Laura Kananen

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Articles

Article: AGING CELL. 2023;22(8):e13868

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.

Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jääskeläinen T; Koskinen S; Lu Y; Magnusson PKE; Hägg S; Jylhävä J
Article: GEROSCIENCE. 2023;45(1):85-103

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.

Kananen L; Hurme M; Bürkle A; Moreno-Villanueva M; Bernhardt J; Debacq-Chainiaux F; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dollé MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom E; Talbot D; Libert C; Raitanen J; Koskinen S; Härkänen T; Stenholm S; Ala-Korpela M; Lehtimäki T; Raitakari OT; Ukkola O; Kähönen M; Jylhä M; Jylhävä J
Article: GERONTOLOGY. 2023;69(4):396-405

Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study.

Mak JKL; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Article: PLOS ONE. 2023;18(3):e0283344

Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden.

Kananen L; Hong X; Annetorp M; Mak JKL; Jylhävä J; Eriksdotter M; Hägg S; Religa D
Article: CLINICAL NUTRITION. 2022;41(12):2973-2979

Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19.

Kananen L; Eriksdotter M; Boström AM; Kivipelto M; Annetorp M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Hägg S; Religa D; Jylhävä J; Cederholm T
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319

Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden.

Mak JKL; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Bäck Jerlardtz V; Engström M; Johnson P; Lundberg LG; Åkesson E; Sühl Öberg C; Olsson M; Cederholm T; Jylhävä J; Religa D
Article: EPIGENOMICS. 2022;14(18):1105-1124

Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues.

Marttila S; Tamminen H; Rajić S; Mishra PP; Lehtimäki T; Raitakari O; Kähönen M; Kananen L; Jylhävä J; Hägg S; Delerue T; Peters A; Waldenberger M; Kleber ME; März W; Luoto R; Raitanen J; Sillanpää E; Laakkonen EK; Heikkinen A; Ollikainen M; Raitoharju E
Article: PSYCHONEUROENDOCRINOLOGY. 2021;130:105276

Childhood adversities are associated with shorter leukocyte telomere length at adult age in a population-based study.

Ämmälä A-J; Suvisaari J; Kananen L; Lönnqvist J; Ripatti S; Pirkola S; Paunio T; Hovatta I
Article: EPIGENETICS & CHROMATIN. 2021;14(1):33

Ageing-associated changes in DNA methylation in X and Y chromosomes.

Kananen L; Marttila S
Article: SCIENTIFIC REPORTS. 2021;11(1):6139

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Kananen L; Enroth L; Raitanen J; Jylhävä J; Bürkle A; Moreno-Villanueva M; Bernhardt J; Toussaint O; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dollé MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom PE; Talbot DCS; Libert C; Koskinen S; Bruunsgaard H; Hansen ÅM; Lund R; Hurme M; Jylhä M
Article: SCIENTIFIC REPORTS. 2020;10(1):13809

Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey.

Kananen L; Hurme M; Jylhä M; Härkänen T; Koskinen S; Stenholm S; Kähönen M; Lehtimäki T; Ukkola O; Jylhävä J
Article: EXPERIMENTAL GERONTOLOGY. 2017;97:60-63

Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence.

Marttila S; Nevalainen T; Jylhävä J; Kananen L; Jylhä M; Hervonen A; Hurme M
Article: CLINICAL EPIGENETICS. 2017;9:20

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.

Nevalainen T; Kananen L; Marttila S; Jylhävä J; Mononen N; Kähönen M; Raitakari OT; Hervonen A; Jylhä M; Lehtimäki T; Hurme M
Article: AGE. 2016;38(3):65

The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies.

Kananen L; Marttila S; Nevalainen T; Kummola L; Junttila I; Mononen N; Kähönen M; Raitakari OT; Hervonen A; Jylhä M; Lehtimäki T; Hurme M; Jylhävä J
Article: ONCOTARGET. 2016;7(15):19228-19241

Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift.

Jylhävä J; Kananen L; Raitanen J; Marttila S; Nevalainen T; Hervonen A; Jylhä M; Hurme M
Article: BMC GENOMICS. 2016;17:103

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study.

Kananen L; Marttila S; Nevalainen T; Jylhävä J; Mononen N; Kähönen M; Raitakari OT; Lehtimäki T; Hurme M
Article: PLOS ONE. 2016;11(11):e0167028

Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals.

Nevalainen T; Kananen L; Marttila S; Jylhävä J; Jylhä M; Hervonen A; Hurme M
Article: ONCOTARGET. 2015;6(40):42468-42477

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.

Walsh KM; Codd V; Rice T; Nelson CP; Smirnov IV; McCoy LS; Hansen HM; Elhauge E; Ojha J; Francis SS; Madsen NR; Bracci PM; Pico AR; Molinaro AM; Tihan T; Berger MS; Chang SM; Prados MD; Jenkins RB; Wiemels JL; ENGAGE Consortium Telomere Group; Samani NJ; Wiencke JK; Wrensch MR
Article: EXPERIMENTAL GERONTOLOGY. 2015;72:227-229

Cytomegalovirus infection accelerates epigenetic aging.

Kananen L; Nevalainen T; Jylhävä J; Marttila S; Hervonen A; Jylhä M; Hurme M
Article: ONCOTARGET. 2015;6(31):30557-30567

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny.

Marttila S; Kananen L; Jylhävä J; Nevalainen T; Hervonen A; Jylhä M; Hurme M
Article: AGE. 2015;37(4):9814

Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study.

Nevalainen T; Kananen L; Marttila S; Jylhä M; Hervonen A; Hurme M; Jylhävä J
Article: BMC GENOMICS. 2015;16(1):179

Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression.

Marttila S; Kananen L; Häyrynen S; Jylhävä J; Nevalainen T; Hervonen A; Jylhä M; Nykter M; Hurme M
Article: SCIENTIFIC REPORTS. 2015;5:8631

Number of sons contributes to ageing-associated inflammation.

Marttila S; Nevalainen T; Kananen L; Jylhävä J; Jylhä M; Hervonen A; Ilonen J; Hurme M
Article: NATURE GENETICS. 2014;46(7):731-735

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.

Walsh KM; Codd V; Smirnov IV; Rice T; Decker PA; Hansen HM; Kollmeyer T; Kosel ML; Molinaro AM; McCoy LS; Bracci PM; Cabriga BS; Pekmezci M; Zheng S; Wiemels JL; Pico AR; Tihan T; Berger MS; Chang SM; Prados MD; Lachance DH; O'Neill BP; Sicotte H; Eckel-Passow JE; ENGAGE Consortium Telomere Group; van der Harst P; Wiencke JK; Samani NJ; Jenkins RB; Wrensch MR
Article: BIOLOGICAL PSYCHOLOGY. 2014;97:35-42

Associations between early life stress, self-reported traumatic experiences across the lifespan and leukocyte telomere length in elderly adults.

Savolainen K; Eriksson JG; Kananen L; Kajantie E; Pesonen A-K; Heinonen K; Räikkönen K
Article: IMMUNITY & AGEING. 2014;11(1):2

Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians.

Marttila S; Jylhävä J; Kananen L; Hervonen A; Jylhä M; Hurme M
Article: NATURE GENETICS. 2013;45(4):422-427e2

Identification of seven loci affecting mean telomere length and their association with disease.

Codd V; Nelson CP; Albrecht E; Mangino M; Deelen J; Buxton JL; Hottenga JJ; Fischer K; Esko T; Surakka I; Broer L; Nyholt DR; Mateo Leach I; Salo P; Hägg S; Matthews MK; Palmen J; Norata GD; O'Reilly PF; Saleheen D; Amin N; Balmforth AJ; Beekman M; de Boer RA; Böhringer S; Braund PS; Burton PR; de Craen AJM; Denniff M; Dong Y; Douroudis K; Dubinina E; Eriksson JG; Garlaschelli K; Guo D; Hartikainen A-L; Henders AK; Houwing-Duistermaat JJ; Kananen L; Karssen LC; Kettunen J; Klopp N; Lagou V; van Leeuwen EM; Madden PA; Mägi R; Magnusson PKE; Männistö S; McCarthy MI; Medland SE; Mihailov E; Montgomery GW; Oostra BA; Palotie A; Peters A; Pollard H; Pouta A; Prokopenko I; Ripatti S; Salomaa V; Suchiman HED; Valdes AM; Verweij N; Viñuela A; Wang X; Wichmann H-E; Widen E; Willemsen G; Wright MJ; Xia K; Xiao X; van Veldhuisen DJ; Catapano AL; Tobin MD; Hall AS; Blakemore AIF; van Gilst WH; Zhu H; CARDIoGRAM consortium; Erdmann J; Reilly MP; Kathiresan S; Schunkert H; Talmud PJ; Pedersen NL; Perola M; Ouwehand W; Kaprio J; Martin NG; van Duijn CM; Hovatta I; Gieger C; Metspalu A; Boomsma DI; Jarvelin M-R; Slagboom PE; Thompson JR; Spector TD; van der Harst P; Samani NJ
Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2012;66(12):1290-1294

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population.

Tiainen A-MK; Männistö S; Blomstedt PA; Moltchanova E; Perälä M-M; Kaartinen NE; Kajantie E; Kananen L; Hovatta I; Eriksson JG
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2012;46(10):1346-1353

History of mental disorders and leukocyte telomere length in late adulthood: the Helsinki Birth Cohort Study (HBCS).

Savolainen K; Räikkönen K; Kananen L; Kajantie E; Hovatta I; Lahti M; Lahti J; Pesonen A-K; Heinonen K; Eriksson JG
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2012;41(5):1400-1408

No association between body size at birth and leucocyte telomere length in adult life--evidence from three cohort studies.

Kajantie E; Pietiläinen KH; Wehkalampi K; Kananen L; Räikkönen K; Rissanen A; Hovi P; Kaprio J; Andersson S; Eriksson JG; Hovatta I
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS. 2012;159B(3):316-327

Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility.

Donner J; Sipilä T; Ripatti S; Kananen L; Chen X; Kendler KS; Lönnqvist J; Pirkola S; Hettema JM; Hovatta I
Article: PLOS ONE. 2012;7(4):e34948

Leukocyte telomere length in the Finnish Diabetes Prevention Study.

Hovatta I; de Mello VDF; Kananen L; Lindström J; Eriksson JG; Ilanne-Parikka P; Keinänen-Kiukaanniemi S; Peltonen M; Tuomilehto J; Uusitupa M
Article: BIOLOGICAL PSYCHIATRY. 2011;69(6):526-533

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways.

Muiños-Gimeno M; Espinosa-Parrilla Y; Guidi M; Kagerbauer B; Sipilä T; Maron E; Pettai K; Kananen L; Navinés R; Martín-Santos R; Gratacòs M; Metspalu A; Hovatta I; Estivill X
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2010;65(11):1181-1184

No evidence for shorter leukocyte telomere length in Parkinson's disease patients.

Eerola J; Kananen L; Manninen K; Hellström O; Tienari PJ; Hovatta I
Article: BIOLOGICAL PSYCHIATRY. 2010;67(12):1163-1170

An association analysis of circadian genes in anxiety disorders.

Sipilä T; Kananen L; Greco D; Donner J; Silander K; Terwilliger JD; Auvinen P; Peltonen L; Lönnqvist J; Pirkola S; Partonen T; Hovatta I
Article: PLOS ONE. 2010;5(5):e10826

Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls.

Kananen L; Surakka I; Pirkola S; Suvisaari J; Lönnqvist J; Peltonen L; Ripatti S; Hovatta I
Article: BIOLOGICAL PSYCHIATRY. 2008;64(8):672-680

An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.

Donner J; Pirkola S; Silander K; Kananen L; Terwilliger JD; Lönnqvist J; Peltonen L; Hovatta I
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All other publications

Other: THE LANCET HEALTHY LONGEVITY. 2023;4(2):e57

DNA methylation states in supercentenarians.

Kananen L
Letter: CLINICAL NUTRITION. 2022;41(2):573-574

Response to Letter to the Editor: Comment on "Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19" (by Café Balcı, MD, Hacettepe University Faculty of Medicine Department of Internal Medicine Division of Geriatric Medicine).

Kananen L; Religa D; Eriksdotter M; Hägg S; Julhävä J; Cederholm T

Employments

Affiliated to Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2024-2027
Postdoctoral Researcher, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2024-2024

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