Laboratoriet för lymfocytdifferentiering – Jonathan Coquets grupp

Publikationer

Alla gruppmedlemmars publikationer

Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2024;144(12):2789-2804.e10
Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Nonmalignant T Cell Proliferation in Cutaneous T-Cell Lymphoma
Zeng Z; Vadivel CK; Gluud M; Namini MRJ; Yan L; Ahmad S; Hansen MB; Coquet J; Mustelin T; Koralov SB; Bonefeld CM; Woetmann A; Geisler C; Guenova E; Kamstrup MR; Litman T; Gjerdrum L-MR; Buus TB; Odum N
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(8):e20231827
Human CD127 negative ILC2s show immunological memory
Matha L; Krabbendam L; Hoyer SM; Heesters BA; Golebski K; Kradolfer C; Ghaedi M; Ma J; Stadhouders R; Bachert C; Cardell L-O; Zhang N; Holtappels G; Reitsma S; Helgers LC; Geijtenbeek TBH; Coquet JM; Takei F; Spits H; Martinez-Gonzalez I
Review: IMMUNOLOGICAL REVIEWS. 2024;323(1):118-125
New insights into ILC2 memory
Martinez-Gonzalez I; Takei F
Article: IMMUNOLOGY AND CELL BIOLOGY. 2024;102(4):232-234
Bridging the gap between scientific discoveries and clinical application at the Utrecht Science Park
Peperzak V; Coquet JM
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque
Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
Journal article: MICROBIOLOGY SPECTRUM. 2023;11(6):e02657-e02623
Characterization of biofilm formation by Exiguobacterium strains in response to arsenic exposure.
Pavez VB; Pacheco N; Castro-Severyn J; Pardo-Esté C; Álvarez J; Zepeda P; Krüger G; Gallardo K; Melo F; Vernal R; Aranda C; Remonsellez F; Saavedra CP
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2023;220(11):e20230101
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M; Coelho A; Krämer A; Saxena A; Sabatier P; Beusch CM; Lönnblom E; Geng M; Do N-N; Xu Z; Zhang J; He Y; Romero Castillo L; Abolhassani H; Xu B; Viljanen J; Rorbach J; Fernandez Lahore G; Gjertsson I; Kastbom A; Sjöwall C; Kihlberg J; Zubarev RA; Burkhardt H; Holmdahl R
Preprint: BIORXIV. 2023
Human CD127 negative ILC2s show immunological memory
Mathä L; Krabbendam L; Martinez-Høyer S; Heesters B; Golebski K; Kradolfer CMA; Ghaedi M; Ma J; Stadhouders R; Bachert C; Cardell LO; Nan Z; Holtappels G; Helgers LC; Geijtenbeek TBH; Coquet JM; Takei F; Spits H; Martinez-Gonzalez I
Article: IMMUNOLOGY AND CELL BIOLOGY. 2023;101(10):936-946
A conversation on allergy: recognizing the past and looking to the future
Melen E; Lambrecht BN; Lloyd CM; Rothenberg ME; Kabashima K; Luciani F; Coquet JM; Ober C; Nawijn MC; Platts-Mills T; von Mutius E
Journal article: MBIO. 2023;14(5):e01174-e01123
A gut commensal bacterium promotes black soldier fly larval growth and development partly via modulation of intestinal protein metabolism.
Luo X; Fang G; Chen K; Song Y; Lu T; Tomberlin JK; Zhan S; Huang Y
Article: SCIENCE IMMUNOLOGY. 2023;8(87):eadf7702
Laboratory mice with a wild microbiota generate strong allergic immune responses
Ma J; Urgard E; Runge S; Classon CH; Mathae L; Stark JM; Cheng L; Alvarez JA; Von Zedtwitz S; Baleviciute A; Hoyer SM; Li M; Gernand AM; Osbelt L; Bielecka AA; Lesker TR; Huang H-J; Vrtala S; Boon L; Beyaert R; Adner M; Gonzalez IM; Strowig T; Du J; Nylen S; Rosshart SP; Coquet JM
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2023;101(7):598-599
Immunology in the Copenhagen area: a renewed focus on diseases of the skin
Coquet JM
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(25):e2218668120
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.
Urbonaviciute V; Romero-Castillo L; Xu B; Luo H; Schneider N; Weisse S; Do N-N; Oliveira-Coelho A; Fernandez Lahore G; Li T; Sabatier P; Beusch CM; Viljanen J; Zubarev RA; Kihlberg J; Bäcklund J; Burkhardt H; Holmdahl R
Journal article: ELIFE. 2023;12:e82626
Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury
Labuz DR; Lewis G; Fleming ID; Thompson CM; Zhai Y; Firpo MA; Leung DT
Journal article: IMMUNOHORIZONS. 2023;7(1):116-124
Enhancing Mucosal-Associated Invariant T Cell Function and Expansion with Human Selective Serum.
Labuz D; Cacioppo J; Li K; Aubé J; Leung DT
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Thesis / dissertation: 2022
Understanding allergies : how infections affect the function of T helper cells
Ma, Junjie
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(10):2987-3001
Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses
Stark JM; Liu J; Tibbitt CA; Christian M; Ma J; Wintersand A; Dunst J; Kreslavsky T; Murrell B; Adner M; Gronlund H; Gafvelin G; Coquet JM
Letter: NATURE IMMUNOLOGY. 2022;23(4):501-502
Comment on: Repositioning T_H cell polarization from single cytokines to complex help
Jankovic D; Ciucci T; Coffman RL; Coquet JM; Le Gros G; Mosmann TR; Sher A; Ronchese F
Article: SCIENCE ADVANCES. 2022;8(12):eabm0220
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekstrom S; Coquet JM; McInerney GM; Murrell B
Article: BLOOD ADVANCES. 2022;6(6):1780-1796
Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion
Stalmann USA; Ticconi F; Snoeren IAM; Li R; Gleitz HFE; Cowley GS; McConkey ME; Wong AB; Schmitz S; Fuchs SNR; Sood S; Leimkuehler NB; Martinez-Hoyer S; Banjanin B; Root D; Bruemmendorf TH; Pearce JE; Schuppert A; Bindels EMJ; Essers MA; Heckl D; Stiehl T; Costa IG; Ebert BL; Schneider RK
Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
Intestinal helminth infection transforms the CD4⁺ T cell composition of the skin
Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylen S
Article: NATURE COMMUNICATIONS. 2022;13(1):155
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Review: FRONTIERS IN IMMUNOLOGY. 2022;13:877005
Tissue Resident and Migratory Group 2 Innate Lymphoid Cells
Mathae L; Takei F; Martinez-Gonzalez I
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates
Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
Journal article: FRONTIERS IN ALLERGY. 2022;3:1062412
IL-33 induces NF-?B activation in ILC2 that can be suppressed by in vivo and ex vivo 17β-estradiol
Trivedi S; Labuz D; Deering-Rice CE; Kim CU; Christensen H; Aamodt S; Huecksteadt T; Sanders K; Warren KJ
Article: ANTIOXIDANTS. 2021;10(12):1936
Genome-Wide RNAi Screening Identifies Novel Pathways/Genes Involved in Oxidative Stress and Repurposable Drugs to Preserve Cystic Fibrosis Airway Epithelial Cell Integrity
Checa J; Martinez-Gonzalez I; Maqueda M; Mosquera JL; Aran JM
Article: CELL REPORTS MEDICINE. 2021;2(11):100450
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(11):45
The Role of PPAR-γ in Allergic Disease
Stark JM; Coquet JM; Tibbitt CA
Article: NATURE COMMUNICATIONS. 2021;12(1):5565
Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases
Lahore GF; Forster M; Johannesson M; Sabatier P; Lonnblom E; Aoun M; He Y; Nandakumar KS; Zubarev RA; Holmdahl R
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabg6356
Single-cell analysis pinpoints distinct populations of cytotoxic CD4⁺ T cells and an IL-10⁺CD109⁺ T_H2 cell population in nasal polyps
Ma J; Tibbitt CA; Georen SK; Christian M; Murrell B; Cardell L-O; Bachert C; Coquet JM
Thesis / dissertation: 2021
Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics
Fernandez Lahore, Gonzalo
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2021;11(6):e427
Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation
Laanesoo A; Urgard E; Periyasamy K; Laan M; Bochkov YA; Aab A; Magilnick N; Pooga M; Gern JE; Johnston SL; Coquet JM; Boldin MP; Wengel J; Altraja A; Bochenek G; Jakiela B; Rebane A
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):590
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis.
Ferrarini MG; Lal A; Rebollo R; Gruber AJ; Guarracino A; Gonzalez IM; Floyd T; de Oliveira DS; Shanklin J; Beausoleil E; Pusa T; Pickett BE; Aguiar-Pulido V
Article: NATURE COMMUNICATIONS. 2021;12(1):2474
A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia
Docking TR; Parker JDK; Jadersten M; Duns G; Chang L; Jiang J; Pilsworth JA; Swanson LA; Chan SK; Chiu R; Nip KM; Mar S; Mo A; Wang X; Martinez-Hoyer S; Stubbins RJ; Mungall KL; Mungall AJ; Moore RA; Jones SJM; Birol I; Marra MA; Hogge D; Karsan A
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens
Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Article: SCIENCE IMMUNOLOGY. 2021;6(55):eabd3489
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
van der Ploeg EK; Golebski K; van Nimwegen M; Fergusson JR; Heesters BA; Martinez-Gonzalez I; Kradolfer CMA; van Tol S; Scicluna BP; de Bruijn MJW; de Boer GM; Tramper-Stranders GA; Braunstahl G-J; van IJcken WFJ; Nagtegaal AP; van Drunen CM; Fokkens WJ; Huylebroeck D; Spits H; Hendriks RW; Stadhouders R; Bal SM
Article: NATURE COMMUNICATIONS. 2021;12(1):610
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation
Norin U; Rintisch C; Meng L; Forster F; Ekman D; Tuncel J; Klocke K; Backlund J; Yang M; Bonner MY; Lahore GF; James J; Shchetynsky K; Bergquist M; Gjertsson I; Hubner N; Backdahl L; Holmdahl R
Review: FRONTIERS IN IMMUNOLOGY. 2021;12:671966
The Fate of Activated Group 2 Innate Lymphoid Cells
Matha L; Martinez-Gonzalez I; Steer CA; Takei F
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:679509
Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity
Matha L; Romera-Hernandez M; Steer CA; Yin YH; Orangi M; Shim H; Chang C; Rossi FM; Takei F
Corrigendum: PLOS ONE. 2021;16(5):e0252257
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production (vol 14, e0214286, 2019)
Mathae L; Shim H; Steer CA; Yin YH; Martinez-Gonzalez I; Takei F
Article: BIOMATERIALS. 2020;262:120316
NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation.
Carreras-Badosa G; Maslovskaja J; Periyasamy K; Urgard E; Padari K; Vaher H; Tserel L; Gestin M; Kisand K; Arukuusk P; Lou C; Langel Ü; Wengel J; Pooga M; Rebane A
Journal article: ELIFE. 2020;9:e55615
Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis
Trivedi S; Labuz D; Anderson CP; Araujo CV; Blair A; Middleton EA; Jensen O; Tran A; Mulvey MA; Campbell RA; Hale JS; Rondina MT; Leung DT
Article: EXPERIMENTAL HEMATOLOGY. 2020;91:22-31
Mechanisms of lenalidomide sensitivity and resistance
Martinez-Hoyer S; Karsan A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(40):24986-24997
Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases
Lahore GF; Raposo B; Lagerquist M; Ohlsson C; Sabatier P; Xu B; Aoun M; James J; Cai X; Zubarev RA; Nandakumar KS; Holmdahl R
Journal article: EXPERIMENTAL HEMATOLOGY. 2020;88:s72
3108 – MOLECULAR MECHANISMS OF LENALIDOMIDE RESISTANCE IN DEL(5Q) MYELODYSPLASTIC SYNDROMES
Martinez-Høyer S; Deng Y; Parker J; Jiang J; Docking R; Mo A; Gharaee N; Jädersten M; Kulasekararaj A; Malcovati L; List A; Hellström-Lindberg E; Platzbecker U; Karsan A
Article: JCI INSIGHT. 2020;5(14):135961
Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period
Steer CA; Matha L; Shim H; Takei F
Editorial comment: SCIENCE IMMUNOLOGY. 2020;5(48):eabc4021
A singular role for interleukin-9 in the development of asthma
Coquet JM
Article: NATURE CELL BIOLOGY. 2020;22(5):526-533
Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome
Martinez-Hoyer S; Deng Y; Parker J; Jiang J; Mo A; Docking TR; Gharaee N; Li J; Umlandt P; Fuller M; Jadersten M; Kulasekararaj A; Malcovati L; List AF; Hellstrom-Lindberg E; Platzbecker U; Karsan A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2020;217(3):e20182293
Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets
Ghaedi M; Shen ZY; Orangi M; Martinez-Gonzalez I; Wei L; Lu X; Das A; Heravi-Moussavi A; Marra MA; Bhandoola A; Takei F
Article: IMMUNITY, INFLAMMATION AND DISEASE. 2020;8(1):8-23
PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ
Batyrova B; Luwaert F; Maravelia P; Miyabayashi Y; Vashist N; Stark JM; Soori SY; Tibbitt CA; Riese P; Coquet JM; Chambers BJ
Conference publication: EXPERIMENTAL HEMATOLOGY. 2020;88:S72
MOLECULAR MECHANISMS OF LENALIDOMIDE RESISTANCE IN DEL(5Q) MYELODYSPLASTIC SYNDROMES
Martinez-Hoyer S; Deng Y; Parker J; Jiang J; Docking R; Mo A; Gharaee N; Jadersten M; Kulasekararaj A; Malcovati L; List A; Hellstrom-Lindberg E; Platzbecker U; Karsan A
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;74(11):2146-2156
miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation.
Vaher H; Runnel T; Urgard E; Aab A; Carreras Badosa G; Maslovskaja J; Abram K; Raam L; Kaldvee B; Annilo T; Tkaczyk ER; Maimets T; Akdis CA; Kingo K; Rebane A
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(9):2221-2222
KLRG1 and NKp46 discriminate subpopulations of human CD117⁺CRTH2^- ILCs biased toward ILC2 or ILC3 (vol 216, 1762, 2019)
Nagasawa M; Heesters BA; Kradolfer CMA; Krabbendam L; Martinez-Gonzalez I; de Bruijn MJW; Golebski K; Hendriks RW; Stadhouders R; Spits H; Bal SM
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1762-1776
KLRG1 and NKp46 discriminate subpopulations of human CD117⁺CRTH2^- ILCs biased toward ILC2 or ILC3
Nagasawa M; Heesters BA; Kradolfer CMA; Krabbendam L; Martinez-Gonzalez I; de Bruijn MJW; Golebski K; Hendriks RW; Stadhouders R; Spits H; Bal SM
Article: IMMUNITY. 2019;51(1):169-184
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
Tibbitt CA; Stark JM; Martens L; Ma J; Mold JE; Deswarte K; Oliynyk G; Feng X; Lambrecht BN; De Bleser P; Nylen S; Hammad H; Henriksson MA; Saeys Y; Coquet JM
Article: CURRENT PROTOCOLS IN IMMUNOLOGY. 2019;125(1):e73
Identification of Group 2 Innate Lymphoid Cells in Mouse Lung, Liver, Small Intestine, Bone Marrow, and Mediastinal and Mesenteric Lymph Nodes.
Romera-Hernández M; Mathä L; Steer CA; Ghaedi M; Takei F
Article: JOURNAL OF AUTOIMMUNITY. 2019;98:86-94
Multi-faceted inhibition of dendritic cell function by CD4⁺ Foxp3⁺ regulatory T cells
Seitz C; Liu S; Klocke K; Joly A-L; Czarnewski PV; Tibbitt CA; Parigi SM; Westerberg LS; Coquet JM; Villablanca EJ; Wing K; Andersson J
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2318
The Metabolic Requirements of Th2 Cell Differentiation
Stark JM; Tibbitt CA; Coquet JM
Article: ONCOIMMUNOLOGY. 2019;8(2):e1527497
IL-33 increases ST2⁺ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Article: PLOS ONE. 2019;14(3):e0214286
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production
Matha L; Shim H; Steer CA; Yin YH; Martinez-Gonzalez I; Takei F
Meeting abstract: BLOOD. 2018;132:176
Resistance to Lenalidomide in Del(5q) MDS Is Mediated By Inhibition of Drug-Induced Megakaryocytic Differentiation
Martinez-Hoyer S; Mo A; Deng D; Jiang J; Docking R; Li J; Chan S; Umlandt P; Fuller M; Jadersten M; Hellstrom-Lindberg E; Platzbecker U; Parker J; Karsan A
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: NATURE COMMUNICATIONS. 2018;9(1):2418
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling
Lam J; van den Bosch M; Wegrzyn J; Parker J; Ibrahim R; Slowski K; Chang L; Martinez-Hoyer S; Condorelli G; Boldin M; Deng Y; Umlandt P; Fuller M; Karsan A
Review: IMMUNOLOGICAL REVIEWS. 2018;283(1):41-53
ILC2 memory: Recollection of previous activation
Martinez-Gonzalez I; Ghaedi M; Steer CA; Matha L; Vivier E; Takei F
Article: PLOS PATHOGENS. 2018;14(5):e1007008
Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection
Feng X; Classon C; Teran G; Yang Y; Li L; Chan S; Ribacke U; Rothfuchs AG; Coquet JM; Nylen S
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):300-310.e11
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients
Sugita K; Steer CA; Martinez-Gonzalez I; Altunbulakli C; Morita H; Castro-Giner F; Kubo T; Wawrzyniak P; Ruckert B; Sudo K; Nakae S; Matsumoto K; O'Mahony L; Akdis M; Takei F; Akdis CA
Article: NUCLEIC ACID THERAPEUTICS. 2017;27(5):295-302
Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells.
Urgard E; Brjalin A; Langel Ü; Pooga M; Rebane A; Annilo T
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(9):1945-1954
miR-146b Probably Assists miRNA-146a in the Suppression of Keratinocyte Proliferation and Inflammatory Responses in Psoriasis.
Hermann H; Runnel T; Aab A; Baurecht H; Rodriguez E; Magilnick N; Urgard E; Šahmatova L; Prans E; Maslovskaja J; Abram K; Karelson M; Kaldvee B; Reemann P; Haljasorg U; Rückert B; Wawrzyniak P; Weichenthal M; Mrowietz U; Franke A; Gieger C; Barker J; Trembath R; Tsoi LC; Elder JT; Tkaczyk ER; Kisand K; Peterson P; Kingo K; Boldin M; Weidinger S; Akdis CA; Rebane A
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):593-595.e3
Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization
Steer CA; Martinez-Gonzalez I; Ghaedi M; Allinger P; Mathae L; Takei F
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2017;95(7):571-572
Factoring in CD4 T cells during treatment of HIV
Coquet JM
Review: TRENDS IN IMMUNOLOGY. 2017;38(6):423-431
Immunological Memory of Group 2 Innate Lymphoid Cells
Martinez-Gonzalez I; Matha L; Steer CA; Takei F
Meeting abstract: LEUKEMIA RESEARCH. 2017;55:S43-S44
RUNX1 LOSS OF FUNCTION DRIVES RESISTANCE TO LENALIDOMIDE IN DEL(5Q) MYELODYSPLASTIC SYNDROME PATIENTS
Martinez-Hoyer S; Mo A; Docking R; Li J; Chan S; Umlandt P; Fuller M; Jadersten M; Hellstrom-Lindberg E; Platzbecker U; Parker J; Karsan A
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):388-399
Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
Anto JM; Bousquet J; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Carlsen KCL; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melen E; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohmann C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Andersson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen K-H; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; Maekelae M; Mestres J; Mowinckel P; Nadif R; Nawijn MC; Pellet J; Pin I; Porta D; Ranciere F; Rial-Sebbag E; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; Wenzel K; Xu C-J
Article: CANCER CELL INTERNATIONAL. 2017;17:18
Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model.
Urgard E; Reigo A; Reinmaa E; Rebane A; Metspalu A
Corrigendum: PLOS ONE. 2017;12(1):e0170833
Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer.
Lokk K; Vooder T; Kolde R; Välk K; Võsa U; Roosipuu R; Milani L; Fischer K; Koltsina M; Urgard E; Annilo T; Metspalu A; Tõnisson N
Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71(11):1513-1525
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015
Bousquet J; Anto JM; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Carlsen KCL; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melen E; Palkonen S; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohman C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Albang R; Anastasova V; Anderson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen KH; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; Gerhard B; Hammad H; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kerkhof M; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; McEachan R; Makela M; Mestres J; Minina E; Mowinckel P; Nadif R; Nawijn M; Oddie S; Pellet J; Pin I; Porta D; Ranciere F; Rial-Sebbag A; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; De Vocht J; Wenger K; Wieser S; Xu C
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(10):1973-1981
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20
Drennan MB; Govindarajan S; Verheugen E; Coquet JM; Staal J; McGuire C; Taghon T; Leclercq G; Beyaert R; van Loo G; Lambrecht BN; Elewaut D
Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2261-2268
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
Carow B; Gao Y; Coquet J; Reilly M; Rottenberg ME
Article: JOURNAL OF CONTROLLED RELEASE. 2016;235:195-204
Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis
Urgard E; Lorents A; Klaas M; Padari K; Viil J; Runnel T; Langel K; Kingo K; Tkaczyk E; Langel U; Maimets T; Jaks V; Pooga M; Rebane A
Journal article: ELIFE. 2016;5:e14243
Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex
Tramantano M; Sun L; Au C; Labuz D; Liu Z; Chou M; Shen C; Luk E
Article: IMMUNITY. 2016;45(1):198-208
Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation
Martinez-Gonzalez I; Matha L; Steer CA; Ghaedi M; Poon GFT; Takei F
Journal article: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2016;47(5):403-409
Dictyostelium discoideum as a surrogate host-microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1.
Bravo-Toncio C; Álvarez JA; Campos F; Ortíz-Severín J; Varas M; Cabrera R; Lagos CF; Chávez FP
Article: CELL REPORTS. 2016;15(3):471-480
Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development
Ghaedi M; Steer CA; Martinez-Gonzalez I; Halim TYF; Abraham N; Takei F
Conference publication: BLOOD. 2015;126(23):5228
Mechanisms of Resistance to Lenalidomide in Del(5q) Myelodysplastic Syndrome Patients
Martinez-Hoyer S; Docking R; Chan S; Jadersten M; Parker J; Karsan A
Review: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(9):780-788
The importance of co-stimulation in the orchestration of T helper cell differentiation
Coquet JM; Rausch L; Borst J
Article: IMMUNITY. 2015;43(2):318-330
Interleukin-21-Producing CD4⁺ T Cells Promote Type 2 Immunity to House Dust Mites
Coquet JM; Schuijs MJ; Smyth MJ; Deswarte K; Beyaert R; Braun H; Boon L; Hedestam GBK; Nutt SL; Hammad H; Lambrecht BN
Article: CARCINOGENESIS. 2015;36(7):792-799
A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer
Martinez-Hoyer S; Sole-Sanchez S; Aguado F; Martinez-Martinez S; Serrano-Candelas E; Luis Hernandez J; Iglesias M; Miguel Redondo J; Casanovas O; Messeguer R; Perez-Riba M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;460(2):295-301
RCAN 1 and 3 proteins regulate thymic positive selection
Serrano-Candelas E; Aleman-Muench G; Sole-Sanchez S; Aubareda A; Martinez-Hoyer S; Adan J; Aranguren-Ibanez A; Pritchard MA; Soldevila G; Perez-Riba M
Review: TRENDS IN IMMUNOLOGY. 2015;36(3):189-195
Lung ILC2s link innate and adaptive responses in allergic inflammation
Martinez-Gonzalez I; Steer CA; Takei F
Article: PLOS ONE. 2015;10(8):e0134569
Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization
Guasch A; Aranguren-Ibanez A; Perez-Luque R; Aparicio D; Martinez-Hoyer S; Carmen Mulero M; Serrano-Candelas E; Perez-Riba M; Fita I
Article: STEM CELLS AND DEVELOPMENT. 2014;23(19):2352-2363
Human Mesenchymal Stem Cells Resolve Airway Inflammation, Hyperreactivity, and Histopathology in a Mouse Model of Occupational Asthma
Martinez-Gonzalez I; Cruz M-J; Moreno R; Morell F; Munoz X; Aran JM
Article: IMMUNITY. 2014;40(3):425-435
Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
Halim TYF; Steer CA; Mathae L; Gold MJ; Martinez-Gonzalez I; McNagny KM; McKenzie ANJ; Takei F
Article: PLOS ONE. 2014;9(1):e85539
The Vertebrate RCAN Gene Family: Novel Insights into Evolution, Structure and Regulation
Serrano-Candelas E; Farre D; Aranguren-Ibanez A; Martinez-Hoyer S; Perez-Riba M
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2013;2(10):e6
IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma.
Coquet JM; Skak K; Davis ID; Smyth MJ; Godfrey DI
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2013;49(4):552-562
Human Mesenchymal Stem Cells Overexpressing the IL-33 Antagonist Soluble IL-1 Receptor-Like-1 Attenuate Endotoxin-Induced Acute Lung Injury
Martinez-Gonzalez I; Roca O; Masclans JR; Moreno R; Salcedo MT; Baekelandt V; Cruz MJ; Rello J; Aran JM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1833(10):2311-2321
Protein kinase CK2-dependent phosphorylation of the human Regulators of Calcineurin reveals a novel mechanism regulating the calcineurin-NFATc signaling pathway
Martinez-Hoyer S; Aranguren-Ibanez A; Garcia-Garcia J; Serrano-Candelas E; Vilardell J; Nunes V; Aguado F; Oliva B; Itarte E; Perez-Riba M
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2013;210(4):715-728
Epithelial and dendritic cells in the thymic medulla promote CD4⁺Foxp3⁺ regulatory T cell development via the CD27-CD70 pathway
Coquet JM; Ribot JC; Babala N; Middendorp S; van der Horst G; Xiao Y; Neves JF; Fonseca-Pereira D; Jacobs H; Pennington DJ; Silva-Santos B; Borst J
Article: IMMUNITY. 2013;38(1):53-65
The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity
Coquet JM; Middendorp S; van der Horst G; Kind J; Veraar EAM; Xiao Y; Jacobs H; Borst J
Article: STEM CELLS AND DEVELOPMENT. 2012;21(18):3270-3277
Engraftment Potential of Adipose Tissue-Derived Human Mesenchymal Stem Cells After Transplantation in the Fetal Rabbit
Martinez-Gonzalez I; Moreno R; Petriz J; Gratacos E; Aran JM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(4):943-54.e4
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar
Anto JM; Pinart M; Akdis M; Auffray C; Bachert C; Basagana X; Carlsen K-H; Guerra S; von Hertzen L; Illi S; Kauffmann F; Keil T; Kiley JP; Koppelman GH; Lupinek C; Martinez FD; Nawijn MC; Postma DS; Siroux V; Smit HA; Sterk PJ; Sunyer J; Valenta R; Valverde S; Akdis CA; Annesi-Maesano I; Ballester F; Benet M; Cambon-Thomsen A; Chatzi L; Coquet J; Demoly P; Gan W; Garcia-Aymerich J; Gimeno-Santos E; Guihenneuc-Jouyaux C; Haahtela T; Heinrich J; Herr M; Hohmann C; Jacquemin B; Just J; Kerkhof M; Kogevinas M; Kowalski ML; Lambrecht BN; Lau S; Carlsen KCL; Maier D; Momas I; Noel P; Oddie S; Palkonen S; Pin I; Porta D; Punturieri A; Ranciere F; Smith RA; Stanic B; Stein RT; van de Veen W; van Oosterhout AJM; Varraso R; Wickman M; Wijmenga C; Wright J; Yaman G; Zuberbier T; Bousquet J
Article: STEM CELLS AND DEVELOPMENT. 2012;21(2):284-295
Fetal Liver-Derived Mesenchymal Stem Cell Engraftment After Allogeneic In Utero Transplantation into Rabbits
Moreno R; Martinez-Gonzalez I; Rosal M; Nadal M; Petriz J; Gratacos E; Aran JM
Article: PLOS ONE. 2012;7(6):e39813
Methylation markers of early-stage non-small cell lung cancer.
Lokk K; Vooder T; Kolde R; Välk K; Võsa U; Roosipuu R; Milani L; Fischer K; Koltsina M; Urgard E; Annilo T; Metspalu A; Tõnisson N
Article: MEDICAL HYPOTHESES. 2011;77(2):174-178
The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging.
Luo C; Urgard E; Vooder T; Metspalu A
Article: TISSUE ENGINEERING - PART C: METHODS. 2011;17(3):275-287
The β-Interferon Scaffold Attachment Region Confers High-Level Transgene Expression and Avoids Extinction by Epigenetic Modifications of Integrated Provirus in Adipose Tissue-Derived Human Mesenchymal Stem Cells
Moreno R; Martinez I; Petriz J; Nadal M; Tintore X; Ramon Gonzalez J; Gratacos E; Aran JM
Article: CANCER INFORMATICS. 2011;10:175-183
Metagenes associated with survival in non-small cell lung cancer.
Urgard E; Vooder T; Võsa U; Välk K; Liu M; Luo C; Hoti F; Roosipuu R; Annilo T; Laine J; Frenz CM; Zhang L; Metspalu A
Article: STEM CELLS AND DEVELOPMENT. 2010;19(10):1579-1588
Characterization of Mesenchymal Stem Cells Isolated from the Rabbit Fetal Liver
Moreno R; Martinez-Gonzalez I; Rosal M; Farwati A; Gratacos E; Aran JM
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(2):365-378
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Zotos D; Coquet JM; Zhang Y; Light A; D'Costa K; Kallies A; Corcoran LM; Godfrey DI; Toellner K-M; Smyth MJ; Nutt SL; Tarlinton DM
Article: JOURNAL OF IMMUNOLOGY. 2009;183(11):7326-7336
Endogenous IL-21 Restricts CD8⁺ T Cell Expansion and Is not Required for Tumor Immunity
Sondergaard H; Coquet JM; Uldrich AP; McLaughlin N; Godfrey DI; Sivakumar PV; Skak K; Smyth MJ
Article: BLOOD CELLS, MOLECULES, AND DISEASES. 2009;43(2):214-220
Boundary sequences stabilize transgene expression from subtle position effects in retroviral vectors
Moreno R; Martinez I; Petriz J; Ramon Gonzalez J; Gratacos E; Aran JM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(14):9394-9401
Inhibiting the Calcineurin-NFAT (Nuclear Factor of Activated T Cells) Signaling Pathway with a Regulator of Calcineurin-derived Peptide without Affecting General Calcineurin Phosphatase Activity
Mulero MC; Aubareda A; Orzaez M; Messeguer J; Serrano-Candelas E; Martinez-Hoyer S; Messeguer A; Perez-Paya E; Perez-Riba M
Article: JOURNAL OF GENE MEDICINE. 2008;10(9):951-964
Restricted transgene persistence after lentiviral vector-mediated fetal gene transfer in the pregnant rabbit model
Moreno R; Rosal M; Martinez I; Vilardell F; Ramon Gonzalez J; Petriz J; Hernandez-Andrade E; Gratacos E; Aran JM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11287-11292
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4^-NK1.1^- NKT cell population
Coquet JM; Chakravarti S; Kyparissoudis K; McNab FW; Pitt LA; McKenzie BS; Berzins SP; Smyth MJ; Godfrey DI
Article: JOURNAL OF IMMUNOLOGY. 2008;180(11):7097-7101
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
Coquet JM; Chakravarti S; Smyth MJ; Godfrey DI
Article: HUMAN MUTATION. 2008;29(5):738-749
N-terminal CFTR missense variants severely affect the behavior of the CFTR chloride channel
Gene GG; Llobet A; Larriba S; de Semiri D; Martinez I; Escalada A; Solsona C; Casals T; Aran JM
Article: JOURNAL OF IMMUNOLOGY. 2007;178(5):2827-2834
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
Coquet JM; Kyparissoudis K; Pellicci DG; Besra G; Berzins SP; Smyth MJ; Godfrey DI
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2007;314:293-323
CD1-restricted T cells and tumor immunity
Swann JB; Coquet JMC; Smyth MJ; Godfrey DI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;202(9):1279-1288
Differential antitumor immunity mediated by NKT cell subsets in vivo
Crowe NY; Coquet JM; Berzins SP; Kyparissoudis K; Keating R; Pellicci DG; Hayakawa Y; Godfrey DI; Smyth MJ
Article: JOURNAL OF IMMUNOLOGY. 2005;175(7):4416-4425
DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells
Pellicci DG; Hammond KJL; Coquet J; Kyparissoudis K; Brooks AG; Kedzierska K; Keating R; Turner S; Berzins S; Smyth MJ; Godfrey DI
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