CBCS - our offer
CBCS offers an extensive portfolio of services, from computational and organic chemistry to phenotypic small molecule screens in cells and model organisms, cell painting and functional precision medicine. CBCS also provides open access to screening and cell culture labs, including a range of instruments as well as fully equipped chemistry labs.
The most common project types carried out by CBCS and research groups in collaboration involve assay development and subsequent small molecule screening. Also, follow-up work after a high-throughput screen with medicinal- or synthetic chemistry support can be carried out by or in collaboration with CBCS.
Services
We offer a range of services in the are of chemical biology field.
Assay Development
Our highly experienced Assay Development — Chemical Biology Consortium Sweden team works with a broad range of bioassay formats, with extensive knowledge in the intricate process of adapting novel bioassays from low-throughput to microtiter-based high-throughput formats. We are equipped with multiple (liquid handling) workstations and readout systems to accommodate a broad range of screening technologies and sizes. Our screens range from isolated biochemical targets to advanced primary cellular systems, phenotypic and high-content screens, plant biology, and whole-organism screening in infectious diseases and cancer.
Assay development and screening in BLS-3
The BSL3 Biomedicum Core Facility is a fully equipped facility performing a wide range of research activities with any pathogens that require a biosafety level 3 laboratory. The facility is equipped with state-of-the-art equipment such as liquid-handling robotics, plate reader, and flow cytometry and expertise staff specialized in high-throughput screening.
Synthetic Organic and Medicinal Chemistry
Access to synthetic organic and medicinal chemistry is a central component of chemical biology and critical for further developing primary screening hits. Our chemistry teams consist of highly experienced, senior synthetic chemists and computational chemists with a background in academia and the pharmaceutical industry, providing each project with unique insight into the molecular basis of the system being studied.
Computational chemistry support
CBCS provides valuable support in Computational Chemistry, enabling researchers to leverage computational tools and techniques to advance their drug discovery projects. With a focus on accelerating the identification and subsequent optimization of potential hits, CBCS offers expertise in both ligand- and structure-based virtual screening. This is a computational approach to identify potential hit candidates, and analogues or derivatives of hit compounds that may exhibit enhanced activity or pharmacological properties, in order to prioritize compounds for further experimental evaluation.
User fees
Stand alone equipment | Acdemic/full cost (SEK) | Corporate (SEK) | PRC* (SEK) |
---|---|---|---|
Bravo (Agilent) automated liquid handler/pipetting robot | 400 | 1,200 | 0 |
Victor3 1420 (Perkin Elmer) multilabel microplate plate reader | 200 | 600 | 0 |
Multidrop 384 (Thermo Scientific) reagent dispenser | 200 | 600 | 0 |
Acustic Dispensing echo 525 and 550 | 1,000 | 1,500 | 0 |
FLIPR Tetra (Molecular Devices) high-throughput cellular screening system | 500 | 1,500 | 0 |
Multidrop Combi (Thermo Scientific) reagent dispenser | 200 | 600 | 0 |
Aquamax 4000 (Molecular Devices) plate washer | 200 | 600 | 0 |
Envision 2104 (Perkin Elmer) multilabel microplate reader | 200 | 600 | 0 |
Automated runs and screening hub
The hourly cost for automated runs and screening hub is 800 SEK for Academic/Full cost users, 2400 SEK for Corporate users and free of charge for PRC*. The prices include all instruments below:
- FLIPR Tetra (Molecular Devices) high-throughput cellular screening system
- Multidrop Combi (Thermo Scientific) reagent dispenser
- Aquamax 4000 (Molecular Devices) plate washer
- Cytomat 2 (Thermo Scientific) automated CO2 incubator
- Envision 2104 (Perkin Elmer) multilabel microplate reader
- PreciseFlex 400 (Brooks Automation) robotic sample handler
Cell culture lab
Academic/full cost (SEK) | Corporate (SEK) | PRC* (SEK) | |
---|---|---|---|
Apricot S3 (SPT Labtech) automated liquid handler/pipetting robot | 200 | 400 | 0 |
Multidrop Combi (Thermo Scientific) reagent dispenser | 200 | 400 | 0 |
Two laminar flow hoods (price per hood) | 200 | 600 | 0 |
High content imaging room
Academia (SEK) | Industry (SEK) | PRC* (SEK) | |
---|---|---|---|
Operetta - Day time (06:00-20:00) | 1,100 | 2,200 | 300 |
Automation - Day time (06:00-20:00) | 300 | 600 | 0 |
Operetta - after 20:00/night/weekend | 300 | 600 | 300 |
Automation - after 20:00/night/weekend | 150 | 300 | 0 |
Harmony - all times | 200 | 400 | 0 |
Organic/Medicinal Chemistry lab
Access to modern instruments including NMR spectrometer, LCMS and preparative HPLC systems, microwave reactor and more via the Drug Discovery & Development platform.
Monthly cost for chemistry fumehoods in a fully equipped organic chemistry lab, with a chemical store containing more than 12 000 reagents is 20,000 SEK (Academic/full cost).
Compound Center and Compound Collection
Access to the screening collection assay ready plates (nL scale):
- 2 kr/compounds; primary screening set 70,000 SEK
- 4 kr/compound for annotated compounds
For industry users the hours for handling/admin are added.
Compound hosting will depend on the number of compounds. Please contact us via Compound Center Portal.
For industry users the hours for handling/admin are added.
Project support with staff scientists
*For academic collaborative service projects accepted after a review process (prioritisations by an objective project review committee (PRC) based on scientific merits and technical feasibilty), the hourly rate is:
Academic collaborative service projects
PRC (SEK) | |
---|---|
Assay development | 300 |
Screening | 500 |
Chemistry | 500 |
For academic service project limited in time (first come, first served) | 800 |
CBCS prioritises academic projects but welcome users from all sectors.
Industry users
For industry users the staff scientist hourly rate is 2,600 SEK.