Igor Adameyko
Principal Researcher
E-mail: igor.adameyko@ki.se
Telephone: +46852487142
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Utvecklingsbiologi och regenerativ medicin, 171 77 Stockholm
About me
- Currently, Dr. Igor Adameyko is a Professor and a Department Chair at Center
for Brain Research of Medical University of Vienna and a group leader at
Karolinska Institutet in Stockholm. Prof. Adameyko is known for the discovery
of multipotency of nerve-associated Schwann cell precursors, a population of
neural crest derived cells with exceptional plasticity and distribution in
the body.
*2015 *Swedish Academy of Sciences Flormanska
Prize
*2015* ERC Consolidator Grant
*2016 * Selected EMBO Young
Investigator
*2017* Hans Wigzell Prize
*2019* Fernstrom Prize
*2020* ERC Synergy Grant (Coordinator)
*2002 University degree with Honors (M.Sc.
in Biochemistry), *Lobachevsky University, Russian Federation.
*2006 Doctoral degree (PhD), *Lobachevsky
University, Russian Federation./ /
/Supervisors: Professor S. Tevosian - Professor A. Veselov/
*2002-2006 */ /*Visiting PhD student* in the lab of Professor
Tevosian,
Department of Genetics, Dartmouth Medical School, USA
Research
- The studies of Dr. Adameyko introduced a radically new concept for
developmental biology in that defined precursor pools existing in a highly
specialized niche use nerves as conduits to migrate and differentiate through
temporally and spatially delineated nerve-Schwann cell communication. Can
Schwann cells be genuinely multipotent? If so, this would transform the above
discoveries into a global concept in which nerve-associated progenitors could
generate various cell types during not only physiological development but
also adulthood. Moreover, any such cell pool could be exploited to regenerate
damaged tissues in tandem with regaining sensory nerve functions. This notion
is plausible since nerves traverse the entire body from early embryonic
development on and their in-growth coincides with the expansion of cell pools
in the organs they target. For decades, the prevailing concept was that the
only function of these peripheral nerves is to maintain activity patterns,
thus mostly sending unidirectional information. Instead, Igor Adameyko
proposed a non-canonical role in which nerve-associated glia also generates
parasympathetic neurons (Science, 2014), neuroendocrine chromaffin cells
(Science, 2017) and mesenchymal stem cells in tooth (Nature, 2014). These
studies also showed that resident Schwann cells retain their potential to
produce other cell fates in adulthood, advocating their utilization as a
source of transplantable cells. At the moment, many other independent
research groups have by now reproduced Adameyko’s original observations,
and expanded the concept of multipotent nerve-associated Schwann cells
building peripheral tissues. Thus, in a period spanning only a few years, the
concept of peripheral nerves serving as a “niche” and migration
“highways” has entered mainstream research, and led to a revision of how
the parasympathetic and sympatho-adrenal systems become established at
precise locations and with adequate cell numbers during fetal development.
Historically, Igor Adameyko’s background is in developmental biology.
Having extensive embryology-based experience, it is only natural that the lab
continues on this path today by exploring the origin of norm and pathology,
congenital diseases and paediatric cancers arising in the early or late
embryo.
“/We believe that our knowledge of embryonic development is extremely
helpful, as it is exactly the time when cells (i.e., different cell types)
experience a diversity of phenotypic states and transitions between such
states. During development, cells change enormously, and the genetic
programmes that are utilised by these altering cell states are later
exploited by the cancer cells as well. Many tumour types show the
developmental aspects in their dynamics, partly resembling a developing organ
or an assembling tissue- as they try to replay aspects of developmental
processes. This is where we think our ongoing work and understanding could
come in and be useful./”
*/Recent key papers:/*
1. Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier
L, Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino
M, Boismoreau F, Hilscher M, Yokota C, Nilsson M, Bronner M, Croci L, Hsiao
W, Guertin D, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV,
*Adameyko I*. Spatio-temporal structure of cell fate decisions in murine
neural crest. *Science* 2019.
2. Furlan A., Dyachuk V., Kastriti M., Abdo H., Hadjab S., Chontorotzea T.,
Akkuratova N., Usoskin D., Kamenev D., Petersen J., Sunadome K., Memic F.,
Marklund U., Fried K., Topilko P., Lallemend F., Kharchenko P., Ernfors P.,
*Adameyko I*. Multipotent Peripheral Glial Cells Generate Neuroendocrine
Cells of the Adrenal Medulla. *Science*. 2017. Jul 7 - 357(6346).
3. Dyachuk V., Furlan A., Khatibi Shahidi M., Giovenco M., Kaukua N.,
Konstantinidou C., Pachnis V., Memic F., Marklund U., Müller T., Birchmeier
C., Fried K., Ernfors P., *Adameyko I.* Parasympathetic neurons originate
from nerve-associated peripheral glial progenitors. *Science*,
4 - 345(6192):82-7, 2014.
*ERC Synergy Grant*
Our ERC Synergy project grant is focusing on neuroblastoma- a devastating
paediatric cancer. There is a huge unmet clinical need as almost 50% of
children that are positively diagnosed die. This cancer, which arises from
the sympathetic nervous system, has some type of embryonic origin starting
during the neural crest differentiation stage towards the sympathoadrenal
cells. Given our domain speciality (i.e., neural crest cells during embryonic
development), we believe that we will have some interesting new ideas to
understand the origin of neuroblastoma and ultimately fight it.
*NeuCrest Network*
We are a part of The NEUcrest project is an Innovative Training Network
funded by the EU’s Horizon 2020 programme
https://science.institut-curie.org/research/biology-chemistry-of-radiations-cell-signaling-and-cancer-axis/umr-3347-normal-and-pathological-signaling/team-monsoro-burq/european-neucrest-itn-network/
[1]
*State-of-the-art-methods*
We extensively apply single cell transcriptomics analysis with an aim to
discover the major principles of neural and immune cell type heterogeneity,
stem cell regulation, evolution of novel cell types and transitions between
gene regulatory networks. At the moment, we attempt to build a MERFISH system
for spatial transcriptomics as well as to establish Slide-seq protocols in
house.
[1] https://science.institut-curie.org/research/biology-chemistry-of-radiations-cell-signaling-and-cancer-axis/umr-3347-normal-and-pathological-signaling/team-monsoro-burq/european-neucrest-itn-network/
Articles
- Article: NATURE COMMUNICATIONS. 2024;15(1):7065
- Article: NATURE NEUROSCIENCE. 2024;27(4):601-605
- Article: NATURE COMMUNICATIONS. 2024;15(1):2367
- Article: NATURE GENETICS. 2023;55(11):1901-1911
- Article: PLOS COMPUTATIONAL BIOLOGY. 2023;19(11):e1011658
- Article: CURRENT BIOLOGY. 2023;33(20):4524-4531.e4
- Article: NATURE COMMUNICATIONS. 2023;14(1):5904
- Article: NATURE COMMUNICATIONS. 2023;14(1):3092
- Article: NATURE COMMUNICATIONS. 2023;14(1):3060
- Article: DEVELOPMENT. 2023;150(9):dev201164
- Article: NATURE NEUROSCIENCE. 2023;26(5):891-901
- Article: NATURE COMMUNICATIONS. 2022;13(1):6949
- Journal article: BIOESSAYS. 2022;44(9)
- Article: EMBO JOURNAL. 2022;41(17):e108780
- Article: NATURE COMMUNICATIONS. 2022;13(1):3878
- Article: CURRENT BIOLOGY. 2022;32(12):2596-2609.e7
- Article: SCIENCE ADVANCES. 2022;8(23):eabm6340
- Article: CANCERS. 2022;14(11):2755
- Article: NATURE COMMUNICATIONS. 2022;13(1):2901
- Article: SCIENTIFIC REPORTS. 2022;12(1):8728
- Article: GIGASCIENCE. 2022;11:giac030
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2022;219(2):e20211406
- Article: CANCER RESEARCH. 2022;82(3):484-496
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:1020000
- Article: NATURE COMMUNICATIONS. 2021;12(1):6830
- Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(176)
- Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2021;99(10):2540-2557
- Article: IMMUNITY. 2021;54(9):2005-2023.e10
- Article: NATURE COMMUNICATIONS. 2021;12(1):5309
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(16):6033-6049
- Article: NATURE GENETICS. 2021;53(5):694-706
- Article: ELIFE. 2020;9:e55212
- Article: NATURE COMMUNICATIONS. 2020;11(1):4816
- Article: NATURE COMMUNICATIONS. 2020;11(1):4175
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(30):17854-17863
- Article: NATURE. 2020;582(7811):246-252
- Article: DEVELOPMENTAL DYNAMICS. 2020;249(6):711-722
- Article: LIVER INTERNATIONAL. 2020;40(4):977-987
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:122
- Article: SCIENTIFIC REPORTS. 2019;9(1):14896
- Article: GENESIS (UNITED STATES). 2019;57(10):e23324
- Article: NATURE COMMUNICATIONS. 2019;10(1):4137
- Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(8):3888-3899
- Article: SCIENCE. 2019;365(6454):695-699
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(30):15068-15073
- Article: SCIENCE. 2019;364(6444):971
- Article: NATURE COMMUNICATIONS. 2019;10(1):2110
- Article: CELL REPORTS. 2019;26(13):3484-3492.e4
- Article: NATURE. 2019;567(7747):234-238
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13:454
- Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:6
- Article: NATURE GENETICS. 2019;51(1):36-41
- Article: DEVELOPMENTAL BIOLOGY. 2018;444(Suppl 1):S308-S324
- Article: SCIENTIFIC REPORTS. 2018;8(1):14145
- Article: NATURE. 2018;560(7719):494-498
- Article: ELIFE. 2018;7:e34465
- Article: SCIENCE SIGNALING. 2018;11(529):eaao1815
- Article: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2017;45:10-14
- Article: SCIENCE. 2017;357(6346):46
- Article: ELIFE. 2017;6:e25902
- Article: THE FASEB JOURNAL. 2017;31(3):1067-1084
- Article: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2017;11(1):129-137
- Article: SCIENCE ADVANCES. 2016;2(8):e1600060
- Article: CELL REPORTS. 2015;12(7):1144-1158
- Article: JOURNAL OF DENTAL RESEARCH. 2015;94(7):945-954
- Article: STEM CELL RESEARCH AND THERAPY. 2015;6(1):59
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;96(4):519-531
- Article: ZOOLOGY. 2014;117(5):293-294
- Article: NATURE. 2014;513(7519):551-554
- Article: SCIENCE. 2014;345(6192):82-87
- Article: EMBO REPORTS. 2014;15(4):383-391
- Article: EMBO JOURNAL. 2013;32(11):1613-1625
- Article: EVODEVO. 2013;4(1):12
- Article: EMBO JOURNAL. 2012;31(18):3718-3729
- Article: DEVELOPMENT. 2012;139(2):397-410
- Article: CELL. 2009;139(2):366-379
- Article: NEUROSCIENCE. 2009;162(4):1106-1119
- Article: JOURNAL OF NEUROSCIENCE. 2008;28(4):963-975
- Article: DEVELOPMENTAL BIOLOGY. 2007;307(2):356-367
- Article: DEVELOPMENTAL DYNAMICS. 2005;234(2):355-362
- Article: DEVELOPMENTAL DYNAMICS. 2005;233(2):540-552
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All other publications
- Editorial comment: CELL STEM CELL. 2023;30(5):501-502
- Review: CURRENT BIOLOGY. 2023;33(8):R319-R331
- Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;138:68-80
- Letter: CANCER CELL. 2021;39(5):590-591
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(2):513-529
- Review: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;518:110998
- Corrigendum: SCIENTIFIC REPORTS. 2020;10(1):2276
- Review: CURRENT OPINION IN CELL BIOLOGY. 2019;61:24-30
- Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019;91:2-12
- Editorial comment: CELL STEM CELL. 2019;24(2):195-197
- Review: DEVELOPMENTAL BIOLOGY. 2018;444:S25-S35
- Editorial comment: SCIENCE. 2018;362(6412):290-291
- Published conference paper: JOURNAL OF INSTRUMENTATION. 2018;13:c02039
- Review: CURRENT OPINION IN NEUROBIOLOGY. 2017;47:196-202
- Review: FRONTIERS IN PHYSIOLOGY. 2017;8:376
- Editorial comment: SCIENCE. 2016;354(6314):833-834
- Published conference paper: JOURNAL OF INSTRUMENTATION. 2016;11:c03006
- Other: STEM CELL INVESTIGATION. 2016;3:74
- Review: FRONTIERS IN PHYSIOLOGY. 2016;7:49
- Editorial comment: CELL CYCLE. 2014;13(18):2805-2806
- Review: EXPERIMENTAL CELL RESEARCH. 2014;321(1):17-24
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(18):3037-3055
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