Laboratoriet för lymfocytdifferentiering – Jonathan Coquets grupp

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Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2024;221(8):e20231827
Human CD127 negative ILC2s show immunological memory
Matha L; Krabbendam L; Hoyer SM; Heesters BA; Golebski K; Kradolfer C; Ghaedi M; Ma J; Stadhouders R; Bachert C; Cardell L-O; Zhang N; Holtappels G; Reitsma S; Helgers LC; Geijtenbeek TBH; Coquet JM; Takei F; Spits H; Martinez-Gonzalez I
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2024;:S0022-202X(24)00377-4
Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Nonmalignant T Cell Proliferation in Cutaneous T-Cell Lymphoma.
Zeng Z; Vadivel CK; Gluud M; Namini MRJ; Yan L; Ahmad S; Hansen MB; Coquet J; Mustelin T; Koralov SB; Bonefeld CM; Woetmann A; Geisler C; Guenova E; Kamstrup MR; Litman T; Gjerdrum L-MR; Buus TB; Ødum N
Article: IMMUNOLOGY AND CELL BIOLOGY. 2024;102(4):232-234
Bridging the gap between scientific discoveries and clinical application at the Utrecht Science Park
Peperzak V; Coquet JM
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508
Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque
Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
Article: IMMUNOLOGY AND CELL BIOLOGY. 2023;101(10):936-946
A conversation on allergy: recognizing the past and looking to the future
Melen E; Lambrecht BN; Lloyd CM; Rothenberg ME; Kabashima K; Luciani F; Coquet JM; Ober C; Nawijn MC; Platts-Mills T; von Mutius E
Article: SCIENCE IMMUNOLOGY. 2023;8(87):eadf7702
Laboratory mice with a wild microbiota generate strong allergic immune responses
Ma J; Urgard E; Runge S; Classon CH; Mathae L; Stark JM; Cheng L; Alvarez JA; Von Zedtwitz S; Baleviciute A; Hoyer SM; Li M; Gernand AM; Osbelt L; Bielecka AA; Lesker TR; Huang H-J; Vrtala S; Boon L; Beyaert R; Adner M; Gonzalez IM; Strowig T; Du J; Nylen S; Rosshart SP; Coquet JM
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2023;101(7):598-599
Immunology in the Copenhagen area: a renewed focus on diseases of the skin
Coquet JM
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(10):2987-3001
Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses
Stark JM; Liu J; Tibbitt CA; Christian M; Ma J; Wintersand A; Dunst J; Kreslavsky T; Murrell B; Adner M; Gronlund H; Gafvelin G; Coquet JM
Letter: NATURE IMMUNOLOGY. 2022;23(4):501-502
Comment on: Repositioning T_H cell polarization from single cytokines to complex help
Jankovic D; Ciucci T; Coffman RL; Coquet JM; Le Gros G; Mosmann TR; Sher A; Ronchese F
Article: SCIENCE ADVANCES. 2022;8(12):eabm0220
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekstrom S; Coquet JM; McInerney GM; Murrell B
Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
Intestinal helminth infection transforms the CD4⁺ T cell composition of the skin
Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylen S
Article: NATURE COMMUNICATIONS. 2022;13(1):155
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates
Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
Article: CELL REPORTS MEDICINE. 2021;2(11):100450
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(11):45
The Role of PPAR-γ in Allergic Disease
Stark JM; Coquet JM; Tibbitt CA
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabg6356
Single-cell analysis pinpoints distinct populations of cytotoxic CD4⁺ T cells and an IL-10⁺CD109⁺ T_H2 cell population in nasal polyps
Ma J; Tibbitt CA; Georen SK; Christian M; Murrell B; Cardell L-O; Bachert C; Coquet JM
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2021;11(6):e427
Dual role of the miR-146 family in rhinovirus-induced airway inflammation and allergic asthma exacerbation
Laanesoo A; Urgard E; Periyasamy K; Laan M; Bochkov YA; Aab A; Magilnick N; Pooga M; Gern JE; Johnston SL; Coquet JM; Boldin MP; Wengel J; Altraja A; Bochenek G; Jakiela B; Rebane A
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens
Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Editorial comment: SCIENCE IMMUNOLOGY. 2020;5(48):eabc4021
A singular role for interleukin-9 in the development of asthma
Coquet JM
Article: IMMUNITY, INFLAMMATION AND DISEASE. 2020;8(1):8-23
PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ
Batyrova B; Luwaert F; Maravelia P; Miyabayashi Y; Vashist N; Stark JM; Soori SY; Tibbitt CA; Riese P; Coquet JM; Chambers BJ
Article: IMMUNITY. 2019;51(1):169-184.e5
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
Tibbitt CA; Stark JM; Martens L; Ma J; Mold JE; Deswarte K; Oliynyk G; Feng X; Lambrecht BN; De Bleser P; Nylen S; Hammad H; Henriksson MA; Saeys Y; Coquet JM
Article: JOURNAL OF AUTOIMMUNITY. 2019;98:86-94
Multi-faceted inhibition of dendritic cell function by CD4⁺ Foxp3⁺ regulatory T cells
Seitz C; Liu S; Klocke K; Joly A-L; Czarnewski PV; Tibbitt CA; Parigi SM; Westerberg LS; Coquet JM; Villablanca EJ; Wing K; Andersson J
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2318
The Metabolic Requirements of Th2 Cell Differentiation
Stark JM; Tibbitt CA; Coquet JM
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: PLOS PATHOGENS. 2018;14(5):e1007008
Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode infection
Feng X; Classon C; Teran G; Yang Y; Li L; Chan S; Ribacke U; Rothfuchs AG; Coquet JM; Nylen S
Editorial comment: IMMUNOLOGY AND CELL BIOLOGY. 2017;95(7):571-572
Factoring in CD4 T cells during treatment of HIV
Coquet JM
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):388-399
Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
Anto JM; Bousquet J; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Carlsen KCL; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melen E; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohmann C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Andersson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen K-H; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; Maekelae M; Mestres J; Mowinckel P; Nadif R; Nawijn MC; Pellet J; Pin I; Porta D; Ranciere F; Rial-Sebbag E; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; Wenzel K; Xu C-J
Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;71(11):1513-1525
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015
Bousquet J; Anto JM; Akdis M; Auffray C; Keil T; Momas I; Postma DS; Valenta R; Wickman M; Cambon-Thomsen A; Haahtela T; Lambrecht BN; Carlsen KCL; Koppelman GH; Sunyer J; Zuberbier T; Annesi-Maesano I; Arno A; Bindslev-Jensen C; De Carlo G; Forastiere F; Heinrich J; Kowalski ML; Maier D; Melen E; Palkonen S; Smit HA; Standl M; Wright J; Asarnoj A; Benet M; Ballardini N; Garcia-Aymerich J; Gehring U; Guerra S; Hohman C; Kull I; Lupinek C; Pinart M; Skrindo I; Westman M; Smagghe D; Akdis C; Albang R; Anastasova V; Anderson N; Bachert C; Ballereau S; Ballester F; Basagana X; Bedbrook A; Bergstrom A; von Berg A; Brunekreef B; Burte E; Carlsen KH; Chatzi L; Coquet JM; Curin M; Demoly P; Eller E; Fantini MP; Gerhard B; Hammad H; von Hertzen L; Hovland V; Jacquemin B; Just J; Keller T; Kerkhof M; Kiss R; Kogevinas M; Koletzko S; Lau S; Lehmann I; Lemonnier N; McEachan R; Makela M; Mestres J; Minina E; Mowinckel P; Nadif R; Nawijn M; Oddie S; Pellet J; Pin I; Porta D; Ranciere F; Rial-Sebbag A; Saeys Y; Schuijs MJ; Siroux V; Tischer CG; Torrent M; Varraso R; De Vocht J; Wenger K; Wieser S; Xu C
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(10):1973-1981
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20
Drennan MB; Govindarajan S; Verheugen E; Coquet JM; Staal J; McGuire C; Taghon T; Leclercq G; Beyaert R; van Loo G; Lambrecht BN; Elewaut D
Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2261-2268
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
Carow B; Gao Y; Coquet J; Reilly M; Rottenberg ME
Review: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(9):780-788
The importance of co-stimulation in the orchestration of T helper cell differentiation
Coquet JM; Rausch L; Borst J
Article: IMMUNITY. 2015;43(2):318-330
Interleukin-21-Producing CD4⁺ T Cells Promote Type 2 Immunity to House Dust Mites
Coquet JM; Schuijs MJ; Smyth MJ; Deswarte K; Beyaert R; Braun H; Boon L; Hedestam GBK; Nutt SL; Hammad H; Lambrecht BN
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2013;2(10):e6
IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma.
Coquet JM; Skak K; Davis ID; Smyth MJ; Godfrey DI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2013;210(4):715-728
Epithelial and dendritic cells in the thymic medulla promote CD4⁺Foxp3⁺ regulatory T cell development via the CD27-CD70 pathway
Coquet JM; Ribot JC; Babala N; Middendorp S; van der Horst G; Xiao Y; Neves JF; Fonseca-Pereira D; Jacobs H; Pennington DJ; Silva-Santos B; Borst J
Article: IMMUNITY. 2013;38(1):53-65
The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity
Coquet JM; Middendorp S; van der Horst G; Kind J; Veraar EAM; Xiao Y; Jacobs H; Borst J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(4):943-54.e4
Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar
Anto JM; Pinart M; Akdis M; Auffray C; Bachert C; Basagana X; Carlsen K-H; Guerra S; von Hertzen L; Illi S; Kauffmann F; Keil T; Kiley JP; Koppelman GH; Lupinek C; Martinez FD; Nawijn MC; Postma DS; Siroux V; Smit HA; Sterk PJ; Sunyer J; Valenta R; Valverde S; Akdis CA; Annesi-Maesano I; Ballester F; Benet M; Cambon-Thomsen A; Chatzi L; Coquet J; Demoly P; Gan W; Garcia-Aymerich J; Gimeno-Santos E; Guihenneuc-Jouyaux C; Haahtela T; Heinrich J; Herr M; Hohmann C; Jacquemin B; Just J; Kerkhof M; Kogevinas M; Kowalski ML; Lambrecht BN; Lau S; Carlsen KCL; Maier D; Momas I; Noel P; Oddie S; Palkonen S; Pin I; Porta D; Punturieri A; Ranciere F; Smith RA; Stanic B; Stein RT; van de Veen W; van Oosterhout AJM; Varraso R; Wickman M; Wijmenga C; Wright J; Yaman G; Zuberbier T; Bousquet J
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(2):365-378
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
Zotos D; Coquet JM; Zhang Y; Light A; D'Costa K; Kallies A; Corcoran LM; Godfrey DI; Toellner K-M; Smyth MJ; Nutt SL; Tarlinton DM
Article: JOURNAL OF IMMUNOLOGY. 2009;183(11):7326-7336
Endogenous IL-21 Restricts CD8⁺ T Cell Expansion and Is not Required for Tumor Immunity
Sondergaard H; Coquet JM; Uldrich AP; McLaughlin N; Godfrey DI; Sivakumar PV; Skak K; Smyth MJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11287-11292
Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4^-NK1.1^- NKT cell population
Coquet JM; Chakravarti S; Kyparissoudis K; McNab FW; Pitt LA; McKenzie BS; Berzins SP; Smyth MJ; Godfrey DI
Article: JOURNAL OF IMMUNOLOGY. 2008;180(11):7097-7101
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
Coquet JM; Chakravarti S; Smyth MJ; Godfrey DI
Article: JOURNAL OF IMMUNOLOGY. 2007;178(5):2827-2834
IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
Coquet JM; Kyparissoudis K; Pellicci DG; Besra G; Berzins SP; Smyth MJ; Godfrey DI
Review: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY. 2007;314:293-323
CD1-restricted T cells and tumor immunity
Swann JB; Coquet JMC; Smyth MJ; Godfrey DI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;202(9):1279-1288
Differential antitumor immunity mediated by NKT cell subsets in vivo
Crowe NY; Coquet JM; Berzins SP; Kyparissoudis K; Keating R; Pellicci DG; Hayakawa Y; Godfrey DI; Smyth MJ
Article: JOURNAL OF IMMUNOLOGY. 2005;175(7):4416-4425
DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells
Pellicci DG; Hammond KJL; Coquet J; Kyparissoudis K; Brooks AG; Kedzierska K; Keating R; Turner S; Berzins S; Smyth MJ; Godfrey DI
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Laboratoriet för lymfocytdifferentiering – Jonathan Coquets grupp

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