Faiez Al Nimer

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Neurologist, Clinical Researcher interested in immunopathogenesis of multiple
sclerosis with focus on HLA, EBV infection and B cell depleting therapies.

Artiklar

Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29(11):3317-3328

B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.

Asplund Högelin K; Ruffin N; Pin E; Hober S; Nilsson P; Starvaggi Cucuzza C; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: LANCET NEUROLOGY. 2022;21(8):693-703

Safety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled trial.

Svenningsson A; Frisell T; Burman J; Salzer J; Fink K; Hallberg S; Hambraeus J; Axelsson M; Nimer FA; Sundström P; Gunnarsson M; Johansson R; Mellergård J; Rosenstein I; Ayad A; Sjöblom I; Risedal A; de Flon P; Gilland E; Lindeberg J; Shawket F; Piehl F; Lycke J
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2022;9(7):962-976

Copy number variations across the blood-brain barrier in multiple sclerosis.

Bedri SK; Evertsson B; Khademi M; Al Nimer F; Olsson T; Hillert J; Glaser A
Article: SCIENCE ADVANCES. 2022;8(17):eabn1823

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.

Bronge M; Högelin KA; Thomas OG; Ruhrmann S; Carvalho-Queiroz C; Nilsson OB; Kaiser A; Zeitelhofer M; Holmgren E; Linnerbauer M; Adzemovic MZ; Hellström C; Jelcic I; Liu H; Nilsson P; Hillert J; Brundin L; Fink K; Kockum I; Tengvall K; Martin R; Tegel H; Gräslund T; Al Nimer F; Guerreiro-Cacais AO; Khademi M; Gafvelin G; Olsson T; Grönlund H
Article: ISCIENCE. 2021;24(9):103078

Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.

Asplund Högelin K; Ruffin N; Pin E; Månberg A; Hober S; Gafvelin G; Grönlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: JOURNAL OF IMMUNOLOGY. 2021;207(1):90-100

Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury.

Needham EJ; Stoevesandt O; Thelin EP; Zetterberg H; Zanier ER; Al Nimer F; Ashton NJ; Outtrim JG; Newcombe VFJ; Mousa HS; Simrén J; Blennow K; Yang Z; Hutchinson PJ; Piehl F; Helmy AE; Taussig MJ; Wang KKW; Jones JL; Menon DK; Coles AJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(17):e2011574118

Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology.

Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Han Y; James T; Khademi M; Al Nimer F; Scicluna P; Huang J; Kockum I; Faridani OR; Olsson T; Piehl F; Jagodic M
Article: CRITICAL CARE. 2021;25(1):103

Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.

Lindblad C; Pin E; Just D; Al Nimer F; Nilsson P; Bellander B-M; Svensson M; Piehl F; Thelin EP
Article: CLINICA CHIMICA ACTA. 2021;512:74-83

Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury.

Minta K; Brinkmalm G; Thelin EP; Al Nimer F; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: SCIENTIFIC REPORTS. 2020;10(1):18075

Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain injury.

Minta K; Brinkmalm G; Al Nimer F; Thelin EP; Piehl F; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2020;7(4):e775

Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS.

Duell F; Evertsson B; Al Nimer F; Sandin Å; Olsson D; Olsson T; Khademi M; Hietala MA; Piehl F; Hansson M
Article: NEUROTHERAPEUTICS. 2020;17(3):1142-1152

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate.

Carlström KE; Chinthakindi PK; Espinosa B; Al Nimer F; Arnér ESJ; Arvidsson PI; Piehl F; Johansson K
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2020;37:101468

Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; no evidence of rebound disease activity.

Juto A; Fink K; Al Nimer F; Piehl F
Article: JOURNAL OF NEUROTRAUMA. 2019;36(20):2850-2862

A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury.

Thelin E; Al Nimer F; Frostell A; Zetterberg H; Blennow K; Nyström H; Svensson M; Bellander B-M; Piehl F; Nelson DW
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2019;57(10):1565-1573

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Minta K; Cullen NC; Nimer FA; Thelin EP; Piehl F; Clarin M; Tullberg M; Jeppsson A; Portelius E; Zetterberg H; Blennow K; Andreasson U
Article: NATURE MEDICINE. 2019;25(8):1290-1300

GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis.

Galli E; Hartmann FJ; Schreiner B; Ingelfinger F; Arvaniti E; Diebold M; Mrdjen D; van der Meer F; Krieg C; Nimer FA; Sanderson N; Stadelmann C; Khademi M; Piehl F; Claassen M; Derfuss T; Olsson T; Becher B
Article: NATURE COMMUNICATIONS. 2019;10(1):3081

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes.

Carlström KE; Ewing E; Granqvist M; Gyllenberg A; Aeinehband S; Enoksson SL; Checa A; Badam TVS; Huang J; Gomez-Cabrero D; Gustafsson M; Al Nimer F; Wheelock CE; Kockum I; Olsson T; Jagodic M; Piehl F
Article: BMJ CASE REPORTS. 2019;12(2):e226832

Morvan's syndrome treated successfully with rituximab and lacosamide.

Sveinsson O; Al Nimer F; Piehl F
Article: CELL. 2018;175(1):85-100.e23

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis.

Jelcic I; Al Nimer F; Wang J; Lentsch V; Planas R; Jelcic I; Madjovski A; Ruhrmann S; Faigle W; Frauenknecht K; Pinilla C; Santos R; Hammer C; Ortiz Y; Opitz L; Grönlund H; Rogler G; Boyman O; Reynolds R; Lutterotti A; Khademi M; Olsson T; Piehl F; Sospedra M; Martin R
Article: ENEURO. 2018;5(2):ENEURO.0335-ENEU17.2018

Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures.

Günther M; Al Nimer F; Piehl F; Risling M; Mathiesen T
Article: PSYCHONEUROENDOCRINOLOGY. 2018;89:53-58

Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers.

Brenner P; Granqvist M; Königsson J; Al Nimer F; Piehl F; Jokinen J
Article: CLINICAL IMMUNOLOGY. 2016;166-167:89-95

Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function.

Lindblom RPF; Aeinehband S; Ström M; Al Nimer F; Sandholm K; Khademi M; Nilsson B; Piehl F; Ekdahl KN
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2016;3(1):e191

Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination.

Al Nimer F; Elliott C; Bergman J; Khademi M; Dring AM; Aeinehband S; Bergenheim T; Romme Christensen J; Sellebjerg F; Svenningsson A; Linington C; Olsson T; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2015;12:192

Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response.

Lindblom RPF; Berg A; Ström M; Aeinehband S; Dominguez CA; Al Nimer F; Abdelmagid N; Heinig M; Zelano J; Harnesk K; Hübner N; Nilsson B; Ekdahl KN; Diez M; Cullheim S; Piehl F
Article: PLOS ONE. 2015;10(7):e0132177

Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light.

Al Nimer F; Thelin E; Nyström H; Dring AM; Svenningsson A; Piehl F; Nelson DW; Bellander B-M
Article: PLOS ONE. 2015;10(4):e0122048

Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis.

Aeinehband S; Lindblom RPF; Al Nimer F; Vijayaraghavan S; Sandholm K; Khademi M; Olsson T; Nilsson B; Ekdahl KN; Darreh-Shori T; Piehl F
Article: MOLECULAR PAIN. 2014;10:78

Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.

Dominguez CA; Carlström KE; Zhang X-M; Al Nimer F; Lindblom RPF; Ortlieb Guerreiro-Cacais A; Piehl F
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1138-1153

Unbiased expression mapping identifies a link between the complement and cholinergic systems in the rat central nervous system.

Lindblom RPF; Ström M; Heinig M; Al Nimer F; Aeinehband S; Berg A; Dominguez CA; Vijayaraghavan S; Zhang X-M; Harnesk K; Zelano J; Hübner N; Cullheim S; Darreh-Shori T; Diez M; Piehl F
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:60

Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury.

Lindblom RPF; Aeinehband S; Parsa R; Ström M; Al Nimer F; Zhang X-M; Dominguez CA; Flytzani S; Diez M; Piehl F
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(7):784-794

Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury.

Al Nimer F; Ström M; Lindblom R; Aeinehband S; Bellander B-M; Nyengaard JR; Lidman O; Piehl F
Article: PLOS ONE. 2013;8(5):e63172

Intense inflammation and nerve damage in early multiple sclerosis subsides at older age: a reflection by cerebrospinal fluid biomarkers.

Khademi M; Dring AM; Gilthorpe JD; Wuolikainen A; Al Nimer F; Harris RA; Andersson M; Brundin L; Piehl F; Olsson T; Svenningsson A
Article: BRAIN BEHAVIOR AND IMMUNITY. 2013;27(1):109-122

Strain influences on inflammatory pathway activation, cell infiltration and complement cascade after traumatic brain injury in the rat.

Al Nimer F; Lindblom R; Ström M; Guerreiro-Cacais AO; Parsa R; Aeinehband S; Mathiesen T; Lidman O; Piehl F
Article: ACTA NEUROCHIRURGICA. 2012;154(4):689-697

iNOS-mediated secondary inflammatory response differs between rat strains following experimental brain contusion.

Günther M; Al Nimer F; Gahm C; Piehl F; Mathiesen T
Article: NEUROMOLECULAR MEDICINE. 2012;14(1):15-29

Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons.

Ström M; Al Nimer F; Lindblom R; Nyengaard JR; Piehl F
Article: BRAIN BEHAVIOR AND IMMUNITY. 2011;25(5):981-990

Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury.

Al Nimer F; Beyeen AD; Lindblom R; Ström M; Aeinehband S; Lidman O; Piehl F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;212(1-2):82-92

Identification of gene regions regulating inflammatory microglial response in the rat CNS after nerve injury.

Diez M; Abdelmagid N; Harnesk K; Ström M; Lidman O; Swanberg M; Lindblom R; Al-Nimer F; Jagodic M; Olsson T; Piehl F
Article: EXPERIMENTAL NEUROLOGY. 2006;199(2):339-347

Sustained survival of xenografted human neural stem/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression.

Wennersten A; Holmin S; Al Nimer F; Meijer X; Wahlberg LU; Mathiesen T
Article: ACTA NEUROCHIRURGICA. 2006;148(2):199-205

Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats.

Rudehill S; Muhallab S; Wennersten A; von Gertten C; Al Nimer F; Sandberg-Nordqvist AC; Holmin S; Mathiesen T
Article: NEUROREPORT. 2004;15(12):1871-1875

MHC expression after human neural stem cell transplantation to brain contused rats.

Al Nimer F; Wennersten A; Holmin S; Meijer X; Wahlberg L; Mathiesen T
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Alla övriga publikationer

Thesis / dissertation: 2012

Genetics in experimental traumatic brain injury

Al Nimer, Faiez

Anställningar

Anknuten till Forskning, Klinisk neurovetenskap, Karolinska Institutet, 2023-2024

Examina och utbildning

Medicine Doktorsexamen, Institutionen för klinisk neurovetenskap, Karolinska Institutet, 2012

Om mig

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI