Ali Mirazimi

Ali Mirazimi

Adjungerad Professor
E-postadress: ali.mirazimi@ki.se
Besöksadress: Nobels väg 7, 17165 Solna
Postadress: H5 Laboratoriemedicin, H5 Klin Mikrobiologi Mirazimi, 141 52 Huddinge
Del av:

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 januari 2026 - 31 december 2027
    Purpose and aims: The overall purpose of the proposed network is to strengthen collaborations and networking in the area of virus and pandemics. The research area contains several research groups that are distributed all over Sweden and covers distinct disciplines. We aim to improve national and international collaborations and transfer of knowledge in the area. We are also aware that that virus-caused diseases is a focus area in pharmaceutical industry and hence we seek to increase collaborations between academy and industry. Finally, we aim to counteract fake news and vaccine resistance.Implementation: Supported by the Swedish Society for Virology (SSV), the applicants will initiate, coordinate, and/or support scientific meetings, PhD courses, the development of a national register for all pathogen-tested samples, and strategic use of BSL2-4 laboratories for pandemic preparedness. The co-applicants arrange digital meetings to plan activities and events, together with other organizations, in order to reach the goals set.Relevance: Virus-caused diseases, outbreaks, and pandemics constitute a huge burden on public health, health care and society. Coordinated efforts are needed to counteract these problems and threats. The described activities and collaborations increase scientific quality, and generation of new and better tools needed to understand and counteract virus-caused diseases, outbreaks, and pandemics.
  • Swedish Research Council
    1 december 2025 - 30 november 2028
    CCHFV is one of the most lethal tick-borne viruses, with high mortality and rapid geographic expansion driven by climate change. Despite its classification by the WHO as a priority pathogen, vaccine development is hampered by limited understanding of protective immune mechanisms, particularly T cell responses. This project aims to close that gap by uncovering how adaptive immunity,with focus to T cells , shapes protection during natural infection and vaccination. Leveraging one of the world’s largest longitudinal biobanks of CCHFV patients, in combination with cutting-edge animal models and advanced single-cell technologies, we will define the phenotype, function, and antigen-specificity of virus-specific T cells. Our dual focus is: (i) elucidating T cell dynamics in human infection, and (ii) mapping protective T cell responses in vaccine recipients. Preliminary data suggest T cells, rather than neutralizing antibodies, play a central role in controlling disease. Our integrated approach combines systemic and tissue-level immunoprofiling, functional assays, and peptide epitope mapping to identify immune correlates of protection. This cross-sectoral collaboration unites academia, hospitals, and public agencies to accelerate the development of next-generation vaccines that position immunity where it matters most—at the site of viral entry. The project will redefine vaccine strategies and enhance pandemic preparedness for this neglected but growing global threat.
  • Swedish Research Council
    1 januari 2025 - 31 december 2028
    The National Doctoral Programme in Virus Infections and Pandemics (NDP-VIP) aims to advance the training and recruitment of PhD students and postdocs in virology and pandemic preparedness. This collaborative initiative involves nine leading Swedish universities and provides an interdisciplinary research environment integrating virology, epidemiology, public health, and social sciences for comprehensive training and understanding of infectious disease dynamics.NDP-VIP offers advanced courses taught by renowned researchers, covering viral pathogenesis, emerging viruses and zoonotic transmission, antiviral and vaccine development, socio-economic impacts of pandemics, and pandemic preparedness. Practical training in cutting-edge methodologies is a core component.The program fosters interdisciplinary cooperation through national virology network meetings, allowing PhD students and postdocs to present their research to the Swedish virology community. These activities aim to strengthen collaborations, facilitate knowledge exchange, and promote cross-disciplinary research and innovation.NDP-VIP’s outreach strategies, including partnerships with the Swedish Society for Virology and international collaborations, aim to attract top-tier candidates and create a vibrant network of young researchers. This initiative seeks to produce leading scientists and enhance Sweden´s capacity to respond to emerging infectious threats, ensuring national resilience and preparedness for future pandemics.
  • CCHFVaCIM
    1 januari 2024 - 31 januari 2028
  • COVID-19 Variant Supplement - Molecular and cellular therapies against COVID-19 using angiotensin-converting enzyme 2 (ACE2)
    Canadian Institutes of Health Research
    1 mars 2021 - 28 februari 2022
  • Canadian Institutes of Health Research
    1 mars 2021 - 28 februari 2022
  • MADCOV2
    Innovative medicine initiative
    2 augusti 2020 - 30 april 2024
  • Vienna Science and Technology Fund
    1 maj 2020 - 14 maj 2023
  • Sex as a Biological Variable Supplement - Molecular and cellular therapies against COVID-19 using angiotensin-converting enzyme 2 (ACE2)
    Canadian Institutes of Health Research
    1 maj 2020 - 30 april 2021
  • Canadian Institutes of Health Research
    1 maj 2020 - 30 april 2021
  • Molecular and cellular therapies against COVID-19 using angiotensin-converting enzyme 2 (ACE2)
    Canadian Institutes of Health Research
    1 februari 2020 - 31 januari 2022
  • Canadian Institutes of Health Research
    1 februari 2020 - 31 januari 2022
  • Swedish Research Council
    1 december 2019 - 31 december 2022
  • Swedish Research Council
    1 december 2018 - 31 december 2023
  • Swedish Research Council
    1 januari 2018 - 31 december 2020
  • Swedish Research Council
    1 januari 2018 - 31 december 2020
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 januari 2017 - 31 december 2020
  • CCHFVaccine
    Horizon 2020
    1 januari 2017 - 31 december 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 januari 2016 - 31 december 2018
  • Infect-ERA utlysning 2014: Second multilateral call for research Projects of Infect-ERA. ESCential, Haploid embryonic stem cell screen to identify host factors essential for highly pathogenic RNA vir
    Swedish Research Council
    1 december 2014 - 31 december 2016
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Anställningar

  • Adjungerad Professor, Laboratoriemedicin, Karolinska Institutet, 2015-2027

Examina och utbildning

  • Docent, Virologi, Karolinska Institutet, 2006
  • MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2000

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