board /
1) Young Editorial Board of /Military Medical Research/
2) Editorial Board Member for /Scientific Reports/
3) Editorial Board (Review Editor), /Frontiers in Molecular Bioscience/
*Funding*
Our projects are financially supported by Alzheimer's Association Research
Grant (U.S.), Petrus och Augusta Hedlunds Stiftelse, Åhlén-stiftelsens
Olle Engkvists Stiftelse, Alzheimerfonden, Stiftelsen Sigurd och Elsa Goljes
Minne, Loo and Hans Osterman Foundation for Medical Research, Gun and Bertil
Stohne's Foundation, Magnus Bergvalls Stiftelse, Karolinska Institutet
Research Foundation Grants, Foundation for Geriatric Diseases at Karolinska
Institutet, and Stiftelsen för Gamla Tjänarinnor.
Forskningsbeskrivning
- Research group [1]
Surveillance by molecular chaperones may decline, and proteins misfold and
self-assemble into amorphous aggregates as well as fibrillar amyloid which
are linked to cureless human diseases. Our research aims to understand how
molecular chaperones interfere with different types of protein aggregation
and alleviate relevant toxicities, and augment specific chaperone capacity
for novel treatment developments, in particular against cancer and
neurodegenerative diseases. On the other side, non-pathological amyloid is
supposed to be shared by spider silk, one of the toughest biomaterials.
Currently, our understanding of amyloid-like formation during spider silk
assembly process and underlying mechanisms are largely missing.
*Selected publications *
*(*corresponding author, #equal contribution)*
[34] Andrade-Talavera Y#, *Chen G#*, Pansieri J#, Arroyo-García L. E,
Toleikis Z, Smirnovas V, Johansson J, Morozova-Roche L, Fisahn A. S100A9
amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in
area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS [2].
/Progress in Neurobiology, // /*2022*.
[33]* Chen G**, Andrade-Talavera Y, Zhong X, Hassan S, Biverstal H, Poska H,
Abelein A, Leppert A, Kronqvist N, Rising A, Hebert H, Koeck P, Fisahn A,
Johansson J. Ability of the BRICHOS domain to prevent neurotoxicity and
fibril formation are dependent on a highly conserved Asp residue [3]. /RSC
Chemical Biology/, 2022.
[32] Manchanda S, Galan-Acosta L, Abelein A, Tambaro S, *Chen G*, Nilsson P,
Johansson J. Intravenous treatment with a molecular chaperone designed
against amyloid-β toxicity improves features of Alzheimer disease pathology
in mouse models [4]. /Molecular Therapy/, 2022, S1525-0016(22)00498-1.
[31] Arndt T, Jaudzems K, Shilkova O, Francis J, Johansson M, Laity P, Sahin
C, Chatterjee U, Kronqvist N, Barajas-Ledesma E, Kumar R, *Chen G*,
Strömberg R, Abelein A, Langton M, Landreh M, Barth A, Holland C, Johansson
J, Rising A. Spidroin N-terminal domain forms amyloid-like fibril based
hydrogels and provides a protein immobilization platform [5]. /Nature
Communications/, 2022, 13(1):4695.
[30] Zhong X, Kumar R, Wang Y, Biverstal H, Jegerschöld C, Koeck P,
Johansson J, Abelein A, *Chen G**. Amyloid fibril formation of Arctic
amyloid-β 1–42 peptide is efficiently inhibited by the BRICHOS domain [6].
/ACS Chemical Biology/, 2022, 17(8):2201-2211.
[29] Tang X, Liu L, Miao Z, Zhang J, Cai X, Zhao B-Q, *Chen G*, Schultzberg
M, Zhao Y, Wang X. Resolution of inflammation is disturbed in acute ischemic
stroke with diabetes mellitus and rescued by resolvin D2 treatment [7]. /Free
Radical Biology and Medicine/, 2022, 188:194-205.
[28] Jiang R, Smailovic U, Haytural H, Tijms B, Li H, Haret R, Shevchenko G,
*Chen G*, Abelein A, Gobom J, Frykman S, Sekiguchi M, Fujioka R, Watamura N,
Sasaguri H, Nystrom S, Hammarstrom P, Saido T, Jelic V, Syvanen S, Zetterberg
H, Winblad B - Bergquist J, Visser P, Nilsson P. Increased CSF-decorin
predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
[8]. /Acta Neuropathologica Communications/, 2022, 10(1):96.
[27] Leppert A, *Chen G*, Lianoudaki D, Williams C, Zhong X, Gilthorpe J,
Landreh M, Johansson J. ATP-independent molecular chaperone activity
generated under reducing conditions [9]. /Protein Science/, 2022, 31(8):
e4378.
[26] Kaldmäe M, Vosselman T, Zhong X, Lama D, *Chen G*, Saluri M, Kronqvis
N, Siau J, Seng Ng A, Ghadessy F, Sabatier P, Vojtesek B, Sarr M, Sahin C,
Österlund N, Ilag L, Väänänen V, Sedimbi S, Arsenian-Henriksson M,
Zubarev R, Nilsson L, Koeck P, Rising A, Abelein A, Fritz N, Johansson J,
Lane D, and Landreh M. A “spindle and thread”-mechanism unblocks p53
translation by modulating N-terminal disorder [10]. /Structure, / 2022,
30(5):733-742.
[25] Oliveira D, Svensson J, Zhong X, Biverstål, *Chen G*#*, Karlström H*#.
Molecular chaperone BRICHOS inhibits CADASIL-mutated NOTCH3 aggregation in
vitro [11]. /Frontiers in Molecular Biosciences/, 2022, 9:812808.
[24] Li X, Qi X, Cai Y, Sun Y, Wen R, Zhang R, Johansson J, Meng Q*, *Chen
G**. Customized flagelliform spidroins form spider silk-like fibers at pH 8.0
with outstanding tensile strength [12]. /ACS Biomaterials Science &
Engineering/, 2022, 8(1): 119-127.
[23] Rising A, Gherardi P, *Chen G*, Johansson J, Oskarsson M, Westermark G,
Westermark P. AA amyloid in human food chain is a possible biohazard [13].
/Scientific Reports/, 2021, 11:21069.
[22] Andrade-Talavera Y, *Chen G*, Kurudenkandy F, Johansson J, Fisahn A.
Bri2 BRICHOS chaperone rescues impaired fast-spiking interneuron behavior and
neuronal network dynamics in an AD mouse model in vitro [14]. /Neurobiology
of Disease/, 2021, 159:105514.
[21] Schmuck B, *Chen G*, Pelcman J, Kronkvist N, Rising A, Johansson J.
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per
liter scale with an E. coli fed-batch culture [15]. /Microbial Cell
Factories/, 2021, 20(1):150.
[20] Zhao Q, Gong S, Jiang R, Li C, *Chen G*, Luo C, Qiu H, Liu J, Wang L,
Zhang R. Echocardiographic prognosis relevance of attenuated right heart
remodeling in idiopathic pulmonary arterial hypertension [16][J]. /Frontiers
in Cardiovascular Medicine/, 2021, 8:650848.
[19] Andrade-Talavera Y, Balleza-Tapia H, Dolz-Gaiton P, *Chen G, * Johansson
J, Fisahn A. Ablation of p75NTR-signaling strengthens gamma-theta rhythm
interaction and counteracts Aβ-induced degradation of neuronal dynamics in
mouse hippocampus in vitro [17][J]. /Translational Psychiatry/, 2021, 11:212.
[18] Tigro H, Kronqvist N, Abelein A, Galan-Acosta L, *Chen G*, Lyashkov A,
Aon M.A, Ferrucci L, Shimmo R, Johansson J, Moaddel R. The synthesis and
characterization of Bri2 BRICHOS coated magnetic particles and their
application to Protein Fishing: Identification of novel binding proteins
[18][J]. /Journal of Pharmaceutical and Biomedical Analysis/, 2021,
198:113996.
[17] Cai H#, *Chen G#*, Yu H, Tang Y, Xiong S, Qi X. One-step heating
strategy for efficient solubilization of recombinant spider silk protein from
inclusion bodies [19][J]. /BMC Biotechnology/, 2020, 20(1):37. (#equal
contributions)
[16] Andrade-Talavera Y, Arroyo-García L, *Chen G*, Johansson J, Fisahn
A. Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing
Aβ-induced desynchronization of fast-spiking interneuron firing in an AD
mouse model [20][J]. /The Journal of Physiology/, 2020, 598(17):3711-3725.
[15] Poska H, Leppert A, Tigro H, Zhong X, Kaldmäe M, Nilsson H,
Hebert H, *Chen G*, Johansson J. Recombinant Bri3 BRICHOS domain is a
bifunctional molecular chaperone [21][J]. /Scientific Reports/, 2020, 10(1):
9817.
[14] *Chen G*, Andrade-Talavera Y, Tambaro S, Leppert A, Nilsson H,
Zhong X, Landreh M, Nilsson P, Hebert H, Biverstål H, Fisahn A, Abelein A,
Johansson J. Augmentation of Bri2 molecular chaperone activity against
amyloid-β reduces neurotoxicity in mouse hippocampus in vitro [22][J].
/Communications Biology/, 2020, 3(1): 32.
[13] Abelein A, *Chen G*, Kitoka K, Aleksis R, Oleskovs F, Sarr M,
Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson
J, Biverstål H. High-yield Production of Amyloid-β Peptide Enabled by a
Customized Spider Silk Domain [23][J]. /Scientific Reports/, 2020, 10(1):235.
[12] Kaldmäe M, Leppert A, *Chen G*, Sarr M, Sahin C, Nordling K,
Kronqvist N, Gonzalvo-Ulla M, Fritz N, Abelein A, Laίn S, Biverstål H,
Jörnvall H, Lane DP, Rising A, Johansson J, Landreh M. High intracellular
stability of the spidroin N-terminal domain in spite of abundant
amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass
spectrometry [24][J]. /The FEBS Journal/, 2020, 287(13):2823-2833.
[11] Leppert A, *Chen G*, Johansson J. BRICHOS: a chaperone with
different activities depending on quaternary structure and cellular location?
[25][J]. /Amyloid/, 2019, 26(sup1):152-153.
[10] Tambaro S, Galan-Acosta L, Leppert A, *Chen G*, Biverstål H,
Presto J, Nilsson P, Johansson J. Blood-brain and blood-cerebrospinal fluid
passage of different BRICHOS molecular chaperone domains [26][J]. /The
Journal of Biological Chemistry/, 2019, 294(8): 2606-2615.
[9] Balleza-Tapia H, Crux S, Andrade-Talavera Y, Dolz-Gaiton P, Papadia
D, *Chen G*, Johansson J, Fisahn A. TrpV1 receptor activation rescues
neuronal function and network gamma oscillations from Aβ-induced impairment
in mouse hippocampus in vitro [27][J]. /eLife/, 2018, 7: e37703.
[8] Sarr M, Kronqvist N, *Chen G*, Aleksis R, Purhonen P, Hebert H,
Jaudzems K, Rising A, Johansson J. A spidroin-derived solubility tag enables
controlled aggregation of a designed amyloid protein [28][J]. /The FEBS
Journal/, 2018, 285(10): 1873-1885.
[7] *Chen G*, Abelein A, Nilsson H, Leppert A, Andrade-Talavera Y,
Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck P, Presto
J, Hebert H, Fisahn A, Johansson J. Bri2 BRICHOS client specificity and
chaperone activity are governed by assembly state [29][J]. /Nature
Communications/, 2017, 8: 2081.
[6] Poska H, Haslbeck M, Kurudenkandy FR, Hermansson E, *Chen G*,
Kostallas G, Abelein A, Biverstål H, Crux S, Fisahn A, Presto J, Johansson
J. Dementia related Bri2 BRICHOS is a versatile molecular chaperone that
efficiently inhibits Abeta42 toxicity in Drosophila [30][J]. /Biochemical
Journal/, 2016, 473(20): 3683-3704.
[5] Lin S, *Chen G*, Liu X, Meng Q. Chimeric spider silk proteins
mediated by intein result in artificial hybrid silks [31][J]. /Biopolymers/,
2016, 105(7): 385-392.
[4] Otikovs M#, *Chen G*#, Nordling K, Landreh M, Meng Q, Jörnvall H,
Kronqvist N, Rising A, Johansson J, Jaudzems K. Back Cover: Diversified
structural basis of a conserved molecular mechanism for ph-dependent
dimerization in spider silk N-terminal domains [32][J]. /ChemBioChem/, 2015,
16(12): 1720-1724. (#equal contributions)
[3] Andersson M#, *Chen G*#, Otikovs M, Landreh M, Nordling K,
Kronqvist N, Westermark P, Jörnvall H, Knight S, Ridderstråle Y, Holm L,
Meng Q, Jaudzems K, Chesler M, Johansson J, Rising A. Carbonic anhydrase
generates CO2 and H+ that drive spider silk formation via opposite effects on
the terminal domains [33][J]. /PLoS Biology/, 2014, 12(8): e100192.(#equal
contributions)
[2] Kronqvist N, Otikovs M, Chmyrov V, *Chen G*, Andersson M, Nordling
K, Landreh M, Sarr M, Jörnvall H, Wennmalm S, Widengren J, Meng Q, Rising A,
Otzen D, Knight SD, Jaudzems K, Johansson J. Sequential pH-driven
dimerization and stabilization of the N-terminal domain enables rapid spider
silk formation [34][J]. /Nature communications/, 2014, 5: 3254.
[1] *Chen G*, Liu X, Zhang Y, Lin S, Yang Z, Johansson J, Rising A,
Meng Q. Full-length minor ampullate spidroin gene sequence [35][J]. /PLoS
ONE/, 2012, 7(12): e52293.
*Gene and structure deposition*
/Genes/
1) /Araneus ventricosus/ clone F29-0811 minor ampullate spidroin gene,
complete cds (NCBI accession number JX513956). 32513 bp, DNA, 2012.
2) /A. ventricosus/ clone AvMiSp2 minor ampullate spidroin mRNA, partial cds
(NCBI accession number JX513955). 239 bp, mRNA, 2012.
3) /A. ventricosus/ clone AvMiSp1 minor ampullate spidroin mRNA, partial cds
(NCBI accession number JX513954). 370 bp, mRNA, 2012.
4) Argiope amoena tubuliform spidroin 1 (TuSp1) mRNA, partial cds. (NCBI
accession number JQ291306). 1273 bp, mRNA, 2012.
5) /A. ventricosus/ aciniform spidroin 1 (AcSp1) mRNA, partial cds (NCBI
accession number HQ008714). 6072 bp, mRNA, 2016.
6) Argiope amoena aciniform spidroin 1 (AcSp1) mRNA, partial cds. (NCBI
accession number HQ008715). 3216 bp, mRNA, 2016.
/Structures/
1) NMR structure of C-terminal domain from /A. ventricosus/ minor ampullate
spidroin (MiSp) (PDB ID: 2MFZ). 2014.
2) NMR structure of N-terminal domain from /A. ventricosus/ minor ampullate
spidroin (MiSp) at pH 7.2 (PDB ID: 2MX8). 2015.
3) NMR structure of N-terminal domain from /A. ventricosus/ minor ampullate
spidroin (MiSp) at pH 5.5 (PDB ID: 2MX9). 2015.
4) EM model of recombinant human Bri2 BRICHOS domain, oligomeric state (EMDB
accession code: EMD-3918). 2017.
5) EM model of recombinant human Bri2 BRICHOS D148N mutation, oligomeric
state (EMDB accession code: EMD-13005). 2021.
6) Cryo-EM structural model of recombinant human Bri2 BRICHOS oligomers
(EMDB accession code: EMD-13866 - PDB accession code: 7Q8X). 2022.
[1] https://ki.se/en/bionut/protein-misfolding-and-prevention-by-molecular-chaperones-in-cancer-and-neurodegenerative
[2] https://www.sciencedirect.com/science/article/pii/S0301008222001526?via%3Dihub
[3] https://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00187J?page=search
[4] https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(22)00498-1
[5] https://www.nature.com/articles/s41467-022-32093-7
[6] https://pubs.acs.org/doi/full/10.1021/acschembio.2c00344
[7] https://www.sciencedirect.com/science/article/pii/S0891584922004580?via%3Dihub
[8] https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-022-01398-5
[9] https://onlinelibrary.wiley.com/doi/10.1002/pro.4378
[10] https://www.sciencedirect.com/science/article/pii/S0969212622000491
[11] https://www.frontiersin.org/articles/10.3389/fmolb.2022.812808/full
[12] https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c01354
[13] https://www.nature.com/articles/s41598-021-00588-w
[14] https://www.sciencedirect.com/science/article/pii/S0969996121002631?via%3Dihub
[15] https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-021-01638-8
[16] https://www.frontiersin.org/articles/10.3389/fcvm.2021.650848/full
[17] https://www.nature.com/articles/s41398-021-01332-8
[18] https://pubmed.ncbi.nlm.nih.gov/33690096/
[19] https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-020-00630-1
[20] https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP279718
[21] https://www.nature.com/articles/s41598-020-66718-y
[22] https://www.nature.com/articles/s42003-020-0757-z
[23] https://www.nature.com/articles/s41598-019-57143-x
[24] https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15169
[25] https://www.tandfonline.com/doi/abs/10.1080/13506129.2019.1582511?journalCode=iamy20
[26] https://www.jbc.org/content/294/8/2606.long
[27] https://elifesciences.org/articles/37703
[28] https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.14451
[29] https://www.nature.com/articles/s41467-017-02056-4
[30] https://portlandpress.com/biochemj/article-abstract/473/20/3683/77446/Dementia-related-Bri2-BRICHOS-is-a-versatile?redirectedFrom=fulltext
[31] https://onlinelibrary.wiley.com/doi/abs/10.1002/bip.22828
[32] https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201500263
[33] https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001921
[34] https://www.nature.com/articles/ncomms4254
[35] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052293
Undervisning
- *Course teaching*
1) DIS summer lab course, abroad studies for students attending universities
in North America.
*Experience from acting supervisor*
/Supervisor of postdoc researcher/
1) Xingmei Qi
2) Ruixin Zhang
/Supervisor of PhD student/
1) Xueying Zhong (KTH, Stockholm)
2) Yu Wang
3) Zihan Zheng
4) Zhen Jin
/Supervision of master students/
1) Axel Leppert
2) Margreet Koopman
3) Maiara Kolbe Musskopf
4) Julia Svensson
5) Hannah Barz
/Supervision of bachelor students/
1) Katarzyna Stojowska, KI Bachelor Degree Project.
Utvalda publikationer
-
Article: SMALL. 2023;19(46):e2304031
-
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497
-
Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366
-
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
-
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
-
Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2022;8(1):119-127
-
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808
-
Article: BMC BIOTECHNOLOGY. 2020;20(1):37
-
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
-
Article: NATURE COMMUNICATIONS. 2017;8(1):2081
-
Article: BIOPOLYMERS. 2016;105(7):385-392
-
Article: CHEMBIOCHEM. 2015;16(12):1720-1724
-
Journal article: CHEMBIOCHEM. 2015;16(12):1824
-
Article: PLOS BIOLOGY. 2014;12(8):e1001921
-
Article: PLOS ONE. 2012;7(12):e52293
Artiklar
-
Journal article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
-
Journal article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
-
Journal article: SMALL. 2023;19(46)
-
Journal article: IBRO NEUROSCIENCE REPORTS. 2023;15:s447
-
Article: BIOLOGY-BASEL. 2023;12(6):805
-
Article: PNAS NEXUS. 2023;2(2):pgac303
-
Article: MOLECULAR THERAPY. 2023;31(2):487-502
-
Article: NATURE COMMUNICATIONS. 2022;13(1):4695
-
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;188:194-205
-
Article: PROTEIN SCIENCE. 2022;31(8):e4378
-
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
-
Article: STRUCTURE. 2022;30(5):733-742.e7
-
Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514
-
Article: SCIENTIFIC REPORTS. 2021;11(1):21069
-
Article: MICROBIAL CELL FACTORIES. 2021;20(1):150
-
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996
-
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212
-
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:650848
-
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(17):3711-3725
-
Article: FEBS JOURNAL. 2020;287(13):2823-2833
-
Article: SCIENTIFIC REPORTS. 2020;10(1):9817
-
Article: SCIENTIFIC REPORTS. 2020;10(1):235
-
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
-
Article: FEBS JOURNAL. 2018;285(10):1873-1885
-
Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2016;32(12):1704-1714
-
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
-
Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2014;30(8):1308-1317
-
Article: NATURE COMMUNICATIONS. 2014;5:3254
-
Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2013;29(9):1323-1331
- Visa fler
Alla övriga publikationer
-
Letter: NANO LETTERS. 2023;23(12):5836-5841
-
Review: PROTEIN SCIENCE. 2023;32(6):e4645
-
Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S54
-
Preprint: 2021;Research Square
-
Preprint: 2021;bioRxiv
-
Preprint: 2021;SSRN Electronic Journal
-
Preprint: 2020;Research Square
-
Preprint: 2020;Research Square
-
Preprint: 2019;Research Square
-
Meeting abstract: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 2019;26(sup1):152-153
-
Conference publication: PROTEIN SCIENCE. 2017;26:18-19
-
Conference publication: PROTEIN SCIENCE. 2017;26:31-32