Karima Chergui

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About me

Karima Chergui is a University lecturer and research group leader for
Molecular neurophysiology [1].
[1] http://ki.se/en/fyfa/molecular-neurophysiology

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):5804
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents
He Y; Kaya I; Shariatgorji R; Lundkvist J; Wahlberg LU; Nilsson A; Mamula D; Kehr J; Zareba-Paslawska J; Biverstal H; Chergui K; Zhang X; Andren PE; Svenningsson P
Article: NPJ PARKINSON'S DISEASE. 2023;9(1):56
Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice
Skiteva O; Yao N; Mantas I; Zhang X; Perlmann T; Svenningsson P; Chergui K
Article: BIOMOLECULES. 2022;13(1):51
Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice
Yao N; Skiteva O; Chergui K
Article: BIOMOLECULES. 2022;12(11):1635
Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice
Sitzia G; Skiteva O; Chergui K
Article: SCIENCE ADVANCES. 2022;8(34):eabo1543
PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons
Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Sodersten E; Svenningsson P; Chergui K; Ringner M; Perlmann T; Holmberg J
Article: JOURNAL OF NEUROCHEMISTRY. 2022;161(2):158-172
LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons
Skiteva O; Yao N; Sitzia G; Chergui K
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):530
Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens
Skiteva O; Yao N; Chergui K
Article: NEUROPHARMACOLOGY. 2020;174:108136
NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism
Sitzia G; Mantas I; Zhang X; Svenningsson P; Chergui K
Article: FRONTIERS IN AGING NEUROSCIENCE. 2020;12:84
Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37
Zhang X; Mantas I; Fridjonsdottir E; Andren PE; Chergui K; Svenningsson P
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2066-2077
Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
Yao N; Skiteva O; Zhang X; Svenningsson P; Chergui K
Article: NEUROSCIENCE LETTERS. 2018;666:11-16
High frequency stimulation induces LTD of AMPA receptor-mediated postsynaptic responses and LTP of synaptically-evoked firing in the dorsolateral striatum
Skiteva O; Yao N; Nouhi M; Chergui K
Article: CNS NEUROSCIENCE & THERAPEUTICS. 2018;24(2):144-153
CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-D-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease
Nouhi M; Zhang X; Yao N; Chergui K
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:166
Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine
Zhang X; Mantas I; Alvarsson A; Yoshitake T; Shariatgorji M; Pereira M; Nilsson A; Kehr J; Andren PE; Millan MJ; Chergui K; Svenningsson P
Article: LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.). 2016;23(9):479-485
The GABA_A receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum
Zhang X; Yao N; Chergui K
Article: NEUROPHARMACOLOGY. 2015;92:108-115
Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B-and GluN2D-containing NMDA receptors
Zhang X; Chergui K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(4):pyu052
Induction of Cannabinoid- and N-Methyl-D-Aspartate Receptor-Mediated Long-Term Depression in the Nucleus Accumbens and Dorsolateral Striatum Is Region and Age Dependent
Zhang X; Feng Z-J; Chergui K
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2014;171(16):3938-3945
Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease
Zhang X; Feng Z-J; Chergui K
Article: EXPERIMENTAL NEUROLOGY. 2014;255:154-160
Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease
Feng Z-J; Zhang X; Chergui K
Article: JOURNAL OF NEUROCHEMISTRY. 2014;129(4):581-590
GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease
Zhang X; Feng Z-J; Chergui K
Article: ADDICTION BIOLOGY. 2013;18(4):605-613
Ethanol inhibits excitatory neurotransmission in the nucleus accumbens of adolescent mice through GABA_A and GABA_B receptors
Mishra D; Chergui K
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36(12):2117-2125
Ethanol Disrupts the Mechanisms of Induction of Long-Term Potentiation in the Mouse Nucleus Accumbens
Mishra D; Zhang X; Chergui K
Article: NEUROPHARMACOLOGY. 2011;60(6):975-981
Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens
Chergui K
Article: JOURNAL OF NEUROSCIENCE. 2009;29(7):2238-2251
Restricted Cortical and Amygdaloid Removal of Vesicular Glutamate Transporter 2 in Preadolescent Mice Impacts Dopaminergic Activity and Neuronal Circuitry of Higher Brain Function
Wallen-Mackenzie A; Nordenankar K; Fejgin K; Lagerstrom MC; Emilsson L; Fredriksson R; Wass C; Andersson D; Egecioglu E; Andersson M; Strandberg J; Lindhe O; Schioth HB; Chergui K; Hanse E; Langstrom B; Fredriksson A; Svensson L; Roman E; Kullander K
Article: JOURNAL OF NEUROCHEMISTRY. 2008;106(4):1758-1765
NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum
Schotanus SM; Chergui K
Article: NEUROPHARMACOLOGY. 2008;54(7):1143-1152
Neurokinin B/NK₃ receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease
Zhang X; Andren PE; Chergui K; Svenningsson P
Article: NEUROPHARMACOLOGY. 2008;54(5):837-844
Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens
Schotanus SM; Chergui K
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2008;27(8):1957-1964
Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors
Schotanus SM; Chergui K
Article: NEUROPHARMACOLOGY. 2006;51(2):272-282
NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A₁ receptors:: Evidence from knockout mice
Schotanus SM; Fredholm BB; Chergui K
Article: SCIENCE. 2006;311(5757):77-80
Alterations in 5-HT_1B receptor function by p11 in depression-like states
Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang XQ; El Yacoubi M; Vaugeois JM; Nomikos GG; Greengard P
Article: JOURNAL OF NEUROSCIENCE. 2005;25(28):6601-6609
Physiological role for casein kinase 1 in glutamatergic synaptic transmission
Chergui K; Svenningsson P; Greengard P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(7):2191-2196
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
Chergui K; Svenningsson P; Greengard P
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2002;365(3):173-180
GABA_B receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo
Erhardt S; Mathé JM; Chergui K; Engberg G; Svensson TH
Article: JOURNAL OF NEUROSCIENCE. 2000;20(22):8443-8451
Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
Calabresi P; Gubellini P; Centonze D; Picconi B; Bernardi G; Chergui K; Svenningsson P; Fienberg AA; Greengard P
Article: JOURNAL OF NEUROSCIENCE. 2000;20(6):2175-2182
Functional GluR6 kainate receptors in the striatum: Indirect downregulation of synaptic transmission
Chergui K; Bouron A; Normand E; Mulle C
Article: NEUROPHARMACOLOGY. 1999;38(2):223-231
Modulation by dopamine D₁-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432
Chergui K; Lacey MG
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(11):2370-2382
Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle
Chergui K; Svenningsson P; Nomikos GG; Gonon F; Fredholm BB; Svennson TH
Article: NEUROPSYCHOPHARMACOLOGY. 1997;17(3):151-161
Chronic nicotine enhances basal and nicotine-induced fos immunoreactivity preferentially in the medial prefrontal cortex of the rat
Nisell M; Nomikos GG; Chergui K; Grillner P; Svensson TH
Article: NEUROSCIENCE. 1997;77(1):175-186
Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions
Panagis G; Nomikos GG; Miliaressis E; Chergui K; Kastellakis A; Svensson TH; Spyraki C
Article: BRAIN RESEARCH. 1996;730(1-2):133-142
Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat
Panagis G; Nisell M; Nomikos GG; Chergui K; Svensson TH
Journal article: BEHAVIOURAL PHARMACOLOGY. 1996;7(Supplement 1):76
CHRONIC NICOTINE SELECTIVELY ENHANCES BASAL AND NICOTINE INDUCED FOS IMMUNOREACTIVITY IN THE MEDIAL PREFRONTAL CORTEX
G NG; M N; K C; P G; H ST
Journal article: BEHAVIOURAL PHARMACOLOGY. 1996;7(Supplement 1):82
VENTRAL PALLIDUM SELF-STIMULATION INCREASES C-FOS EXPRESSION IN REWARD-RELATED BRAIN REGIONS
G P; G NG; E M; K C; A K; H ST; C S
Article: JOURNAL OF NEUROCHEMISTRY. 1995;65(6):2603-2611
UPTAKE OF DOPAMINE RELEASED BY IMPULSE FLOW IN THE RAT MESOLIMBIC AND STRIATAL SYSTEMS IN-VIVO
SUAUDCHAGNY MF; DUGAST C; CHERGUI K; MSGHINA M; GONON F
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1995;5(3):405
P-11-4 Pattern of presynaptic activity in the mesolimbic dopamine system determines postsynaptic events
Svensson TH; Chergui K; Nomikos GG; Gonor F; Mathé JM
Journal article: NEUROSCIENCE. 1994;62(3):641-645
NONLINEAR RELATIONSHIP BETWEEN IMPULSE FLOW, DOPAMINE RELEASE AND DOPAMINE ELIMINATION IN THE RAT-BRAIN IN-VIVO
CHERGUI K; SUAUDCHAGNY MF; GONON F
Journal article: NEUROREPORT. 1994;5(10):1185-1188
SUBTHALAMIC NUCLEUS MODULATES BURST FIRING OF NIGRAL DOPAMINE NEURONS VIA NMDA RECEPTORS
CHERGUI K; AKAOKA H; CHARLETY PJ; SAUNIER CF; BUDA M; CHOUVET G
Journal article: ANESTHESIOLOGY. 1993;79(5):1072-1082
ACTIVATION OF BRAIN NORADRENERGIC NEURONS DURING RECOVERY FROM HALOTHANE ANESTHESIA
SAUNIER CF; AKAOKA H; DELACHAPELLE B; CHARLETY PJ; CHERGUI K; CHOUVET G; BUDA M; QUINTIN L
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(8):1024-1028
SEROTONIN DIFFERENTIALLY MODULATES RESPONSES MEDIATED BY SPECIFIC EXCITATORY AMINO-ACID RECEPTORS IN THE RAT LOCUS-CERULEUS
CHARLETY PJ; CHERGUI K; AKAOKA H; SAUNIER CF; BUDA M; ASTONJONES G; CHOUVET G
Journal article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 1993;347(4):353-362
THE 5-HT(1A) RECEPTOR SELECTIVE LIGANDS, (R)-8-OH-DPAT AND (S)-UH-301, DIFFERENTIALLY AFFECT THE ACTIVITY OF MIDBRAIN DOPAMINE NEURONS
ARBORELIUS L; CHERGUI K; MURASE S; NOMIKOS GG; HOOK BB; CHOUVET G; HACKSELL U; SVENSSON TH
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(2):137-144
TONIC ACTIVATION OF NMDA RECEPTORS CAUSES SPONTANEOUS BURST DISCHARGE OF RAT MIDBRAIN DOPAMINE NEURONS INVIVO
CHERGUI K; CHARLETY PJ; AKAOKA H; SAUNIER CF; BRUNET JL; BUDA M; SVENSSON TH; CHOUVET G
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1992;219(1):169-172
INHIBITION OF LOCUS-CERULEUS NEURONS BY THE PHENCYCLIDINE ANALOG, N-[1-(2-BENZO(B)THIOPHENYL)CYCLOHEXYL]PIPERIDINE - EVIDENCE FOR POTENT INDIRECT ADRENOCEPTOR AGONIST PROPERTIES
CHERGUI K; AKAOKA H; BRUNET JL; CHARLETY PJ; SAUNIER CF; BUDA M; PRIVAT A; VIGNON J; KAMENKA JM; CHOUVET G
Journal article: NEUROSCIENCE. 1992;49(1):63-72
RELATIONSHIP BETWEEN DOPAMINE RELEASE IN THE RAT NUCLEUS-ACCUMBENS AND THE DISCHARGE ACTIVITY OF DOPAMINERGIC-NEURONS DURING LOCAL INVIVO APPLICATION OF AMINO-ACIDS IN THE VENTRAL TEGMENTAL AREA
SUAUDCHAGNY MF; CHERGUI K; CHOUVET G; GONON F
Journal article: JOURNAL OF NEUROSCIENCE METHODS. 1992;42(1-2):119-128
COMBINING INVIVO VOLUME-CONTROLLED PRESSURE MICROEJECTION WITH EXTRACELLULAR UNIT RECORDING
AKAOKA H; SAUNIER CF; CHERGUI K; CHARLETY P; BUDA M; CHOUVET G
Journal article: ACTA PHYSIOLOGICA. 1991;142(1):105-112
BURST FIRING OF MESENCEPHALIC DOPAMINE NEURONS IS INHIBITED BY SOMATODENDRITIC APPLICATION OF KYNURENATE
CHARLETY PJ; GRENHOFF J; CHERGUI K; DELACHAPELLE B; BUDA M; SVENSSON TH; CHOUVET G
Journal article: COMPTES RENDUS - BIOLOGIES. 1991;313(2):139-144
NMDA RECEPTORS ARE INVOLVED IN SPONTANEOUS BURST FIRING OF DOPAMINERGIC MESENCEPHALIC NEURONS
CHERGUI K; CHARLETY PJ; AKAOKA H; BRUNET JL; SAUNIER CF; BUDA M; SVENSSON TH; CHOUVET G
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All other publications

Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S14-S15
GluN2D-containing NMDA receptors in cholinergic interneurons control dopamine release in the mouse striatum
Zhang X; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S576-S577
Ethanol inhibits neurotransmission in the nucleus accumbens of juvenile mice through the activation of GABA receptors
Mishra D; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S26-S27
Gender-related differences in synaptic transmission and plasticity in the mouse striatum and nucleus accumbens
Schotanus SM; Chergui K
Editorial comment: CURRENT OPINION IN PHARMACOLOGY. 2007;7(1):1-2
Many ways to Rome - multiple approaches to novel drugs
Chergui K; Fredholm BB; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S17
Role of dopamine and NMDA receptor subunits in the induction of long term potentiation in the nucleus accumbens
Schotanus SM; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S15-S16
Regulation of synaptic transmission in the striatum by protein kinases
Chergui K
Published conference paper: JOURNAL OF MOLECULAR NEUROSCIENCE. 2005;26(2-3):239-244
Adenosine-dopamine interactions revealed in knockout mice
Salmi P; Chergui K; Fredholm BB
Review: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1997;280(1):83-97
Neurochemical characteristics of amisulpride, an atypical dopamine D-2/D-3 receptor antagonist with both presynaptic and limbic selectivity
Schoemaker H; Claustre Y; Fage D; Rouquier L; Chergui K; Curet O; Oblin A; Gonon F; Carter C; Benavides J; Scatton B
Review: NEUROSCIENCE. 1996;72(1):141-156
Burst stimulation of the medial forebrain bundle selectively increases Fos-like immunoreactivity in the limbic forebrain of the rat
Chergui K; Nomikos GG; Mathe JM; Gonon F; Svensson TH

Employments

Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2010-

Degrees and Education

Docent, Karolinska Institutet, 2006

About me

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Degrees and Education

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