Bennie Lemmens

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About me

Assistant Professor & Principal investigator at Department of Medical Biochemistry and Biophysics / Group Leader SciLifeLab Lemmens laboratory ↳ DNA replication ↳ Time-resolved genetics ↳ Nanoscale imaging 2022-2027: ASPIRE award for Innovative Cancer Research (Mark foundation, US) 2022-2026: 100% KID grant for top-ranked junior group leaders at KI 2020-2021: Awarded start-up grant in Medicine by the Åke Wiberg foundation 2020-2021: Awarded start-up grant by the Jeanssons foundation 2020-2021: Blue Sky Continuation Award for Innovative Cancer Research 2020-2021: Awarded Special KI research grant for top-ranked junior scientists 2020-2024: KID funding to support doctoral education 2020-2024: Awarded 4-year Starting Grant by the Swedish Research Council (VR) 2019-2020: Blue Sky Award for Innovative Cancer Research (KI-Cancer/StratCan) 2018-2019: Awared KI research grant for young scientists 2017-2020: Awared 3-year fellowship by the Swedisch Cancer foundation 2016-2017: Awared KI research grant for young scientists 2014-2016: Awarded 2-year fellowship by the Wenner-Gren foundation

Research

My research group focuses on understanding how human cells copy their DNA and maintain genome stability. We apply advanced genetics and imaging techniques to control and visualize DNA replication in time and space.

Articles

Article: CELL DEATH AND DIFFERENTIATION. 2023;30(7):1666-1678

Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET.

Kanellis DC; Zisi A; Skrott Z; Lemmens B; Espinoza JA; Kosar M; Björkman A; Li X; Arampatzis S; Bartkova J; Andújar-Sánchez M; Fernandez-Capetillo O; Mistrik M; Lindström MS; Bartek J
Article: NUCLEIC ACIDS RESEARCH. 2022;50(11):6235-6250

THO complex deficiency impairs DNA double-strand break repair via the RNA surveillance kinase SMG-1.

Kamp JA; Lemmens BBLG; Romeijn RJ; González-Prieto R; Olsen JV; Vertegaal ACO; van Schendel R; Tijsterman M
Article: NATURE COMMUNICATIONS. 2021;12(1):7126

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.

Kamp JA; Lemmens BBLG; Romeijn RJ; Changoer SC; van Schendel R; Tijsterman M
Article: MOLECULAR CELL. 2018;71(1):117-128.e3

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation.

Lemmens B; Hegarat N; Akopyan K; Sala-Gaston J; Bartek J; Hochegger H; Lindqvist A
Article: NATURE COMMUNICATIONS. 2015;6:8909

Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers.

Lemmens B; van Schendel R; Tijsterman M
Article: GENETICS. 2013;195(3):1187-1191

CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans.

Waaijers S; Portegijs V; Kerver J; Lemmens BBLG; Tijsterman M; van den Heuvel S; Boxem M
Article: PLOS GENETICS. 2013;9(3):e1003339

A role for the malignant brain tumour (MBT) domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

Johnson NM; Lemmens BBLG; Tijsterman M
Article: PLOS GENETICS. 2013;9(2):e1003276

COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining.

Lemmens BBLG; Johnson NM; Tijsterman M
Article: CURRENT BIOLOGY. 2006;16(19):1950-1955

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.

Mamely I; van Vugt MA; Smits VAJ; Semple JI; Lemmens B; Perrakis A; Medema RH; Freire R

All other publications

Review: JOURNAL OF CELL BIOLOGY. 2019;218(12):3892-3902

DNA replication and mitotic entry: A brake model for cell cycle progression.

Lemmens B; Lindqvist A
Review: CHROMOSOMA. 2011;120(1):1-21

DNA double-strand break repair in Caenorhabditis elegans.

Lemmens BBLG; Tijsterman M

Grants

ASPIRE award for Innovative Cancer Research

The Mark Foundation for Cancer Research

1 November 2023 - 1 November 2027
DNA replication and repair: a clearer picture on timing and therapies

Swedish Research Council

1 January 2020 - 31 December 2023

Employments

Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2020-
Assistant Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021-2027

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