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About me

Cecilia Williams is currently a visiting professor at Karolinska Institutet – besides her permanent position as professor at KTH Royal Institute of Technology. Cecilia also holds an adjunct position at University of Houston. Williams received her PhD training in DNA sequencing technologies and the p53 tumor suppressor gene in the lab of Mathias Uhlén and Joakim Lundeberg at KTH. She moved to Jan-Åke Gustafsson’s lab at Karolinska Institutet in 2005, where she focused on the role of estrogen receptor beta in breast cancer. In 2009, she joined the Center of Nuclear Receptors and Cell Signaling at University of Houston as Assistant Professor and received a tenured Associate Professorship in 2015, before returning to a professorship at KTH. Her main activities at BioNut is focused at understanding hormonal signaling and the role of non-coding RNAs in cancer, and activities include the supervision of two doctoral students and collaborations with affiliated faculties specialized in nuclear receptors.

Research description


A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Canc Genome Atlas Res Network, Berger Ac, Korkut A, Kanchi Rs, Hegde Am, Lenoir W, et al
CANCER CELL 2018;33(4):690-705.e9

Regulation of sex hormone receptors in sexual dimorphism of human cancers
Zheng D, Williams C, Vold Ja, Nguyen Jh, Harnois Dm, Bagaria Sp, et al
Cancer letters 2018;438():24-31

Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia
Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, et al
Oncotarget 2018;9(28):19730-19744

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ma R, Karthik Gm, Lövrot J, Haglund F, Rosin G, Katchy A, et al
Journal of the National Cancer Institute 2017;109(3):1-14

Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant
Simon M, Mesmar F, Helguero L, Williams C
PloS one 2017;12(2):e0172832-

Insufficient antibody validation challenges oestrogen receptor beta research
Andersson S, Sundberg M, Pristovsek N, Ibrahim A, Jonsson P, Katona B, et al
Nature communications 2017;8():15840-

The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells
Monteiro Fl, Vitorino R, Wang J, Cardoso H, Laranjeira H, Simões J, et al
Cancer letters 2017;396():42-52

Estrogen receptor beta as target for colorectal cancer prevention
Williams C, Dileo A, Niv Y, Gustafsson JÅ
Cancer letters 2016;372(1):48-56

Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205 - PROX1 mechanism
Nguyen-vu T, Wang J, Mesmar F, Mukhopadhyay S, Saxena A, Mccollum Cw, et al
Oncotarget 2016;7(27):42159-42171

Expression Profiles of Estrogen-Regulated MicroRNAs in Breast Cancer Cells
Katchy A, Williams C
Methods in molecular biology (Clifton, N.J.) 2016;1366():373-393

RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J, Zhao C, Zhuang T, Jonsson P, Sinha I, Williams C, et al
Oncogene 2016;35(15):1955-64

Vitamin D Induces Global Gene Transcription in Human Corneal Epithelial Cells: Implications for Corneal Inflammation
Reins Ry, Mesmar F, Williams C, Mcdermott Am
Investigative ophthalmology & visual science 2016;57(6):2689-98

Estrogen receptor signaling during vertebrate development
Bondesson M, Hao R, Lin Cy, Williams C, Gustafsson Ja

Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer
Dey P, Velazquez-villegas La, Faria M, Turner A, Jonsson P, Webb P, et al
PloS one 2015;10(5):e0128239-

miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene
Tsouko E, Wang J, Frigo De, Aydoğdu E, Williams C
Carcinogenesis 2015;36(9):1051-60

Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer
Jonsson P, Coarfa C, Mesmar F, Raz T, Rajapakshe K, Thompson Jf, et al
Molecular endocrinology (Baltimore, Md.) 2015;29(11):1634-45

Coexposure to Phytoestrogens and Bisphenol A Mimics Estrogenic Effects in an Additive Manner
Katchy A, Pinto C, Jonsson P, Trang Nv, Pandelova M, Riu A, et al

Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival
Dória Ml, Ribeiro As, Wang J, Cotrim Cz, Domingues P, Williams C, et al
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014;28(10):4247-64

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer
Zhao C, Qiao Y, Jonsson P, Wang J, Xu L, Rouhi P, et al
Cancer research 2014;74(14):3983-94

Gestational bisphenol A exposure and testis development
Williams C, Bondesson M, Krementsov Dn, Teuscher C
Endocrine disruptors (Austin, Tex.) 2014;2(1):-

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer
Wang J, Tsouko E, Jonsson P, Bergh J, Hartman J, Aydogdu E, et al
Molecular oncology 2014;8(8):1690-702

Profiling of estrogen-regulated microRNAs in breast cancer cells
Katchy A, Williams C
Journal of visualized experiments : JoVE 2014;(84):e51285-

Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells
Jonsson P, Katchy A, Williams C
Endocrine-related cancer 2014;21(2):143-60

The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation
Zhu J, Zhao C, Kharman-biz A, Zhuang T, Jonsson P, Liang N, et al
Oncogene 2014;33(34):4340-51

Estrogen receptor expression induces changes in the microRNA pool in human colon cancer cells
Edvardsson K, Trang Nv, Kalasekar Sm, Ponten F, Gustafsson Ja, Williams C
CARCINOGENESIS 2013;34(7):1431-41

Liver x receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
Nguyen-vu T, Vedin Ll, Liu K, Jonsson P, Lin Jz, Candelaria Nr, et al

Oestrogen receptors in breast cancer: basic mechanisms and clinical implications
Williams C, Lin Cy
Ecancermedicalscience 2013;7():370-

Studies in experimental autoimmune encephalomyelitis do not support developmental bisphenol a exposure as an environmental factor in increasing multiple sclerosis risk
Krementsov Dn, Katchy A, Case Lk, Carr Fe, Davis B, Williams C, et al
Toxicological sciences : an official journal of the Society of Toxicology 2013;135(1):91-102

Estradiol-activated estrogen receptor alpha does not regulate mature microRNAs in T47D breast cancer cells
Katchy A, Edvardsson K, Aydogdu E, Williams C

Estrogen Receptors beta 1 and beta 2 Have Opposing Roles in Regulating Proliferation and Bone Metastasis Genes in the Prostate Cancer Cell Line PC3
Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson Ja
MOLECULAR ENDOCRINOLOGY 2012;26(12):1991-2003

Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells
Dahlman-wright K, Qiao Y, Jonsson P, Gustafsson JÅ, Williams C, Zhao C
Carcinogenesis 2012;33(9):1684-91

Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells
Ehrlund A, Jonsson P, Vedin Ll, Williams C, Gustafsson JÅ, Treuter E
PloS one 2012;7(3):e32080-

MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer
Aydogdu E, Katchy A, Tsouko E, Lin Cy, Haldosen La, Helguero L, et al
CARCINOGENESIS 2012;33(8):1502-11

Estrogen Receptor beta Induces Antiinflammatory and Antitumorigenic Networks in Colon Cancer Cells
Edvardsson K, Strom A, Jonsson P, Gustafsson Ja, Williams C

The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells
Alvarez-baron Cp, Jonsson P, Thomas C, Dryer Se, Williams C
Molecular endocrinology (Baltimore, Md.) 2011;25(8):1326-36

Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression
Williams C, Helguero L, Edvardsson K, Haldosen La, Gustafsson Ja

Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells
Hartman J, Edvardsson K, Lindberg K, Zhao C, Williams C, Ström A, et al
Cancer research 2009;69(15):6100-6

A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells
Williams C, Edvardsson K, Lewandowski Sa, Strom A, Gustafsson Ja
ONCOGENE 2008;27(7):1019-32

Gene array identification of Ipf1/Pdx1(-/-) regulated genes in pancreatic progenitor cells
Svensson P, Williams C, Lundeberg J, Ryden P, Bergqvist I, Edlund H

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment
Williams C, Wirta V, Meletis K, Wikstrom L, Carlsson L, Frisen J, et al
EXPERIMENTAL CELL RESEARCH 2006;312(10):1798-812

Estrogen receptors in seminal vesicle and prostate; Do they play a role in male fertility?
Schwend T, Imamov O, Williams C, Gustafsson Ja

Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression
Richter K, Wirta V, Dahl L, Bruce S, Lundeberg J, Carlsson L, et al
BMC GENOMICS 2006;:75-

The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes
Persson Ae, Edstrom Dw, Backvall H, Lundeberg J, Ponten F, Ros Am, et al

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer
Ling G, Ahmadian A, Persson A, Unden Ab, Afink G, Williams C, et al
ONCOGENE 2001;20(53):7770-8

The mutagenic effects of long-wave ultraviolet A in human skin; Studied by analysing the p53 gene in single cells
Edstrom Dw, Persson Ae, Backvall H, Lundeberg J, Ponten F, Ros Am, et al

Analysis of p53 mutations in single cells obtained from histological tissue sections
Persson Ae, Ling G, Williams C, Backvall H, Ponten J, Ponten F, et al

A high frequency of sequence alterations is due to formalin fixation of archival specimens
Williams C, Ponten F, Moberg C, Soderkvist P, Uhlen M, Ponten J, et al

Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene: implications for mutation detections
Odeberg J, Ahmadian A, Williams C, Uhlen M, Ponten F, Lundeberg J
GENE 1999;235(1-2):103-9

p53 mutations in lung cancer associated with residential radon exposure
Yngveson A, Williams C, Hjerpe A, Lundeberg J, Soderkvist P, Pershagen G

Radon and p53 mutations in lung cancer.
Yngveson A, Williams C, Hjerpe A, Lundeberg J, Soderkvist P, Pershagen G
EPIDEMIOLOGY 1999;10(4):S83-S83

Assessment of sequence-based p53 gene analysis in human breast cancer: messenger RNA in comparison with genomic DNA targets
Williams C, Norberg T, Ahmadian A, Ponten F, Bergh J, Inganas M, et al
CLINICAL CHEMISTRY 1998;44(3):455-62

Clones of normal keratinocytes and a variety of simultaneously present epidermal neoplastic lesions contain a multitude of p53 gene mutations in a xeroderma pigmentosum patient
Williams C, Ponten F, Ahmadian A, Ren Zp, Ling G, Rollman O, et al
CANCER RESEARCH 1998;58(11):2449-55

Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31
Odeberg J, Rosok O, Gudmundsson Gh, Ahmadian A, Roshani L, Williams C, et al
GENOMICS 1998;50(2):213-21

Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma
Ahmadian A, Ren Zp, Williams C, Ponten F, Odeberg J, Ponten J, et al
ONCOGENE 1998;17(14):1837-43

Single-cell genetic analysis of the p53 gene in human basal cell carcinoma (BCC)
Gao L, Ponten F, Williams C, Lundeberg J, Ponten J

Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin
Ren Zp, Ahmadian A, Ponten F, Nister M, Berg C, Lundeberg J, et al

Genomic analysis of single cells from human basal cell cancer using laser-assisted capture microscopy
Ponten F, Williams C, Ling G, Ahmadian A, Nister M, Lundeberg J, et al

Molecular pathology in basal cell cancer with p53 as a genetic marker
Ponten F, Berg C, Ahmadian A, Ren Zp, Nister M, Lundeberg J, et al
ONCOGENE 1997;15(9):1059-67

Multiple p53 mutations are common in basal cell carcinoma
Ponten F, Berg C, Uhlen M, Ponten J

Berg C, Hedrum A, Holmberg A, Ponten F, Uhlen M, Lundeberg J
CLINICAL CHEMISTRY 1995;41(10):1461-6

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