Morphological Phenotype Analysis (FENO)

The great surge in numbers of mutant mice has made efficient phenotyping a necessity in order to find and adequately describe the changes caused by the genetic manipulation. Pathology is a major and integral part of the phenotyping process.

With support from WCN, The Unit for Morphological Phenotype Analysis (FENO) was established as a competence and service facility for mouse pathology at KI in 2002, and as such specializing in the pathology of genetically engineered mice.

FENO offers

  • A full necropsy and histopathology service to analyse and describe pathological changes in tissues and organs - with attention for species differences.
  • Processing of tissues, stainings, and qualified pathologic analysis, separate or in combination.
  • Immunohistochemistry on frozen/paraffin embedded tissues.
  • Photograhic registration of results including fluorescent microscopic methods.
  • Slide digitalisation and image analysis.
  • Microscopic analysis of prenatal lethal mutants.
  • Advice on protocols: animal selection and tissue sampling, breeding schemes.

We have a fixed pricelist.


Poomy Pandey

H5 Department of Laboratory Medicine

Raoul Kuiper

Board certified in animal pathology
H5 Department of Laboratory Medicine

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2 images of mouse liver
Scientific image: RNA-scope™ for EgFP on Leica Bond RXm using Leica's red staining kit.
Scientific image: The image is a combined image of normal bright field microscopy (upper left) with spectral brieght field microscopy using the Vectra 3 system (Akoya Biosciences)