Vladimir Stepanov

Publications
Public outreach and news

Articles

Article: PROCEEDINGS OF THE ESTONIAN ACADEMY OF SCIENCES. 2023;72(4):418-425

Dopamine transporter interaction with blockers and transportable substrates: insights from kinetics study

Stepanov V
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2021;64(16):12003-12021

[¹¹C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Liu L; Johnson PD; Prime ME; Khetarpal V; Lee MR; Brown CJ; Chen X; Clark-Frew D; Coe S; Conlon M; Davis R; Ensor S; Esposito S; Moren AF; Gai X; Green S; Greenaway C; Haber J; Halldin C; Hayes S; Herbst T; Herrmann F; He-mann M; Hsai MM; Kotey A; Mangette JE; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Varnas K; Varrone A; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: SYNAPSE. 2020;74(10):e22157

Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non-human primate and human brain

Varnas K; Stepanov V; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2429-2439

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [¹⁸F]PF-06684511

Arakawa R; Takano A; Stenkrona P; Stepanov V; Nag S; Jahan M; Gryback P; Bolin M; Chen L; Zhang L; He P; Villalobos A; McCarthy TJ; Halldin C; Varrone A
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(15):8608-8633

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Liu L; Prime ME; Lee MR; Khetarpal V; Brown CJ; Johnson PD; Miranda-Azpiazu P; Chen X; Clark-Frew D; Coe S; Davis R; Dickie A; Ebneth A; Esposito S; Gadouleau E; Gai X; Galan S; Green S; Greenaway C; Giles P; Halldin C; Hayes S; Herbst T; Herrmann F; Hessmann M; Jia Z; Kiselyov A; Kotey A; Krulle T; Mangette JE; Marston RW; Menta S; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Svedberg M; Takano A; Taylor M; Thomas W; Toth M; Vaidya D; Vanras K; Weddell D; Wigginton I; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: NEUROPHARMACOLOGY. 2020;162:107809

The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans

Varnas K; Cselenyi Z; Arakawa R; Nag S; Stepanov V; Moein MM; Johnstrom P; Kingston L; Elmore CS; Halldin C; Farde L
Article: NEUROPSYCHOPHARMACOLOGY. 2019;44(10):1706-1713

Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain

Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Bundgaard C; Bang-Andersen B; Sanchez C; Halldin C; Farde L; Finnema SJ
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45(9):1605-1617

Dual tracer tau PET imaging reveals different molecular targets for ¹¹C-THK5351 and ¹¹C-PBB3 in the Alzheimer brain

Chiotis K; Stenkrona P; Almkvist O; Stepanov V; Ferreira D; Arakawa R; Takano A; Westman E; Varrone A; Okamura N; Shimada H; Higuchi M; Halldin C; Nordberg A
Article: NEUROPHARMACOLOGY. 2018;135:455-463

The metabotropic glutamate receptor 5 radioligand [¹¹C]AZD9272 identifies unique binding sites in primate brain

Varnas K; Jureus A; Finnema SJ; Johnstrom P; Raboisson P; Amini N; Takano A; Stepanov V; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2018;57:12-19

Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates

Stepanov V; Takano A; Nakao R; Amini N; Miura S; Hasui T; Kimura H; Taniguchi T; Halldin C
Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):96

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Lemoine L; Gillberg P-G; Svedberg M; Stepanov V; Jia Z; Huang J; Nag S; Tian H; Ghetti B; Okamura N; Higuchi M; Halldin C; Nordberg A
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2017;20(9):683-691

Fenfluramine Reduces [¹¹C] Cimbi-36 Binding to the 5-HT_2A Receptor in the Nonhuman Primate Brain

Yang K-C; Stepanov V; Martinsson S; Ettrup A; Takano A; Knudsen GM; Halldin C; Farde L; Finnema SJ
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;46:50-53

Development of [¹¹C]/[³H-1]THK-5351-A potential novel carbon-11 tau imaging PET radioligand

Stepanov V; Svedberg M; Jia Z; Krasikova R; Lemoine L; Okamura N; Furumoto S; Mitsios N; Mulder J; Langstrom B; Nordberg A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(2):308-320

Characterization of [¹¹C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Nielsen J; Bundgaard C; Bang-Andersen B; Grimwood S; Halldin C; Farde L; Finnema SJ
Article: CURRENT RADIOPHARMACEUTICALS. 2017;10(1):35-40

Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.

Igawa H; Stepanov V; Tari L; Okuda S; Yamamoto S; Kasai S; Nagisa Y; Haggkvist J; Svedberg M; Toth M; Takano A; Halldin C
Article: NEUROIMAGE. 2016;141:10-17

A human [¹¹C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor

Takano A; Stenkrona P; Stepanov V; Amini N; Martinsson S; Tsai M; Goldsmith P; Xie J; Wu J; Uz T; Halldin C; Macek TA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(8):pyw023

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [¹⁸F]Lu AF10628

Varnas K; Finnema SJ; Stepanov V; Takano A; Toth M; Svedberg M; Nielsen SM; Khanzhin NA; Juhl K; Bang-Andersen B; Halldin C; Farde L
Article: SYNAPSE. 2016;70(6):253-263

Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [¹¹C]T-773 in nonhuman primates

Takano A; Stepanov V; Nakao R; Amini N; Gulyas B; Kimura H; Halldin C
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(12):2394-2403

NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.

Aonurm-Helm A; Anier K; Zharkovsky T; Castrén E; Rantamäki T; Stepanov V; Järv J; Zharkovsky A
Article: JOURNAL OF MEMBRANE BIOLOGY. 2015;248(4):775-781

Thermal Stability of Dopamine Transporters

Kukk S; Stepanov V; Jarv J
Article: MOLECULAR IMAGING AND BIOLOGY. 2015;17(4):445-449

Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [¹¹C]T-773

Toth M; Haggkvist J; Stepanov V; Takano A; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Gulyas B; Halldin C
Article: SYNAPSE. 2015;69(7):345-355

Evaluation of a novel PDE10A PET radioligand, [¹¹C]T-773, in nonhuman primates: Brain and whole body PET and brain autoradiography

Takano A; Stepanov V; Gulyas B; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015;58(5):202-208

Development of a series of novel carbon-11 labeled PDE10A inhibitors

Stepanov V; Miura S; Takano A; Amini N; Nakao R; Hasui T; Nakashima K; Taniguchi T; Kimura H; Kuroita T; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(2):146-154

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A

Harada A; Suzuki K; Miura S; Hasui T; Kamiguchi N; Ishii T; Taniguchi T; Kuroita T; Takano A; Stepanov V; Halldin C; Kimura H
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu081

Amphetamine Decreases α_2C-Adrenoceptor Binding of [¹¹C]ORM-13070: A PET Study in the Primate Brain

Finnema SJ; Hughes ZA; Haaparanta-Solin M; Stepanov V; Nakao R; Vamas K; Varrone A; Arponen E; Marjamaki P; Pohjanoksa K; Vuorilehto L; Babalola PA; Solin O; Grimwood S; Sallinen J; Farde L; Scheinin M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2014;55(7):1164-1170

¹⁸F-MCL-524, an ¹⁸F-Labeled Dopamine D₂ and D₃ Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study

Finnema SJ; Stepanov V; Nakao R; Sromek AW; Zhang T; Neumeyer JL; George SR; Seeman P; Stabin MG; Jonsson C; Farde L; Halldin C
Article: NEUROIMAGE. 2014;84:342-353

Characterization of [¹¹C]Cimbi-36 as an agonist PET radioligand for the 5-HT_2A and 5-HT_2C receptors in the nonhuman primate brain

Finnema SJ; Stepanov V; Ettrup A; Nakao R; Amini N; Svedberg M; Lehmann C; Hansen M; Knudsen GM; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2012;55(6):206-210

An efficient one-step radiosynthesis of [18F]FE-PE2I, a PET radioligand for imaging of dopamine transporters

Stepanov V; Krasikova R; Raus L; Loog O; Hiltunen J; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(8):1313-1321

Imaging of the Striatal and Extrastriatal Dopamine Transporter with ¹⁸F-LBT-999: Quantification, Biodistribution, and Radiation Dosimetry in Nonhuman Primates

Varrone A; Stepanov V; Nakao R; Toth M; Gulyas B; Emond P; Deloye JB; Vercouillie J; Stabin MG; Jonsson C; Guilloteau D; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2008;53(6-8):370-373

Kinetic mechanism of dopamine transporter interaction with 1-(2-(bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909).

Stepanov V; Järv J
Article: APPLIED RADIATION AND ISOTOPES. 2007;65(3):293-300

Synthesis of ³H-labeled N-(3-iodoprop-2E-enyl)-2β-carbomethoxy-3β(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments

Stepanov V; Schou M; Jarv J; Halldin C
Article: NEUROSCIENCE LETTERS. 2006;410(3):218-221

Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane.

Stepanov V; Järv J
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Meeting abstract: NEUROIMAGE. 2010;52:S61-S62

Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain

Finnema SJ; Varnas K; Stepanov V; Varrone A; Gulyas B; Arponen E; Helin S; Solin O; Haaparanta M; Sallinen J; Ingman K; Scheinin M; Farde L; Halldin C

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