Toppublikationer

Här listas aktuella publikationer i högt rankade vetenskapliga tidskrifter där forskare vid Institutionen för medicin Huddinge medverkar.

Toppublikationer vid Centrum för infektionsmedicin (CIM)

Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingström, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars I. Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Strålin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Björkström, Jan-Inge Henter, Mattias Svensson, and Karolinska KI/K COVID-19 Study Group. PNAS February 9, 2021 118 (6)

Dias J, Leeansyah E, Sandberg J
Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.
Dias J, Leeansyah E, Sandberg J
Proc. Natl. Acad. Sci. U.S.A. 2017 07;114(27):E5434-E5443

Sandberg J, Norrby-Teglund A, Leeansyah E
Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.
Sandberg J, Norrby-Teglund A, Leeansyah E
PLoS Biol. 2017 Jul;15(7):e2003167

Dias J, Sobkowiak M, Sandberg J, Leeansyah E
Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity.
Dias J, Sobkowiak M, Sandberg J, Leeansyah E
J. Leukoc. Biol. 2016 07;100(1):233-40

Malin Flodström Tullberg
Enteroviral proteases: structure, host interactions and pathogenicity.
Laitinen O, Svedin E, Kapell S, Nurminen A, Hytönen V, Flodström-Tullberg M
Rev. Med. Virol. 2016 07;26(4):251-67

Malin Flodström Tullberg
An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.
Domsgen E, Lind K, Kong L, Hühn M, Rasool O, van Kuppeveld F, et al
Sci Rep 2016 12;6():39378

Johan K. Sandberg, Edwin Leeansyah
Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.
Paquin-Proulx D, Gibbs A, Bächle S, Checa A, Introini A, Leeansyah E, et al
J. Immunol. 2016 09;197(5):1843-51

Johan K. Sandberg, Edwin Leeansyah
MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.
Gibbs A, Leeansyah E, Introini A, Paquin-Proulx D, Hasselrot K, Andersson E, et al
Mucosal Immunol 2017 01;10(1):35-45

Jenny Mjösberg
The heterogeneity of human CD127(+) innate lymphoid cells revealed by single-cell RNA sequencing.
Björklund ÅK, Forkel M, Picelli S, Konya V, Theorell J, Friberg D, et al
Nat Immunol 2016 Apr;17(4):451-60

Mattias Svensson
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.
Kvedaraite E, Lourda M, Ideström M, Chen P, Olsson-Åkefeldt S, Forkel M, et al
Gut 2016 10;65(10):1632-41

Susanna Brighenti, Jagadees Rao Muvva
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.
Rekha RS, Rao Muvva SS, Wan M, Raqib R, Bergman P, Brighenti S, et al
Autophagy 2015 ;11(9):1688-99

Hans-Gustaf Ljunggren, Yenan Bryceson
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes TD, Han H, Chiang SCC, Foley B, Mattsson K, Larsson S, Schaffer M, Malmberg K-J, Ljunggren H-G, Miller JS, Bryceson YT. Immunity (2015) Online 17 March. Article.

Johan Sandberg
HIV Type 1 Disease Progression to AIDS and Death in a Rural Ugandan Cohort Is Primarily Dependent on Viral Load Despite Variable Subtype and T-Cell Immune Activation Levels.
Eller MA, Opollo MS, Liu M, Redd AD, Eller LA, Kityo C, et al
J Infect Dis 2015 May;211(10):1574-84

Toppublikationer vid avdelningen för endokrinologi och Lipidlaboratoriet

Mikael Rydén, Peter Arner
The Adipose Transcriptional Response to Insulin Is Determined by Obesity, Not Insulin Sensitivity

Mikael Rydén, Peter Arner, Daniel P Andersson, Erik Arner, Yvonne Widlund, Niklas Mejhert
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.
Rydén M, Uzunel M, Hård JL, Borgström E, Mold JE, Arner E, et al
Cell Metab 2015 Sep;22(3):408-17

Toppublikationer vid avdelningen för gastroenterologi och reumatologi

Hannes Hagström, Per Stål, Rolf Hultcrantz
Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up.
Ekstedt M, Hagström H, Nasr P, Fredrikson M, Stål P, Kechagias S, et al
Hepatology 2015 May;61(5):1547-54

Toppublikationer vid avdelningen för infektionssjukdomar och hud

Anders Sönnerborg
Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.
Hofstra LM, Sauvageot N, Albert J, Alexiev I, Garcia F, Struck D, Van de Vijver DA, Åsjö B, Beshkov D, Coughlan S, Descamps D, Griskevicius A, Hamouda O, Horban A, Van Kasteren M, Kolupajeva T, Kostrikis LG, Liitsola K, Linka M, Mor O, Nielsen C, Otelea D, Paraskevis D, Paredes R, Poljak M, Puchhammer-Stöckl E, Sönnerborg A, Staneková D, Stanojevic M, Van Laethem K, Zazzi M, Zidovec Lepej S, Boucher CA, Schmit JC, Wensing AM; SPREAD Program.
Clin Infect Dis. 2016 Mar 1;62(5):655-63. doi: 10.1093/cid/civ963. Epub 2015 Nov 29.

Anders Sönnerborg, Amanda Häggblom
Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.
Neogi U, Häggblom A, Singh K, Rogers LC, Rao SD, Amogne W, et al
J Antimicrob Chemother 2016 Feb;71(2):367-71

Anders Sönnerborg, Amanda Häggblom
Viral failure in HIV-1 subtype C infected patients receiving anti-retroviral therapy in a national health care setting: A real-life prospective cohort study.
Häggblom A, Svedhem V, Singh K, Sönnerborg A, Neogi U. Lancet HIV 2016.

Anders Sönnerborg
Gut microbiota linked to sexual practice and HIV infection
Noguera-Julian M, Rocafort M, Guillén Y, Rivera J, Casadellà M, Nowak P, Hildebrand F, Zeller G, Parera M, Bellido R, Rodríguez C, Carrillo J, Mothe B, Coll J, Bravo I, Estany C, Herrero C, Saz J, Sirera G, Torrela A, Navarro J, Crespo M, Brander C, Negredo E, Blanco J, Guarner F, Luz Calle M, Bork P, Sönnerborg A, Clotet B, Paredes R. . eBiomedicine 2016

Anders Sönnerborg
Global epidemiology of drug resistance following failure of WHO recommended first line regimens for adult HIV-1 infection – a multicenter retrospective cohort study.
Gupta R Sönnerborg A for the TenoRes collaboration. Lancet Infectious Diseases 2016, http://dx.doi.org/10.1016/S1473-3099(15)00536

Anders Sönnerborg
Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals.
Stenkvist J, Nyström J, Falconer K, Sönnerborg A, Weiland O
J Hepatol 2014 Oct;61(4):957-61

Ola Weiland
ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection.
Andreone P, Colombo MG, Enejosa JV, Koksal I, Ferenci P, Maieron A, et al
Gastroenterology 2014 Aug;147(2):359-365.e1

Soo Aleman
Diabetes and Cirrhosis Are Risk Factors for Hepatocellular Carcinoma After Successful Treatment of Chronic Hepatitis C.
Hedenstierna M, Nangarhari A, Weiland O, Aleman S
Clin Infect Dis 2016 09;63(6):723-9

Patient-reported outcomes assessment in chronic hepatitis C treated with sofosbuvir and ribavirin: the VALENCE study.
Younossi ZM, Stepanova M, Zeuzem S, Dusheiko G, Esteban R, Hezode C, et al
J Hepatol 2014 Aug;61(2):228-34

Toppublikationer vid avdelningen för hjärt- och lungsjukdomar

Dina Melki och Tomas Jernberg
Implications of introducing high-sensitivity cardiac troponin T into clinical practice
Melki D, Lugnegård J, Alfredsson J, Lind S, Eggers KM, Lindahl B, Jernberg T.
J Am Coll Cardiology (2015) Online 20 April. Original investigation.

Karolina Szummer
Association between the use of fondaparinux vs low-molecular-weight heparin and clinical outcomes in patients with non-ST-segment elevation myocardial infarction.
Szummer K, Oldgren J, Lindhagen L, Carrero JJ, Evans M, Spaak J, et al
JAMA 2015 Feb;313(7):707-16

Toppublikationer vid avdelningen för Hematologi/ HERM

Per Ljungman, Avdelningen för hematologi
Stem cell transplantation in severe congenital neutropenia: an analysis from the European Society for Blood and Marrow Transplantation.
Fioredda F, Iacobelli S, van Biezen A, Gaspar B, Ancliff P, Donadieu J, et al
Blood 2015 Oct;126(16):1885-92; quiz 1970

Per Ljungman, Avdelningen för hematologi
Immunogenicity, safety, and tolerability of 13-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal polysaccharide vaccine in recipients of allogeneic hematopoietic stem cell transplant aged ≥2 years: an open-label study.
Cordonnier C, Ljungman P, Juergens C, Maertens J, Selleslag D, Sundaraiyer V, et al
Clin Infect Dis 2015 Aug;61(3):313-23

Hareth Nahi, Centrum för hematologi och regenerativ medicin (HERM)
Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.
Lokhorst HM, Plesner T, Laubach JP, Nahi H, Gimsing P, Hansson M, et al
N Engl J Med 2015 Sep;373(13):1207-19

Övriga toppublikationer

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S, Jacob J, et al
Immunity 2018 01;48(1):120-132.e8

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.
Stone V, Hankaniemi M, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, et al
Diabetologia 2018 02;61(2):476-481

Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R Monocyte-Derived Cells in Periodontitis.
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al
J. Immunol. 2017 12;199(12):4023-4035

Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW
Nature (2018) Online 3 January. Letter.

Länk till abstrakt i Nature

Rickard Sandberg, Integrated Cardio Metabolic Centre (ICMC), CMB
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes.
Segerstolpe �, Palasantza A, Eliasson P, Andersson E, Andréasson A, Sun X, et al
Cell Metab. 2016 10;24(4):593-607