Kristian Borg

Long-lasting post-COVID symptoms have severe implications for affected individuals, the healthcare system, and society as a whole. This project focuses on two common symptoms in this patient group, cognitive and olfactory deficits. We aim to increase the knowledge regarding (a) long-term effects (up to 3 years) on cognitive and olfactory function after mild COVID-19, (b) factors associated with recovering from such deficits, (c) neurological bases of cognitive and olfactory deficits, and (d) associations between remaining deficits and returning to previous levels of functioning and activities (e.g. work). The proposed project is a follow-up of an ongoing study

following these patients over time is critical for understanding the long-term effects. The project consists of 3 parts: (1) Longitudinal follow-up of a clinical sample of post-COVID patients following mild COVID-19 with a third cognitive, olfactory, and functional assessment, (2) A second magnetic resonance imaging assessment of a subgroup of this sample and matched controls, (3) A new online questionnaire targeting functioning and well-being of a large sample of post-COVID patients, diagnosed during the first years of the pandemic. Together, the results of this project will provide important new knowledge regarding the long-term effects of COVID-19 on cognitive and olfactory performance, which factors may affect the development in these domains over time, and how they relate to functioning in everyday life.

Despite the heavy burden of stroke and the demands from ‘Socialstyrelsen’ of improving post-acute care, an effective structured follow-up to promote a patient-tailored rehabilitation remains largely lacking in the current stroke care.The overall aim of this study is to find a cost-effective solution to facilitate patient-tailored rehabilitation that improves daily and social activities and health-related quality of life for persons discharged from hospital after stroke. We have recently developed a novel digital graphic tool, Rehabkompassen®, which based on patient-reported outcome measurements captures the patient´s complex health status after stroke. Here, this tool will be used in a parallel, open-label, 2-arm prospective and multicenter pragmatic randomized controlled trial between 2022-2026. All participants (n = 1106) will be randomized according to permuted block design, and receive a usual out-patient visit without (control group, n = 553) or with (intervention group, n = 553) Rehabkompassen®, at 3-month after stroke. The effectiveness of the tool on daily and social activities, quality of life and its health-economic effects will be compared at 12-month out-patient visit post stroke.We hypothesize that the Rehabkompassen® may provide a patient-tailored rehabilitation that improves recovery, independence, and quality of life among people with stroke in a cost-effective way. The tool may thus be implemented in the post-acute continuum of stroke care.

Stroke is a leading cause of disability and with a heavy burden for the society. Despite the demands from ‘Socialstyrelsen’ of improving post-acute care, an effective structured follow-up to promote a patient-tailored rehabilitation remains largely lacking in the current stroke care.The overall aim of this study is to find a cost-effective solution to facilitate patient-tailored rehabilitation that improves daily and social activities and health-related quality of life for persons discharged from the acute care after stroke. We have recently developed a novel digital graphic tool, Rehabkompassen®, which based on patient-reported outcome measurements captures the patient´s complex health status after stroke. Here, this tool will be used in a parallel, open-label, 2-arm prospective and multicenter pragmatic randomized controlled trial between 2022-2026. All participants (n = 1106) will be randomized according to permuted block design

and receive a usual care without (control group, n = 553) or with (intervention group, n = 553) Rehabkompassen®, within 3-month after stroke. The effectiveness of the tool on daily and social activities, quality of life and its health-economic effects will be compared at 12-month follow-up post stroke.We hypothesize that the digital tool Rehabkompassen® will provide a patient-tailored rehabilitation that improves recovery, independence, and quality of life among people with stroke in a cost-effective way.

Long-lasting post-COVID symptoms may have severe implications for affected individuals and the healthcare system. This project focuses on two common symptoms in this patient group, cognitive and olfactory deficits. We aim to increase the knowledge regarding (a) nature, severity, and duration of long-term effects on cognitive and olfactory function after mild COVID, (b) which individuals are more likely to be affected by and recover from such deficits, (c) underlying mechanisms, and (d) associations between these deficits and returning to previous levels of functioning. Longitudinal follow-up of these patients is vital to understand the long-term effects. It is further unknown how many individuals are affected by subclinical cognitive impairments following a COVID-19 infection. The project consists of 3 parts: (1) Longitudinal follow-up of a clinical sample (Danderyd rehabilitation medicine clinic) of post-COVID patients with repeated cognitive, olfactory, and functional assessments, (2) Magnetic resonance imaging assessments of a subgroup of this sample and a matched control group, (3) Repeated cognitive testing of a population sample comparing cognitive trajectories of persons with and without previous COVID-19. These data collections will provide important new knowledge regarding the long-term effects of COVID-19 on cognitive and olfactory performance, which factors may affect the longitudinal development in these domains, and how they relate to functioning in other areas.