Nenad Bogdanovic

Nenad Bogdanovic

Affiliated to Teaching/Tutoring | Docent
Visiting address: Blickagången 16, 14152 Huddinge
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Klinisk geriatrik Religa, 171 77 Stockholm

About me

  • Nenad Bogdanovic is croatian-born medical doctor, PhD, senior specialist in geriatric medicine, neurology, consultant neuropathologist and university-trained neuroanatomist at Karolinska University Hospital in Stockholm, Sweden, clinical researcher. He is a professor in geriatric medicine affiliated at Karolinska In-stitutet, Oslo University and visiting professor at medical faculty Zagreb and visiting Professor at Neural System Lab at Boston University. He is clinical researcher on neurodegenerative disorders and was acting head of Research, Education Innovation and Development at Clinic Theme Aging, and acted as a Clinical Chief at The Aging Brain Clinic Karolinska University Hospital. From 2013 – 2017, clinical and scientific lead, professor at Geriatric Clinic, Memory center Oslo University Hospital. Between 2008-2012 was a Senior Medical Director in Neuroscience and Alzheimer’s Disease Therapeutic Area with successful track record of achievement in pharmaceutical companies, Wyeth and Pfizer. As a medical manager had respon-sibility for implementation of medical strategies in dementia therapeutic areas and act as an essential con-tributor to the successful commercialization of products, including KOL engagement, marketing, sales, regulatory in European countries. Member and lead of external safety committee expert groups, Kyowa-Kirin Pharma, Orion Pharma and Green Valley. Led and managed collaboration projects with Servier and joined preclinical project between Karolinska-DiNippon Sumitomo and  NSGENE Denmark. Acts as an external consultant at GE Healthcare for amyloid imaging ligand PIB and Flutemetamol. 
    Combines medical and scientific expertise with excellent collaboration, communication and presentation skills and a track record in drug development. Demonstrates an in-depth expertise in clinical geriatrics, clinical neurology, medical management and leadership, neurodegenerative disorders, brain imaging and biomarkers, clinical trials, neuropathology, preclinical and clinical translational research, education, and supervision in an international and competitive environment. 
    The clinical expertise is specifically focused on holistic geriatric issues, frailty, sarcopenia, malnutrition and cognitive impairment and application of sociomedical methodology and organization of dementia pa-tient wellbeing. The scientific interest is focused on the early clinical signs and blood biomarkers of cogni-tive impairment and clinical characterization of the age-related dementias.
    Awarded 2004 as a Master of Education at Karolinska Institutet and as a university lector, supervisor, re-search leader, responsible for graduate, postgraduate and geriatric specialization courses at Karolinska medical faculty and Swedish National Board of Health and Welfare, and Medical faculty Zagreb 
    Cofounder of two Alzheimer disease mutations, Swedish and Arctic mutation. Holder of three patents for apparatuses for determining the volume of solid body and it’s in real-time measurement in 2009, method for purifying amyloid plaque in 2005, disease marker for Alzheimer’s disease and its use in 2003. 
    Member of Swedish, Croatian and Norwegian Medical Associations, British Association of Pharmaceutical Physicians, cofounder of European BrainNet, Scandinavian Association of Neuropathology, GMC UK – registered as a specialist of geriatric medicine, Affiliate member of Royal College of Physicians, Central Ethical Committee in Stockholm, European Project in Frontal Lobe and dementia with Lewy Bodies, Edi-tor in Aging Clinical and Experimental Research, International scientific evaluation committee for British Brain Bank, Member of Croatian Alzheimer’s disease Association. Member of Croatian and Swedish Geriatric Association, member of EUGMS and SIG-delirium and dementia groups, and executive lead in COST Programming CA 21122 in EUGMS. External expert for geriatric medicine expert group in Croatian Ministry of Health. H-index 71 

Research

  • project 1. Typical and Atypical Alzheimer - a diagnostic challenge
    project 2. Vitamin D3 and brain function
    project 3. Pathomechanisms and biomarkers of Alzheimer's disease:
    unraveling novel diagnostic tools and therapeutic targets. (sandwich project
    Stockholm - Oslo)
    project 4. Clinical Application of a New Brain Connectivity Marker to Detect
    Early Alzheimer’s Disease

Teaching

    1. Awarded with Annual highest pedagogic prize at Karolinska Institutet –
      “Master of Education” – 2004
      2. core Ph.D. course in Neuroanatomy, Neurodevelopment and
      Neurodegeneration at Karolinska Institutet 2000 – 2010, 2022 - ongoing
      3. Teaching and heading the geriatric medicine specialization courses (SK
      courses) 2017 – ongoing
      4. teaching, psychologists, speech pathologist, medical students
      5. the examination of medical students

    Graduate Teaching

    • Geriatric medicine

    • Neurodegenerative disorders

    Postgraduate Teaching

    • Geriatrics

    • Neurodegeneration and dementia

    • Neuroanatomy

    • Neuropathology

    Specialist Training Courses

    • Advanced clinical education in dementia for healthcare professionals and medical specialists

Articles

All other publications

Grants

  • Swedish Research Council
    1 December 2023 - 30 November 2026
    This study aims to prevent the development of dementia in individuals with mild cognitive impairment (MCI) through innovative solutions for early detection, precision diagnostics, and individualized evidence-based prevention and treatment.The epidemiological part will focus on two aspects: the impact of depression and sleep disturbances on cognitive impairment and dementia development and use register data and AI to develop a risk prediction model to identify people at risk for MCI, Alzheimer disease, and other dementia early in primary health care. Both risk factors and protective factors will be examined, thus the model will suggest individuals who should be further evaluated for MCI, Alzheimer´s, and other forms of dementia and provide support for preventive advice and interventions.The clinical part aims to determine the clinical and health economic value of a precision diagnostic algorithm based on a combination of digital cognitive tests and blood-based biomarkers in the assessment of subjective cognitive complaints (SCC) in primary care. The study will actively screen for SCC among individuals at increased risk of dementia, with risk factors including age, hypertension, and/or type II diabetes mellitus. Digital cognitive tests and blood-based biomarkers will be utilized to diagnose SCC, mild cognitive impairment (MCI), and dementia due to Alzheimer´s disease, as well as to examine how these biomarkers predict disease conversion after two years.
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    This interdisciplinary research proposal at the interface between biophysical chemistry, optics/photonics, cell biology and molecular medicine, aims to solidify instrumentation and further advance a new methodology for quantitative spatio-temporally resolved fluorescence microscopy imaging via massively parallel Fluorescence Correlation Spectroscopy (mpFCS) that we have recently developed. The methodology, which has the ultimate, single-molecule sensitivity, will be used in basic and translational studies to:Aim 1a. Dissect in live cells kinetic mechanisms through which gene transcription networks self-adjust their essential variables and control their own biological function.Aim 1b. Provide in live cells quantitative biophysical data and mechanistic insights on how the functional dynamics of oligodendrocyte transcription factor (OLIG2) can be rescued by treatment with novel prospective drug candidates. Aim 2.   Implement this new technology in a translational research study aiming to develop a reliable and affordable non-immune, blood-based assay for early diagnosis of amyloid diseases, such as Alzheimer’s disease (AD).Aim 3a. Development of a system for massively parallel dual-color Fluorescence Cross-Correlation Spectroscopy (mpFCCS).Aim 3b. Develop a fiber optic probe to allow parallelized FCS recordings in behaving animals.
  • The epidemiology of Parkinson’s disease in Croatia and the influence of genetic factors and microbiota on the progression and treatment outcomes of the disease
    Croatian Science Foundation
    1 February 2020 - 31 January 2024
  • Southern and Eastern Norway Regional Health Authority
    1 January 2014 - 31 December 2015
  • Western Norway Regional Health Authority
    1 January 2013 - 31 December 2019

Employments

  • Affiliated to Teaching/Tutoring, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2025-2028

Degrees and Education

  • Docent, karolinska institutet, 2004

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