Leonard Girnitas forskargrupp


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Leonard Girnita, MD, PhD, docent, gruppledare
Ada Girnita, MD, PhD, projektledare
Takashi Shibano, PhD, postdoc
Dawei Song, MD, doktorand
Sonia Oana Cismas, MD, doktorand
Iara Rocha Trocoli Drakensjö, MD, doktorand
Eric Trocmé, MD, doktorand
Simin Zhang, MD, doktorand
Xiaohao Wang, MD, doktorand
Caitrin Crudden, PhD
Mireia Cruz De los Santos, student
Sylvya Pasca, student
Diana Florescu, MD, doktorand


Naida Suleymanova, doktorand
Claire Worrall, MD, PhD, postdoc
Iulian Oprea, Md, PhD, postdoc
Beclem Bocstancioglu, PhD, postdoc
Daiana Vasilcanu, MD, PhD, forskare
Julianna Serly, PhD, postdoc
Tingting Ling, MD, PhD, postdoc
Elfar Ulfarsson, MD, doktorand
Eugenio Triay, MD, doktorand
Huiyuan Zheng, doktorand
Natalia Natalishvili, MD, doktorand
Chen Qiu, MD, besökande doktorand
Dan Stefanescu, MD, besökande doktorand
Daniela Nedelcu, besökande doktorand
Tiehong Zhang, besökande doktorand

Utvalda publikationer

Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth.
Crudden C, Shibano T, Song D, Dragomir MP, Cismas S, Serly J, et al
Cancer Res 2020 Nov;():

The Long Noncoding RNA CCAT2 induces chromosomal instability through BOP1 - AURKB signaling.
Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, et al
Gastroenterology 2020 Aug;():

Decrypting noncoding RNA interactions, structures, and functional networks.
Fabbri M, Girnita L, Varani G, Calin GA
Genome Res 2019 09;29(9):1377-1388

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.
Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, et al
Genome Res 2018 04;28(4):432-447

Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes.
Suleymanova N, Crudden C, Shibano T, Worrall C, Oprea I, Tica A, et al
Oncogene 2017 10;36(41):5734-5744

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.
Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al
Oncogene 2017 06;36(23):3274-3286

β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma.
Zheng H, Shen H, Oprea I, Worrall C, Stefanescu R, Girnita A, et al
Proc Natl Acad Sci U S A 2012 Dec;109(50):20620-5

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor.
Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, et al
Proc Natl Acad Sci U S A 2012 May;109(18):7055-60

Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor.
Girnita A, Zheng H, Grönberg A, Girnita L, Ståhle M
Oncogene 2012 Jan;31(3):352-65

Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Yin S, Girnita A, Strömberg T, Khan Z, Andersson S, Zheng H, et al
Neuro Oncol 2010 Jan;12(1):19-27

Malignant solitary fibrous tumour of the orbit.
Girnita L, Sahlin S, Orrego A, Seregard S
Acta Ophthalmol 2009 Jun;87(4):464-7

Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.
Natalishvili N, Axelson M, Girnita L, Larsson O, Vasilcanu D
Exp Cell Res 2009 May;315(8):1458-67

New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.
Vitale M, Prestat G, Lopes D, Madec D, Kammerer C, Poli G, et al
J Org Chem 2008 Aug;73(15):5795-805

Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis.
Sehat B, Andersson S, Girnita L, Larsson O
Cancer Res 2008 Jul;68(14):5669-77

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.
Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, et al
Oncogene 2008 Mar;27(11):1629-38

Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin.
Vasilcanu R, Vasilcanu D, Sehat B, Yin S, Girnita A, Axelson M, et al
Mol Pharmacol 2008 Mar;73(3):930-9

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Vasilcanu D, Girnita A, et al
J Biol Chem 2007 Apr;282(15):11329-38

The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection.
Vasilcanu D, Weng WH, Girnita A, Lui WO, Vasilcanu R, Axelson M, et al
Oncogene 2006 May;25(22):3186-95

The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
Girnita A, All-Ericsson C, Economou MA, Aström K, Axelson M, Seregard S, et al
Clin Cancer Res 2006 Feb;12(4):1383-91

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Strömberg T, Ekman S, Girnita L, Dimberg LY, Larsson O, Axelson M, et al
Blood 2006 Jan;107(2):669-78

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Menu E, Jernberg-Wiklund H, Stromberg T, De Raeve H, Girnita L, Larsson O, et al
Blood 2006 Jan;107(2):655-60

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, et al
J Biol Chem 2005 Jul;280(26):24412-9

Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach.
Ulfarsson E, Karström A, Yin S, Girnita A, Vasilcanu D, Thoren M, et al
Clin Cancer Res 2005 Jul;11(13):4674-80

Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.
Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M
Cancer Res 2004 Jan;64(1):236-42

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.
Girnita L, Girnita A, Larsson O
Proc Natl Acad Sci U S A 2003 Jul;100(14):8247-52

Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Girnita L, Girnita A, Brodin B, Xie Y, Nilsson G, Dricu A, et al
Cancer Res 2000 Sep;60(18):5278-83

A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.
Girnita L, Girnita A, Wang M, Meis-Kindblom JM, Kindblom LG, Larsson O
Oncogene 2000 Aug;19(37):4298-301

Selected reviews and book chapters

The tale of a tail: The secret behind IGF-1R's oncogenic power.
Crudden C, Girnita L
Sci Signal 2020 May;13(633):

Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer.
Chen B, Li J, Chi D, Sahnoune I, Calin S, Girnita L, et al
Cells 2019 12;8(12):

Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey.
Crudden C, Song D, Cismas S, Trocmé E, Pasca S, Calin GA, et al
Cells 2019 10;8(10):

Blurring Boundaries: Receptor Tyrosine Kinases as functional G Protein-Coupled Receptors.
Crudden C, Shibano T, Song D, Suleymanova N, Girnita A, Girnita L
Int Rev Cell Mol Biol 2018 ;339():1-40

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling.
Girnita L, Takahashi SI, Crudden C, Fukushima T, Worrall C, Furuta H, et al
Prog Mol Biol Transl Sci 2016 ;141():277-311

Non-coding RNAs: the cancer genome dark matter that matters!
Ling H, Girnita L, Buda O, Calin GA
Clin Chem Lab Med 2017 May;55(5):705-714

Differential regulation of IGF-1 and Insulin signaling by GRKs
Girnita L, Girnita A and Crudden C
Book chapter in:  Gurevich  and J. Tesmer(eds.), G Protein-Coupled Receptor Kinases, Advances in Biochemistry in Health and Disease.

Targeting the IGF-1R: The Tale of the Tortoise and the Hare.
Crudden C, Girnita A, Girnita L
Front Endocrinol (Lausanne) 2015 ;6():64

The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment?
Crudden C, Ilic M, Suleymanova N, Worrall C, Girnita A, Girnita L
Growth Horm IGF Res 2015 Feb;25(1):2-12

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation.
Girnita L, Worrall C, Takahashi S, Seregard S, Girnita A
Cell Mol Life Sci 2014 Jul;71(13):2403-27