Cecilia Williams

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Hormonsignalering och icke-kodande RNA i cancer

Cecilia Williams leder en grupp på KI som delas med hennes labb på KTH och SciLifeLab. Hon doktorerade inom applicering av DNA-sekvenseringsteknologier för cancer vid KTH, gjorde postdoc inom transkriptom och stamceller, och kom som forskare till Karolinska Institutet 2005. 2009 började hon på Center of Nuclear Receptors and Cell Signaling vid University of Houston som biträdande lektor och fick tjänst som lektor där 2015. Hennes huvudsakliga verksamhet på BioNut är inriktad på att förstå hormonell signalering och rollen av icke-kodande RNA i cancer (fokus östrogenreceptorer), och innefattar handledning av doktorander.

Utbildning
1994 M.S. (Civ. Ing.) i kemiteknik med inriktning bioteknik, Kungliga Tekniska Högskolan, Stockholm
2002 Ph.D. Bioteknik, Kungliga Tekniska Högskolan. /Molecular Archaeology of Cancer - Analys av den mänskliga p53-tumörsuppressorgenen.

Utvalda publikationer

Article: BMC BIOLOGY. 2023;21(1):277

Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1.

Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):20

High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice.

Hases L; Stepanauskaite L; Birgersson M; Brusselaers N; Schuppe-Koistinen I; Archer A; Engstrand L; Williams C
Editorial comment: FRONTIERS IN ENDOCRINOLOGY. 2022;13:883229

Editorial: Role of Sex Steroids and Their Receptor in Cancers.

Giovannelli P; Ramaraj P; Williams C
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2022;1390:213-225

ERβ and Inflammation.

Hases L; Archer A; Williams C
Editorial comment: ESSAYS IN BIOCHEMISTRY. 2021;65(6):847-856

Nuclear receptors: from molecular mechanisms to therapeutics.

Frigo DE; Bondesson M; Williams C
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(3):692-706

Genome-wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity.

Indukuri R; Jafferali MH; Song D; Damdimopoulos A; Hases L; Zhao C; Archer A; Williams C
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(11):1216-1225

Menopausal hormone therapies and risk of colorectal cancer: a Swedish matched-cohort study.

Liu Q; Simin J; Debelius J; Fall K; Sadr-Azodi O; Engstrand L; Williams C; Brusselaers N
Article: CANCER CELL. 2018;33(4):690-705.e9

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

Berger AC; Korkut A; Kanchi RS; Hegde AM; Lenoir W; Liu W; Liu Y; Fan H; Shen H; Ravikumar V; Rao A; Schultz A; Li X; Sumazin P; Williams C; Mestdagh P; Gunaratne PH; Yau C; Bowlby R; Robertson AG; Tiezzi DG; Wang C; Cherniack AD; Godwin AK; Kuderer NM; Rader JS; Zuna RE; Sood AK; Lazar AJ; Ojesina AI; Adebamowo C; Adebamowo SN; Baggerly KA; Chen T-W; Chiu H-S; Lefever S; Liu L; MacKenzie K; Orsulic S; Roszik J; Shelley CS; Song Q; Vellano CP; Wentzensen N; Cancer Genome Atlas Research Network; Weinstein JN; Mills GB; Levine DA; Akbani R
Article: NATURE COMMUNICATIONS. 2017;8:15840

Insufficient antibody validation challenges oestrogen receptor beta research.

Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramström M; Söderberg O; Williams C; Asplund A

Artiklar

Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2024;242:106526

Estrogen receptor beta expression and role in cancers.

Monteiro FL; Stepanauskaite L; Archer A; Williams C
Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis.

Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke VM; Archer A; Williams C; Kutter C
Article: TOXICOLOGICAL SCIENCES. 2023;193(2):119-130

Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish.

Thrikawala S; Mesmar F; Bhattacharya B; Muhsen M; Mukhopadhyay S; Flores S; Upadhyay S; Vergara L; Gustafsson J-Å; Williams C; Bondesson M
Article: PROTEIN & CELL. 2023;14(2):123-136

NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation.

Cheng Y; Lu X; Li F; Chen Z; Zhang Y; Han Q; Zeng Q; Wu T; Li Z; Lu S; Williams C; Xia W
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2023;20(5):4181

Statistical Analysis of SARS-CoV-2 Using Wastewater-Based Data of Stockholm, Sweden.

Chekkala A; Atasoy M; Williams C; Cetecioglu Z
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2023;858(Pt 3):160023

Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm: What lessons can be learned from the Swedish perspective?

Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Article: CANCERS. 2022;14(24):6029

SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets.

Monteiro FL; Stepanauskaite L; Williams C; Helguero LA
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(18):10408

Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice.

Hases L; Birgersson M; Indukuri R; Archer A; Williams C
Journal article: ANNALS OF ONCOLOGY. 2022;33:s640

223P Gene expression profiles in endocrine-resistant breast cancer

Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Article: CANCERS. 2022;14(13):3098

Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens.

Huang D; Huang Z; Indukuri R; Bangalore Revanna C; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
Article: CANCERS. 2022;14(6):1414

A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer.

Monteiro FL; Williams C; Helguero LA
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:203-221

An Optimized ChIP-Seq Protocol to Determine Chromatin Binding of Estrogen Receptor Beta.

Indukuri R; Damdimopoulos A; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:1-23

Antibody Validation for Estrogen Receptor Beta.

Birgersson M; Katona B; Lindskog C; Pontén F; Williams C
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:930227

ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions.

Song D; He H; Indukuri R; Huang Z; Stepanauskaite L; Sinha I; Haldosén L-A; Zhao C; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:313-343

Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells.

Archer A; Kutter C; Williams C
Article: ACTA ONCOLOGICA. 2021;60(7):881-887

Prediagnostic use of estrogen-only therapy is associated with improved colorectal cancer survival in menopausal women: a Swedish population-based cohort study.

Simin J; Liu Q; Wang X; Fall K; Williams C; Callens S; Engstrand L; Brusselaers N
Article: CANCER LETTERS. 2021;506:23-34

Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor.

Song D; He H; Sinha I; Hases L; Yan F; Archer A; Haldosen L-A; Zhao C; Williams C
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2021;755(Pt 1):142939

Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater.

Jafferali MH; Khatami K; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354

The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers.

Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: FRONTIERS IN ENDOCRINOLOGY. 2021;12:650625

Estrogen Receptor Beta Influences the Inflammatory p65 Cistrome in Colon Cancer Cells.

Indukuri R; Hases L; Archer A; Williams C
Article: CANCER LETTERS. 2020;492:54-62

Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes.

Hases L; Indukuri R; Birgersson M; Nguyen-Vu T; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-Å; Katajisto P; Archer A; Williams C
Article: SCIENTIFIC REPORTS. 2020;10(1):16160

High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner.

Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-André M; Williams C
Article: PEERJ. 2020;8:e9434

Comparison of serum exosome isolation methods on co-precipitated free microRNAs.

Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
Article: MABS. 2020;12(1):1794421

The Antibody Society's antibody validation webinar series.

Voskuil JLA; Bandrowski A; Begley CG; Bradbury ARM; Chalmers AD; Gomes AV; Hardcastle T; Lund-Johansen F; Plückthun A; Roncador G; Solache A; Taussig MJ; Trimmer JS; Williams C; Goodman SL
Article: CANCER MEDICINE. 2019;8(18):7705-7719

Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.

Mesmar F; Dai B; Ibrahim A; Hases L; Jafferali MH; Jose Augustine J; DiLorenzo S; Kang Y; Zhao Y; Wang J; Kim M; Lin C-Y; Berkenstam A; Fleming J; Williams C
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(12):22220-22233

A miR-206 regulated gene landscape enhances mammary epithelial differentiation.

Wang J; Aydoğdu E; Mukhopadhyay S; Helguero LA; Williams C
Article: BMC CANCER. 2019;19(1):684

Sexual dimorphism in the incidence of human cancers.

Zheng D; Trynda J; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(12):3086-3098

Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.

Ibrahim A; Hugerth LW; Hases L; Saxena A; Seifert M; Thomas Q; Gustafsson J-Å; Engstrand L; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1966:79-99

Antibody Validation Strategy for Nuclear Receptors.

Katona B; Ibrahim A; Sundberg M; Williams C
Journal article: CELL SYSTEMS. 2018;7(4):422-437.e7

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.

Korkut A; Zaidi S; Kanchi RS; Rao S; Gough NR; Schultz A; Li X; Lorenzi PL; Berger AC; Robertson G; Kwong LN; Datto M; Roszik J; Ling S; Ravikumar V; Manyam G; Rao A; Shelley S; Liu Y; Ju Z; Hansel D; de Velasco G; Pennathur A; Andersen JB; O'Rourke CJ; Ohshiro K; Jogunoori W; Nguyen B-N; Li S; Osmanbeyoglu HU; Ajani JA; Mani SA; Houseman A; Wiznerowicz M; Chen J; Gu S; Ma W; Zhang J; Tong P; Cherniack AD; Deng C; Resar L; Cancer Genome Atlas Research Network; Weinstein JN; Mishra L; Akbani R
Article: ONCOTARGET. 2018;9(28):19730-19744

Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.

Danielsson F; Fasterius E; Sullivan D; Hases L; Sanli K; Zhang C; Mardinoglu A; Al-Khalili C; Huss M; Uhlén M; Williams C; Lundberg E
Journal article: CANCER RESEARCH. 2017;77:4401

Role of estrogen signaling in colon microenvironment during obesity

Archer A; Pettersson L; Gonzalez-Granillo M; Savva C; Korach-Andre M; Williams C
Journal article: CANCER RESEARCH. 2017;77:2819

Intestinal estrogen receptor beta attenuates colon cancer signaling pathways in vivo

Pettersson L; Saxena A; Vu T; Gustafsson J-A; Archer A; Williams C
Article: CANCER LETTERS. 2017;396:42-52

The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells.

Monteiro FL; Vitorino R; Wang J; Cardoso H; Laranjeira H; Simões J; Caldas M; Henrique R; Amado F; Williams C; Jerónimo C; Helguero LA
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):1-14

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells.

Ma R; Karthik G-M; Lövrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: PLOS ONE. 2017;12(2):e0172832

Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant.

Simon M; Mesmar F; Helguero L; Williams C
Article: ONCOTARGET. 2016;7(27):42159-42171

Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism.

Nguyen-Vu T; Wang J; Mesmar F; Mukhopadhyay S; Saxena A; McCollum CW; Gustafsson J-Å; Bondesson M; Williams C
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(6):2689-2698

Vitamin D Induces Global Gene Transcription in Human Corneal Epithelial Cells: Implications for Corneal Inflammation.

Reins RY; Mesmar F; Williams C; McDermott AM
Article: ONCOGENE. 2016;35(15):1955-1964

RING finger protein 31 promotes p53 degradation in breast cancer cells.

Zhu J; Zhao C; Zhuang T; Jonsson P; Sinha I; Williams C; Strömblad S; Dahlman-Wright K
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1366:373-393

Expression Profiles of Estrogen-Regulated MicroRNAs in Breast Cancer Cells.

Katchy A; Williams C
Article: MOLECULAR ENDOCRINOLOGY. 2015;29(11):1634-1645

Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer.

Jonsson P; Coarfa C; Mesmar F; Raz T; Rajapakshe K; Thompson JF; Gunaratne PH; Williams C
Article: CARCINOGENESIS. 2015;36(9):1051-1060

miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene.

Tsouko E; Wang J; Frigo DE; Aydoğdu E; Williams C
Article: PLOS ONE. 2015;10(5):e0128239

Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer.

Dey P; Velazquez-Villegas LA; Faria M; Turner A; Jonsson P; Webb P; Williams C; Gustafsson J-Å; Ström AM
Article: MOLECULAR ONCOLOGY. 2014;8(8):1690-1702

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer.

Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Article: FASEB JOURNAL. 2014;28(10):4247-4264

Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival.

Dória ML; Ribeiro AS; Wang J; Cotrim CZ; Domingues P; Williams C; Domingues MR; Helguero LA
Article: ONCOGENE. 2014;33(34):4340-4351

The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation.

Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Strömblad S; Treuter E; Dahlman-Wright K
Article: CANCER RESEARCH. 2014;74(14):3983-3994

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer.

Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: ENDOCRINE-RELATED CANCER. 2014;21(2):143-160

Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells.

Jonsson P; Katchy A; Williams C
Article: TOXICOLOGICAL SCIENCES. 2014;138(1):21-35

Coexposure to phytoestrogens and bisphenol a mimics estrogenic effects in an additive manner.

Katchy A; Pinto C; Jonsson P; Nguyen-Vu T; Pandelova M; Riu A; Schramm K-W; Samarov D; Gustafsson J-Å; Bondesson M; Williams C
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(84):e51285

Profiling of estrogen-regulated microRNAs in breast cancer cells.

Katchy A; Williams C
Article: ENDOCR DISRUPTORS (AUSTIN). 2014;2(1):e29088

Gestational bisphenol A exposure and testis development.

Williams C; Bondesson M; Krementsov DN; Teuscher C
Article: TOXICOLOGICAL SCIENCES. 2013;135(1):91-102

Studies in experimental autoimmune encephalomyelitis do not support developmental bisphenol a exposure as an environmental factor in increasing multiple sclerosis risk.

Krementsov DN; Katchy A; Case LK; Carr FE; Davis B; Williams C; Teuscher C
Article: CARCINOGENESIS. 2013;34(7):1431-1441

Estrogen receptor β expression induces changes in the microRNA pool in human colon cancer cells.

Edvardsson K; Nguyen-Vu T; Kalasekar SM; Pontén F; Gustafsson J-Å; Williams C
Article: BREAST CANCER RESEARCH. 2013;15(3):R51

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

Nguyen-Vu T; Vedin L-L; Liu K; Jonsson P; Lin JZ; Candelaria NR; Candelaria LP; Addanki S; Williams C; Gustafsson J-Å; Steffensen KR; Lin C-Y
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1991-2003

Estrogen receptors β1 and β2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3.

Dey P; Jonsson P; Hartman J; Williams C; Ström A; Gustafsson J-Å
Article: CARCINOGENESIS. 2012;33(9):1684-1691

Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells.

Dahlman-Wright K; Qiao Y; Jonsson P; Gustafsson J-Å; Williams C; Zhao C
Article: CARCINOGENESIS. 2012;33(8):1502-1511

MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer.

Aydoğdu E; Katchy A; Tsouko E; Lin C-Y; Haldosén L-A; Helguero L; Williams C
Journal article: CANCER RESEARCH. 2012;72(8_Supplement):547

Abstract 547: Mapping of estrogen receptor-dependent and independent signaling pathways for xeno- and phytoestrogens

Katchy AC; Pinto C; Bondesson M; Williams C
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;128(3-5):145-153

Estradiol-activated estrogen receptor α does not regulate mature microRNAs in T47D breast cancer cells.

Katchy A; Edvardsson K; Aydogdu E; Williams C
Article: PLOS ONE. 2012;7(3):e32080

Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells.

Ehrlund A; Jonsson P; Vedin L-L; Williams C; Gustafsson J-Å; Treuter E
Journal article: CANCER RESEARCH. 2011;71(24_Supplement):p1-02-04-p1-02-04

P1-02-04: Estrogen Receptor beta Inhibits Breast Cancer EMT by Regulating the Expression of miR-200.

Thomas C; Gayani R; Nikolos F; Hao R; Katchy A; McCollum C; Williams C; Bondesson M; Krishnamurthy S; Esteva F; Gustafsson J-A
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(8):1326-1336

The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells.

Alvarez-Baron CP; Jonsson P; Thomas C; Dryer SE; Williams C
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(6):969-979

Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells.

Edvardsson K; Ström A; Jonsson P; Gustafsson J-Å; Williams C
Journal article: CANCER RESEARCH. 2011;71(8_Supplement):271

Abstract 271: Rapid regulation of ion channel KCNK5 by ERα in breast cancer cell lines MCF-7 and T47D promotes cell proliferation

Alvarez-Baron CP; Jonsson P; Dryer S; Williams C
Journal article: CANCER RESEARCH. 2009;69(24_Supplement):1162

Mammary Stem Cell-Like Gene Expression and Relation to Cancer.

Williams C; Helguero L; Edvardsson K; Haldosén L; Gustafsson J
Article: CANCER RESEARCH. 2009;69(15):6100-6106

Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells.

Hartman J; Edvardsson K; Lindberg K; Zhao C; Williams C; Ström A; Gustafsson J-A
Article: BREAST CANCER RESEARCH. 2009;11(3):R26

Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression.

Williams C; Helguero L; Edvardsson K; Haldosén L-A; Gustafsson J-A
Article: ONCOGENE. 2008;27(7):1019-1032

A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells.

Williams C; Edvardsson K; Lewandowski SA; Ström A; Gustafsson J-A
Article: BMC DEVELOPMENTAL BIOLOGY. 2007;7:129

Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.

Svensson P; Williams C; Lundeberg J; Rydén P; Bergqvist I; Edlund H
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment.

Williams C; Wirta V; Meletis K; Wikström L; Carlsson L; Frisén J; Lundeberg J
Article: BMC GENOMICS. 2006;7:75

Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression.

Richter K; Wirta V; Dahl L; Bruce S; Lundeberg J; Carlsson L; Williams C
Article: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE. 2002;18(6):287-293

The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes.

Persson AE; Edström DW; Bäckvall H; Lundeberg J; Pontén F; Ros A-M; Williams C
Article: ONCOGENE. 2001;20(53):7770-7778

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

Ling G; Ahmadian A; Persson A; Undén AB; Afink G; Williams C; Uhlén M; Toftgård R; Lundeberg J; Pontén F
Article: ANALYTICAL BIOCHEMISTRY. 2000;287(1):25-31

Analysis of p53 mutations in single cells obtained from histological tissue sections.

Persson AE; Ling G; Williams C; Bäckvall H; Pontén J; Pontén F; Lundeberg J
Article: AMERICAN JOURNAL OF PATHOLOGY. 1999;155(5):1467-1471

A high frequency of sequence alterations is due to formalin fixation of archival specimens.

Williams C; Pontén F; Moberg C; Söderkvist P; Uhlén M; Pontén J; Sitbon G; Lundeberg J
Article: GENE. 1999;235(1-2):103-109

Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detection.

Odeberg J; Ahmadian A; Williams C; Uhlén M; Pontén F; Lundeberg J
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 1999;8(5):433-438

p53 Mutations in lung cancer associated with residential radon exposure.

Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
Article: ONCOGENE. 1998;17(14):1837-1843

Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma.

Ahmadian A; Ren ZP; Williams C; Pontén F; Odeberg J; Pontén J; Uhlén M; Lundeberg J
Article: GENOMICS. 1998;50(2):213-221

Cloning and characterization of ZNF189, a novel human Krüppel-like zinc finger gene localized to chromosome 9q22-q31.

Odeberg J; Røsok O; Gudmundsson GH; Ahmadian A; Roshani L; Williams C; Larsson C; Pontén F; Uhlén M; Asheim HC; Lundeberg J
Article: CANCER RESEARCH. 1998;58(11):2449-2455

Clones of normal keratinocytes and a variety of simultaneously present epidermal neoplastic lesions contain a multitude of p53 gene mutations in a xeroderma pigmentosum patient.

Williams C; Pontén F; Ahmadian A; Ren ZP; Ling G; Rollman O; Ljung A; Jaspers NG; Uhlén M; Lundeberg J; Pontén J
Article: CLINICAL CHEMISTRY. 1998;44(3):455-462

Assessment of sequence-based p53 gene analysis in human breast cancer: messenger RNA in comparison with genomic DNA targets.

Williams C; Norberg T; Ahmadian A; Pontén F; Bergh J; Inganäs M; Lundeberg J; Uhlén M
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s145

Single-cell genetic analysis of the p%3 gene in human basal cell carcinoma(BCC)

Gao L; Ponten F; Williams C; Lundeberg J; Ponten J; Uhlen M
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s48

p53 gene mutations are common in clones of morphologically normal keratinocytes as well as in neoplastic lesions in xeroderma pigmentosum (XP)

Pontén F; Williams C; Ahmadian A; Ling G; Uhlén M; Lundeberg J; Pontén J
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1997;382(1-2):45-55

Genomic analysis of single cells from human basal cell cancer using laser-assisted capture microscopy.

Pontén F; Williams C; Ling G; Ahmadian A; Nistér M; Lundeberg J; Pontén J; Uhlén M
Article: ONCOGENE. 1997;15(9):1059-1067

Molecular pathology in basal cell cancer with p53 as a genetic marker.

Pontén F; Berg C; Ahmadian A; Ren ZP; Nistér M; Lundeberg J; Uhlén M; Pontén J
Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;150(5):1791-1803

Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin.

Ren ZP; Ahmadian A; Pontén F; Nistér M; Berg C; Lundeberg J; Uhlén M; Pontén J
Journal article: MELANOMA RESEARCH. 1996;6(SUPPLEMENT 1):s53

Multiple p53 mutations are common in basal cell carcinoma

Pontén F; Berg C; Uhlén M; Pontén J
Article: CLINICAL CHEMISTRY. 1995;41(10):1461-1466

Direct solid-phase sequence analysis of the human p53 gene by use of multiplex polymerase chain reaction and alpha-thiotriphosphate nucleotides.

Berg C; Hedrum A; Holmberg A; Pontén F; Uhlén M; Lundeberg J
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2023

Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease

Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C
Review: ENDOCRINOLOGY. 2023;164(6):bqad063

ERβ in Granulosa Cell Tumors and Its Clinical Potential.

Birgersson M; Indukuri R; Antonson P; Nalvarte I; Archer A; Williams C
Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):289A

Sensing of protein and DNA complexes using solid-state nanopores

Jain S; Birgersson M; Kipen J; Jalden J; Stemme G; Niklaus F; Raja SN; Williams C; Herland A
Preprint: MEDRXIV. 2022

New primer sets to detect recent human adenovirus F41 variants in wastewater: Is it linked to the new acute hepatitis?

Perez-Zabaleta M; Williams C; Cetecioglu Z
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S640

Gene expression profiles in endocrine-resistant breast cancer

Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-07-07-p1-07-07

Endoresist: Prognostic and predictive gene profiles in endocrine-resistant breast cancers

Schagerholm C; Robertson S; Holm B; Lindberg K; Sifakis E; Hases L; Williams C; Hartman J
Preprint: SSRN ELECTRONIC JOURNAL. 2022

Long-Term SARS-CoV-2 Surveillance in the Wastewater of Stockholm: What Lessons Can Be Learned from the Swedish Perspective?

Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Conference publication: CANCER RESEARCH. 2020;80(16):2081

Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes

Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Conference publication: CANCER RESEARCH. 2020;80(16):4085

Blocking Fra-1 sensitises triple-negative breast cancer to olaparib

Song D; He H; Sinha I; Pettersson L; Yan F; Haldosen L-A; Zhao C; Williams C
Preprint: BIORXIV. 2020

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens

Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-André M; Williams C
Preprint: RESEARCH SQUARE. 2019

Comparison of Serum Exosome Isolation Methods on Co-precipitated Free MicroRNAs

Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
Corrigendum: ONCOGENE. 2019;38(2):299-300

Correction: The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation.

Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Strömblad S; Treuter E; Dahlman-Wright K
Review: CANCER LETTERS. 2018;438:24-31

Regulation of sex hormone receptors in sexual dimorphism of human cancers.

Zheng D; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2018;29(26)

Deep immunological profiling of the murine brain and spleen after high fat diet by CODEX multiplexed imaging.

Gnann C; Casals AM; Xu H; Kheder S; Archer A; Mulder J; Mitsios N; Williams C; Lundberg E; Ayoglu B
Conference publication: CANCER RESEARCH. 2017;77:3614

Antibody validation revises estrogen receptor beta research

Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A
Conference publication: CANCER RESEARCH. 2017;77:5493

The cistrome of estrogen receptor beta in colorectal cancer cells

Indukuri R; Wang J; Mesmar F; Williams C
Conference publication: CANCER RESEARCH. 2017;77:4920

Inflammation and estrogen receptor beta modulate bacterial diversity of the gut

Ibrahim AF; Thomas Q; Saxena A; Williams C
Review: CANCER LETTERS. 2016;372(1):48-56

Estrogen receptor beta as target for colorectal cancer prevention.

Williams C; DiLeo A; Niv Y; Gustafsson J-Å
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(12)

Microarray Analysis of Vitamin D Treated Human Corneal Epithelial Cells

Reins RY; Mesmar F; Williams C; McDermott AM
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1849(2):142-151

Estrogen receptor signaling during vertebrate development.

Bondesson M; Hao R; Lin C-Y; Williams C; Gustafsson J-Å
Conference publication: CANCER RESEARCH. 2013;73:p4-07-12-p4-07-12

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer

Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Review: ECANCERMEDICALSCIENCE. 2013;7:370

Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.

Williams C; Lin C-Y
Conference publication: CANCER RESEARCH. 2013;73(8):4915

Estrogen receptor β is expressed within breast cancer cells with stem cell like capacity and confers endocrine sensitivity

Ma R; Govindasamy KM; Rosin G; Gustafsson J; Katchy A; Lindstrom L; Hilliges C; Viberg L; Blomqvist L; Frisell J; Williams C; Fredriksson I; Bergh J; Hartman J
Conference publication: CANCER RESEARCH. 2012;72:1207

Opposite effects on proliferation and bone metastasis genes by Estrogen Receptor B1 and Estrogen Receptor B2 in the prostate cancer cell line PC3

Dey P; Jonsson P; Hartman J; Williams C; Gustafsson J-A; Strom A
Conference publication: CANCER RESEARCH. 2011;71:p3-03-08-p3-03-08

microRNAs in Mammary Stem-Like Cells and Triple-Negative Breast Cancer; Conserved Functions and Treatment Potential.

Williams C; Aydogdu E; Katchy A; Lin C-Y; Baldosen L-A; Helguero L
Conference publication: CANCER RESEARCH. 2010;70:2076

Mammary stem cell-like miRNA expression and relation to cancer

Aydogdu E; Helguero L; Haldosen L-A; Williams CM
Conference publication: CANCER RESEARCH. 2010;70:2921

Antitumorigenic effects by ERβ in three different human colorectal cancer cell lines

Edvardsson K; Strom A; Gustafsson J-A; Williams C
Conference publication: CANCER RESEARCH. 2009;69(24):589S-590S

Mammary Stem Cell-Like Gene Expression and Relation to Cancer

Williams C; Helguero L; Edvardsson K; Haldosen L-A; Gustafsson J-A
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S233

Estrogen receptors in seminal vesicle and prostate;: Do they play a role in male fertility?

Schwend T; Imamov O; Williams C; Gustafsson J-A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(3):815

The mutagenic effects of long-wave ultraviolet A in human skin;: Studied by analysing the p53 gene in single cells

Edström DW; Persson Å; Bäckvall H; Lundeberg J; Pontén F; Ros AM; Williams C
Conference publication: EPIDEMIOLOGY. 1999;10(4):S83

Radon and p53 mutations in lung cancer.

Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
Book chapter: SKIN CANCER AND UV RADIATION. 1997;p. 709-714

Multiple p53 Mutations are Common in Basal Cell Carcinoma

Ponten F; Berg C; Uhlen M; Ponten J
Visa fler

Forskningsbidrag

How estrogen receptors of the colon create a microenvironment that suppress carcinogenesis - for cancer prevention and treatment

Swedish Research Council

1 January 2023 - 31 December 2026
QuantumSense - Quantum Tunneling Sensing of Biomolecules for High-Throughput Decoding of DNA and RNA

Swedish Research Council

1 December 2018 - 30 November 2024
Estrogen-regulated lncRNAs as mediators of tumor-repressive functions in colon

Swedish Research Council

1 January 2018 - 31 December 2021
Utilizing large-scale genomic techniques to decipher nuclear receptor and microRNA mechanisms in cancer

VINNOVA

1 June 2014 - 28 February 2018
Elucidating the mechanism of ERbeta in colon carcinogenesis

National Cancer Institute

1 August 2013 - 31 May 2019
Epigenetic regulation in mammary stem/progenitor cells and its contribution to malignant transformation

Fundação para a Ciência e Tecnologia

15 March 2012 - 14 July 2015

Om mig

Utvalda publikationer

Artiklar

Alla övriga publikationer

Forskningsbidrag

Nyheter från KI

Kalenderhändelser från KI