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Research description

I am now working with 1) the project that aims to unravel the mechanisms behind how the novel endogenous chaperone Bri2 BRICHOS inhibits Aβ accumulation, and also how Bri2 BRICHOS acts as a general molecular chaperone, for better understanding of Bri2 BRICHOS used in future AD treatment. For this purpose, we will study the details of inhibition of Aβ fibrillation and general molecular chaperone activity respectively, and also determine tertiary and/or quaternary structures to unravel the mechanisms at molecular level behind the effects of Bri2 BRICHOS; 2) the project of using highly soluble tag (NT domain derived from spider silk protein to generate Aβ42 peptide in a large scale with and without blood brain barrier panetrating tags; and also prepare homogenous C13 and N15 labelled Aβ42 fibrils for solid NMR structure stud  

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