Apostolos Bossios

Apostolos Bossios

Principal Researcher | Docent
Visiting address: Nobels väg 13, 17177 Solna
Postal address: C6 Institutet för miljömedicin, C6 Lung- och luftvägsforskning Bossios, 171 77 Stockholm
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About me

    • Associate Professor (Docent) of Respiratory Medicine
    • Senior Consultant Respiratory Physician at Karolinska University Hospital.
    • Principal Researcher at the Institute of Environmental Medicine, Unit of Lung and Airway Research.
    • Research group leader at the Institute of Environmental Medicine, Unit of Lung and Airway Research.
    • Research Group Leader at the Center for Molecular Medicine

Research

  • I am a respiratory physician-scientist, combining active clinical duties with clinical and translational research on airway diseases, particularly severe asthma and bronchiectasis.

    My research aims to link the clinical symptoms and signs of severe asthma and bronchiectasis with the underlying inflammatory and immunological mechanisms. Our goal is to contribute to a better understanding of these diseases, ultimately improving the well-being of our patients.

    Currently, our focus is on the role of T-regulatory cells in the immunoregulation of inflammation in airway diseases.

Teaching

  • I actively participate in medical education at the graduate and post-graduate levels. 

    Teaching  at the graduate level for medical and dental students  and the 
    post-graduate level for nurses at  Karolinska Institutet.

    PhD supervisor

    On-going

    • Pia Ghosh MD,   Karolinska Institutet. Principal supervisor
    • Lorenz Wirth Msc, Karolinska Institutet.Co-supervisor.
    • Yitao Gong, Msc, Karolinska Institutet.Co-supervisor


    Completed

    • You Lu, M.D. , PhD 2011, Gothenburg University, Principal Supervisor.
    • Carina Malmhäll MSc , Ph.D. 2014, Gothenburg University, Co-supervisor.
    • Stig Hagstad, MD , Ph.D. 2015, Gothenburg University, Co-supervisor.
    • Berne Eriksson, MD , Ph.D. 2017, Gothenburg University, Co-supervisor.
    • Elza Evren M.Sci. , Ph. D 2022, Karolinska Institutet, Co-supervisor.
    • Valentyna Yasinska, MD (Ph. D 2023, Karolinska Institutet, Co-supervisor.
    • Yuanyan Wang MD, Ph.D. 2025, Karolinska Institutet. Co-supervisor.

Articles

All other publications

Grants

  • Severe Asthma with bronchiectasis – exploring the role of regulatory T cells.
    The Swedish Heart-Lung Foundation
    1 January 2025 - 31 December 2027
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Biomass burning for cooking and heating produces a toxic cocktail of particulate matter (PM) and gaseous pollutants, resulting in chronic lung issues. Around 0.5-0.6 million deaths occur annually in India, mainly in the Indo-Gangetic Plains, from exposure to indoor air pollutants, indicating the multifaceted healthcare, economic and environmental burden in households, where biomass burning prevails. And yet, ground-based indoor exposure data are sparse, there is poor awareness about air pollution, and clean energy initiatives are lagging. We hypothesize that biomass combustion and PM exposure is related to specific pollutant classes (triggers) and their synergistic interactions, which trace early metabolic changes in plasma to diagnose asthma, lung aging, and chronic pulmonary obstructions. We aim to 1) conduct socioeconomic and health surveys and develop real-time indoor pollutant monitoring using automated sensor networks, 2) analyze organic compounds and oxidative metals that cause pulmonary stress, and 3) identify novel biomarkers in plasma and combine this with integrative transcriptomics, epidemiological and environmental chemical data. The proposed synergistic and integrated work packages on PM characteristics and metabolomics will establish causality with exposure posing a breakthrough for early clinical diagnosis. This strategy will help healthcare measures and mitigation plans advance the UN Sustainable Development Goals 3 and 7 for better air quality and health.
  • Understanding the role of diabetes and bronchiectasis as sub-phenotypes in severe asthma.
    Swedish Heart-Lung Foundation
    1 January 2023 - 31 December 2025
  • Swedish Heart-Lung Foundation
    1 January 2021 - 31 December 2022
  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • Unfolding treatable traits of obesity and Bronchiectasis as sub-phenotypes in severe asthma.
    Swedish Heart-Lung Foundation
    1 January 2021 - 31 December 2022
  • Swedish Heart-Lung Foundation
    1 January 2020 - 31 December 2022
  • Swedish Heart-Lung Foundation
    1 January 2019 - 31 December 2021
  • Swedish Heart-Lung Foundation
    1 January 2019 - 31 December 2020

Employments

  • Principal Researcher, Institute of Environmental Medicine, Karolinska Institutet, 2022-

Degrees and Education

  • Docent, Karolinska Institutet, 2021

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